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Halothane hepatitis in Iran:A review of 59 cases

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World Journal of Gastroenterology 2008年第34期14卷 5322-5326页

作者： Payam Eghtesadi-Araghi Amir-ali Sohrabpour Homayoon Vahedi Mehdi Saberi-firoozi Digestive Disease research Center Shariati HospitalMedical Sciences/University of Tehran Gastroenterology research Center Shiraz University of Medical Sciences Digestive Disease research Center Shariati Hospital Medical Sciences/University of Tehran

AIM:To study halothane hepatitis (HH) in Iran and its associated risk factors. METHODS: We retrospectively studied files of all cases diagnosed with HH referred to three referral hospitals and four private centers in Iran from April 1994 to September 2006. Information on age at surgery, gender, medications history, obesity, history of previous exposure, previous reaction to halothane, familial history, type of surgery, perioperative hypoxia or sepsis, morbidity and mortality were recorded and analyzed. rESULTS: A total of 59 cases were identifi ed. Forty- eight (81%) were women. The median age at the time of surgery was 44 years (range, 18 to 80 years). Sixty percent of patients were above 40-year-old. Obesity was observed in 22.2%. Previous history of exposures to halothane was noted in 61% of which 50% had history of post-exposure reaction. Coronary artery bypass graft (CABG), cholecystectomy, and cosmetic surgeries (mainly weight reduction) were the most frequent surgeries. The mortality rate was 12.2%. In patients developing encephalopathy, it was as high as 50%. CONCLUSION: HH remains an important cause of morbidity and mortality in centers still using this anesthetic. However, a large percentage of these casescould have been avoided. To lessen occurrence of further cases of HH, the authors suggest that in female patients having a history of surgery (or delivery) with general anesthesia, the use of halothane should be absolutely avoided. Utilization of proper substitutes in adults’ anesthesia is advocated.

关键词： Anesthesia Inhalation Halothane Hepatitis Drug-Induced

Optimization of design parameters for controlled rocking steel braced dual-frames

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Earthquake Engineering and Engineering Vibration 2022年第4期21卷 1053-1068页

作者： Sobhan Ghasemi M.firoozi Nezamabadi Abdolreza S.Moghadam Mahmood Hosseini Department of Civil Engineering South Tehran BranchIslamic Azad UniversityTehranIran Structural Engineering research Center International Institute of Earthquake Engineering and Seismology(IIEES)TehranIran

A controlled rocking concentrically steel braced frame(Cr-CSBF)is introduced as an alternative to conventional methods to prevent major structural damage during large *** is equipped with elastic post-tensioned(PT)cables and replaceable devices or fuses to provide overturning resistance and dissipate energy,*** Cr-CSBFs are not officially legalized in globally valid codes for new buildings,it is expected to be presented in them in the near *** main goal of this study is to determine the optimal design parameters consist of the yield strength and modulus of elasticity of the fuse,the initial force of the PT cable,and the gravity load on the rocking column,considering different heights of the frame,spanning ratios and ground motion types for dual-configuration *** time-history analyses are performed in *** study aims to define the optimal input variables as effective design parameters of Cr-CSBFs by comparing four seismic responses consisting of story drift,roof displacement,roof acceleration and base shear,and also using the Euclidean metric optimization *** the previous research,this study is innovative and first of its *** results demonstrate that the optimal design parameters are variable for various conditions.

关键词： self-centering rocking steel braced frame design parameters optimization low damage

Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B_(12) status

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World Journal of Gastroenterology 2008年第23期14卷 3662-3671页

作者： Pooneh Mokarram Fakhraddin Naghibalhossaini Mehdi Saberi firoozi Seyed Vahid Hosseini Ahmad Izadpanah Heshmetalah Salahi Seyed ali Malek-Hosseini Abdoulrasool Talei Mehra Mojallal Department of Biochemistry Shiraz University of Medical SciencesSchool of MedicineShiraz 71345Iran Department of Internal Medicine and Gastroenterohepatology research Centre Shiraz University of Medical SciencesShiraz 71345Iran Department of Surgery(colorectal ward) and Gastroenterohepatology research Centre Shiraz University of Medical SciencesShiraz 71345Iran Department of Surgery and Organ Transplantation research Centre Namazee HospitalShiraz University of Medical SciencesShiraz 71345Iran Department of Surgery and Institute of Cancer research Shiraz University of Medical SciencesShiraz 71345Iran Pathology Laboratory Dena HospitalShiraz 71345Iran

