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Regulation of pathological BBB restoration via nanostructured ROS-responsive glycolipid-like copolymer entrapping siVEGF for glioblastoma targeted therapeutics

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Nano Research 2022年第2期15卷 1455-1465页

作者： Lijuan Wen Yu Peng Kai Wang Zhihua huang shiying He Ruiwen Xiong Longping Wu Fengtian Zhang Fuqiang Hu National Engineering Research Center for Modernization of Tranditional Chinese Medicine-Hakka Medical Resources Branch College oj PharmacyGannan Medical UniversityGanzhou 341000China College of Pharmaceutical Sciences Zhejiang UniversityHangzhou 310058China Department of Orthopedics First Affiliated Hospital of Gannan Medical UniversityGanzhou 341000China Department of Orthopedics Second Affiliated Hospital of Soochow UniversitySuzhou 215004China Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of Education Gannan Medical UniversityGanzhou 341000China

Glioblastoma(GBM)is one of the malignant brain tumors with high mortality and no curative *** elevated vascular endothelial growth factor(VEGF)in GBM seriously disrupts the blood brain barrier(BBB)with an increased permeability,resulting in poor outcome and *** interference has shown strong potential to inhibit VEGF expression,thus it is necessary to development an effective and safe gene delivery system possessing the ability to cross the BBB and target GBM *** study aims to explore the anti-GBM effect of angiopep-2(Ap)peptide modified reactive oxygen species(ROS)cleavable thioketal(TK)linked glycolipid-like nanocarrier(CSTKSA)delivering anti-VEGF siRNA(R),termed as Ap-CSTKSA/R *** functionalized modification produced an enhanced cellular uptake and a stronger bio-distribution of Ap-CSTKSA/R complexes in U87 MG cells and brain tumor tissues,***-CSTKSA/R complexes exhibited great superiority in GBM growth inhibition and finally translated into the longest survival period mainly via receptor-mediated targeting delivery,VEGF gene silencing accompanied with remarkable angiogenesis inhibition,and suppressed expression of caveolin-1 which is involved in BBB functional regulation in the occurrence and treatment of *** study indicated that Ap functionalization on ROS-responsive glycolipid-like copolymer exhibits a promising and effective gene delivery platform for GBM targeted treatment.

关键词： glioblastoma ROS-responsive siRNA blood brain barrier copolymer

Correlativity study between expression of DNA double-strand break repair protein and radiosensitivity of tumor cells

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Frontiers of Medicine 2009年第1期3卷 26-29页

作者： Liang Zhuang shiying YU Xiaoyuan huang Yang CAO Huihua XIONG Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China Cancer Biology Research Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China

DNA double-strand break(DSB)is generally regarded as the most lethal of all DNA lesions after ***80,DNA-PK catalytic subunit(DNA-PKcs)and ataxia telangiectasia mutated(ATM)proteins are major DSB repair *** this study,survival fraction at 2Gy(SF2)values of eight human tumor cell lines(including four human cervical carcinoma cell lines HeLa,SiHa,C33A,Caski,three human breast carcinoma cell lines MCF-7,MDA-MB-231,MDA-MB-453,and one human lung carcinoma cell line A549)were acquired by clone formation assay,and western blot was applied to detect the expressions of Ku80,DNA-PKcs and ATM *** correlativity of protein expression with SF2 value was analyzed by Pearson linear correlation *** found that the expression of the same protein in different cell lines and the expression of three proteins in the same cell line had a signiﬁcant *** SF2 values were also different in eight tumor cell lines and there was a positive correlativity between the expression of DNA-PKcs and SF2(r=0.723,P=0.043),but Ku80 and ATM expression had no correlation with SF2(P>0.05).Theseﬁndings suggest that the expression level of DNA-PKcs protein can be an indicator for predicting the radiosensitivity of tumor cells.

