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Utilizing auxin dwarf genes to optimize seed yield and lodging resistance in rapeseed

The Crop Journal 2024年第4期12卷 1208-1221页

作者： Hongxiang Lou Yan Peng Chunyun Wang Zongkai Wang Bowen Zhao ali mahmoud el-badri Maria Batool Bo Wang Jing Wang Zhenghua Xu Jie Zhao Jie Kuai Guangsheng Zhou MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River Hubei Hongshan LaboratoryCollege of Plant Science and TechnologyHuazhong Agricultural UniversityWuhan 430070HubeiChina National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina Field Crops Research Institute Agricultural Research CenterGiza 12619Giza GovernorateEgypt

Direct-seeding rapeseed production at high plant density raises the risk of *** investigated the use of dwarf genes to improve rapeseed plant architecture to balance yield and *** genotypes with different plant architectures(dwarf sca^(HS5),semi-dwarf+/sca^(HS5),and tall ^(HS5))were evaluated under varying nitrogen rates(N1,N2,and N3:120,240,and 360 kg N ha^(-1))and plant densities(D1,D2,and D3:15,45,and 75 plants m^(-2))from 2019 to *** results showed that increasing N rate positively influenced yield while decreasing lodging resistance in all *** plant density(D2-D3)enhanced lodging resistance and yield in sca^(HS5) and+/sca^(HS5),but reduced yield in ^(HS5).Compared to the two parents,+/sca^(HS5) exhibited moderate expressions of IAA3,GH3.15,and SAUR30 in stems under N2D3,resulting in reduced plant height and increased ***,+/sca^(HS5) had a thicker silique layer than ^(HS5) by 14.7%,and it had a significant correlation between branch height/angle and *** N rate led to increased lignin and pectin contents,while cellulose content *** plant density resulted in greater stem cellulose content and CSLA3/7 expression in sca^(HS5) and+/sca^(HS5),but decreased in ^(HS5).Compared to ^(HS5),+/sca^(HS5) exhibited higher expressions of ARAD1 and GAUT4,along with a 51.1%increase in pectin content,leading to improved lodging resistance under ***,+/sca^(HS5) showed a 46.4%higher yield and 38.9%lodging resistance than ^(HS5) under N2D3,while sca^(HS5) demonstrated strong lodging resistance but lower yield ***,this study underscores the potential of utilizing auxin dwarf genes to optimize the trade-off between yield and lodging resistance in rapeseed and the possibility of maximizing yield potential by optimizing the plant architecture of+/sca^(HS5) through nitrogen reduction and dense planting.

关键词： Rapeseed Plant density Nitrogen Lodging Auxin

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Hybrid Model of Power Transformer Fault Classification Using C-set and MFCM – MCSVM

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 672-685页

作者： ali Abdo Hongshun Liu Yousif mahmoud Hongru Zhang Ying Sun Qingquan Li Jian Guo Shandong Provincial Key Laboratory of UHV Transmission Technology and Equipment School of Electrical EngineeringShandong UniversityJinan 250061China

This paper aims to increase the diagnosis accuracy of the fault classification of power transformers by introducing a new off-line hybrid model based on a combination subset of the et method(C-set)&modified fuzzy C-mean algorithm(MFCM)and the optimizable multiclass-SVM(MCSVM).The innovation in this paper is shown in terms of solving the predicaments of outliers,boundary proportion,and unequal data existing in both traditional and intelligence *** into consideration the closeness of dissolved gas analysis(DGA)data,the C-set method is implemented to subset the DGA data samples based on their type of faults within unrepeated ***,the MFCM is used for removing outliers from DGA samples by combining highly similar data for every subset within the same cluster to obtain the optimized training data(OTD)*** is also used to minimize dimensionality of DGA samples and the uncertainty of transformer condition *** that,the optimized MCSVM is trained by using the(OTD).The proposed model diagnosis accuracy is 93.3%.The obtained results indicate that our model significantly improves the fault identification accuracy in power transformers when compared with other conventional and intelligence models.

