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Positron Emission Tomography Molecular Imaging for Phenotyping and Management of Lymphoma

Phenomics 2022年第2期2卷 102-118页

作者： Xiaohui Zhang Han Jiang Shuang Wu Jing Wang Rui Zhou Xuexin He Shufang Qian Shuilin Zhao Hong Zhang ali cahid civelek Mei Tian Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangChina Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009ZhejiangChina Institute of Nuclear Medicine and Molecular Imaging of Zhejiang University Hangzhou 310009ZhejiangChina PET-CT Center Fujian Medical University Union HospitalFuzhou 350001FujianChina Department of Medical Oncology The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009ZhejiangChina Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310027ZhejiangChina College of Biomedical Engineering&Instrument Science Zhejiang UniversityHangzhou 310027ZhejiangChina Department of Radiology and Radiological Science Johns Hopkins MedicineBaltimoreMD 21287USA Human Phenome Institute Fudan UniversityShanghai 201203China

Positron emission tomography(PET)represents molecular imaging for non-invasive phenotyping of physiological and biochemical processes in various oncological *** imaging with 18F-fluorodeoxyglucose(18F-FDG)for glucose metabolism evaluation is the standard imaging modality for the clinical management of *** of the 18F-FDG PET applications is the detection and pre-treatment staging of lymphoma,which is highly sensitive.18F-FDG PET is also applied during treatment to evaluate the individual chemo-sensitivity and accordingly guide the response-adapted *** the end of the therapy regiment,a negative PET scan is indicative of a good prognosis in patients with advanced Hodgkin’s lymphoma and diffuse large B-cell ***,adjuvant radiotherapy may be *** PET studies using non-18F-FDG radiotracers,such as 68Ga-labeled pentixafor(a cyclic pentapeptide that enables sensitive and high-contrast imaging of C-X-C motif chemokine receptor 4),68Ga-labeled fibroblast activation protein inhibitor(FAPI)that reflects the tumor microenvironment,and 89Zr-labeled atezolizumab that targets the programmed cell death-ligand 1(PD-L1),may complement 18F-FDG and offer essential tools to decode lymphoma phenotypes further and identify the mechanisms of lymphoma therapy.

关键词： Positron emission tomography(PET) Lymphoma Glucose metabolism Staging Response assessment

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International Nuclear Medicine Consensus on the Clinical Use of Amyloid Positron Emission Tomography in Alzheimer’s Disease

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Phenomics 2023年第4期3卷 375-389页

作者： Mei Tian Chuantao Zuo ali cahid civelek Ignasi Carrio Yasuyoshi Watanabe Keon Wook Kang Koji Murakami Valentina Garibotto John OPrior Henryk Barthel Yihui Guan Jiaying Lu Rui Zhou Chentao Jin Shuang Wu Xiaohui Zhang Yan Zhong Hong Zhang Molecular Imaging-Based Precision Medicine Task Group of A3(China-Japan-Korea)Foresight Program PET Center Huashan HospitalFudan UniversityShanghai 200235China Human Phenome Institute Fudan UniversityShanghai 201203China Department of Nuclear Medicine and PET Center The Second Affiliated Hospital of Zhejiang University School of MedicineHangzhou 310009China National Center for Neurological Disorders and National Clinical Research Center for Aging and Medicine Huashan HospitalFudan UniversityShanghai 200040China Department of Radiology and Radiological Science Division of Nuclear Medicine and Molecular ImagingJohns Hopkins MedicineBaltimore 21287USA Department of Nuclear Medicine Hospital Sant PauAutonomous University of BarcelonaBarcelona 08025Spain Laboratory for Pathophysiological and Health Science RIKEN Center for Biosystems Dynamics ResearchKobeHyogo 650‑0047Japan Department of Nuclear Medicine Seoul National University College of MedicineSeoul 03080Korea Department of Radiology Juntendo University HospitalTokyo 113‑8431Japan Diagnostic Department University Hospitals of Geneva and NIMTlabUniversity of GenevaGeneva 1205Switzerland Department of Nuclear Medicine and Molecular Imaging Lausanne University HospitalLausanne 1011Switzerland Department of Nuclear Medicine Leipzig University Medical CenterLeipzig 04103Germany Key Laboratory of Medical Molecular Imaging of Zhejiang Province Hangzhou 310009China The College of Biomedical Engineering and Instrument Science of Zhejiang University Hangzhou 310007China Key Laboratory for Biomedical Engineering of Ministry of Education Zhejiang UniversityHangzhou 310007China 不详

