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Second-line treatment of metastatic gastric cancer:Current options and future directions

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World Journal of Gastroenterology 2015年第41期21卷 11621-11635页

作者： Dheepak Kanagavel Mikhail Fedyanin alexey Tryakin Sergei Tjulandin Department of Clinical Pharmacology andChemotherapy N. N. Blokhin Russian Cancer Research Center

Gastric cancer remains one among the leading causes of cancer-related deaths, regardless of its decreasing incidence and newly available treatment options. Most patients present at an advanced stage and are treated with upfront systemic chemotherapy. Those patients receiving first-line therapy may initially respond to treatment, but many of them relapse over time. In such condition, second-line treatment for disease progression remains the only available option. Although there exists no standard approach in the second-line setting, several phase Ⅲ trials have shown modest survival benefit in patients receiving irinotecan, taxane and ramucirumab over the best supportive care or active agents. This review analyzes the currently available treatment regimens and future directions of research in the second-line setting for metastatic gastric cancer with the best available evidence. Additionally, the prognostic factors that influence patient survival in those receiving second-line therapy are discussed.

关键词： Metastatic gastric cancer Second-line chemotherapy

Machine Learning Application for Prediction of Sapphire Crystals Defects

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Journal of Electronic Science and Technology 2020年第1期18卷 1-9页

作者： Yulia Vladimirovna Klunnikova Maxim Vladimirovich Anikeev alexey Vladimirovich Filimonov Ravi Kumar Institute of Nanotechnology Electronics and Engineering EquipmentSouthern Federal UniversityTaganrog 347928 Institute of Computer Technology and Information Security Southern Federal UniversityTaganrog347928 Department of Physical Electronics Peter the Great St.Petersburg Polytechnic UniversitySt.Petersburg 195251 the Department of Metallurgical and Materials Engineering Indian Institute of Technology MadrasChennai600036

We investigate the impact of different numbers of positive and negative examples on machine learning for sapphire crystals defects prediction. We obtain the models of crystal growth parameters influence on the sapphire crystal growth. For example, these models allow predicting the defects that occur due to local overcooling of crucible walls in the thermal node leading to the accelerated crystal growth. We also develop the prediction models for obtaining the crystal weight, blocks, cracks, bubbles formation, and total defect characteristics. The models were trained on all data sets and later tested for generalization on testing sets, which did not overlap the training *** training and testing, we find the recall and precision of prediction, and analyze the correlation among the features. The results have shown that the precision of the neural network method for predicting defects formed by local overcooling of the crucible reached 0.94.

关键词： Defects machine learning sapphire crystals

Observation of Zitterbewegung in photonic microcavities

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Light(Science & Applications) 2023年第6期12卷 1084-1090页

作者： Seth Lovett Paul M.Walker alexey Osipov alexey Yulin Pooja Uday Naik Charles E.Whittaker Ivan A.Shelykh Maurice S.Skolnick Dmitry N.Krizhanovskii Department of Physics and Astronomy University of SheffieldS37RH SheffieldUK Department of Physics and Technology ITMO UniversitySt.Petersburg 197101Russia Science Institute University of IcelandDunhagi 3IS-107 ReykjavikIceland

We present and experimentally study the effects of the photonic spin–orbit coupling on the real space propagation of polariton wavepackets in planar semiconductor microcavities and polaritonic analogues of *** particular,we demonstrate the appearance of an analogue Zitterbewegung effect,a term which translates as‘trembling motion’in English,which was originally proposed for relativistic Dirac electrons and consisted of the oscillations of the centre of mass of a wavepacket in the direction perpendicular to its *** a planar microcavity,we observe regular Zitterbewegung oscillations whose amplitude and period depend on the wavevector of the *** then extend these results to a honeycomb lattice of coupled microcavity *** to the planar cavity,such lattices are inherently more tuneable and versatile,allowing simulation of the Hamiltonians of a wide range of important physical *** observe an oscillation pattern related to the presence of the spin-split Dirac cones in the *** both cases,the experimentally observed oscillations are in good agreement with theoretical modelling and independently measured bandstructure parameters,providing strong evidence for the observation of Zitterbewegung.

关键词： planar versatile analogues

A Neural Circuit for Gut-Induced Sugar Preference

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Neuroscience Bulletin 2021年第5期37卷 754-756页

作者： Xin Cao Hai-Yan Yin Henning Ulrich alexey Semyanov Yong Tang International Collaborative Centre on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengdu 610075China Acupuncture&Chronobiology Key Laboratory of Sichuan Province Chengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of Sao PauloSao Paulo 05508Brazil Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscowRussia 117997 Sechenov First Moscow State Medical University MoscowRussia 119146

Glucose is an essential source of energy in humans. Over the past decades, consumption of sugar has increased greatly and constitutes a large part of the global energy intake [1]. Currently, overconsumption of sugar is a serious problem around the world and contributes to the high incidence of obesity, type 2 diabetes mellitus, hypertension, and all-cause mortality [1].