关键词： Combination subset of set(C-set)method modified fuzzy C-means(MFCM) optimizable multiclass-SVM(MCSVM) optimized training data(OTD)

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Pyronaridine combined with diminazene aceturate inhibits Babesia in vitro and in vivo

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Asian Pacific Journal of Tropical Biomedicine 2024年第3期14卷 93-99页

作者： Shimaa Abd el-Salam el-Sayed Mohamed Z.Sayed-Ahmed Shaimaa Ahmed Awad ali Nourah Alsadaan Nawazish Alam mahmoud S.Alkhoudary Ikuo Igarashi Mohamed Abdo Rizk National Research Center for Protozoan Diseases Obihiro University of Agriculture and Veterinary MedicineInada-ChoObihiroHokkaido 080-8555Japan Department of Biochemistry and Chemistry of Nutrition Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt Department of Clinical Pharmacy College of PharmacyJazan UniversityJazan 45142Saudi Arabia Medical-Surgical Department College of NursingJouf UniversitySakaka 72388Saudi Arabia Critical Care and Emergency Nursing Faculty of NursingMansoura UniversityEgypt College of Nursing Jouf UniversitySakaka 72388Saudi Arabia Faculty of Pharmacy Mansoura UniversityMansoura 35516DakahliaEgypt Department of Internal Medicine and Infectious Diseases Faculty of Veterinary MedicineMansoura UniversityMansoura 35516Egypt

Objective:To evaluate the combination therapy of pyronaridine tetraphosphate and diminazene aceturate against Babesia in vitro and in ***:Bioinformatic analysis was performed using atom pair *** in vitro combination test was performed against Babesia bovis and Theileria ***,the in vivo chemotherapeutic efficacy of pyronaridine tetraphosphate in combination with diminazene aceturate was investigated against the growth of Babesia microti in mice using a fluorescence inhibitory ***:Pyronaridine tetraphosphate and diminazene aceturate exhibited nearly similar molecular *** in vitro combination of pyronaridine tetraphosphate and diminazene aceturate was synergistic on Babesia bovis and additive on Theileria *** addition,5 mg/kg pyronaridine tetraphosphate combined with 10 mg/kg diminazene aceturate inhibited Babesia microti growth significantly compared with those observed after treatment with 25 mg/kg diminazene aceturate alone from day 6 post treatment to day 12 post *** combination therapy also normalized the hematological parameters of infected ***:An oral dose of pyronaridine tetraphosphate combined with a subcutaneous dose of diminazene aceturate inhibits Babesia in vitro and in mice,suggesting it might be a new paradigm for the treatment of babesiosis.

关键词： Babesia Pyronaridine tetraphosphate Diminazene aceturate Babesiosis Theileria

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Existence results and behavior analysis for nonlinear age-dependent population dynamics problems with conformable fractional operator

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International Journal of Biomathematics 2024年第5期17卷 229-256页

作者： Hiba el Asraoui M'hamed el Omari ali el Mfadel Khalid Hilal Laboratory of Applied Mathematics Scientific Computing Sultan Moulay Slimane University BP 523 Beni MellalMorocco

In this paper,we investigate the existence of solutions and analyze the large-time behavior for Gurtin-Maccamy population model involving conformable fractional *** a preliminary step,we construct a generic structure of the solution associated with our proposed model by utilizing some basic properties and tools of conformable fractional *** establish the existence of a unique solution of the given model with the given initial *** last,by using the upper and lower solutions for the characteristic equation,we define the upper and lower boundaries for the obtained solution and describe the large-time behavior of the total population.

