检索结果-南通市图书馆

Treatment of alopecia totalis/universalis/focalis with vitamin D and analogs:Three case reports and a literature review

引用

World Journal of Clinical Pediatrics 2021年第6期10卷 192-199页

作者： Dimitrios T Papadimitriou Christina Bothou Eleni Dermitzaki alexios alexopoulos George Mastorakos Department of Pediatric-Adolescent Endocrinology and Diabetes Athens Medical CenterAthens 15125Greece Endocrine Unit Aretaieion University HospitalAthens 11528Greece Department of Endocrinology Diabetology and Clinical NutritionUniversity Hospital Zurich(USZ)University of Zurich(UZH)CH-8091 ZurichSwitzerland Special Unit of Dermatology First Department of PediatricsNational and Kapodistrian University of Athens Medical SchoolAgia Sofia Children's HospitalAthens 11527Greece

BACKGROUND Alopecia areata(AA)is an inflammatory disease with autoimmune,environmental,and inherited components directed at the hair follicle,either limited to patchy hair loss over the scalp(Focalis,AF),total loss of scalp hair(Totalis,AT),or total loss of both scalp and body hair(Universalis,AU).Despite multiple treatment modalities,no therapy *** D deficiency in patients with AA/AT/AF influences disease severity and duration,inversely correlating with inflammation *** SUMMARY Three girls presented with AT(P1),AU(P2),and AF(P3)at the ages of 1,5,and 5 years,*** P1-P2,all available treatments implemented for 2 years had *** started an initial 6-mo repletion with oral cholecalciferol 2000/4000 IU/d,with no apparent *** we attempted immunomodulation using oral calcitriol and its analog *** calcitriol,0.5 mcg/d P1 regrew hair within 6 *** 4 years,a relapse with loss of eyebrow hair was resolved after doubling the calcitriol dose to 0.5 mcg×2/d;the results have been maintained for 6 years to *** calcitriol,0.25 mcg×3/d P2 led to the development of asymptomatic hypercalcemia-hypercalciuria,which was immediately resolved by switching to paricalcitol 2 mcg×3/d;mild tolerable hypercalciuria was *** regrowth was observed at 6 mo,stabilizing only as fur at 12 *** in P3 was resolved completely within 3 mo on a daily high dose(8000 IU)of *** Vitamin D may have immunomodulating therapeutic impact on AT/AU/AF,which needs to be explored with further pilot clinical trials.

关键词： Alopecia totalis Alopecia universalis Alopecia focalis Calcitriol Paricalcitol Vitamin D Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：