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Plant-derived anticancer agents: A green anticancer approach

Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1129-1150页

作者： Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal Barkat ali Sayed Afzal Shah ali talha khalil Department of Plant Sciences Quaid-i-Azam University Islamabad45320Pakistan Department of Zoology University of GujratSub Campus RawalpindiPakistan Department of Eastern Medicine and Surgery Qarshi UniversityLahorePakistan UNESCO UNISA Africa chair in nanoscience and nanotechnology South Africa Nanosciences African Network(NANOAFNET) South Africa

Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment *** are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed.

关键词： Cancer Limitations of anticancer drugs Phytochemicals Analogs

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Dietary isoflavones,the modulator of breast carcinogenesis:Current landscape and future perspectives

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 186-193页

作者： Javed Iqbal Banzeer Ahsan Abbasi ali talha khalil Barkat ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid ali Department of Plant Sciences Quaid-i-Azam University Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa chair in nanoscience and nanotechnology Nanosciences African Network(NANOAFNET) Department of Zoology University of GujratSub Campus

Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, U V radiation,and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in RRCAI and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender,race, ethnicity, weight, reproductive factors, exo-and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work(circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action.

关键词： Dietary isoflavones Breast cancer Signaling pathways Natural phytoestrogens

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Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 501-509页

作者： Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood ali talha khalil Barkat ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad Department of Plant Sciences Quaid-i-Azam University Nanosciences African Network(NANOAFNET) iThemba LABS-National Research Foundation Somerset West Department of Zoology University of GujratSub Campus Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa Chair in Nanoscience and Nanotechnology College of Graduate StudiesUniversity of South Africa College of Life Sciences Shaanxi Normal University

The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the *** many cases,BC becomes resistant to chemotherapy,radiation and hormonal *** BC therapies are associated with adverse side effects,drug resistance and *** research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against *** have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo *** have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC ***,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed.

关键词： Breast cancer miRNAs Dietary phytochemicals In vitro In vivo

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Antifungal, phytotoxic and hemagglutination activity of methanolic extracts of Ocimum basilicum

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Journal of Traditional Chinese Medicine 2016年第6期36卷 794-798页

作者： Kafeel Ahmad ali talha khalil Yusra Ramla Somayya Centre of Biotechnology and Microbiology University of Peshawar

OBJECTIVE: To report some of the pharmacological features of the medicinal plant Ocimum ***: In the current studies, Antifungal activity of crude methanolic fraction of Ocimum basilicum was determined against eight pathogenic fungal strains using tube dilution assay. The methanolic fraction was also investigated for phytotoxic and hemagglutination ***: Of the eight strains investigated only Candida albicans and Curvilaria lunata were found to be least affected by plant extract while the rest were significantly inhibited. Moderate phytotoxic activity was observed against lemna minor. Hemagglutination activity showed absence of phytolectins and hence no agglutination of ***: The crude extract of Ocimum basilicum has significant properties against fungi and phytotoxic substances.

关键词： Plants,toxic Antifungal agents Pathogenicity Ocimum basilicum

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Synergistic antibacterial effect of honey and Herba Ocimi Basilici against some bacterial pathogens

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Journal of Traditional Chinese Medicine 2013年第6期33卷 810-814页

作者： ali talha khalil Imran Khan Kafeel Ahmad Yusra ali Khan Momin Khan Muhammad Jaseem Khan Department of Biotechnology Quaid-i-Azam University Centre of Biotechnology and Microbiology University of Peshawar Institute of Paramedical Sciences Khyber Medical University

OBJECTIVE： To evaluate the antibacterial activity of the combination of different honey brands and methanolic fraction of Herba Ocimi Basilici using agar well diffusion assay. METHODS： The antibacterial activity was deter- mined against thirteen pathogenic bacterial clini- cal isolates including six gram negative （Klebsiella pneumonia, Pseudomonas aeroginosa, Escherichia coli, Salmonella typhi, Salmonella typhimirium, Xanthomonas campestris） and six gram positive strains （Enterococcus faecalis faecalis, Bacillus subti- lis, Staphylococcus aureus, Clostridium perfringens type C, Clostridium perfringens type D, CIostridium chauvoei）. Agar well diffusion method was used while zones of inhibition were measured with verni- er scale. RESULTS： At higher concentration, all the honey brands showed good to significant activity. Thehighest activity was observed for Hamdard brand honey （27.60±0.40） against Enterococcus faecalis. CONCLUSION： These results revealed that combi- nations of plant extracts of Herba Ocimi Basilici with honey can be used for the development of potent and novel antibacterial agents.

