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Synthesis and characterization of polymeric responsive CMC/Pectin hydrogel films loaded with Tamarix aphylla extract as potential wound dressings

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BIOCELL 2021年第5期45卷 1273-1285页

作者： barkat ali KHAN FAZAL KARIM MUHAMMAD KHaliD KHAN FAHEEM HAIDER SADIQULLAH KHAN Drug Delivery and Cosmetics Laboratory Gomal Center of Pharmaceutical SciencesFaculty of PharmacyGomal UniversityD.I.Khan29050Pakistan Department of Environmental Science Faculty of Engineering&TechnologyGomal UniversityD.I.Khan29050Pakistan

The fourth most predominant overwhelming type of trauma is burn injuries *** wound healing dressings help in the wound healing process in a lower time with less *** used dry wound dressing,like absorbent gauze or absorbent cotton,possess limited therapeutic effects and require repeated use,which further exaggerates patients’*** contrast,hydrogels films present a promising alternative to improve healing by guaranteeing a moisture balance at the wound *** aim of the current study was to synthesize Tamarix aphylla(***)extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing *** Na-CMC/Pectin hydrogels films were synthesized and characterized for HPLC analysis,FTIR,surface morphology,rheology,tensile strength,swelling behavior,drug release kinetics,and in vivo wound healing in an animal *** confirmed the existence of strong interaction between both polymers but no interaction with the *** photographs showed successful embedding of extract in small pores of hydrogel film and showed smooth and homogenous *** and texture profiles indicated that hydrogels behaved as strong *** and erosion were dependent on the amount of the *** showed drug content of three selected formulation(A3,E3 and S3)as 85±0.1%,82.5±0.4%and 80±0.3%,*** release of the drug from the hydrogel was controlled by a Fickian diffusion *** vivo wound healing activity of hydrogel film confirmed that *** extract successfully promoted healing rate by significantly reducing(P<0.05)the size of wound closure compared to the control group,evidenced by intensive collagen formation in histopathological and biochemical *** capability of these hydrogels for burn wounds could be valuable for medical uses as a new window of safe and effective medication.

关键词： Tamarix aphylla Hydrogel film Burn wound Carboxymethyl cellulose Pectin

Dietary isoflavones,the modulator of breast carcinogenesis:Current landscape and future perspectives

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Asian Pacific Journal of Tropical Medicine 2018年第3期11卷 186-193页

作者： Javed Iqbal Banzeer Ahsan Abbasi ali Talha Khalil barkat ali Tariq Mahmood Sobia Kanwal Sayed Afzal Shah Wajid ali Department of Plant Sciences Quaid-i-Azam University Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa chair in nanoscience and nanotechnology Nanosciences African Network(NANOAFNET) Department of Zoology University of GujratSub Campus

Breast cancer is a frightful disease and serious concern in women around the world causing significant health care burden in both developed and developing countries. Extensive research work has shown that breast cancer provides strong resistance to chemical agents, U V radiation,and hormonal treatments. It is generally accepted that cell genetics is not the only main reason for breast cancer and genetic risk factors, for example, mutations in RRCAI and BRCA2 genes constitute 5%-10% of all breast cancer rates. Other related factors include age, gender,race, ethnicity, weight, reproductive factors, exo-and endogenous hormonal exposures, oral contraceptives use, ultraviolet radiation, diet, and night work(circadian disruption). Many studies have revealed that dietary isoflavones regulate breast cancer occurrence, recurrence and prognosis. Dietary isoflavones have long been part of Asian population diet and there is a significant increase as compared to dietary isoflavones intake among other populations. Dietary isoflavones are natural phytoestrogens having both estrogenic and anti-estrogenic potentials on breast cancer cells in culture, animal models and in experimental trials. This literature survey provides a comprehensive overview on the tumor preventive and tumor promoting potentials of dietary isoflavones on breast cancer. In addition, this paper provides a literature review of dietary isoflavones and their effects on up-regulation and down-regulation of different signaling pathways, genes and proteins. Finally, future perspectives of dietary isoflavones and breast cancer researchers are also critically discussed, which will provide a deeper insight regarding the inner molecular mechanisms of action.