关键词： Age-dependent population conformable fractional operator upper and lower boundary of the solution dynamics of populations

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Combinational therapy with Myc decoy oligodeoxynucleotides encapsulated in nanocarrier and X-irradiation on breast cancer cells

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Oncology Research 2024年第2期32卷 309-323页

作者： BEHROOZ JOHARI MILAD PARVINZAD LEILAN mahmoud GHARBAVI YOUSEF MORTAZAVI ali SHARAFI HAMED REZAEEJAM Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

The Myc gene is the essential oncogene in triple-negative breast cancer(TNBC).This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell *** and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 *** nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan(Chi-Se-DEC),which was then encapsulated in niosome-nanocarriers(NISM@Chi-Se-DEC).FT-IR,DLS,FESEM,and hemolysis tests were applied to confirm its characterization and physicochemical ***,cellular uptake,cellular toxicity,apoptosis,cell cycle,and scratch repair assays were performed to evaluate its anticancer effects on cancer *** anticancer assessments were repeated under X-ray irradiation conditions(fractionated 2Gy).Physicochemical characteristics of niosomes containing SeNPs and ODNs showed that it is synthesized *** revealed that the anticancer effect of NISM@Chi-Se-DEC can be significantly improved in combination with X-ray irradiation *** can be concluded that NISM@Chi-Se-DEC nanocarriers have the potential as a therapeutic agent for cancer treatment,particularly in combination with radiation therapy and in-vivo experiments are necessary to confirm the efficacy of this nano-drug.

关键词： Combinational therapy Antisense therapy Myc signaling pathway Niosomes Radiation therapy SeNPs

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Perception beyond sight:Investigating the cognitive maps of congenitally blind individuals in urban environments

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Frontiers of Architectural Research 2024年第4期13卷 809-821页

作者： Anwar Ibrahim Hikmat Hali Zainab mahmoud College of Architecture and Design Jordan University of Science and TechnologyIrbidJordan College of Engineering and Architecture Al Yamamah UniversityRiyadhKSA

This study explores the challenges faced by congenitally blind individuals in navigating urban ***,this research investigates the factors that contribute to the construction of city mental mapping for individuals who are born ***-one congenitally blind individuals from the University of Jordan were asked to define and describe specific elements of the city based on their personal experiences and ***,participants were guided through two urban paths:familiar and *** participants were asked to complete a survey regarding their experiences during the *** collected data was analyzed by using thematic *** results revealed that congenitally blind individuals construct their mental image of the city by using their three senses of touching,hearing,and smelling,as well as their safety and *** mental image consists of five key elements:links,reference points,areas,separators,and *** the small size of the study sample and the specificity of the context,the results of this study will tremendously help planners in designing highly inclusive urban *** characteristics that can be recognized by the blinds will enhance their accessibility of urban spaces,encourage independent mobility,increase the quality of life and social inclusion for them.

关键词： Mental map City image Congenital blind Cognitive mapping Environmental perception

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Targeted anti-tumor synergistic effects of Myc decoy oligodeoxynucleotides-loaded selenium nanostructure combined with chemoradiotherapy on LNCaP prostate cancer cells

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Oncology Research 2024年第1期32卷 101-125页

作者： ROGHAYEH GHORBANI mahmoud GHARBAVI ali SHARAFI elHAM RISMANI HAMED REZAEEJAM YOUSEF MORTAZAVI BEHROOZ JOHARI Department of Medical Biotechnology School of MedicineZanjan University of Medical SciencesZanjanIran Nanotechnology Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Zanjan Pharmaceutical Biotechnology Research Center Zanjan University of Medical SciencesZanjanIran Department of Pharmaceutical Biotechnology School of PharmacyZanjan University of Medical SciencesZanjanIran Molecular Medicine Department Biotechnology Research CenterPasteur Institute of IranPasteur AvenueTehranIran Department of Radiology Technology School of Allied Medical SciencesZanjan University of Medical SciencesZanjanIran