关键词： Ku80 DNA-PK(cs)-binding protein,human ataxia telangiectasia mutated protein tumor cell lines radiosensitivity

西藏麦地卡湿地三个核心区土壤纤毛虫群落特征及其影响因素

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生物资源 2024年第1期46卷 51-60页

作者：黄倩李明燕朱时应李天顺普布西藏大学生态环境学院/生命科学系高原动物学实验室西藏拉萨850000

土壤纤毛虫是土壤原生动物的一部分,对土壤环境质量动态变化具有重要的指示作用。为了深入了解麦地卡湿地土壤纤毛虫群落特征及其与环境因子的关系,于2019年7月,根据西藏麦地卡湿地地理特征,在3个核心保护区随机选取6个样地,用“梅花五... 详细信息

土壤纤毛虫是土壤原生动物的一部分,对土壤环境质量动态变化具有重要的指示作用。为了深入了解麦地卡湿地土壤纤毛虫群落特征及其与环境因子的关系,于2019年7月,根据西藏麦地卡湿地地理特征,在3个核心保护区随机选取6个样地,用“梅花五点法”进行采样,共收集30个土样,采用“非淹没培养法”和“活体观察法”进行培养和形态学鉴定。共鉴定到土壤纤毛虫76种,隶属9纲18目33科44属。优势纲为旋毛纲(Sporadotrichia),共计27种,占总物种数的35.5%;核残迹纲(Karyorelictea)最少,仅为1种。C/P系数(0.23)<1,说明麦地卡湿地土壤环境良好。多样性指数在3个核心区间均无显著差异。6个样地Jaccard相似性系数范围为0.07~0.31,属于极不相似和中等不相似之间,说明各样地群落分布差异性较大。Mantel分析和冗余分析(redundancy analysis,RDA)结果显示,含水量是影响土壤纤毛虫群落结构的驱动因子。

关键词：麦地卡土壤纤毛虫多样性理化因子

CMPAS 1 km融合降水产品在四川省的精细化评估

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高原山地气象研究 2024年第1期44卷 59-68页

作者：蒋雨荷吴薇黄晓龙李施颖刘霄雷薇高原与盆地暴雨旱涝灾害四川省重点实验室成都610072 四川省气象探测数据中心成都610072 新疆维吾尔自治区石河子市气象局石河子832000

利用2020年9月—2021年8月四川省地面自动站逐小时降水观测数据,对比检验了1 km逐小时降水实时(RT)与近实时(NRT)融合产品在四川省的适用性。结果表明:(1)RT与NRT的整体评估结果相近,NRT略优于RT。(2)两种融合降水产品的晴雨准确率均为9... 详细信息

利用2020年9月—2021年8月四川省地面自动站逐小时降水观测数据,对比检验了1 km逐小时降水实时(RT)与近实时(NRT)融合产品在四川省的适用性。结果表明:(1)RT与NRT的整体评估结果相近,NRT略优于RT。(2)两种融合降水产品的晴雨准确率均为96.83%,能较准确地反映出有无降水。(3)国家站在盆地与川西高原以高估为主,在攀西地区则以低估为主;区域考核站与非考核站在盆地均以高估为主,在川西高原与攀西地区则以低估为主,RT较NRT的分布更离散。(4)两种产品均具有与观测较一致的日变化趋势,误差峰值出现在强对流天气频发的夏季,谷值出现在降水较少的冬季。(5)NRT的分量级评估结果略优于RT;当降水量级为小雨时,融合产品均高估于实况;当量级为中雨至大暴雨时,融合产品低估于实况,且随着降水量级的增大,误差随之增大,TS评分减小。

关键词：实时降水融合产品近实时降水融合产品精细化评估

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长江源区高寒草甸生长季载畜量对模拟增温的响应

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中国沙漠 2024年第4期44卷 165-173页

作者：李成阳黄樱宜林千策沈琳丽罗诗影梁志辉李臻明彭飞薛娴岭南师范学院地理科学学院广东湛江524048 中国科学院西北生态环境资源研究院干旱区生态安全与可持续发展重点实验室甘肃兰州730000

