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COMPARATIvE TREATMENT OF ACNE vULGARIS USING PALOMAR LUX APPLIQU´E TECHNIQUE AND DIRECT INTRALESIONAL INJECTION

Journal of Innovative Optical Health Sciences 2009年第3期2卷 279-287页

作者： ELINA A.GENINA alexey N.BASHKATOv vALERY v.TUCHIN GEORGY v.SIMONENKO vERA N.SHERSTNEvA ILYA v.YAROSLAvSKY GREGORY B.ALTSHULER Department of Optics and Biophotonics Saratov State University 83 Astrakhanskaya str. Saratov 410012Russia Saratov State Medical University 112 B.Kazachya str. Saratov 410012Russia Palomar Medical Technologies Inc. 82 Cambridge St.Burlington 01803MAUSA

Intralesional injection of triamcinolone(TMC)preparations is an effective therapy for cystic acne ***,invasive delivery techniques limit the use of this modality to a relatively narrow class of *** permeability can be enhanced through creating a lattice of microzones(islets)of light-induced limited thermal damage in the upper layers of *** this paper,we directly compared safety and efficacy of delivering TMC acetonide with this novel technique versus conventional intralesional injection for treatment of inflammatory acne lesions.A combination of an intense pulsed light system and a specially designed appliqu´e with a pattern of absorbing centers has been used to create the lattice of islets of damage(LID).Quantitative analysis has included estimation of the following parameters:redness,diameter,and height of acne *** photography has been used to document dynamics of lesion development at successive visits(two hours,24 hours and one week post-treatment).Seven subjects have participated in the *** difference in lesion dynamics between the treatment and control groups was observed at two-hours *** 24-hours/one-week follow-ups,TMC-injected and TMC-LID-delivered groups have demonstrated 82%/93%and 80%/89%improvement in height of lesions in comparison to control(60%/68%).Delivery of TMC with the newly proposed LID technique is at least as effective as intralesional injection for treating inflammatory acne *** of skin permeability using LID approach is a promising technique for accelerating delivery of various compounds to their target areas in the skin.

关键词： Acne vulgaris drug delivery skin permeability enhancement.

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Accounting for natural-climatic conditions in the design of roads in western Siberia

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Research in Cold and Arid Regions 2015年第4期7卷 307-315页

作者： vladimir N.Efimenko Sergey v.Efimenko alexey v.Sukhorukov Tomsk State University of Architecture and Building

The paper proposes a methodological scheme that thoroughly accounts for natural-climatic conditions which can impair the stability and longevity of transport facilities （roadways）, to ensure the best possible quality of the initial road design. Factors determining the formation of water-heating mode subgrade soils are allocated, and an information database for mathematical modeling of geocomplexes is shown. values of strength and deformability of clay soils are calculated within the limits of the defined, homogeneous road districts in Western Siberia to provide the required level of reliability of design solutions.

关键词： transport facilities road-climatic zoning water-heating mode subgrade soils design geocomplexes

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Euxinia as a dominant process during OAEla(Early Aptian)on the Eastern Russian Platform and during OAElb(Early Albian)in the Middle Caspian

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Science China Earth Sciences 2017年第1期60卷 58-70页

作者： Svetlana O. ZORINA Oksana v. PAvLOvA Bulat M. GALIULL1N vladimir P. MOROZOv alexey A. ESKIN Institute of Geology and Petroleum Technologies Kazan Federal University 4/5 Kremlyovskaya street Kazan 420008 Russian Federation

A detailed study of the mineral composition and microstructure of the black shales associated with OAE1 a （Eastern Russian Platform）, OAElb （Middle Caspian）, and the host rocks has been carried out using X-ray diffraction, scanning electron microscopic, and microprobe analyses. The results provide important constraints for depositional environments in the sedimentary basins. Black shales with pyrite framboids imply euxinic （sulfidic） conditions with increased organic matter preservation. Disintegrating framboids suggest partial or complete dissolution of the organic matter inside the framboids due to increasing water oxygenation. OAEla on the Eastern Russian Platform is heterogeneous as it includes thin interbeds of concretionary coccolith limestones within the interval of bituminous shales, and correlates with the Lower Aptian Rhagodiscus angustus nannofossil zone. The coccolith limestones indicate short intermittent episodes of interrupted stagnation, rapid oxygenation, and restoration of normal marine conditions. The presence of montmorillonite, albite, microcline, and diopside in the bituminous siltstones and in the host siltstones of OAEla on the Eastern Russian Platform, as well as a high content of titanium in the black siltstones correlated with OAEIb in the Middle Caspian allow proposing significant input of pyroclastic material into the extant sea.

