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Relation of binge eating disorder with impulsiveness in obese individuals

World Journal of Psychiatry 2017年第2期7卷 114-120页

作者： Cenk Ural Hasan Belli Mahir Akbudak ali solmaz Zuhal Dogan Bektas Fatih Celebi Department of Psychiatry Health Sciences University Bagcilar Education And Research Hospital Department of Psychiatry Mardin State Hospital Department of General Surgery Health Sciences University Bagcilar Education And Research Hospital

AIM To investigate the levels of impulsiveness, and the relationship between the binge eating disorder(BED) and the levels of impulsiveness in obese *** Two hundred and forty-one obese patients who were included in the study and candidate for bariatric surgery(weight loss surgery) were clinically interviewed to identify the BED group, and patients were divided into two groups: Those with BED and those without BED. The comorbidity rate of groups was determined by using structured clinical interview for DSM-Ⅳ(SCID-Ⅰ). A sociodemographic data form including the story of previous psychiatric treatment, structured clinical interview for DSM-Ⅳ(SCID-Ⅰ), Beck Anxiety Inventory, Beck Depression Inventory(BDI) and Barratt Impulsiveness Scale-11 were applied to both of the *** In regard to 241 obese individuals included in the study, total score and score of attention subscale for BED(+) group were significantly high(P < 0.05). In addition, suicide attempt, story of psychiatric consultation, and score for BDI were again significantly high in the BED(+) group(P < 0.05).CONCLUSION In assessment of obese individuals, assessment of associated psychopathology such as impulsive characteristics and suicide attempt in addition to disrupted eating behaviors will allow to have a more extensive view.

关键词： Binge eating Obesity Impulsiveness

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Human microbiome and prostate cancer development:current insights into the prevention and treatment

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Frontiers of Medicine 2021年第1期15卷 11-32页

作者： solmaz Ohadian Moghadam Seyed ali Momeni Uro-Oncology Research Center Tehran University of Medical SciencesTehranIran

The huge communities of microorganisms that symbiotically colonize humans are recognized as significant players in health and *** human microbiome may influence prostate cancer *** date,several studies have focused on the effect of prostate infections as well as the composition of the human microbiome in relation to prostate cancer *** studies suggest that the microbiota of men with prostate cancer significantly differs from that of healthy men,demonstrating that certain bacteria could be associated with cancer development as well as altered responses to *** healthy individuals,the microbiome plays a crucial role in the maintenance of homeostasis of body *** may contribute to the emergence of health problems,including malignancy through affecting systemic immune responses and creating systemic inflammation,and changing serum hormone *** this review,we discuss recent data about how the microbes colonizing different parts of the human body including urinary tract,gastrointestinal tract,oral cavity,and skin might affect the risk of developing prostate ***,we discuss strategies to target the microbiome for risk assessment,prevention,and treatment of prostate cancer.

关键词： microbiome prostate cancer prevention treatment molecular pathological epidemiology(MPE) biomarker

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Preparation, characterization and in vivo evaluation of alginate-coated chitosan and trimethylchitosan nanoparticles loaded with PR8 influenza virus for nasal immunization

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Asian Journal of Pharmaceutical Sciences 2019年第2期14卷 216-221页

作者： Jafar Mosafer Amir-Hossein Sabbaghi ali Badiee solmaz Dehghan Mohsen Tafaghodi Research Center of Advanced Technologies in Medicine Torbat Heydariyeh University of Medical Sciences School of Pharmacy Mashhad University of Medical Sciences Student Research Committee Mashhad University of Medical Sciences Nanotechnology Research Center Pharmaceutical Technology Institute Mashhad University of Medical Sciences

For efficient mucosal vaccine delivery, nanoparticulate antigens are better taken by microfold cells in the nasal associated lymphoid tissue and also dendritic cells. Nanoparticles based on polymers such as chitosan(CHT) and its water soluble derivative, trimethylchitosan(TMC), could be successfully used as carrier/adjuvant for this purpose. Sodium alginate, a negatively charged biopolymer, could modify the immunostimulatory properties of CHT and TMC NPs and increase their stability. Sodium alginate(ALG)-coated chitosan(CHT)and trimethylchitosan(TMC) nanoparticles(NPs) loaded with inactivated PR8 influenza virus were successfully prepared by direct coating of the virus with CHT or TMC polymers to evaluate their immunoadjuvant potential after nasal immunization. After nasal immunizations in BALB/c mice, PR8-CHT formulation elicited higher IgG2 a and Ig G1 antibody titers compared with PR8-TMC. ALG coating of this formulation(PR8-CHT-ALG) significantly decreased the antibody titers and a less immune response was induced than PR8-TMC-ALG formulation. PR8-TMC-ALG formulation showed significantly higher Ig G2 a/Ig G1 ratio, as criteria for Th1-type immune response, compared with PR8-CHT-ALG and PR8 virus alone. Altogether, the PR8-TMC-ALG formulation could be considered as an efficient intranasal antigen delivery system for nasal vaccines.

