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Effectiveness and safety of generic and brand direct acting antivirals for treatment of chronic hepatitis C

World Journal of Clinical Cases 2022年第34期10卷 12566-12577页

作者： Maheeba Abdulla Aysha Mohamed Al Ghareeb hamed ali Hasan Yusuf Husain Nafeesa Mohammed Jehad Al Qamish Department of Internal Medicine Salmaniya Medical ComplexArabian Gulf UniversityManama 2904Bahrain Department of Internal Medicine Salmaniya Medical ComplexManama 2904Bahrain Internal Medicine Department Ibn AlNafees HospitalManama 3302Bahrain

BACKGROUND Direct acting antivirals(DAAs)are a very effective treatment for hepatitis C virus(HCV).However,brand DAAs are *** licensing of cheaper generic DAAs may address this issue,but there is a lack of clinical studies comparing the efficacy of generic vs brand DAA *** To compare the efficacy and safety of generic against brand DAAs for chronic hepatitis C treatment in *** This was a retrospective observational study involving 289 patients with chronic HCV infection during 2016 to *** were 149 patients who were treated with brand DAAs,while 140 patients were treated with generic *** used DAAs were Ombitasvir/Paritaprevir/Ritonavir±Dasabuvir±Ribavirin,and Sofosbuvir/Daclatasvir±*** at 12 wk post treatment was the main outcome *** Overall,87 patients(30.1%)had cirrhosis and 68.2%had genotype 1 HCV *** 12 wk post treatment,SVR was achieved by 271(93.8%)of the *** patients who were treated with generic medications,134(95.7%)achieved SVR at 12 wk post treatment,compared to 137(91.9%)among those treated with brand medications(P=0.19).Having cirrhosis[odds ratio(OR):9.41,95%confidence interval(CI):2.47–35.84]and having HCV genotype 3(OR:3.56,95%CI:1.03–12.38)were significant independent predictors of not achieving *** transaminase,gamma-glutamyl transpeptidase,and total bilirubin levels decreased significantly following therapy with both generic and brand *** Generic and brand DAAs demonstrate comparable effectiveness in the treatment of chronic hepatitis C *** are safe and equally effective in improving biochemical markers of hepatic inflammation.

关键词： Hepatitis C virus Direct acting antivirals Generic Brand Sofosbuvir Ombitasvir Ledipasvir Daclatasvir Paritaprevir Ritonavir Dasabuvir Ribavirin Sustained virologic response

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MIMO Antenna for UWB Communications

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International Journal of Communications, Network and System Sciences 2016年第5期9卷 177-183页

作者： Joseph Jervase-Yak ali hamed Al-Shamsi Department of Electrical and Computer Engineering Sultan Qaboos University Muscat Oman Telecommunications Regulatory Authority Muscat Oman

Design of ultra-wideband antennas is challenging in the stringent requirements that are often conflicting to achieve a wide impedance bandwidth while maintaining high radiation efficiency, uniform gain and compact size. A Multiple-Input Multiple-Output (MIMO) antenna system can enhance the overall antenna performance but at having to overcome new challenges such as reducing the mutual coupling and the correlation between the elements. A printed circular disc compact planar antenna is selected in this work due to its UWB performance and compact size for the MIMO antenna system. A parametric analysis is carried out to achieve an optimal design. The system developed consists of two elements with an overall size of 59 × 27 mm. The designed antenna system operates over the whole of the UWB bandwidth from 3.1 to 10.6 GHz with radiation efficiency up to 85% and reflection coefficients less that ?10 dB. The envelope correlation is less than ?60 dB throughout the UWB band while the diversity gain approaches 10 throughout the entire UWB bandwidth and Total Active Reflection Coefficient (TARC) between the antenna elements is less ?11 dB. Thus the proposed MIMO antenna outperforms similar antenna systems reported in the literature.

