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Genomic Profile of SARS-COV-2 Associated with COVID-19 Outbreaks in N’Djamena, Chad

Advances in Bioscience and Biotechnology 2024年第7期15卷 432-442页

作者： Mathieu Hota Henry Yandai Fissou Dezoumbe Koutaya Djallaye Djimtoïbaye Mahamat moussa ali cole Doctorale Sciences Techniques et Environnement Universit de NDjamena NDjamena Tchad Institut de Recherche en Elevage pour le Dveloppement NDjamena Tchad Laboratoire des Grandes pidmies Tropicales du CHU le Bon Samaritain NDjamena Tchad Facult des Sciences de la Sant Humaine (FSSH) Universit de NDjamena NDjamena Tchad

Background: SARS-CoV-2 has circulated worldwide with dramatic consequences. In Chad, we have no data reported of variants. The aim of this study was to identify the SARS-CoV-2 variants that circulated during the epidemic from 2020 to 2021. Methods: This is a cross-sectional, descriptive study carried out between 2020 and 2021. Samples from patients with suspected COVID-19 were tested in five laboratories in N’Djamena. One hundred quality samples of the positives were sequenced in Kinshasa using Oxford nanopore technologies minion and the Protocol Midnight SARS-CoV2. Data were processed using Excel version 16 software. Results: Of the 100 samples sequenced, 77 (77%) produced sequences, 23 (23%) did not. The genomic profiles were wild-type Wuhan and minor mutations (19A, 19B (A), 20A (B.1, B.2), 20B (AV.1), 20D (B.1.1.1 /C.36), 20C), variant of concern Alpha (20I), variant of concern Delta (21A/J), variant of interest Eta (21D), variant of concern Omicron (21K) and unclassified variant under surveillance (B.1.640). Of these variants, the maximums were detected in patients aged 26 - 35 with 30.26% and 25.26% in 36 - 45. However, 24.67% were in travelers and 75.32% in residents, 35.06% in those vaccinated against COVID-19 and 62.33% in non-vaccinates. The estimated case-fatality rate was 2.44% (107/4374). Conclusion: This work has provided preliminary data on COVID-19 and SARS-CoV-2 variants circulating during the 2020-2021 epidemics in Chad.

关键词： COVID-19 SARS-CoV-2 Genomic Profile Variant Chad

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Eradication Treatment of Helicobacter pylori Infection: Evaluation of Therapeutic Strategies in N’Djamena

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Open Journal of Gastroenterology 2024年第2期14卷 59-67页

作者： Mayanna Habkréo ali Mahamat moussa Tahir Mahamat Saleh Djerabet Franckly Fany Haby Mairé Dehainssala Adama Ngaré Mahamat ali Hachim Service de Medecine Interne et Gastroenterologie Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad Service de Medecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad Service de Médecine Hopital de l’Amitié Tchad-Chine N’Djamena Tchad

Background: Helicobacter pylori (Hp) infection is the most widespread bacterial infection in the world. The infection is generally acquired in childhood, but can persist into adulthood. Eradication therapy has undergone several modifications. The aim of this study was to evaluate the different therapeutic strategies used in the eradication of Helicobacter pylori infection in the Centre Hospitalier Universitaire La Reference Nationale of N’Djaména. Patients and Methods: This was a prospective, descriptive analytical study spread over one year, from September 2021 to September 2022. Patients at least 15 years of age presenting with dyspeptic symptoms, seen consecutively in a hepato-gastroenterology consultation and with a positive stool test for H. pylori infection, were included in the study. Equally, 1/3 of patients were treated with dual or triple therapy. The remaining third received quadritherapy. Results: A total of 268 patients were included in the study (mean age 38.40 ± 14.66 with extremes of 16 and 80 years). Males predominated in 58% of cases. Overall therapeutic efficacy was 88.9%. According to different therapeutic strategies, efficacy was 90.75% for dual therapy with PPI (Rabeprazole) and Amoxicillin. On the other hand, efficacy was 87% and 88.88% for PPI-based triple therapy and dual antibiotic therapy, and for PPI-based quadruple therapy and triple antibiotic therapy. Conclusion: H. pylori infection is a common disease in Chad. Dual therapy with rabeprazole combined with a high dose of amoxicillin over a period of at least two weeks showed similar if not better efficacy than triple or quadruple therapy.

