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Decline and fall of aging astrocytes:the human perspective

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Neural Regeneration Research 2025年第6期20卷 1713-1714页

作者： alexei Verkhratsky Alexey Semyanov Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Department of Neurosciences University of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina Department of Stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania International Collaborative Center on Big Science Plan for Purinergic Signalling Chengdu University of Traditional Chinese MedicineChengduSichuan ProvinceChina Department of Physiology Jiaxing University College of MedicineJiaxingZhejiang ProvinceChina

“Last scene of all that ends this strange,eventful history,is second childishness and mere oblivion.I am sans teeth,sans eyes,sans taste,sans everything.”William Shakespeare‘As You Like It'Act 2,Sc.7,l.139Aging of the human brain is characterized by a progressive decline of its functional capacity;this decline however varies widely,and cognitive longevity differs substantially between individuals.

关键词： aging teeth progressive

Antiproton-nucleus reactions at intermediate energies

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Nuclear Science and Techniques 2015年第2期26卷 104-110页

作者： alexei Borisovich Larionov Frankfurt Institute for Advanced Studies National Research Centre Kurchatov Institute

Antiproton-induced reactions on nuclei at the beam energies from hundreds Me V up to several Ge V provide an excellent opportunity to study interactions between the antiproton and secondary particles(mesons, baryons and antibaryons) with nucleons. The antiproton projectile is unique in the sense that most of the annihilation particles are relatively slow in the target nucleus frame. Hence, the prehadronic effects do not much influence their interactions with the nucleons of the nuclear residue. Moreover, the particles with momenta less than about 1 Ge V/c are sensitive to nuclear mean field potentials. This paper discusses the microscopic transport calculations of the antiproton-nucleus reactions and is focused on three related problems:(i) antiproton potential determination,(ii) possible formation of strongly bound antiproton-nucleus systems, and(iii) strangeness production.

关键词：原子核反应反质子能量相互作用次级粒子核平均场核系统 iii

Understanding the epidemiology and outcomes of out-of-hospital cardiac arrest in the former Union of Soviet Socialist Republics:Observations from the Crimean peninsula

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World Journal of Emergency Medicine 2022年第1期13卷 67-68页

作者： alexei Birkun Department of Anesthesiology Resuscitation and Emergency MedicineMedical Academy named after S.I.Georgievsky of V.I.Vernadsky Crimean Federal UniversitySimferopol 295051Russian Federation

Out-of-hospital cardiac arrest(OHCA)is widely recognized as a global health ***,little is known about OHCA epidemiology in the former Union of Soviet Socialist Republics(USSR)territories.[1,2]The15 post-Soviet states ... 详细信息

关键词： occupy Republic cardiac

Alterations of protein homeostasis in Alzheimer's disease:beyond Procrustean bed of endoplasmic reticulum stress and unfolded protein response

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Neural Regeneration Research 2024年第8期19卷 1645-1646页

作者： Dmitry Lim alexei Verkhratsky Department of Pharmaceutical Sciences Universitàdel Piemonte Orientale“Amedeo Avogadro”NovaraItaly Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain&Department of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Department of Stem Cell Biology State Research Institute Centre for Innovative MedicineVilniusLithuania Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyangLiaoning ProvinceChina

Alzheimer’s disease(AD)is a major age-related form of dementia with a number of cases exponentially growing,causing enormous social and economic impact on individuals and *** hallmarks of AD,evident in postmortem AD brains,include a massive loss of the grey matter in the neocortex,extracellular deposition of amyloid-β(Aβ)in the form of senile plaques and cerebrovascular amyloid angiopathy,and intra-neuronal accumulation of neurofibrillary tangles,formed by hyper-phosphorylated tau protein.

关键词： Alzheimer homeostasis cortex

Social attitude and willingness to attend cardiopulmonary resuscitation training and perform resuscitation in the Crimea

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World Journal of Emergency Medicine 2018年第4期9卷 237-248页

作者： alexei Birkun Yekaterina Kosova Department of Anaesthesiology Resuscitation and Emergency Medicine Medical Academy named after S. I. Georgievsky of V. I. Vernadsky Crimean Federal University 295051 Lenin Blvd 5/7 Simferopol Russian Federation Department of Applied Mathematics Taurida Academy of V. L Vernadsky Crimean Federal University 295007 Prospect Vernadskogo 4 Simferopol Russian Federation

BACKGROUND: To promote potentially life-saving bystander cardiopulmonary resuscitation(CPR), the proportion of CPR-trained general public and their attitude toward CPR should be assessed, which is yet to be done in the former Soviet Union countries. As a case study, the survey is aimed to investigate the prevalence of CPR training, CPR knowledge, attitude and willingness to attend training and attempt CPR in the general population of the ***: A personal interview survey was done from November 2017 to January 2018 with quota sampling refl ecting age, gender and territorial distribution of the Crimean ***: Out of 384 persons surveyed, 53% were trained in CPR. Of trained, 24% passed training within the last year, 44% attended a single course. Among the non-trained, 51% never thought about the need to attend training. Knowledge of CPR is generally poor. About 52% wish to learn CPR, 79% and 91% are willing to attempt CPR on a stranger or a loved one, respectively. Lack of knowledge is the strongest barrier to attempt CPR. People aged ≥60, those with educational level lower than high school, widowed and retired are mostly untrained and unwilling to learn CPR. Females and unemployed are mostly untrained, but willing to be ***: There is a need for increasing CPR training and retraining, and improving awareness and motivation to learn CPR in the Crimean population, targeting the least trained groups. The results could be used as a reference point for future studies in the former USSR countries, utilising the same methodology.