AIM:To evaluate joint effects of Methylentetra-hydrofolate reductase(MTHFr) C677T genotypes,and serum folate/vitamin B12 concentrations on promoter methylation of tumor-associated genes among Iranian colorectal cancer patients. METHODS:We examined the associations between MTHFr C677T genotype,and promoter methylation of P16,hMLH1,and hMSH2 tumor-related genes among151 sporadic colorectal cancer patients. The promoter methylation of tumor-related genes was determined by methylation-specific PCr. Eighty six patients from whom fresh tumor samples were obtained and 81 controls were also examined for serum folate and vitamin B12 concentrations by a commercial radioimmunoassay kit. rESULTS:We found 29.1% of cases had tumors with at least one methylated gene promoter. In case-case comparison,we did not find a significant association between methylation in tumors and any single genotype. However,in comparison to controls with the CC genotype,an increased risk of tumor methylation was associated with the CT genotype(Or = 2.5;95% CI,1.1-5.6) . In case-case comparisons,folate/vitamin B12 levels were positively associated with tumor methylation. Adjusted odds ratios for tumor methylation in cases with high(above median) versus low(below median) serum folate/vitamin B12 levels were 4.9(95% CI,1.4-17.7) ,and 3.9(95% CI,1.1-13.9) ,respectively. The frequency of methylated tumors was significantly higher in high methyl donor than low methyl donor group,especially in those with MTHFr CT(P = 0.01) ,and CT/TT(P = 0.002) genotypes,but not in those with the CC genotype(P = 1.0) . CONCLUSION:We conclude that high concentrations of serum folate/vitamin B12 levels are associated with the risk of promoter methylation in tumor-specific genes,and this relationship is modified by MTHFr C677T genotypes.

关键词： Metthylentetrahydrofolate reductase Folate Vitamin 1322 Methylation Colorectal cancer

Enhancement of the transfection efficiency of DNA into Crocus sativus L. cells via PEI nanoparticles

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Journal of Integrative Agriculture 2018年第8期17卷 1768-1778页

作者： Behnam firoozi Nasser Zare Omid Sofalian Parisa Sheikhzade-Mosadegh Department of Agronomy and Plant Breeding Faculty of Agriculture and Natural Resources University of Mohaghegh Ardabili

Over the past decade, several natural and synthetic cationic polymers have been utilized for gene delivery into cells. Among them, polyethylenimine(PEI) was used for gene therapy successfully. The present study investigated the effect of PEI and ultrasound waves on ssD NA delivery into saffron cells. Gel retardation, dynamic light scattering(DLS) and scanning electron microscopy(SEM) assays were employed to determine the physicochemical properties of PEI/f-DNA polyplex(complex of PEI and fluorescently labeled DNA). Moreover, the cytotoxicity of PEI, PEI/f-DNA polyplex and ultrasound were investigated on saffron cells at different concentrations. The gel retardation results indicated that the formation and neutralization of the PEI/f-DNA polyplex were completed at N/P=5. The particle size distribution of the polyplexes was from 50 to 122 nm. The experimental results revealed that the cytotoxicity of the PEI/f-DNA polyplex was lower than that of PEI alone, hence the cells showed both dose-and exposure duration-dependent responses. Furthermore, the viability of saffron cells declined extremely after 5 and 10 min sonication but this reduction was not significant at 2 min exposure duration. The results also indicated that the combined utilization of ultrasound and PEI nanoparticles increased the transfection efficiency of saffron cells up to two times higher than those obtained by PEI or ultrasound separately.