In the present study,we investigated the synergistic effects of targeted methotrexate-selenium nanostructure containing Myc decoy oligodeoxynucleotides along with X-irradiation exposure as a combination therapy on LNCaP prostate cancer *** decoy ODNs were designed based on the promoter of Bcl-2 gene and analyzed by molecular docking and molecular dynamics *** were loaded on the synthesized Se@BSA@Chi-MTX *** physicochemical characteristics of nanostructures were determined by FTIR,DLS,UV-vis,TEM,EDX,in vitro release,and hemolysis ***,the cytotoxicity properties of them with and without X-irradiation were investigated by uptake,MTT,cell cycle,apoptosis,and scratch assays on the LNCaP cell *** results of DLS and TEM showed negative charge(−9 mV)and nanometer size(40 nm)for Se@BSA@Chi-DEC-MTX NPs,*** results of FTIR,UV-vis,and EDX showed the proper interaction of different parts and the correct synthesis of *** results of hemolysis showed the hemocompatibility of this nanoparticle in concentrations less than 6 mg/*** ODNs release from the nanostructures showed a pH-dependent manner,and the release rate was 15%higher in acidic *** targeted Se@BSA@Chi-labeled ODN-MTX NPs were efficiently taken up by LNCaP cells by targeting the prostate-specific membrane antigen(PSMA).The significant synergistic effects of nanostructure(containing MTX drug)treatment along with X-irradiation showed cell growth inhibition,apoptosis induction(~57%),cell cycle arrest(G2/M phase),and migration inhibition(up to 90%)compared to the *** results suggested that the Se@BSA@Chi-DEC-MTX NPs can potentially suppress the cell growth of LNCaP *** nanostructure system can be a promising approach for targeted drug delivery and chemoradiotherapy in prostate cancer treatment.

关键词： Chemoradiotherapy Combination therapy Decoy oligodeoxynucleotides Myc transcription factor Selenium nanoparticle Prostate cancer

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Rao Algorithms-Based Structure Optimization for Heterogeneous Wireless Sensor Networks

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Computers, Materials & Continua 2024年第1期78卷 873-897页

作者： Shereen K.Refaay Samia A.ali Moumen T.el-Melegy Louai A.Maghrabi Hamdy H.el-Sayed Faculty of Computers and Artificial Intelligence Sohag UniversitySohag82524Egypt Faculty of Engineering Assiut UniversityAssiut711745Egypt College of Engineering University of Business and TechnologyJeddah23411Saudi Arabia

The structural optimization of wireless sensor networks is a critical issue because it impacts energy consumption and hence the network’s *** studies have been conducted for homogeneous networks,but few have been performed for heterogeneouswireless sensor *** paper utilizes Rao algorithms to optimize the structure of heterogeneous wireless sensor networks according to node locations and their initial *** proposed algorithms lack algorithm-specific parameters and metaphorical *** proposed algorithms examine the search space based on the relations of the population with the best,worst,and randomly assigned *** proposed algorithms can be evaluated using any routing protocol,however,we have chosen the well-known routing protocols in the literature:Low Energy Adaptive Clustering Hierarchy(LEACH),Power-Efficient Gathering in Sensor Information Systems(PEAGSIS),Partitioned-based Energy-efficient LEACH(PE-LEACH),and the Power-Efficient Gathering in Sensor Information Systems Neural Network(PEAGSIS-NN)recent routing *** compare our optimized method with the Jaya,the Particle Swarm Optimization-based Energy Efficient Clustering(PSO-EEC)protocol,and the hybrid Harmony Search Algorithm and PSO(HSA-PSO)*** efficiencies of our proposed algorithms are evaluated by conducting experiments in terms of the network lifetime(first dead node,half dead nodes,and last dead node),energy consumption,packets to cluster head,and packets to the base *** experimental results were compared with those obtained using the Jaya optimization *** proposed algorithms exhibited the best *** proposed approach successfully prolongs the network lifetime by 71% for the PEAGSIS protocol,51% for the LEACH protocol,10% for the PE-LEACH protocol,and 73% for the PEGSIS-NN protocol;Moreover,it enhances other criteria such as energy conservation,fitness convergence,packets to cluster head,and packets to the base sta

关键词： Wireless sensor networks Rao algorithms optimization LEACH PEAGSIS

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Urban electric Vehicle Charging Station Placement Optimization with Graylag Goose Optimization Voting Classifier