关键词： Helicobacter pylori Therapeutic Strategies Eradication Dyspepsia Chad

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Evaluation of the Strategy and Efficacy of Treatment of Chronic Viral Hepatitis C with the Sofosbuvir/Daclatasvir Combination in a Resource-Limited Country

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Open Journal of Gastroenterology 2024年第7期14卷 233-240页

作者： Mayanna Habkreo ali Mahamat moussa Adama Ahmed Ngare Abdraman Kossou Tahir Mahamat Saleh Maire Dehainsala Mahamat ali Hachim Mahamat ali Bolti Oumaima Djarma Joseph Madtoingue Service de Gastroentrologie/Mdecine Interne du Centre Hospitalier Universitaire la Rfrence Nationale NDjamena Chad Service de Gastroentrologie du Centre Hospitalier Universitaire la Renaissance NDjamena Chad Service de Maladies Infectieuses du Centre Hospitalier Universitaire la Renaissance NDjamena Chad Service de Maladies Infectieuses du Centre Hospitalier Universitaire la Rfrence Nationale NDjamena Chad

Introduction: The treatment of viral hepatitis C (HCV), a major public health problem, has evolved considerably since the introduction of direct-acting anti-virals (DAAs). The aim of this study was to evaluate the strategy for initiating treatment with Sofosbuvir/Daclatasvir, and also to assess its efficacy. Patients and Methods: Included were patients aged at least 15 years, with detectable hepatitis C viremia and treated with a pan-genotypic Sofosbuvir/Daclatasvir regimen at the Centre “Hospitalier Universitaire la Référence Nationale de N’Djamena” between October 2019 and October 2023. The APRI score was used to assess fibrosis. Cure was defined by an undetectable viral load 12 weeks after the end of treatment. Results: A total of 835 patients were included (sex ratio 1.55, mean age 50.5 ± 13.73, extremes 20 and 84 years). The 60 - 69 age group was the most represented. The mean APRI score was 0.42 ± 0.29, with extremes of 0.019 and 1.84. The mean viral load was 2,316,193.086 IU/mL. All subjects had good renal function. Cytolysis was absent in 70% of cases. Without genotyping, a pan-genotypic regimen was used in all patients: Sofosbuvir (400 mg)/Daclatasvir (60 mg). The cure rate was 99.4%, with good tolerability. However, four cases of failure were recorded out of the 668 patients who underwent follow-up HCV-PCR testing after 12 weeks of treatment. Conclusion: The Sofosbuvir/Daclatasvir regimen is highly effective, with an excellent safety profile. However, the still high cost of these molecules limits their accessibility to a large proportion of patients.

关键词： Efficacy Tolerance Sofosbuvir/Daclatasvir HCV Chad

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Visceral Leishmaniasis at the National Reference University Hospital Center of N’Djamena (Chad): Epidemiological, Clinical, Diagnostic, Therapeutic and Prognostic Aspects

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Advances in Infectious Diseases 2024年第2期14卷 478-486页

作者： Joseph Mad-Toïngué Mahamat ali Ahmat Oumaïma Mahamat Djarma alifa Adjibera Philippe ali Mahamat moussa Ngakoutou Rangar Choua Ouchemi Mahamat ali Bolti Djiddi ali Sougoudi Mamissou Didi Mahamat Doungous Atim Service des Maladies Infectieuses CHU de Référence Nationale N’Djamena Chad Service de Gastroentérologie et Médecine Interne CHU de Référence Nationale N’Djamena Chad Service de Pneumologie et Phtisiologie CHU de Référence Nationale N’Djamena Chad Service de Chirurgie viscérale CHU de Référence Nationale N’Djamena Chad Service de Médecine CHU de la Renaissance N’Djamena Chad