关键词： Dietary isoflavones Breast cancer Signaling pathways Natural phytoestrogens

Plant-derived anticancer agents: A green anticancer approach

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Asian Pacific Journal of Tropical Biomedicine 2017年第12期7卷 1129-1150页

作者： Javed Iqbal Banzeer Ahsan Abbasi Tariq Mahmood Sobia Kanwal barkat ali Sayed Afzal Shah ali Talha Khalil Department of Plant Sciences Quaid-i-Azam University Islamabad45320Pakistan Department of Zoology University of GujratSub Campus RawalpindiPakistan Department of Eastern Medicine and Surgery Qarshi UniversityLahorePakistan UNESCO UNISA Africa chair in nanoscience and nanotechnology South Africa Nanosciences African Network(NANOAFNET) South Africa

Cancer is a frightful disease and represents one of the biggest health-care issues for the human race and demands a proactive strategy for cure. Plants are reservoirs for novel chemical entities and provide a promising line for research on cancer. Hitherto, being effective, chemotherapy is accompanied by certain unbearable side effects. Nevertheless,plants and plant derived products is a revolutionizing field as these are Simple, safer, ecofriendly, low-cost, fast, and less toxic as compared with conventional treatment *** are selective in their functions and acts specifically on tumor cells without affecting normal cells. Carcinogenesis is complex phenomena that involves many signaling cascades. Phytochemicals are considered suitable candidates for anticancer drug development due to their pleiotropic actions on target events with multiple manners. The research is in progress for developing potential candidates(those can block or slow down the growth of cancer cells without any side effects) from these phytochemicals. Many phytochemicals and their derived analogs have been identified as potential candidates for anticancer therapy. Effort has been made through this comprehensive review to highlight the recent developments and milestones achieved in cancer therapies using phytomolecules with their mechanism of action on nuclear and cellular factors. Furthermore, drugs for cancer treatment and their limitations have also been discussed.

关键词： Cancer Limitations of anticancer drugs Phytochemicals Analogs

Role of dietary phytochemicals in modulation of miRNA expression:Natural swords combating breast cancer

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Asian Pacific Journal of Tropical Medicine 2018年第9期11卷 501-509页

作者： Banzeer Ahsan Abbasi Javed Iqbal Tariq Mahmood ali Talha Khalil barkat ali Sobia Kanwal Sayed Afzal Shah Riaz Ahmad Department of Plant Sciences Quaid-i-Azam University Nanosciences African Network(NANOAFNET) iThemba LABS-National Research Foundation Somerset West Department of Zoology University of GujratSub Campus Department of Eastern Medicine and Surgery Qarshi University UNESCO UNISA Africa Chair in Nanoscience and Nanotechnology College of Graduate StudiesUniversity of South Africa College of Life Sciences Shaanxi Normal University

The National Cancer Institute had projected breast cancer(BC) as one of the topmost prevalent malignancies around the *** many cases,BC becomes resistant to chemotherapy,radiation and hormonal *** BC therapies are associated with adverse side effects,drug resistance and *** research work has shown that these dietary phytochemicals(DPs) may exert therapeutic effects by regulating the miRNA expression.A large number of DPs have been researched as miRNA regulatory agents against BC and some other DPs have not yet been tested against *** have discussed the effects of curcumin,diallyl disulphide,3,3′ diindolylmethane,ellagic acid,genistein,indole-3-carbinol,quercetin,resveratrol,and sulforaphane on regulation of expression of BC miRNAs in a wide range of in vitro and in vivo *** have also shown some of the possible DPs(Oleanolic acid,capsaicin,benzyl isothiocyanate,epigallocatechin gallate,phenethyl isothiocyanate and ursolic acid) that have shown miRNA regulatory activities and have not yet been tested against BC ***,current limitations,challenges,future perspectives of DPs and BC research are also critically discussed.