关键词： intake mortality sugar

Gradient-induced long-range optical pulling force based on photonic band gap

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Light(Science & Applications) 2024年第5期13卷 865-874页

作者： Wenlong Lu alexey V.Krasavin Sheng Lan Anatoly V.Zayats Qiaofeng Dai Guangdong Basic Research Center of Excellence for Structure and Fundamental Interactions of Matter Guangdong Provincial Key Laboratory of Nanophotonic Functional Materials and DevicesSchool of Information and Optoelectronic Science and EngineeringSouth China Normal UniversityGuangzhou 510006China Department of Physics and London Centre for Nanotechnology King’s College LondonLondon WC2R 2LSUK

Optical pulling provides a new degree of freedom in optical *** is generally believed that long-range optical pulling forces cannot be generated by the gradient of the incident ***,we theoretically propose and numerically demonstrate the realization of a long-range optical pulling force stemming from a self-induced gradient field in the manipulated *** analogy to potential barriers in quantum tunnelling,we use a photonic band gap design in order to obtain the intensity gradients inside a manipulated object placed in a photonic crystal waveguide,thereby achieving a pulling *** the usual scattering-type optical pulling forces,the proposed gradient-field approach does not require precise elimination of the reflection from the manipulated *** particular,the Einstein-Laub formalism is applied to design this unconventional gradient *** magnitude of the force can be enhanced by a factor of up to 50 at the optical resonance of the manipulated object in the waveguide,making it insensitive to *** developed approach helps to break the limitation of scattering forces to obtain longrange optical pulling for manipulation and sorting of nanoparticles and other *** developed principle of using the band gap to obtain a pulling force may also be applied to other types of waves,such as acoustic or water waves,which are important for numerous applications.

关键词： optical waveguide scattering

OPTICAL PROPERTIES OF SKIN,SUBCUTANEOUS,AND MUSCLE TISSUES:A REVIEW

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Journal of Innovative Optical Health Sciences 2011年第1期4卷 9-38页

作者： alexey N.BASHKATOV ELINA A.GENINA VALERY V.TUCHIN Institute of Optics and Biophotonics Saratov State University Saratov 410012Russia Institute of Precise Mechanics and Control of RAS Saratov 410028Russia

The development of optical methods in modern medicine in the areas of diagnostics,therapy,and surgery has stimulated the investigation of optical properties of various biological tissues,since the efficacy of laser treatment depends on the photon propagation and fluence rate distribution within irradiated *** this work,an overview of published absorption and scattering properties of skin and subcutaneous tissues measured in wide wavelength range is *** principles of measurements of the tissue optical properties and techniques used for processing of the measured data are outlined.

关键词： Absorption coefficient scattering coefficient anisotropy factor reduced scattering coefficient refractive index

Advances in femtosecond laser direct writing of fiber Bragg gratings in multicore fibers:technology,sensor and laser applications

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Opto-Electronic Advances 2022年第4期5卷 48-68页

作者： alexey Wolf Alexander Dostovalov Kirill Bronnikov Mikhail Skvortsov Stefan Wabnitz Sergey Babin Novosibirsk State University Novosibirsk 630090Russia Institute of Automation and Electrometry of the SB RAS Novosibirsk 630090Russia Department of Information Electronics and Telecommunications EngineeringSapienza University of RomeRome 00184Italy

In this article,we review recent advances in the technology of writing fiber Bragg gratings(FBGs)in selected cores of multicore fibers(MCFs)by using femtosecond laser *** writing technology of such a key element as the FBG opens up wide opportunities for the creation of next generation fiber lasers and sensors based on *** advantages of the technology are shown by using the examples of 3D shape sensors,acoustic emission sensors with spatially multiplexed channels,as well as multicore fiber Raman lasers.

关键词： multicore fiber fiber Bragg grating femtosecond laser micromachining fiber laser fiber sensor

TASK-3:New Target for Pain-Relief

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Neuroscience Bulletin 2020年第8期36卷 951-954页

作者： Wen-Jing Ren Henning Ulrich alexey Semyanov Peter Illes Yong Tang International Collaborative Centre on Big Science Plan for Purine Signaling Chengdu University of Traditional Chinese MedicineChengdu 610075China Acupuncture and Chronobiology Key Laboratory of Sichuan Province Chengdu 610075China Department of Biochemistry Institute of ChemistryUniversity of Sao PauloSao Paulo 05508Brazil Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesMoscowRussia 117997 Rudolf-Boehm-Institut fiir Pharmakologie und Toxikologie Universitaet Leipzig04109 LeipzigSachsenGermany

Morphine and other opioids are among the most effective analgesics for treating ***,drug dependence and other deleterious side effects of opioids have limited their clinical *** studies suggest that the use of opioids for pain control may even exacerbate disease outcomes in some pain-producing conditions,such as acute pancreatitis[1].

关键词： Relief delete producing

Investigation into the operation of an autothermal two-section subbituminous coal fluidized bed gasifier

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International Journal of Coal Science & Technology 2023年第3期10卷 190-203页

作者： Nikolay Abaimov Alexander Ryzhkov alexey Dubinin Lu Ding Vladimir Tuponogov Sergey Alekseenko Ural Federal University EkaterinburgRussia 6200022 Institute of Clean Coal Technology East China University of Science and TechnologyShanghai 200237China Institute of Thermophysics Siberian BranchRussian Academy of SciencesNovosibirskRussia 630090

Using a newly developed experimental setup,the features and advantages of an autothermal single-casing atmospheric sub-bituminous coal fluidized bed air-blown gasifier,combining a combustion and gasification section,and mixing the dispersed phase(inert material,char)and heat exchange between them through an annular transfer device,have been *** increase the efficiency of the gasifier,an experimental-computational method was developed find the conditions for optimal operation,combining changing the annular flow's geometry and regulating the primary air for gasification.A simple and reliable multizone thermodynamic calculation model makes it possible to predict the composition of char and syngas in the gasification section with acceptable *** method confirmed that a two-section fluidized bed gasifier can provide efficient gasification of solid fuels and is suitable for use in small-scale cogeneration *** with a heating value of 3.6-4.5 MJ/m^(3)and CGE of 38.2%-42.3%was obtained in the experimental setup without optimizing the primary air flow *** optimization,the indicators increased to the heating value of syngas of 5.20-5.34 MJ/m^(3)and CGE of 42.5%-50.0%.With heat regeneration of 0.8,CGE increases to 70%.

关键词： Coal Syngas Gasification Bubbling fluidized bed Thermodynamics Modeling