Introduction: leishmaniasis is a group of parasitic diseases caused by a parasite of the genus Leishmania transmitted by the bite of an infected vector called a sandfly. There are four forms. Visceral leishmaniasis is the most severe form. The aim of our work is to study the epidemiological, clinical, diagnostic, therapeutic and prognostic aspects of the disease in the Infectious Diseases Department of the Centre Hospitalier Universitaire de Référence Nationale in N'Djaména. Methodology: Patients were recruited on the basis of clinical signs suggestive of visceral leishmaniasis, i.e. prolonged fever, splenomegaly and altered general condition. Biological confirmation was performed with a rapid diagnostic test using recombinant K39 parasite antigen, which is known to have good specificity and sensitivity. Epidata version 3.1 software was used to process patient data. Results: From 05/04/21 to 15/12/23, 153 positive cases were managed. The mean age of patients was 18 years, with a sex ratio of 9.2. Of these patients, 103 (67.3%) had recently stayed at gold mining sites. Patients testing positive were treated with sodium stibogluconate combined with paromomycin for 17 days. The mortality rate was 13.2%. Conclusion: Leishmaniasis is a serious and little-known disease in Chad. In order to respond to the disease, it is necessary to reinforce the capacities of health structures and to carry out appropriate actions in the outbreaks.

关键词： Visceral Leishmaniasis Gold Mining Sites Chad

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Tuberculosis in the Carcinal Environment in Chad Due to the Mycobacterium Tuberculosis Circulante Complex

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Journal of Biosciences and Medicines 2024年第2期12卷 214-224页

作者： Ahmat Idriss Ahmat Mahamat Tahir Ngaré Hassan Ngandolo Bongo Nare Richard Mahamat Adanao Adoudou Mbah Ntepe Leonel Javeres Hamidou Yacoubou ali Mahamat moussa Laboratory for Diagnostic Research and Scientific Expertise University of N’Djamena N’Djamena Chad Veterinary and Zootechnical Research Laboratory of Farcha N’Djamena Livestock and Development Research Institute N’Djamena Chad Institute of Medical Research and Medicinal Plant Studies (IMPM) Ministry of Scientific Research and Innovation Yaoundé Cameroon Cameroon Ministry of Public Health Yaoundé Cameroon Faculty of Human Health Sciences University of N’Djamena N’Djamena Chad

Tuberculosis (TB) is a serious infectious disease and its control is considered a challenge, particularly among vulnerable populations such as prisoners. The prevalence of TB in prisons is an alarming public health problem in many countries. The aim of this study is to describe the epidemiology of tuberculosis and the strategies for controlling this disease in the Chadian prison population. During the course of our study, the prevalence of tuberculosis in prisons was 9.64%. The age group between 55 years and over (43.33%) was the most represented in this study, and all patients were men with a frequency of 62.66%. The cross-tabulation of Culture_7H9G and Culture_7H9P showed that out of our total positive sample, we found a total of 87 positive strains and 63 negative strains. Our study shows that it is essential to know the prevalence of tuberculosis in all the country’s prisons. Indeed, this can serve as an indication of the need for action in prisons to reduce TB rates, in particular by improving the structure of prison environments, diagnosing new cases quickly and accurately, identifying drug-resistant strains and implementing effective, direct treatment observed in people with tuberculosis.

关键词： Mycobacterium Prison Tuberculosis and Chad

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Structural Characterization and Antioxidant Activity of Lignin Extracted from Ficus Carica L.