关键词： Breast cancer miRNAs Dietary phytochemicals In vitro In vivo

Inflammation responsive tofacitinib loaded albumin nanomedicine for targeted synergistic therapy in ulcerative colitis

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Nano Research 2023年第7期16卷 9873-9884页

作者： Bang Li Xiaoyan Liu Qi Long Xiaoduan Zhuang Yanfei Gao barkat ali Haoting Chen Dongyang Zhang Xinying Wang Weisheng Guo Department of Gastroenterology Zhujiang HospitalSouthern Medical UniversityGuangzhou 510282China Department of Minimally Invasive Interventional Radiology the State Key Laboratory of Respiratory DiseaseSchool of Biomedical Engineering&The Second Affiliated HospitalGuangzhou Medical UniversityGuangzhou 510260China

Patients with ulcerative colitis(UC)often loss responses over long term usage of conventional ***,a pan-Janus kinases(JAK)inhibitor is approved for moderate to severe UC treatment,while dose-limiting systemic side effects including infections,cancers and lymphoma limit its popularity of clinical *** study sought to construct an anti-mucosal vascular addressin cell-adhesion molecule-1(anti-MAdCAM-1)antibody modified reactive oxygen species(ROS)responsive human serum albumin-based nanomedicine denoted as THM,to improve the therapeutic efficacy of tofacitinib for UC *** has the drug releasing properties in response to ROS *** vitro studies show that THM selectively adhered to the endothelial cells and had obvious anti-inflammatory effect on ***,the nanomedicine can inhibit the phenotypic switching of M1 macrophages and promote M2 polarization to produce anti-inflammatory medicators during wound *** addition,in vivo fluorescence imaging verified that THM exhibited enhanced preferential accumulation and extended retention in inflamed ***,THM significantly reduced the production of proinflammatory cytokines in the colon and suppressed the homing of T cells to the gut in dextran sodium sulfate induced experimental *** work elucidates that the inflamed colon-targeted delivery of tofacitinib by nanomedicine is promising for UC treatment and sheds light on addressing the unmet medical need.

关键词： ulcerative colitis mucosal vascular addressin cell-adhesion molecule-1(MAdCAM-1) tofacitinib reactive oxygen species(ROS)-responsive targeted delivery

Cow manure and cow manure-derived biochar application as a soil amendment for reducing cadmium availability and accumulation by Brassica chinensis L. in acidic red soil

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Journal of Integrative Agriculture 2017年第3期16卷 725-734页

作者： Yasmin Khan Kiran ali barkat CUI Xiao-qiang FENG Ying PAN Feng-shan TANG Lin YANG Xiao-e Key Laboratory of Environmental Remediation and Ecological Health/Ministry of Education College of Environmental and Resource SciencesZhejiang University State Key Laboratory of Food Science and Technology School of Food Science and TechnologyJiangnan University National Agricultural Research Centre Islamabad

Organic amendment is a promising,in situ phytostabilization approach to alleviate the phytotoxic effects of heavy metal contaminated *** aim of this study was to evaluate the feasibility of cow manure（CM）and its derived biochar（CMB）as a soil amendment on cadmium（Cd）availability and accumulation in low and high Cd-accumulating cultivars of Brassica chinensis *** in an acidic red *** and CMB were applied to Cd-contaminated acidic red soil at the rates of 0,3.0and 6.0%（w/w）.Application of CMB was significantly more effective than that of CM,as it reduced the availability of Cd in soil by 34.3–69.9%and its bioaccumulation in the low Cd accumulator,Aijiaoheiye 333,by 51.2 and 67.4%,*** addition of CMB significantly increased the extractability and accumulation of trace metals（Zn,Mn,Fe,and Cu）by plants and improved plant biomass *** application,combined with utilizing low Cd accumulating cultivars represents a new,sustainable strategy to alleviate the toxic effects on Cd and improve food safety.

