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Unravelling the physicochemical and antimicrobial mechanisms of human serum albumin/tannic acid coatings for medical-grade polycaprolactone scaffolds

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Bioactive Materials 2024年第12期42卷 68-84页

作者： Silvia Cometta Bogdan C.Donose alfredo juarez-saldivar Akhilandeshwari Ravichandran Yanan Xu Nathalie Bock Tim R.Dargaville Aleksandar D.Rakic Dietmar W.Hutmacher Faculty of Engineering School of MechanicalMedical and Process EngineeringQueensland University of TechnologyBrisbaneQLD4000Australia Australian Research Council Training Centre for Multiscale 3D Imaging Modelling and Manufacturing(M3D Innovation)Queensland University of TechnologyKelvin GroveQLD4059Australia Max Planck Queensland Centre Queensland University of TechnologyBrisbaneQLD4000Australia School of Electrical Engineering and Computer Science The University of QueenslandBrisbaneQLD4072Australia Unidad Academica Multidisciplinaria Reynosa Aztlan Universidad Autonoma de TamaulipasReynosa88740Mexico Central Analytical Research Facility(CARF) Queensland University of TechnologyBrisbaneQLD4000Australia Faculty of Health School of Biomedical SciencesQueensland University of TechnologyBrisbaneQLD4000Australia Translational Research Institute WoolloongabbaQLD4102Australia Centre for Materials Science School of Chemistry and PhysicsQueensland University of TechnologyBrisbaneQLD4000Australia Australian Research Council Training Centre for Cell and Tissue Engineering Technologies Queensland University of TechnologyBrisbaneQLD4059Australia

Biofilm-related biomaterial infections are notoriously challenging to treat and can lead to chronic infection and persisting *** date,a large body of research can be reviewed for coatings which potentially prevent bacterial infection while promoting implant *** only a very small number has been translated from bench to *** study provides an in-depth analysis of the stability,antibacterial mechanism,and biocompatibility of medical grade polycaprolactone(mPCL),coated with human serum albumin(HSA),the most abundant protein in blood plasma,and tannic acid(TA),a natural polyphenol with antibacterial *** docking studies demonstrated that HSA and TA interact mainly through hydrogen-bonding,ionic and hydrophobic interactions,leading to smooth and regular *** vitro bacteria adhesion testing showed that coated scaffolds maintained their antimicrobial properties over 3 days by significantly reducing *** colonization and biofilm ***,amplitude modulation-frequency modulation(AMFM)based viscoelasticity mapping and transmission electron microscopy(TEM)data suggested that HSA/TA-coatings cause morphological and mechanical changes on the outer cell membrane of *** leading to membrane disruption and cell death while proving non-toxic to human primary *** results support this antibiotic-free approach as an effective and biocompatible strategy to prevent biofilm-related biomaterial infections.

关键词： Bacterial infection Biofilm Human serum albumin Tannic acid Polycaprolactone 3D printing Scaffold

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