关键词： Chitosan Trimethyl chitosan Alginate PR8 influenza virus Nasal immunization

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Tissue adhesive hemostatic microneedle arrays for rapid hemorrhage treatment

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Bioactive Materials 2023年第5期23卷 314-327页

作者： Reihaneh Haghniaz Han-Jun Kim Hossein Montazerian Avijit Baidya Maryam Tavafoghi Yi Chen Yangzhi Zhu solmaz Karamikamkar Amir Sheikhi ali Khademhosseini Department of Bioengineering University of CaliforniaLos Angeles410 Westwood PlazaLos AngelesCA90095United States California NanoSystems Institute University of CaliforniaLos Angeles570 Westwood PlazaLos AngelesCA90095United States Terasaki Institute for Biomedical Innovation 11570 W Olympic BoulevardLos AngelesCA90024United States Department of Chemical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States Department of Biomedical Engineering The Pennsylvania State UniversityUniversity ParkPA16802United States

Blood loss by hemorrhaging wounds accounts for over one-third of~5 million trauma fatalities worldwide every *** not controlled in a timely manner,exsanguination can take lives within a few *** new biomaterials that are easy to use by non-expert patients and promote rapid blood coagulation is an unmet medical ***,biocompatible,and biodegradable microneedle arrays(MNAs)based on gelatin methacryloyl(GelMA)biomaterial hybridized with silicate nanoplatelets(SNs)are developed for hemorrhage *** SNs render the MNAs hemostatic,while the needle-shaped structure increases the contact area with blood,synergistically accelerating the clotting time from 11.5 min to 1.3 min in *** engineered MNAs reduce bleeding by~92%compared with the untreated injury group in a rat liver bleeding ***-containing MNAs outperform the hemostatic effect of needle-free patches and a commercial hemostat in vivo via combining micro-and nanoengineered ***,the tissue adhesive properties and mechanical interlocking support the suitability of MNAs for wound closure *** hemostatic MNAs may enable rapid hemorrhage control,particularly for patients in developing countries or remote areas with limited or no immediate access to hospitals.

关键词： Hemostat Microneedles Hemorrhage Bleeding Gelatin methacryloyl Silicate nanoplatelets

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Coagulase gene polymorphism of Staphylococcus aureus isolates: A study on dairy food products and other foods in Tehran, Iran

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Food Science and Human Wellness 2016年第4期5卷 186-190页

作者： Mohammad Mehdi Soltan Dallal Mohammad Reza Khoramizadeh solmaz Agha Amiri ali Akbar Saboor Yaraghi Ramin Mazaheri Nezhad Fard Division of Food Microbiology Department of PathobiologySchool of Public HealthTehran University of Medical SciencesTehranIran Food Microbiology Research Center Tehran University of Medical SciencesTehranIran Department of Medical Biotechnology School of Advanced Technologies in MedicineIran Biosensor Research Center Endocrinology and Metabolism Cellular and Molecular Science InstituteTehran University of Medical SciencesIran Division of Immunology Department of PathobiologySchool of Public HealthTehran University of Medical SciencesTehranIran

Coagulase is considered as a major determinant factor for the identification of Staphylococcus aureus *** 3-end coding region of the coagulase(coa)gene contains a series of 81-bp tandem repeats,which differ in the number and location of enzymatic restriction sites among different *** PCR-RFLP has been used widely to type *** isolates in epidemiological *** current study was conducted to investigate the coagulase gene polymorphisms in *** isolated from various food samples using an in house PCR-RFLP method.A total of 100 strains of *** were isolated from food *** were typed by PCR-RFLP analysis using NdeI restriction digestion of the coagulase gene PCR *** showed that amplification of coagulase genes from *** produced different PCR *** isolates were grouped into 18 genotypes using RFLP analysis results of the *** this study,the *** isolates have been shown to include more than one coagulase genotype,but only had a few coa genotypes predominated.

关键词： Staphylococcus aureus PCR-RFLP Coagulase gene Food samples

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Frequency and safety of COVID-19 vaccination in children with multisystem inflammatory syndrome:a telephonic interview-based analysis

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World Journal of Pediatrics 2022年第10期18卷 700-705页

作者： Kubra Aykac Kubra Ozturk Osman Oguz Demir Dilan Demir Gumus Sevgi Aslan Ela Cem Miray Yilmaz Celebi Mustafa Dogan Karabacak Gulsum Alkan Fatma Dilsad Aksoy Burcu Ceylan Cura Yayla Eda Kepenekli solmaz Celebi Melike Emiroglu Ilker Devrim ali Bulent Cengiz Mehmet Ceyhan Yasemin Ozsurekci Faculty of Medicine Department of Pediatric Infectious DiseasesHacettepe UniversityAnkaraTurkey Goztepe Prof.Dr.Suleyman Department of Pediatric RheumatologyYalcın City HospitalIstanbulTurkey Faculty of Medicine Department of Pediatric DiseasesHacettepe UniversityAnkaraTurkey Department of Pediatric Infectious Diseases Marmara University School of MedicineIstanbulTurkey Department of Pediatric Infectious Diseases Dr.Behçet Uz Children’s HospitalízmirTurkey Faculty of Medicine Department of Pediatric Infectious DiseasesSelcuk UniversityKonyaTurkey Faculty of Medicine Department of Pediatric Infectious DiseasesUludag UniversityBursaTurkey Department of Pediatric Infectious Diseases University of Health Science Ankara Training and Research HospitalAnkaraTurkey

Coronavirus disease 2019(COVID-19)vaccines are currently approved or authorized to prevent serious outcomes,such as severe disease,hospitalization,and *** Pfizer-BioNTech vaccine is recommended for everyone aged five and older in the United States(US)to prevent severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection[1,2].However,it is unclear whether children with a history of multisystem,inflammatory syndrome in children(MIS-C)may be at risk for a MIS-like response following COVID-19 vaccination or SARS-CoV-2 reinfection[2].Therefore,physicians remain uncertain about vaccinating children with a history of *** study investigates the occurrence of severe,systemic side effects of COVID-19 vaccines and the recurrence of the MIS-C symptoms in children with a history of MIS-C to overcome vaccine hesitancy.

关键词： vaccination vaccine Pfizer

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