关键词： Anti-infective agents Honey Gram-negative bacteria Gram-positive bacteria Well dif-fusion assay

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Antibacterial activity of honey in north-west Pakistan against select human pathogens

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Journal of Traditional Chinese Medicine 2014年第1期34卷 86-89页

作者： ali talha khalil Imran Khan Yusra ali Khan Zabta Khan Shinwari Kafeel Ahmad Jangrez Khan Department of Biotechnology Quaid-i-Azam University Centre of Biotechnology and Microbiology University of Peshawar Department of Biochemistry Quaid-i-Azam University

OBJECTIVE:To investigate the antimicrobial activity of commercially available honey and raw honey samples in Khyber Pakhtunkhwa,Pakistan,against pathogenic bacterial ***:Well diffusion assays were performed to screen pure and diluted honey samples for antibacterial activity against six Gram-negative and six Gram-positive bacterial *** of inhibition were measured and compared with 10 mg ***:When honey samples were diluted to20%-70%,the honey samples showed no activity to mild antibacterial *** highest antibacterial activity was recorded when 90%and pure undiluted honey samples were tested and compared with a control Gentamycin disc(10 mg).CONCLUSION:Commercially processed honey and raw honey samples from north-west of Pakistan possess good antimicrobial potential.

关键词： Anti-bacterial agents Disk diffusion an-timicrobial tests Honey

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Evaluation of antileishmanial,antibacterial and brine shrimp cytotoxic potential of crude methanolic extract of Herb Ocimum basilicum(Lamiacea)

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Journal of Traditional Chinese Medicine 2015年第3期35卷 316-322页

作者： Imran Khan Kafeel Ahmad ali talha khalil Jangrez Khan Yusra ali Khan Muhammad Shahab Saqib Muhammad Naveed Umar Hilal Ahmad Department of Biotechnology Quaid-i-Azam University Centre of Biotechnology and Microbiology University of Peshawar Department of Biochemistry Quaid-i-Azam University Islamabad Department of Chemistry University of Malakand Institute of Biotechnology and Genetic Engineering Agriculture UniversityPeshawar

OBJECTIVE:To collect and screen for ethnopharmacological properties(antileishmanial,antibacterial and brine lethality assays) of medicinal plant Ocimum basilicum from Peshawar region(34.008 latitude and 71.57 altitudes).METHODS:In the present study a general antileishmanial activity against Leishmania tropica strain was carried *** antibacterial potential of the plant was performed against 06 gram positive and 06 gram negative *** shrimp cytotoxicity assay at different concentrations were ***:The anti-promastigotes profile of the plant showed good antileishmanial activity exhibited LC_(50) value 21.67 μg/*** result for gram positive antibacterial activity revealed that the *** leaves extract possesses significant inhibitory activity at highest two concentrations ranging from20.66 ± 0.31 to 31.86 ± 0.80 for Clostridium perfringens type C and Bacillus subtitilis,respectively,as compared to the gentamycin(27.36 ± 0.55 and21.80 ± 0.72,respectively).For gram negative bacteria good activity was observed.A highest zone of inhibition was recorded for Pseudomonas aeroginosa(28.83 ± 0.28) atthe highest concentration(10 mg/mL).The LC_(50) value obtained for brine shrimp lethality assay was 91.56 μg/***:The herb basil possesses effective cidal activities which make this plant a good candidate for the isolation of antiprotozoal and antibacterial compounds which may lead to the development of novel drug.

关键词： Ocimum basilicum Cytotoxicity tests,immunologic Anti-bacterial agents Antileishmanial activity

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Efficacy and safety of thermobalancing therapy with Dr Allen’s Device for chronic low back pain:A randomised controlled trial

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World Journal of Orthopedics 2023年第12期14卷 878-888页

作者： Simon Allen Abid Rashid Ariana Adjani Muhammad Akram Fahad Said Khan Rehan Sherwani Muhammad talha khalil Director and Head of Medical Research Fine TreatmentOxford OX27SLUnited Kingdom Director of Faculty of Medical Sciences Government College University FaisalabadFaisalabad 38000Pakistan Senior Researcher Fine TreatmentOxford OX27SLUnited Kingdom Department of Eastern Medicine Government College University FaisalabadFaisalabad 38000Pakistan Faculty of Medical and Health Sciences University of Poonch RawalakotRawalakot 12350Pakistan College of Statistical and Actuarial Science University of the PunjabLahore 54000Pakistan