关键词： Antenna Efficiency Diversity Gain MIMO Antenna Total Active Reflection Coefficient (TARC) Ultra-Wideband (UWB) Antenna

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Phytochemical studies of various polarities leave crude extracts of Omani Datura metel *** evaluation of their antimicrobial potential

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Journal of Coastal Life Medicine 2015年第3期 214-219页

作者： ali Saleh hamed Al-Jafari Mohammad Amzad Hossain School of Pharmacy College of Pharmacy and NursingUniversity of NizwaP.O.Box 33Postal Code 616NizwaSultanate of Oman

Objective:To identify the chemical constituents and evaluate antimicrobial potential of various crude extracts from leaves of Datura metel grown in ***:The leaf samples were collected from the University of Nizwa and extracted with methanol by using Soxhlet *** isolated crude extract was defatted with distilled water and extracted with solvents of different polarities including hexane,chloroform,ethyl acetate and *** compositions of the crude extracts were analyzed by gas chromatography-mass spectrometer and their antimicrobial potential was evaluated by agar disc diffusion method against one Gram positive bacteria Staphylococcus aureus and two Gram negative bacteria Escherichia coli and Pseudomonus ***:The crude extracts were composed of different organic compounds such as alkaloids,hydrocarbons,aromatic hydrocarbons,organic acids,terpenoids,vitamin *** methanol and its fractionated crude extracts showed antimicrobial potential with inhibition zone in the range of 0-13 ***:The selective crude extract from the leaves of Datura metel could be used as natural antibiotics.

关键词： Datura metel Soxhlet extractor Crude extracts Gas chromatography-mass spectrometry analysis Antimicrobial activity

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立面收进框架—剪力墙高层建筑结构抗震性能分析

立面收进框架—剪力墙高层建筑结构抗震性能分析

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作者： MASHRAH WALEED ali hamed（阿里）兰州交通大学

学位级别：硕士

近年来,为满足生产和人民生活的需要,高层建筑飞速发展。基于中国的地震活动,所有的建筑,特别是有立面收进高层建筑结构,都要考虑到地震作用以及规范标准,同时还有立面收进对高层建筑的抗震性能的影响。本文以兰澳花苑高层建筑为研究对... 详细信息

近年来,为满足生产和人民生活的需要,高层建筑飞速发展。基于中国的地震活动,所有的建筑,特别是有立面收进高层建筑结构,都要考虑到地震作用以及规范标准,同时还有立面收进对高层建筑的抗震性能的影响。本文以兰澳花苑高层建筑为研究对象,分别利用有限元分析软件SAP2000 v16.1建立了立面收进与非立面收进两种高层建筑结构模型,并利用时程分析法研究了立面收进高层建筑在El Centro、Altadena和ARRY06三种地震波作用下的抗震性能和非立面收进高层建筑在El Centro地震波作用下的抗震性能。以下两点是该研究的主要结论:首先,研究了立面收进对总高度106.4米的34层的立面收进框架剪力墙混凝土RC高层建筑的影响。结果表明,一、立面收进高层建筑结构周期比等于0.885,证明了立面收进高层的扭转为常规扭转。二、所有模型结果分析(包括模型顶部位移分析,层间位移分析,层间位移角分析和层间位移比分析,地震作用水平力P,模型中X和Y方向地震作用下正负楼层剪力及弯矩曲线,X和Y方向的扭转和模型X和Y方向的刚度比2?)在ARRY06地震波作用下是最为大的,而在El Centro地震波作用下是最小的。三、在三种地震波(El Centro、Altadena和ARRY06)作用下立面收进高层建筑模型的抗震侧刚度和内力在收进层有突变,证实了第七层为结构的薄弱层。在地震的作用下,高层建筑的破坏是从结构的薄弱层开始的,而第七层的薄弱特征直接影响着高层建筑结构的抗震能力,会导致严重的变形。其次,运用SAP2000 V16.1来分析总高度106.4米的34层两栋混凝土RC高层建筑塔楼模型(第一个模型有收进,第二个模型无收进)在同一场地条件、地震波(El Centro)以及规范下的地震作用,并且对比了这两栋高层建筑抗震性能分析的结果,从而分析了立面收进对高层建筑抗震性能的影响。本文研究证实立面收进直接影响高层建筑。设置立面收进的高层建筑模型具有扭转应变,而不设计立面收进高层建筑模型不具有扭转应变。有立面收进高层建筑模型的位移比无立面收进高层建筑模型的位移要小,但是有立面收进高层建筑模型的内力有突变。我们在设计高层建筑时,若利用立面收进,则可以使高层建筑的位移减小,但同时高层建筑的内力会突变。