关键词： PEI/f-DNA polyplex plant cell transfection saffron sonication

Glisson’s capsule in The Avicenna’s Canon of Medicine

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Hepatobiliary Surgery and Nutrition 2023年第5期12卷 804-805页

作者： Sajjad Sadeghi Elnaz Dostmohammadi Mahdi firoozi Department of Traditional Medicine School of Traditional MedicineShahid Beheshti University of Medical SciencesTehranIran Anesthesia Technology Student Research CommitteeSorkheh School of Allied Medical SciencesSemnan University of Medical SciencesSemnanIran Medical Surgical Nursing Sorkheh School of Allied Medical SciencesSemnan University of Medical SciencesSemnanIran

The rich history of anatomy in Persian Medicine is evident and significant(1).In the medieval era,there were a large number of experienced Persian physicians who studied and were experts in the field of human dissecti... 详细信息

关键词： Glisson’s capsule Francis Gleason Avicenna The Canon of Medicine

Assessment and Potential Survey of Lands in Khuzestan Province Using the Buckley Geometric Mean Model and Geographic Information System (GIS)

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Open Journal of Geology 2017年第3期7卷 234-241页

作者： Mohammad ali firoozi Majid Goodarzi rahman Shirali Department of Geography and Urban Planning Faculty of Earth Sciences and GIS Shahid Chamran University of Ahvaz Ahvaz Iran Geography and rural Planning Shahid Chamran University of Ahvaz Ahvaz Iran

Today environmental assessment is considered and used as the basis and foundation of any kind of human activity. This is the science which gives human the consciousness about abilities and disabilities of his surroundings. This study tried to assess and provide the potential survey of lands in Khuzestan province for agricultural activities by taking into account the climatic elements and displaying different elements in different seasons. To achieve this goal, first produced data were analyzed in GIS software and then the data was tested by professors and experts of department of soil science and was weighted using the Buckley geometric mean model. Finally, the obtained weights were applied in the software and the obtained results are as follow: except some east parts of Khuzestan province which have proper climate for agricultural activities, other regions are not in good conditions and it is necessary to use cultivation with low water requirements and high resistance to heat and sunlight in these areas.

关键词： Land Assessment Climatic Parameters Khuzestan Province GIS Buckley Geometric Mean

Selective leaching of arsenic from copper converter flue dust by Na2S and its stabilization with Fe2(SO4)3

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Transactions of Nonferrous Metals Society of China 2020年第6期30卷 1674-1686页

作者： Amirhossein SHAHNAZI Sadegh firoozi Davoud HAGHSHENAS FATMEHSArI Department of Mining and Metallurgical Engineering Amirkabir University of Technology424 Hafez Ave.Tehran 15875-4413Iran

The alkaline leaching of arsenic (As2O3) by Na2S, together with its precipitation by Fe2(SO4)3 was studied. response surface methodology based on central composite design was employed to quantify and qualify the effect of pertinent factors and to develop statistical models for optimization purposes. Based on the obtained results, 89% of arsenic is removed from the dust under following optimum predicted conditions: Na2S concentration of 100 g/L and solid to liquid ratio of 0.163 g/mL at 80 °C. It is found that solid to liquid ratio and Na2S concentration are the significant factors influencing the leaching process. In the precipitation process, more than 99.93% of arsenic from the leaching solution is removed in the form of amorphous ferric arsenate, at pH 4.8 when Fe3+ to arsenic and H2O2 to arsenic molar ratios are set at 5:1 and 4:1, respectively. Also, Fe3+ to arsenic ratio and pH are the most significant factors, and the interaction between these terms is significant.

关键词： flue dust arsenic response surface methodology alkaline leaching precipitation

risk factors of gastroesophageal reflux disease in Shiraz,southern Iran

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World Journal of Gastroenterology 2007年第41期13卷 5486-5491页

作者： Mehdi Saberi-firoozi Farnaz Khademolhosseini Maryam Yousefi Davood Mehrabani Najaf Zare Seyed Taghi Heydari Gastroenterohepatology research Center/Department of Internal Medicine Nemazee HospitalSchool of MedicineShiraz University of Medical SciencesShirazIran Department of Biostatistics School of Public HealthShiraz University of Medical SciencesShirazIran Gastroenterohepatology research Center/Department of Internal Medicine Nemazee HospitalSchool of MedicineShiraz University of Medical SciencesShirazIran Department of BiostatisticsLorestan University of Medical SciencesKhoramabadIran