关键词： OAEIa OAElb Black shales Pyrite framboids Euxinia Oxygenation Eastem Russian Platform MiddleCaspian Cretaceous

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A new species of Nanohyla(Anura:Microhylidae)from the lowland forests of southern vietnam

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Zoological Research 2023年第4期44卷 732-736页

作者： vladislav A.Gorin alexey v.Trofimets Svetlana S.Gogoleva Le Xuan Dac Nikolay A.Poyarkov Department of vertebrate Zoology Lomonosov Moscow State UniversityMoscow 119991Russia Joint vietnam-Russia Tropical Science and Technology Research Centre Cau GiayHanoi 122000Vietnam A.N.Severtsov Institute of Ecology and Evolution Russian Academy of SciencesMoscow 119071Russia

DEAR EDITOR,We describe a new species of Nanohyla from the Song Hinh Protected Forest in Phu Yen Province,southern vietnam,based on an integrative taxonomic *** new species represents a divergent lineage(16S rRNA gene uncorrected P-distance>5.3%),which clearly differs from any other Nanohyla species based on a series of morphological characters,most notably the presence of white spots on the top of its ***,Nanohyla albopunctata *** characterized by small body size(male snout-vent length(SvL)18.2-20.2 mm);moderately slender body habitus;rounded snout;distinct tympanum;rounded canthus rostralis;loreal region slightly concave;skin on dorsum tubercular,ventral surfaces smooth;mid-vertebral skin ridge and dorsomedial stripe absent;superciliary tubercles absent.

关键词： Morphological vietnam slightly

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Investigating the Whole-lithosphere Structure of a Mineral System——Pathways and Source of Ore-forming Fluids Imaged with Magnetotelluric Modeling

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Acta Geologica Sinica(English Edition) 2021年第S1期95卷 73-75页

作者： Matthew J.COMEAU Michael BECKEN alexey v.KUvSHINOv Sodnomsambuu DEMBEREL Erdenechimeg BATMAGNAI Shoovdor TSERENDUG Institut für Geophysik Universitat MünsterGermany Institute of Geophysics ETHZürichSwitzerland Institute of Astronomy and Geophysics Mongolian Academy of SciencesUlaanbaatarMongolia

Whole-lithosphere structure has direct implications for both the genesis of minerals and the locations of mineral emplacement;thus knowledge of the deep structural framework of the lithosphere can advance understandin... 详细信息

关键词： magnetotellurics electrical resistivity lithosphere structure mineral exploration metal belt oreforming fluids mineral emplacement fluid transport

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Pulsed laser reshaping and fragmentation of upconversion nanoparticles-from hexagonal prisms to ID nanorods through“Medusa”-like structures

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Nano Research 2021年第4期14卷 1141-1148页

作者： Laszlo Sajti Denis N.Karimov vasilina v.Rocheva Nataliya A.Arkharova Kirill v.Khaydukov Oleg I.Lebedev alexey E.voloshin Alla N.Generalova Boris N.Chichkov Evgeny v.Khaydukov AIT Austrian Institute of Technology GmbH Wiener Neustadt2700Austria Federal Scientific Research Centre“Crystallography and Photonics”Russian Academy of Sciences Moscow119333Russia Laboratoire CRISMAT UMR6508CNRS-ENSIACENUniversite CaenCaen14050France Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences Moscow 117997Russia Institutfiir Quantenoptik Leibniz Universitat HannoverHannover30167Germany Center of Biomedical Engineering Institute of Molecular Medicine Sechenov First Moscow State Medical UniversityMoscow119991Russia

One dimensional(1D)nanostructures attract considerable attention,enabling a broad application owing to their unique ***,the precise mechanism of 1D morphology attainment remains a matter of *** this study,ultrafast picosecond(ps)laser-induced treatment on upconversion nanoparticles(UCNPs)is offered as a tool for 1 D-nanostructures ***,reshaping through recrystallization process and bioadaptation of initially hydrophobic(β-Na_(1.5)Y_(1.5_)F_(6):Yb^(3+),Tm^(3+)/β-Na_(1.5)Y_(1.5_)F_(6))core/shell nanoparticles by means of one-step laser treatment in water are demonstrated.“True”1D nanostructures through"Medusa^-like structures can be obtained,maintaining anti-Stokes luminescence functionalities.A matter of the one-dimensional UCNPs based on direction of energy migration processes is *** proposed laser treatment approach is suitable for fast UCNP surface modification and nano-to-nano transformation,that open unique opportunities to expand UCNP applications in industry and biomedicine.

关键词： upconversion nanoparticles fluoride crystals upconversion nanorods one-dimensional(1D)structures laser-induced reshaping

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Traditional taxonomy: Quo vadis?

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Integrative Zoology 2016年第6期11卷 500-505页

作者： alexey A.KOTOv Maria A.GOLOLOBOvA Laboratory of Aquatic Ecology and Invasions A.N.Severtsov Institute of Ecology and EvolutionMoscowRussia Laboratory for Palaeoclimatology Palaeoecology and PalaeomagnetismKazan Federal UniversityKazanRussia Faculty of Biology M.V.Lomonosov Moscow State UniversityMoscowRussia

TRADITIONAL TAXONOMY “Taxonomy is the science of naming,describing and classifying organisms and includes all plants,animals and microorganisms of the world”(Convention on Biological Diversity 2016).It is obvious that progress in biological science is impossible without taxonomic ef*** the last 250 years,taxonomists have named almost two million species of animals,plants and mi*** recently taxonomy has entered a deep crisis(Agnarson&Kuntner 2007;Walter&Winterton 2007);in particular,this crisis involves the science of traditional taxonomy.