关键词：立面收进高层建筑框架-剪力墙抗震性能动力时程分析法

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中国—伊斯兰文化交流融合实证研究 ——基于兰州清真寺建筑的视角

中国—伊斯兰文化交流融合实证研究 —...

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作者： MASHRAH WALEED ali hamed（阿里）西北师范大学

学位级别：硕士

从伊斯兰教进入了中国以后,伊斯兰文化和当地文化不断的融合和交流,在长期交流的过程中形成了中华民族的一个新兴民族。中国穆斯林文化是中华传统文化和阿拉伯伊斯兰两大文化体系融合的成果,他吸收了两大文化的精粹,具有旺盛的生命力,... 详细信息

从伊斯兰教进入了中国以后,伊斯兰文化和当地文化不断的融合和交流,在长期交流的过程中形成了中华民族的一个新兴民族。中国穆斯林文化是中华传统文化和阿拉伯伊斯兰两大文化体系融合的成果,他吸收了两大文化的精粹,具有旺盛的生命力,给中国文化增添了一道亮丽的风景。中国西北地区是中国穆斯林一个主要的分布区域,而回族人口数量众多。因为甘肃作为西北“丝绸之路”上的重要节点,也是伊斯兰教进入了中国的一个很重要节点。兰州作为甘肃的省会城市,地处西北中心,是重要的交通枢纽,所以兰州市的人民文化早就有了多元的基础,多样的丰富习俗和传统。目前为止兰州穆斯林生活各方面发展的很快,包括穆斯林生活中最重要的宗教清真寺建筑,因此研究兰州伊斯兰建筑的形成、发展与变化特点、空间布局特征、建筑特色,是深入了解近代中国文化和伊斯兰文化在兰州伊斯兰建筑文化融合的重要环节,也是研究中国文化和伊斯兰文化的完美结合的标本。本论文以兰州清真寺建筑为对象,拍摄了兰州穆斯林清真寺建筑大量实证照片,并对相关的文献资料进行了研究。因此为了更详细的研究兰州伊斯兰清真寺建筑文化各方面,本论以两大项而进行了研究。一、通过清真寺建筑的设计方面（包括建筑风格、平面布置）和建筑的各部分结构（礼拜殿、宣礼塔与望月楼、大穹顶、讲经堂、大门等）来研究中阿两大文化对兰州伊斯兰建筑结构的影响。二、通过兰州清真寺建筑的装饰艺术,包括装饰色彩及寓意、装饰花纹、装饰材料及做法来研究在兰州清真寺建筑美术方面中阿两种文化的完美融合和建筑物的丰富多样性。研究的结果表明:兰州伊斯兰清真寺建筑有大的发展和变化,不管是结构方面、装饰艺术、功能方面,兰州清真寺建筑以中国传统装饰中应用和伊斯兰教文化中的原则而突出了宗教内容,取得了个性鲜明的面貌,反映了中国穆斯林审美心理和本族对宗教建筑的充分兴趣,融合了他们自己的宗教文化和自己国家传统文化结合在一起完美多彩成果。

关键词：兰州穆斯林中阿文化清真寺建筑设计和装饰特色

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Quantification of Radiation Use Efficiency and Yield of Wheat as Influenced by Different Levels of Nitrogen and Water Stress under Semi-Arid Conditions of Faisalabad

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Agricultural Sciences 2018年第7期9卷 873-887页