AIM: To determine the prevalence and symptoms of gastroesophageal reflux disease (GErD) in a healthy general population in relation to demographic,lifestyle and health-seeking behaviors in Shiraz,southern Iran. METHODS: A total of 1978 subjects aged > 35 years who referred to Gastroenterohepatology research Center and who completed a questionnaire consisting of 27 questions for GErD in relation to demographic,lifestyle and health-seeking behaviors were included in this study for a period of five months. The validity and reliability of the questionnaire were determined. rESULTS: The prevalence of GErD was 15.4%,which was higher in females (17.3%),in rural areas (19.8%),and in illiterate subjects (21.5%) and those with a mean age of 50.25 years. The prevalence was significantly lower in subjects having fried food (14.8%),and fruit and vegetables (14.6%). More symptoms were noticed in subjects consuming pickles (22.1%),taking aspirin (21%) and in subjects with psychological distresses (27.2%) and headaches (22%). The correlation was statistically significant between GErD and halitosis (18.3%),dyspepsia (30.6%),anxiety (19.5%),nightmares (23.9%) and restlessness (18.5%). Their health seeking behavior showed that there was a significant restriction of diet (20%),consumption of herbal medicine (19%),using over-the-counter drugs (29.9%) and consulting with physicians (24.8%). Presence of GErD symptoms was also significantly related to a previous family history of the disease (22.3%).CONCLUSION: GErD is more common in females,rural and illiterate subjects and correlated with consumption of pickles,occurrence of headache,psychological distress,dyspepsia,halitosis,anxiety,nightmare and restlessness,and a family history of GErD and aspirin intake,but the correlation was negative with consumption of fat and fiber intake.

关键词： reflux risk factors Prevalence Southern Iran

Prevalence and risk factors of gastroesophageal reflux disease in Qashqai migrating nomads, southern Iran

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World Journal of Gastroenterology 2009年第8期15卷 961-965页

作者： Ahmad Mostaghni Davood Mehrabani Farnaz Khademolhosseini Seyed Jalil Masoumi Fariba Moradi Najaf Zare Mehdi Saberi-firoozi Gastroenterohepatology research Center Nemazee Hospital Shiraz University of Medical Sciences Shiraz Iran Office of Vice Chancellor for Health Affairs Shiraz University of Medical Sciences Shiraz Iran Department of Biostatistics School of Medicine Shiraz University of Medical Sciences Shiraz Iran

AIM： To investigate the prevalence and risk factors of gastroesophageal reflux disease （GErD） symptoms in Qashqai migrating nomads with a different life style in Fars province, southern Iran. METHODS： In summer 2006, 748 Qashqai migrating nomads aged 25 years or more were enrolled using a multiple-stage stratified cluster random sampling method. A questionnaire consisting of demographic characteristics, lifestyle and GErD symptoms （heartburn, regurgitation, chest pain, dysphagia, hoarseness and cough） as completed for each subject. rESULTS： The questionnaire was completed in 717 subjects. The prevalence rate of GErD, defined as reflux occurring at least one time per week in the preceding year, was 33% （237 subjects）. The prevalence was higher in older individuals （36.0% vs 28.9%, P 〈 0.05） and in those with other gastrointestinal complaints （51.0% vs 27.8%, P 〈 0.001）, but not different in obese and non-obese subjects. It was also higher in those consuming fruits and vegetables more than once a week （36.2% vs 17.3%, P 〈 0.001）. GErD had a positive correlation with smoking （42.1% vs 27.8%, P 〈 0.001）, but a negative relation with non-alcoholic beverages. The association between GErD and non-steroidal antiinflammatory drugs （NSAIDs） consumption was also significant （40.2% vs 25.4%, P 〈 0.001）. CONCLUSION： The prevalence of GErD （33%） is very high in Qashqai migrating nomads which may be due to a lower socioeconomic and educational level of these people and difference in the life style. Older age, frequent consumption of fruits and vegetables, smoking and NSAIDs are risk factors for GErD in this population.

关键词： Gastroesophageal reflux disease Prevalence risk factors Nomads Iran