关键词： Brassica chinensis biochar cow manure red soil phytostabilization trace metals

A Survey on Biosafety Practices in Lab Personnel in 12 Selected Areas of Karachi,Pakistan

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Journal of Biosafety and Biosecurity 2019年第1期1卷 68-72页

作者： Shafiq Ahmad barkat ali Shabnam Khan Anum Fatima Muhammad Saeed ali Asghar Syeda Sadaf Akber Rakhshanda Baqai Shahana Urooj Kazmi Department of Clinical Microbiology and Immunology Dadabhoy Institute of Higher EducationKarachiPakistan

The objective of this study was to realize the degree of biosafety precautions and measures recorded among different Private Hospitals and Diagnostic labs personnel situated in different areas of Karachi,*** thirty two private hospital based laboratory technicians were selected from all 12 selected areas in *** laboratory technicians were interviewed then a survey form was completed by the *** survey was conducted in 3 months duration from May 2017 to July *** total number of members in this study was 132,of which 85 were males and 47 were *** presented that 65%of the laboratory technicians did not use any type of PPE and 35%of the respondents recapped used syringes frequently while 25%recapped *** avoiding the reuse of syringes,Pakistani governments recommend that they be cut before discarding;however,only 65%of the respondents followed the given *** though mouth pipetting is considered outdated,45%of the technicians continue to do so for numerous *** of this survey established an absence of awareness about good and proper lab practices and lab biosafety measures among lab technicians in Karachi,Pakistan.

关键词： Antimicrobial resistance Extended spectrum beta lactamase(ESBL) Urinary tract infections(UTIs) Gram negative bacteria(GNB)

A Review of the Tettigoniidae Krauss, 1902 (Tettigonioidea: Ensifera: Orthoptera) with a New Species from Pakistan

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Journal of Agricultural Science and Technology(A) 2021年第1期11卷 1-21页

作者： Surriya Sanam Riffat Sultana barkat ali Bughio Saiqa Sanam Department of Zoology University of SindhJamshoroSindhPakistan

The Tettigoniidae commonly known as katydids or bush crickets(Ensifera:Orthoptera)is reviewed,with five genera and twelve species viz:Trigonocorypha unicolor Stal 1873,*** Uvarov 1922,Phaneroptera spinosa Bei-Beienko 1965,*** Walker 1869,*** Be-Bienko 1954,*** Burmeister 1838,Holochlora japonica Brunner von Wattenwyl 1878,*** Stal 1873,*** Ingrisch 1990,Ducetia japonica Thunberg 1815,Letana bulbosa Ingrisch 1990 including one new species Holochlora?*** distribution records of species within various districts of Sindh Pakistan are *** taxonomic keys to the various genera and species of Tettigoniidae occurring in Sindh Pakistan are *** variation within nominal species is discussed.

关键词： Tettigoniidae Pakistan new species Holochlora taxonomic keys

Pre-Operative Assessment and Education

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Surgical Science 2012年第1期3卷 10-14页

作者： Rozina barkat ali Nasreen S. Lalani Amina Malik The Aga Khan University Karachi Pakistan

Introduction: Surgery is a major event in an individual’s life. The complete surgical episode is known as perioperative period. Perioperative nursing in general includes three phases;pre-operative, intra-operative and post-operative. The first and initial phase (pre-operative) involves the rendering of nursing care to the patients who are planned to undergo surgery (Spry, 2005) [1]. It was evident through literature that during this phase, assessment and education of the patient is the prime responsibility of health care providers to minimize the risk during the surgery and to have better outcomes of the patients. Hence, a seven weeks project was initiated at surgical care units of Aga Khan University Hospital, Karachi, Pakistan. In this project, based on the need assessment, education sessions were conducted for the health care workers which were followed by the distribution of flash cards for their references. In addition, file review and pre operative patient’s interview was conducted for the outcome evaluation. Purpose: To create awareness among healthcare workers to minimize the risk of morbidity and mortality of patients undergoing surgery and to reinforce nurses of surgical areas for the accurate assessment and education of patients, undergoing surgery. Methodology: All three surgical care units of the University teaching hospital were selected as project site and to conduct the project, permission and verbal consent was obtained from manager of these units. A total of 30 patients undergoing surgery were included in the project and were followed for their complete pre-operative assessment and education by nurses and other health care workers. For the data collection, a tool for pre operative assessment and education was developed. Based on the assessment, altogether three educational sessions were conducted for all health care workers working in the surgical care areas. Data was tabulated in Excel and percentages were calculated to analyze the data of before

关键词： Preoperative Assessment Education Anesthesia Surgery