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Computers, Materials & Continua 2024年第7期80卷 1163-1177页

作者： Amel ali Alhussan Doaa Sami Khafaga el-Sayed M.el-kenawy Marwa M.Eid Abdelhameed Ibrahim Department of Computer Sciences College of Computer and Information SciencesPrincess Nourah bint Abdulrahman UniversityP.O.Box 84428Riyadh11671Saudi Arabia Department of Communications and electronics Delta Higher Institute for Engineering and TechnologyMansoura35511Egypt Faculty of Artificial Intelligence Delta University for Science and TechnologyMansoura35712Egypt Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt

To reduce the negative effects that conventional modes of transportation have on the environment,researchers are working to increase the use of electric *** demand for environmentally friendly transportation may be hampered by obstacles such as a restricted range and extended rates of *** establishment of urban charging infrastructure that includes both fast and ultra-fast terminals is essential to address this ***,the powering of these terminals presents challenges because of the high energy requirements,whichmay influence the quality of *** the maximum hourly capacity of each station based on its geographic location is necessary to arrive at an accurate estimation of the resources required for charging *** is vital to do an analysis of specific regional traffic patterns,such as road networks,route details,junction density,and economic zones,rather than making arbitrary conclusions about traffic *** vehicle traffic is simulated using this data and other variables,it is possible to detect limits in the design of the current traffic engineering ***,the binary graylag goose optimization(bGGO)algorithm is utilized for the purpose of feature ***,the graylag goose optimization(GGO)algorithm is utilized as a voting classifier as a decision algorithm to allocate demand to charging stations while taking into consideration the cost variable of traffic *** on the results of the analysis of variance(ANOVA),a comprehensive summary of the components that contribute to the observed variability in the dataset is *** results of the Wilcoxon Signed Rank Test compare the actual median accuracy values of several different algorithms,such as the voting GGO algorithm,the voting grey wolf optimization algorithm(GWO),the voting whale optimization algorithm(WOA),the voting particle swarm optimization(PSO),the voting firefly algorithm(FA),and the voting genetic algori

关键词： electric vehicle graylag goose optimization metaheuristics optimization machine learning

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Standardization of meibomian gland dysfunction in an Egyptian population sample using a non-contact meibography technique

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 61-65页

作者： Ahmed Mohamed Karara Zeinab el-Sanabary Mostafa ali el-Helw Tamer Ahmed Macky Mohamad Amr Salah Eddin Abdelhakim Department of Ophthalmology Kasr Al-Ainy HospitalCairo UniversityCairo 11431Egypt

AIM:To develop normative data for meibomian gland dysfunction(MGD)parameters,using non-contact meibography technique of Sirius Costruzione Strumenti Oftalmici(CSO)machine,in an Egyptian population ***:Observational,cross-sectional,analytic study,in which 104 Egyptian volunteers were *** upper lids were examined,using“Sirius CSO”*** eyelid was given a degree of meibomian gland loss(MGL),which was calculated by the software of the ***:Mean percentage MGL in right upper lid was of 30.9%±12.6%,and that of left upper lid was 32.6%±11.8%.Thirty-four volunteers(32.7%)had first-degree MGL in their right upper lid,and 67.3%had second-degree *** volunteer(1%)had zero-degree MGL in left upper lid,28(26.9%)had first-degree loss,and 75(72.1%)had second-degree *** of MGL in right upper eyelid was not related to age,but degree of MGL in left upper eyelid increased with *** was statistically significant difference between both genders for degree of MGL in right eye(P=0.036)and in left eye(P=0.027).CONCLUSION:Noncontact meibography is a useful non-invasive tool for diagnosing *** is diagnosed in 100%of apparently normal individuals;26.9%-32.7%of which have first-degree MGL,and 67.3%-72.1%have second-degree MGL.

关键词： Egyptian population meibomian gland dysfunction non-contact meibography standardization upper lid

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