作者： Muhammad Ishfaq Usman Zulfiqar Muhammad Ahmad Ch Basit Mustafa ali hamed Muhammad Shafique Aslam Muhammad Zohaib Anjum Department of Agronomy University of Agriculture Faisalabad Pakistan Department of Forestry and Range Management University of Agriculture Faisalabad Pakistan

Crop production is greatly influenced by water and nutrition stress in semi-arid areas. Nitrogen and water are two most important yield limiting factors which effect economic production of wheat. Drought initiates when large area of land suffers from absence of precipitation for temporary periods. Though, not only water scarceness but also low relative humidity and high temperature are other climate factors which induce drought condition. Whereas Effective nutrition (nitrogen) maintains crops metabolic activities and has the potential to lessen drought stress. According to study carried out to explore the influence of varying levels of potential soil moisture deficit (PSMD) and nitrogen, an experiment was planned at agronomy research area, University of Agriculture, Faisalabad. It was laid out in randomized complete block design (RCBD) with split plot arrangement, and replicated thrice. Two factors: potential soil moisture deficit levels (I1: irrigation at 50 mm PSMD, I2: irrigation at 75 mm PSMD and I3: irrigation at 100 mm PSMD) were randomized in main plots, while sub plot nitrogen levels {control (No nitrogen), 50, 100 and 150 kg N ha-1} were randomized. Adequate nitrogen application along with sufficient irrigation management gave highest yield. Under water deficit conditions adequate nitrogen application ameliorates the drought stress. Highest plant height (86.27 cm), number of productive tillers (320.0), grain·spike-1(49.73), test weight (50.55 g) and grain yield (6.72 t·ha-1) were observed with 75 mm PSMD and 150 kg·ha-1 application of nitrogen. While radiation use efficiency for dry matter accumulation of wheat ranged from 1.53 - 1.87 g·MJ-1 whereas, radiation use efficiency for grain yield ranged from 0.421 - 0.473 g·MJ-1. Results revealed that highest RUE obtained I3 (75 mm PSMD) and nitrogen application at 150 kg·ha-1. Judicial application of irrigation and fertilizer not only boosts the yield but also saves resource and increases former output.

关键词： Quantification Potential Soil Moisture Deficit Nitrogen Wheat

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Synthesis and characterization of carbon-coated cobalt ferrite nanoparticles

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International Journal of Minerals,Metallurgy and Materials 2016年第9期23卷 1104-1111页

作者： hamed Bakhshi ali Shokuhfar Nima Vahdati Advanced Materials and Nanotechnology Lab Department of Materials Science and Engineering K.N.Toosi University of Technology Department of Materials Science and Engineering Saveh Branch Islamic Azad University

Cobalt ferrite nanoparticles（CFNPs） were prepared via a reverse micelle method. The CFNPs were subsequently coated with carbon shells by means of thermal chemical vapor deposition（TCVD）. In this process, acetylene gas（C2H2） was used as a carbon source and the coating was carried out for 1, 2, or 3 h at 750℃. The Ar/C2H2 ratio was 10：1. Heating during the TCVD process resulted in a NP core size that approached 30 nm; the thickness of the shell was less than 10 nm. The composition, structure, and morphology of the fabricated composites were characterized using X-ray diffraction, simultaneous thermal analysis, transmission electron microscopy, high-resolution transmission electron microscopy, and selected-area diffraction. A vibrating sample magnetometer was used to survey the samples＇ magnetic properties. The deposited carbon shell substantially affected the growth and magnetic properties of the CFNPs. Micro-Raman spectroscopy was used to study the carbon coating and revealed that the deposited carbon comprised graphite, multiwalled carbon nanotubes, and diamond-like carbon. With an increase in coating time, the intensity ratio between the amorphous and ordered peaks in the Raman spectra decreased, which indicated an increase in crystallite size.