青藏高原高寒草甸是中国重要畜牧业基地,也是气候变化敏感区和生态脆弱带。为探究气候变暖对长江源区高寒草甸生长季载畜量的影响,以长江源区北麓河流域典型高寒草甸为研究对象,开展了模拟增温试验。测定了高寒草甸植物地上生物量和牧... 详细信息

青藏高原高寒草甸是中国重要畜牧业基地,也是气候变化敏感区和生态脆弱带。为探究气候变暖对长江源区高寒草甸生长季载畜量的影响,以长江源区北麓河流域典型高寒草甸为研究对象,开展了模拟增温试验。测定了高寒草甸植物地上生物量和牧草品质,确定了高寒草甸的数量载畜量和营养载畜量,以期为制定合理的高寒草甸载畜量提供科学依据。结果表明:(1)增温(150 W·m^(-2))增加了高寒草甸5、30 cm深土壤年均温度,降低了0~10 cm土层的年均含水量,但增加了20~40 cm土层的水分。(2)增温使2017、2018年的6月(生长季前期)群落地上生物量分别显著增加了78.55、79.74 g·m^(-2),但对生长季后期(2017、2018年的9月)无显著影响;杂类草和禾本科植物占群落地上生物量的比重增加,但莎草科植物比重降低。(3)增温使群落和杂类草植物中的粗蛋白和粗脂肪含量降低,牧草品质下降。(4)增温处理下每公顷数量载畜量、可消化蛋白载畜量、代谢能载畜量在2017年6月分别增加了2.37±0.22、6.72±0.41、3.89±0.32羊单位,在2018年6月分别增加了2.41±0.30、6.29±0.25、3.95±0.17羊单位;但生长季后期无显著变化。根据研究区实际,在气温上升背景下,长江源区高寒草甸生长季前期以数量载畜量安排放牧为宜,生长季后期应以代谢能载畜量安排放牧为宜。

关键词：青藏高原气候变暖牧草品质生物量载畜量

考虑分布式光伏不确定性的输配电系统供电能力评估

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广东电力 2024年第6期37卷 11-20页

作者：徐良德黄馨仪郭挺陈中豪刘明波林舜江胡林麟李诗颖广东电网有限责任公司广州供电局广东广州510000 华南理工大学电力学院广东广州510641 华南理工大学广东省绿色能源技术重点实验室广东广州510641

输电断面供电能力计算是保证电力系统安全运行的基本任务。近年来,为加速实现“双碳”目标,分布式光伏海量分散接入各配电系统中,而各个配电系统又与输电系统紧密互联,成为规模巨大的输配一体系统。因此,在计算输电系统中各断面的供电... 详细信息

输电断面供电能力计算是保证电力系统安全运行的基本任务。近年来,为加速实现“双碳”目标,分布式光伏海量分散接入各配电系统中,而各个配电系统又与输电系统紧密互联,成为规模巨大的输配一体系统。因此,在计算输电系统中各断面的供电能力时,有必要考虑光伏发电大量接入带来的不确定性,并降低其计算负担。为此提出一种考虑分布式光伏不确定性的输配电系统供电能力的评估方法,建立含分布式光伏的输配电系统供电能力计算模型,针对输配电系统规模大、约束复杂的特点,提出一种基于目标级联分析法的分布式求解算法,实现输配电系统解耦及上下层优化问题的并行独立求解。此外,在求解下层配电系统优化子问题时,采用列与约束生成算法将其分解后进行求解。所提方法既考虑了分布式光伏的不确定性,确保了配电系统的安全运行,还可以保持输电系统和配电系统之间的独立性。

关键词：输电断面供电能力光伏不确定性目标级联分析法列与约束生成算法

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Learning Effects of the General Subject AI Teacher-Led Courses: A Pilot Study

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Frontiers of Education in China 2023年第4期18卷 377-399页

作者： huang Fuquan WU Xiaoqi QIU shiying LIU Yuliang ZENG Wenjie CHEN Siyu The Lab for Neuroscience and Artificial Intelligence in Moral Learning South China Normal UniversityGuangzhou 510631China