Alzheimer’s disease(AD)is the main cause of dementia,with its diagnosis and management remaining *** positron emission tomography(PET)has become increasingly important in medical practice for patients with *** integrate and update previous guidelines in the field,a task group of experts of several disciplines from multiple countries was assembled,and they revised and approved the content related to the application of amyloid PET in the medical settings of cognitively impaired individuals,focusing on clinical scenarios,patient preparation,administered activities,as well as image acquisition,processing,interpretation and *** addition,expert opinions,practices,and protocols of prominent research institutions performing research on amyloid PET of dementia are *** the increasing availability of amyloid PET imaging,a complete and standard pipeline for the entire examination process is essential for clinical *** international consensus and practice guideline will help to promote proper clinical use of amyloid PET imaging in patients with AD.

关键词： Positron emission tomography(PET) Alzheimer’s disease Amyloid Brain imaging Expert consensus

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A model System for Validation of PET Radiopharmaceuticals: Focusing on Tumor Microenvironment

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International Journal of Medical Physics, Clinical Engineering and Radiation Oncology 2013年第1期2卷 19-29页

作者： Xiao-Feng Li Huijie Jiang Yuanyuan Ma Tao Huang Xindao Yin A. cahid civelek Baozhong Shen Department of Diagnostic Radiology Division of Nuclear medicine University of Louisville School of Medicine Louisville USA Department of Diagnostic Radiology University of Louisville School of Medicine Louisville USA Department of Radiology The 4th Hospital of Harbin Medical University Harbin China Memorial Sloan-Kettering Cancer Center New York USA

Positron emission tomography (PET) imaging has emerged as an important clinical tool for cancer management, and specifically targeted radiopharmaceuticals play critical roles on PET molecular imaging. Solid cancers have highly complex and heterogeneous microenvironment, this review focused on those microenvironmental factors such as hypoxia, proliferation and perfusion and, accordingly, a novel test system for validation of current and novel targeted imaging radiopharmaceuticals. In this review, we have introduced the establishment of cancer and metastases models in nude mice, visualization of microenvironmental components of hypoxia, proliferation, perfusion, stroma and necrosis in cancers and metastases for establishing the microenvironment based model system, and validation of several radio- pharmaceuticals such as 18F-fluoro-2-deoxyglucose (18F-FDG) 18F-fluorothymidine (18F-FLT), 18F-misonidazole (18F- FMISO) using the system. We found that 18F-FLT accumulates in proliferating cancer cells, while 18F-FMISO and 18F-FDG mostly accumulate in hypoxic and non-proliferative cancer cells, 18F-FDG shares roughly similar intratumoral distribution pattern with 18F-FMISO and IAZGP, but mutually excludes 18F-FLT. This model system validated current tracers for imaging glucose metabolism, hypoxia and proliferation in cancer and metastases, therefore, can be used for novel targeted radiopharmaceuticals validation.

关键词： 18F-Fluoro-2-Deoxyglucose 18F-Fluorothymidine 18F-Misonidazole Microenvironment Hypoxia Proliferation

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Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study

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World Journal of Stem Cells 2021年第5期13卷 470-484页

作者： Serdar Kabatas Erdinç civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can ali Genç Tunç Akkoç Erdal Karaöz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research HospitalIstanbul 34255Turkey Pediatric Allergy-Immunology Marmara UniversityInstitute of Health SciencesIstanbul 34854Turkey Center for Stem Cell&Gene Therapy Research and Practice University of Health SciencesIstanbul 34255Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery Istanbul Biruni UniversityFaculty of MedicineIstanbul 34010Turkey Department of Neurosurgery Istanbul Medicine HospitalIstanbul 34203Turkey Department of Neurosurgery Istanbul Asya HospitalIstanbul 34250Turkey Pediatric Allergy-Immunology Marmara UniversityIstanbul 34899Turkey Center for Regenerative Medicine and Stem Cell Research&Manufacturing(LivMedCell) Liv HospitalIstanbul 34340Turkey Department of Histology and Embryology Istinye UniversityFaculty of MedicineIstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice Istinye UniversityIstanbul 34340Turkey

BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric *** a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from *** To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with *** The study inclusion criteria were determined as the presence of substantial deficit and disability caused by ***’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 *** different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)*** For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±*** patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 *** treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of *** exhibited significant improvements in all neurological functions through a 12-mo *** mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z

关键词： Hypoxic-ischemic encephalopathy Pediatric Stem cell Wharton jelly

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Phase I study on the safety and preliminary efficacy of allogeneic mesenchymal stem cells in hypoxic-ischemic encephalopathy

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World Journal of Experimental Medicine 2021年第2期11卷 17-29页

作者： Serdar Kabataş Erdinçcivelek Necati Kaplan Eyüp Can Savrunlu Gülseli Berivan Sezen Mourat Chasan Halil Can ali Genç Yener Akyuva Osman Boyalı Furkan Diren Erdal Karaoz Department of Neurosurgery University of Health SciencesGaziosmanpaşa Training and Research Hospitalİstanbul 34255Turkey Pediatric Allergy-Immunology Marmara UniversityInstitute of Health Sciencesİstanbul 34854Turkey Center for Stem Cell and Gene Therapy Research and Practice University of Health Sciencesİstanbul 34255Turkey Department of Neurosurgery Istanbul Rumeli UniversityÇorlu Reyap HospitalTekirdağ59860Turkey Department of Neurosurgery İstanbul Biruni UniversityFaculty of Medicineİstanbul 34010Turkey Department of Neurosurgery İstanbul Medicine Hospitalİstanbul 34203Turkey Department of Neurosurgery İstanbul Asya Hospitalİstanbul 34250Turkey Department of Neurosurgery Mustafa Kemal UniversityFaculty of MedicineHatay 31060Turkey Center for Regenerative Medicine and Stem Cell Research and Manufacturing(LivMedCell) Liv Hospitalİstanbul 34340Turkey Department of Histology and Embryology İstinye UniversityFaculty of Medicineİstanbul 34010Turkey Center for Stem Cell and Tissue Engineering Research and Practice İstinye Universityİstanbul 34340Turkey

BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is a leading cause of morbidity and mortality in the adult as well as in the neonate,with limited options for treatment and significant *** To investigate the safety and preliminary efficacy of allogeneic mesenchymal stem cells(MSCs)in HIE *** Patients who had HIE for at least 6 mo along with significant dysfunction and disability were *** patients were given Wharton’s jelly-derived MSCs at 1×106/kg intrathecally,intravenously,and intramuscularly twice a month for two *** therapeutic effects and prognostic implications of MSCs were evaluated by multiple *** independence measure(FIM),modified Ashworth,and Karnofsky scales were used to assess any side effects,neurological and cognitive functions,and overall *** The 8 subjects included in the study had a mean age of 33.25±10.18 *** HIE exposure and mean post-HIE durations were 45.63±10.18 and 19.67±29.04 mo,*** FIM score was 18.38±1.06,mean modified Ashworth score was 43.5±4.63,and mean Karnofsky score was *** the first 24 h,5 of the patients experienced a subfebrile state,accompanied by mild headaches due to intrathecally administration and muscle pain because of intramuscularly *** and functional examinations,laboratory tests,electroencephalography,and magnetic resonance imaging were performed to assess safety of *** FIM score increased by 20.88±3.31 in the first month(P=0.027)and by 31.38±14.69 in 12 mo(P=0.012).The rate of patients with an FIM score of 126 increased from 14.58%to 16.57%in the first month and 24.90%in 12 *** Multiple triple-route Wharton’s jelly-derived MSC administrations were found to be safe for HIE patients,indicating neurological and functional *** on the findings obtained here,further randomized and placebo research could be performed.

关键词： Hypoxic-ischemic encephalopathy Stem cell Transplantation Wharton's jelly

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