关键词： nanoparticles cobalt ferrite carbon coatings chemical vapor deposition Raman spectroscopy

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Peak displacement patterns for the performance-based seismic design of steel eccentrically braced frames

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Earthquake Engineering and Engineering Vibration 2019年第2期18卷 379-393页

作者： ali Fakhraddini hamed Saffari Mohammad Javad Fadaee Department of Civil Engineering Shahid Bahonar University of Kerman

Performance-based seismic design(PBSD) aims to assess structures at different damage states. Since damage can be directly associated to displacements, seismic design with consideration of displacement seems to be logical. In this study, simple formulae to estimate the peak floor displacement patterns of eccentrically braced frames(EBFs) at different performance levels subjected to earthquake ground motions are proposed. These formulae are applicable in a PBSD and especially in direct displacement-based design(DDBD). Parametric study is conducted on a group of 30 EBFs under a set of 15 far field and near field accelerograms which they scaled to different amplitudes to adapt various performance levels. The results of thousands of nonlinear dynamic analyses of EBFs have been post-processed by nonlinear regression analysis in order to recognize the major parameters that influence the peak displacement pattern of these frames. Results show that suggested displacement patterns have relatively good agreement with those acquired by an exact nonlinear dynamic analysis.

关键词： performance-based seismic design direct displacement-based design displacement pattern eccentrically braced frames steel building

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On active synchronization of fractional-order Bloch chaotic system and its practical application in secure image transmission

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International Journal of Intelligent Computing and Cybernetics 2018年第2期11卷 181-196页

作者： hamed Tirandaz ali Karami-Mollaee Department of Electrical and Computer Engineering Hakim Sabzevari UniversitySabzevarIran

Purpose-The purpose of this paper is to propose a novel and secure image transmission based on the unpredictable behavior of the chaotic ***/methodology/approach-The proposed approach includes two main contributions:synchronization scheme and transmission *** synchronization scheme benefits the advantage of the fractional-order active synchronization method.A new control law is derived to asymptotically synchronize the underlined fractional-order Bloch chaotic *** validity of the proposed synchronization scheme is proved by the Lyapunov stability ***,a novel image transmission scheme is designed to transfer image data via chaotic signals,which modulates the encrypted data in the sender signals and demodulates it at the receiver ***-Numerical simulations are provided to show the validity and effectiveness of the proposed image transmission ***,the performance of the image transmission system is evaluated using some illustrative examples and their corresponding statistical *** results demonstrate the effectiveness of the proposed method in comparison with other proposed methods in this ***/value–A new chaos-based image transmission system is developed based on the synchronization of Bloch chaotic *** introduced transmission system is interesting and could be applicable to any kind of secure image/video transmission.

关键词： Active control Bloch chaotic system Fractional calculus Image transmission system Secure communication

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Photocatalytic Synthesis of Gold Nanoparticles Using Preyssler Acid and Their Photocatalytic Activity

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催化学报 2011年第6期32卷 978-982页

作者： ali AYATI ali AHMADPOUR Fatemeh F.BAMOHARRAM Majid M.HERAVI hamed RASHIDI Department of Chemical Engineering Ferdowsi University of Mashhad Department of Chemistry School of SciencesIslamic Azad University Department of Chemistry School of SciencesAlzahra University

Preyssler acid H14[NaP5W30O110] was used as reducing agent and stabilizer for the synthesis of gold nanoparticles by photolysis of Au(III)/Preyssler acid/propan-2-ol *** acid plays both the role of transferring electrons from propan-2-ol to Au(III) and stabilizing the ***-2-ol was used as sacrificial reagent for the photoformation of reduced Preyssler *** nanoparticles (Au NPs) were characterized by UV-Vis spectroscopy,transmission electron microscopy (TEM),and particle size distribution (PSD) *** synthesized Au NPs had a uniform hexagonal morphology and their size was about 17 *** catalytic performance of these NPs for photodegradation of methyl orange (MeO) was investigated in aqueous ***-Vis studies showed that Au NPs can catalyze photodegradation of this azo *** pseudo-first-order rate constants were also calculated for this reaction.

关键词：固体超强碱氧化钙硝酸钾氧化铝氧化锆氢氧化钾硝酸钙

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