The development of artificial intelligence(AI)technologyandthedemand for general-subject teaching give birth to general-subject AI teacher-led *** this study,79 fourth-grade pupils from two classes in a primary school in Guangzhou City are selected as the *** research methods of interview,classroom observation,and questionnaire survey are used to explore the effects of the AI general-subject teacher on pupils’learning effectiveness based on the framework of anthropomorphic learning process *** results show that the AI general-subject teacher can significantly enhance pupils’learning motivation(including intrinsic motivation and extrinsic motivation),increase pupils’learning engagement(including behavioral engagement,cognitive engagement,and emotional engagement),and improve pupils’learning outcomes(including knowledge and skills,process and method,emotional attitude and values).The findings confirm the important role of the AI general-subject teacher as the main instructor to promote pupils’efficient learning and provide a significant reference for solving the shortage problem of excellent teachers and reducing the burden on teachers and reducing the burden on teachers.

关键词： artificial intelligence(AI)teacher general-subject teacher learning motivation learning engagement learning outcomes

全球IMERG卫星反演和ERA5陆面再分析降水在四川地区的适用性研究

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气象与环境学报 2024年第3期40卷 65-75页

作者：黄晓龙向筱铭王丽伟李施颖蒋雨荷四川省气象探测数据中心四川成都610072 高原与盆地暴雨旱涝灾害四川省重点实验室四川成都610072 吉林省气象信息中心吉林长春130062

利用2019—2020年中国气象局地面站降水观测资料,使用相关系数、平均值误差、均方根误差、命中率、空报率以及关键成功指数6种定量评估指标,分析全球新一代降水测量计划IMERG多卫星联合反演和欧洲中期天气预报中心第五代陆面再分析ERA5... 详细信息

利用2019—2020年中国气象局地面站降水观测资料,使用相关系数、平均值误差、均方根误差、命中率、空报率以及关键成功指数6种定量评估指标,分析全球新一代降水测量计划IMERG多卫星联合反演和欧洲中期天气预报中心第五代陆面再分析ERA5L降水产品在四川地区的精度和区域适用性。结果表明:两种产品在川西高原东侧存在强降水带,大致呈准南北向分布;在盆地内与台站观测的一致性优于盆地周边山区,ERA5L相比IMERG更能准确捕捉到强降水中心。IMERG和ERA5L降水较台站观测分别偏多15.2%和33.3%。两种产品在川西高原对降水事件捕获能力相对盆地高,误报率低。从不同时间尺度检验上看,两种产品与台站观测的量级和趋势变化一致,相对台站观测以偏高为主。ERA5L相对IMERG而言,与台站观测相关性高,命中率高,CSI评分高,偏差低,但误报率相对高一些。总体上,IMERG和ERA5L降水产品在四川均表现出一定的应用潜力,但在不同降水强度和地形条件下精度差异明显,需要对产品进行订正。

关键词：降水卫星反演陆面再分析 IMERG ERA5L 精度评价

Reliability analysis of Lan Chengyu corroded pipeline with associated defects

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Petroleum 2015年第3期1卷 244-250页

作者： Qin Li Chunmei Sun Zhiqiang huang Xiang Xiao Haiping Thang shiying Zhao Institute of Mechanical and Electrical Engineering Southwest Petroleum UniversityChengdu 610500China

Traditional reliability evaluation method for corroded pipeline exists the problem of not considering the associated *** therefore propose a new calculation method considering the associated *** this paper,the traditional and new methods are respectively used to calculate and contrastively analyze the failure probability of corroded pipeline;we then perform the research of residual life prediction for the corroded pipeline,followed by the sensitivity calculation of all random evaluation *** then the Monte Carlo method(MCS)is applied to verify the rationality of the new *** research results show that:the method considering associated defect is more objective,and truly react corroded pipeline's dynamic reliability changes;obtain new method to predict residual life of corroded pipeline;corrosion depth,radial corrosion rate have a significant impact on reliability of corroded pipeline considering associated *** calculation results of the method are more accurate,more time-saving.

关键词： Corroded pipeline Associated pipeline Reliability analysis The remaining life Sensitivity