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Journal of Renewable Materials 2019年第4期7卷 345-354页

作者： Ibtissem moussa Ramzi Khiari ali moussa Gérard Mortha Mohamed Farouk Mhenni University of Monastir Faculty of SciencesUR13 ES 63-Research Unity of Applied Chemistry&EnvironmentAvenue of the environment5019 MonastirTunisia University of Monastir National Engineering School of MonastirStreet of Ibn El Jazzar5000 MonastirTunisia Higher Institute of Technological Studies of Ksar-Hellal Department of Textile-TunisiaAvenue of Hadj Ali Soua.5070 Ksar-HellalTunisia University of Grenoble Alpes CNRSGrenoble INPLGP2F-38000 GrenobleFrance

The most abundant phenolic biopolymer in the biosphere is the *** phenolic biopolymer commonly exists in combination with polysaccharides and other cell wall *** this study,the solvent system dioxane-water is used to extract lignin,which is considered as unaltered native *** dioxane lignin extracted from fig stems was characterized regarding to its structural feature,quantification of its functional groups,molecular weight,and evaluation of its thermal *** and molecular weight distribution of the studied lignin indicated that isolated lignin contained a low amount of sugar(c.a.19%)and had a high weight-average molecular weight(10068 ***-1).Lignin sample had approximately the same amounts of guaiacyl(G)and p-hydroxyphenyl(H)units with relatively fewer syringyl(S)*** isolated lignin revealed good antioxidant ***,it proved to have a high potential of application in new antioxidants formulations.

关键词： Ficus Carica L. lignin organosolv molecular weight NMR spectroscopy antioxidant activity

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Application of Prunus amygdalus By-products in Eco-friendly Dyeing of Textile Fabrics

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Journal of Renewable Materials 2018年第1期6卷 55-67页

作者： Ibtissem moussa Noureddine Baaka Ramzi Khiari ali moussa Gérard Mortha Mohamed Farouk Mhenni University of Monastir Faculty of SciencesUR13ES63-Research Unity of Applied Chemistry&Environment5000 MonastirTunisia Higher Institute of Technological Studies of Ksar Hellal Department of TextilesRue Hadj Ali Soua-B.P.n°68-5070 Ksar HellalTunisia Institute of Engineering University of Grenoble AlpesCNRSGrenoble INPLGP2F-38000 GrenobleFrance National Engineering School of Monastir 5019 MonastirTunisia

Natural dyes have become an interesting subject of study because of their better ecological properties in comparison to their synthetic *** article concerns the dyeing of wool,silk,and polyamide fabrics with natural dyes extracted from almond shells and *** developed method of dyeing by these extracts is interesting and very attractive for several reasons:firstly,the extracts used are the black liquor discharged from the industries of delignification,which is a chemical process for removing lignin from agricultural wastes to produce a cellulosic fiber;(ii)these natural dyes are renewable and available in large quantities;(iii)this method is economical;and(iv)lastly,the dyeing performances of the obtained dyed textiles are very *** color of each dyed material was investigated in terms of the CIELAB coordinates and their fastness properties measured by washing,rubbing,and light.

关键词： Almond shell almond stem fastness properties natural dyes residual lignin

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Superior Mesenteric Artery Syndrome: First Chadian Observation

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Surgical Science 2017年第8期8卷 358-364页

作者： Choua Ouchemi ali Mahamat moussa moussa Kalli Taday moussa Telniaret Armel Sadie Ismael Guire Sani Rachid Service de Chirurgie Générale H&ocirc pital Général de Référence Nationale (HGRN) N’Djaména Tchad Service de Médecine Interne et Gastroentérologie H&ocirc pital Général de Référence Nationale (HGRN) N’Djaména Tchad Service de Radiologie H&ocirc pital Général de Référence Nationale (HGRN) N’Djaména Tchad Université Abdou Moumouni Niamey Niger

Introduction: The extrinsic compression of the third portion of the duodenum between the superior mesenteric artery and the aorta defines superior mesenteric artery syndrome. It determines an acute or chronic high intestinal obstruction pattern. We report the first observed case in Chad. Observation: HH was a 19 year-old woman with abdominal pain and intermittent postprandial vomiting since she was 5 years old. During last 11 months, post-prandial vomiting was more frequent, and non resolved after medical treatment. Unquantified weight loss was reported. Body mass index at hospitalization was 9.8. An injected abdominal scan demonstrated significant gastroduodenal distension, upstream of a stenosis of the third duodenal portion. Aorto-mesenteric space and angle were reduced. At laparotomy internal derivation by duodenojejunostomy was done. Postoperative situation was uneventful. Conclusion: Superior mesenteric artery syndrome determines an acute or chronic intestinal obstruction. Injected abdominal scan is fundamental for diagnosis. The treatment is firstly conservative but the need of surgery is common.