关键词： Cardiopulmonary resuscitation Cardiac arrest First aid Training Survey

Glial-neuronal Sensory Organs:Evolutionary Journey from Caenorhabditis elegans to Mammals

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Neuroscience Bulletin 2020年第5期36卷 561-564页

作者： Yong Tang Peter Illes alexei Verkhratsky International Collaborative Centre on Big Science Plan for Purine Signalling Chengdu University of Traditional Chinese MedicineChengdu 610075China Acupuncture and Tuina School Chengdu University of TCMChengdu 610075China Key Laboratory of Sichuan Province for Acupuncture and Chronobiology Chengdu 610075China Rudolf-Boehm-Institut für Pharmakologie und Toxikologie Universitat LeipzigLeipzig 04107Germany Faculty of Biology Medicine and HealthThe University of ManchesterManchester MI39PTUK

Recently,a paper published in Science reported discovery of sensory peripheral glial cells[1].This paper demonstrated a rather unexpected property of non-myelinating Schwann cells(also known as Remak cells)dwelling in the subepidermal border of the skin[2].These glial cells and their interactions with nociceptive nerve terminals were characterized using a variety of genetic labelling tools,transmission electron microscopy,immunocytochemistry.

关键词： myelin border property

Astrocyte syncytium:from neonatal genesis to aging degeneration

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Neural Regeneration Research 2024年第2期19卷 395-396页

作者： Min Zhou Shiying Zhong alexei Verkhratsky Department of Neuroscience Ohio State University Wexner Medical CenterColumbusOHUSA Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achücarro Basque Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoSpain Department of Neurosciences University of the Basque Country UPV/EHU and CIBERNEDLeioaSpain

Modern neuroscience began from all reaching and fierce conflict between“neuronismo and reticulismo”——between neuronal and reticular theories of the organization of the nervous system;the conflict culminated in December of 1906 in Stockholm where Santiago Ramon y Cajal(the proponent of the neuronal doctrine)and Camillo Golgi(who advocated the syncytial reticular organization of neural networks)delivered their Noble prize lectures(Verkhratsky,2009).

关键词： degeneration neonatal aging

Astrocytes in Post-traumatic Stress Disorder

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Neuroscience Bulletin 2022年第8期38卷 953-965页

作者： Baoman Li Dianjun Zhang alexei Verkhratsky Department of Forensic Analytical Toxicology School of Forensic MedicineChina Medical UniversityShenyang 110122China Faculty of Biology Medicine and HealthThe University of ManchesterManchester M139PTUK Department of Stem Cell Biology State Research Institute Centre for Innovative Medicine01102 VilniusLithuania

Although posttraumatic stress disorder(PTSD)is on the rise,traumatic events and their consequences are often hidden or minimized by patients for reasons linked to PTSD *** experiences can be broadly classified into mental stress(MS)and traumatic brain injury(TBI),but the cellular mechanisms of MS-or TBI-induced PTSD remain *** evidence has shown that the morphological remodeling of astrocytes accompanies and arguably contributes to fearful memories and stressrelated *** this review,we summarize the roles of astrocytes in the pathogenesis of MS-PTSD and *** synthesize and secrete neurotrophic,proand anti-inflammatory factors and regulate the microenvironment of the nervous tissue through metabolic pathways,ionostatic control,and homeostatic clearance of *** or trauma-associated impairment of these vital astrocytic functions contribute to the pathophysiological evolution of PTSD and may present therapeutic targets.

关键词： Astrocytes Traumatic brain injury Traumatic events Neurotrophic factors Serotonin

Glial decline and loss of homeostatic support rather than inflammation defines cognitive aging

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Neural Regeneration Research 2022年第3期17卷 565-566页

作者： alexei Verkhratsky Natalia Lazareva Alexey Semyanov Faculty of Biology Medicine and HealthThe University of ManchesterManchesterUK Achucarro Center for Neuroscience IKERBASQUEBasque Foundation for ScienceBilbaoDepartment of NeurosciencesUniversity of the Basque Country UPV/EHU and CIBERNEDLeioaSpain Sechenov First Moscow State Medical University MoscowRussia Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of SciencesFaculty of BiologyMoscow State UniversityMoscowRussia

The preservation of cognitive longevity and arresting the pandemic of senile dementia engulfing the modern world is arguably the major challenge faced by biomedical research in the 21st *** is the leading risk factor for neurodegenerative diseases and vascular dementia,and yet there is a clear distinction between physiological and pathological brain aging.

关键词： inflammation senile aging