BACKGROUND Lumbar disc herniation and non-specific low back pain are common conditions that seriously affect patients’health-related quality of life(HRQoL).Although empirical evidence has demonstrated that novel Thermobalancing therapy and Dr Allen’s Device can relieve chronic low back pain,there have been no randomised controlled trials for these *** To evaluate the efficacy of Dr Allen’s Device in lumbar disc herniation(LDH)and non-specific low back pain(NSLBP).METHODS A randomised clinical trial was conducted investigating 55 patients with chronic low back pain due to LDH(n=28)or NSLBP(n=27),out of which 15 were randomly assigned to the control group and 40 were assigned to the treatment *** intervention was treatment with Dr Allen’s Device for 3 *** in HRQoL were assessed using the Numerical Pain Rating Scale and the Japanese Orthopedic Association Back Pain *** Thermobalancing therapy with Dr Allen’s Device showed a significant reduction in pain in the treatment group(P<0.001),with no recorded adverse *** pain assessment scales showed a significant improvement in patients’perception of pain indicating improvement in *** The out-of-hospital use of Thermobalancing therapy with Dr Allen’s Device for Low Back Treatment relieves chronic low back pain significantly and without adverse effects,improves the level of activity and HRQoL among patients with LDH and *** study demonstrates the importance of this safe first-line therapy that can be used for effective at-home management of chronic low back pain.

关键词： Chronic low back pain Lumbar disc herniation Non-specific low back pain Thermobalancing therapy Dr Allen’s Device Numerical pain rating scale

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Role of T cells in cancer immunotherapy:Opportunities and challenges

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Cancer Pathogenesis and Therapy 2023年第2期1卷 116-126页

作者： Hossain Ahmed Aar Rafi Mahmud Mohd.Faijanur-Rob-Siddiquee Asif Shahriar Partha Biswas Ebrahim khalil Shimul Shahlaa Zernaz Ahmed Tanzila Ismail Ema Nova Rahman Arif Khan Furkanur Rahaman Mizan talha Bin Emran Department of Biotechnology and Genetic Engineering University of Development Alternative(UODA)4/4BBlock ALalmatiaDhaka1209Bangladesh Department of Biochemistry and Molecular Biology Mawlana Bhashani Science and Technology UniversityTangail1902Bangladesh Department of Biochemistry and Molecular Biology Faculty of Biological ScienceUniversity of DhakaDhaka1000Bangladesh Department of Immunology and Microbiology School of MedicineUniversity of Texas Rio Grande ValleyMcAllenTX78504USA Department of Genetic Engineering and Biotechnology Faculty of Biological Science and TechnologyJashore University of Science and Technology(JUST)Jashore7408Bangladesh Department of Biochemistry and Microbiology North South UniversityDhaka1229Bangladesh Department of Biochemistry and Molecular Biology Jahangirnagar UniversitySavarDhaka1342Bangladesh Department of Food Science and Technology Chung-Ang UniversityAnseong17546Republic of Korea Department of Pharmacy BGC Trust University BangladeshChittagong4381Bangladesh Department of Pharmacy Faculty of Allied Health SciencesDaffodil International UniversityDhaka1207Bangladesh

Immunotherapies boosting the immune system's ability to target cancer cells are promising for the treatment of various tumor types,yet clinical responses differ among patients and ***,there has been increasing interest in novel cancer immunotherapy practices aimed at triggering T cell-mediated anti-tumor ***-directed cytotoxicity mediated by T lymphocytes has become a central focal point in the battle against cancer utilizing the immune *** molecular and cellular mechanisms involved in the actions of T lymphocytes have directed new therapeutic approaches in cancer immunotherapy,including checkpoint blockade,adoptive and chimeric antigen receptor(CAR)T cell therapy,and cancer *** review addresses all the strategies targeting tumor pathogenesis,including metabolic pathways,to evaluate the clinical significance of current and future immunotherapies for patients with cancer,which are further engaged in T cell activation,differentiation,and response against tumors.

关键词： Immunotherapy T cell Cancer Immune system Metabolic pathways

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