关键词： taxonomy Taxonomy Diversity

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Preliminary analyses of the frozen mummies of mammoth(Mammuthus primigenius),bison(Bison priscus)and horse(Equus sp.)from the Yana-Indigirka Lowland,Yakutia,Russia

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Integrative Zoology 2014年第4期9卷 471-480页

作者： Gennady G.BOESKOROv Olga R.POTAPOvA Eugeny N.MASHCHENKO Albert v.PROTOPOPOv Tatyana v.KUZNETSOvA Larry AGENBROAD alexey N.TIKHONOv Diamond and Precious Metal Geology Institute Siberian Branch of Russian Academy of SciencesYakutskRussia The Mammoth Site of Hot Springs Museum Hot SpringsSouth DakotaUSA Paleontological Institute Russian Academy of SciencesMoscowRussia Department of the Mammoth Fauna Studies Academy of Sciences of the Sakha(Yakutia)Republic YakutskRussia M.v.Lomonosov Moscow State University MoscowRussia Zoological Institute Russian Academy of SciencesSt.PetersburgRussia

The frozen bodies of a young woolly mammoth(Mammuthus primigenius),a wild horse(Equus sp.)and a steppe bison(Bison priscus)were recently found in the northern Yakutia(northeastern Siberia).All specimens have preserved bones,skin and soft *** the woolly mammoth and the Pleistocene horse were represented by partial frozen bodies,the steppe bison body was recovered in an absolutely complete *** specimens were found frozen in the permafrost,with some of the tissues *** wild horse and steppe bison are of Holocene age,and the mammoth is of Late Pleistocene age.

关键词： bison horse mammoth mummy Siberia

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PHOTOTHERAPY OF GINGIvITIS:PILOT CLINICAL STUDY

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 437-446页

作者： ELINA A.GENINA vLADIMIR A.TITORENKO vALERY v.TUCHIN GEORGY v.SIMONENKO alexey N.BASHKATOv GENNADY M.SHUB ALEXANDER v.LEPILIN ILYA v.YAROSLAvSKY GREGORY B.ALTSHULER Saratov State University Saratov410012Russia Saratov State Medical University Saratov410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia Palomar Medical Technology Inc.Burlington MA 01803USA

The goal of this work was to evaluate the safety and efficacy of the Red Light Emitted Toothbrush(R-LETB)emitting at wavelength of 663 nm with power density of 3.3mW/cm2 in combination with 0.1%-methylene blue(MB)solution for the reduction of plaque and treatment of gingivitis.A microbiological in vitro study and a pilot clinical study were *** microbiological study has shown total suppression of pathogenicflora after a 3-min exposure to the dye solution followed by a 20-sec treatment with the *** the clinical study,37 subjects of both sexes with gingivitis were enrolled and randomly assigned to one of two *** in thefirst(treatment)group were instructed to rinse their mouth with MB solution provided for 1 min and then brush the teeth with the R-LETB and standardized *** second(control)group used only the toothpaste and a regular *** in both groups followed their respective procedures 2 times a day(morning and evening)for 30 *** of plaque,gingival bleeding,and inflammation were evaluated at 14-day and 30-day *** the both groups,all indices improved in comparison with ***,the treatment group demonstrated more pronounced improvement of the studied indices that was attributed to additional anti-microbial action of red light and MB on gum ***,the use of R-LETB with MB appears to have a multifactor therapeutic action on oral pathological microflora:mechanical removal of the bacteria and suppressing action on microorganisms due to photodynamic reaction.

关键词： Tooth brushing methylene blue photodynamic therapy pathogenic bacteria

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Quantification of glucose and glycerol diffusion in myocardium

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Journal of Innovative Optical Health Sciences 2015年第3期8卷 46-55页

作者： Daria K.Tuchina alexey N.Bashkatov Elina A.Genina valery v.Tuchin Research-Educational Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Laboratory of Laser Diagnostics of Technical and Living Systems Institute of Precise Mechanics and Control RAS Saratov 410028 Russia Optoelectronics and Measurement Techniques Laboratory P.O.Box 4500 University of Oulu FIN-90014OuluFinland

The results on determination of glucose and glycerol difusion cofficients in myocardium tissuse are *** method is based on the measurement and analysis of temporal dependence of tissue optical collimated transmittance umder action of a hyperosmotic *** temporal tissue response is related to the rate of the agent and water diffusion in a *** diffusion coefficients for tssue fAuid fluxes at glucose and glycerol application to the myocardium at 20℃ have been estimated as(4.75±3.40)×10^(-7) and(7.71±4.63)×10^(-7) cm^(2)/s,respectively.

关键词： Difusion cofficient optical clearing delhydration scattering.

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