关键词： Superior Mesenteric Artery Syndrome Intestinal Obstruction Duodenojejunostomy Chad

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Hepatocellular Carcinoma in Chad: A Retrospective Study of 219 Cases

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Open Journal of Gastroenterology 2023年第11期13卷 382-392页

作者： ali Mahamat moussa Pascal Pineau Mayanna Habkreo Gumbo Nedjim Tahir Mahamat Saleh Adoum Abderrazak Fouda Mahamat ali Hachim Adawaye Chatté Bessimbaye Nadlaou moussa Kalli Choua Ouchemi Service de Médecine Interne et Gastroentérologie Centre Hospitalier Universitaire La Référence Nationale N’Djamena Tchad Unité “Organisation Nucléaire et Oncogenèse” Institut National de la Santé et de la Recherche Médicale U993 Paris France Service de Médecine Interne Centre Hospitalier Universitaire La Renaissance N’Djamena Tchad Programme de Lutte contre le VIH et SIDA Hépatites et Infectins Sexuellement Transmissibles Ministère de la Santé Publique N’Djamena Tchad Service du Laboratoire Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad Service de Chirurgie Générale Centre Hospitalier Universitaire La Reference Nationale N’Djamena Tchad

Background: Although hepatocellular carcinoma was historically considered an important scourge in Middle Africa, there is no publication describing this disease in Chad. Methods: We conducted a retrospective analysis of 219 patients with hepatocellular carcinoma (HCC) attending care at the University Reference Hospital of Ndjamena between 2007 and 2016. Results: This series of HCC was characterized by a male predominance (M:F = 2.4) with a mean tumor onset at the end of the fifth decade of life (49.9 ± 14.7 years). Tumors appear on a cirrhotic liver in 70% of cases and were already multifocal at diagnosis in two thirds of the patients. Alpha-fetoprotein was above the physiological threshold (10 ng/mL) in 73.4% of cases measured and above the so-called diagnostic level (400 ng/mL) in 53.4% of patients. The principal risk factor was chronic infection with hepatitis B virus, detected in 52.6% of cases. Patients seropositive for hepatitis C virus were infrequent (8.6%) and heavy alcohol intake was even less prevalent (5.9%). Remarkably, a very large subset of patients did not present any infectious or lifestyle risk factor (43.4%). Mean AFP values or fibrosis assessment scores are usually lower in these patients than in HBV-infected ones. Conclusions: The etiological spectrum of HCC is far from being fully established in Chad. Further epidemiological research is warranted to identify risk factors involved in a large proportion of cases. Exposure to aflatoxin B1 and dysmetabolic conditions affecting the liver have to be investigated as priority.

关键词： Chad Middle Africa Hepatocellular Carcinoma Hepatitis Viruses Alcohol Idiopathic

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Synthesis of Flower-Like Bi2Te3 Nano Structure and Studying Its Structural and Thermo-electric Properties

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Journal of Physical Science and Application 2016年第1期6卷 76-81页

作者： Emad Kh. Al-shakarchi Manal A. Abbood ali M. moussa Physics Department AI-Nahrain University Baghdad Iraq School of Applied Science University of Technology Baghdad Iraq

Flower-like Bi2Te3 nanostructures were successfully synthesised for the first time by a simple magnetron technique or D.C. sputtering method. The phase and morphology of the products were characterized by X-ray diffraction （XRD）, manning electron microscope （SEM） and atomic force microscope （AFM）. It was found that the as-deposited Bi2Te3 has a well re-crystallized Rhombohedral phase and consisted of a wealth of flower-like structure, also the thermo-electric properties of Bi2Te3 were examined and we find that the Seebeck coefficient is 136.6μ volt/K.

关键词： Flower-like Bi2Te3 D.C. sputtering thin film.

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