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Evaluation of HPV molecular Tests in Primary Screening for Cervical Cancer in Brazil

Open Journal of Obstetrics and Gynecology 2014年第8期4卷 470-478页

作者： José E.Levi Adhemar Longatto-Filho José Eluf-Neto Célia L.Rodrigues Cristina m.Oliveira Adriana C.Carloni Adriana T.Lorenzi maricy Tacla José H.Fregnani alexandre m.ab’saber Cristovam Scapulatempo Luisa LVilla National Institute of Science and Technology for the Diseases Associated to Papillomaviruses(INCT-HPV) Sao PauloBrazil Virology Lab Tropical Medicine InstituteUniversidade de Sao PauloSao PauloBrazil Laboratory of medical Investigation(LIm)14 Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil ICVS/3B’s-PT Government Associate Laboratory Life and Health Sciences Research Institute(ICVS)School of Health SciencesUniversity of MinhoBragaPortugal molecular Oncology Research Center Pio XII FoundationBarretosBrazil Department of Preventive medicine Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Infectious Diseases Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Ginecology and Obstetrics Faculdade de MedicinaUniversidade de São PauloSao PauloBrazil Center for the Researcher Support Pio XII FoundationBarretos Cancer HospitalBarretosBrazil Department of Pathology Faculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Department of Radiology Center on Translational Oncology InvestigationSao Paulo State Cancer InstituteFaculdade de MedicinaUniversidade de Sao PauloSao PauloBrazil Santa Casa de Sao Paulo medical School Sao PauloBrazil

Background: Incorporation of HPV tests into cervical cancer screening programs may be advantageous over conventional cytology, especially in developing nations, where the largest burden of cervical cancer is observed. Objectives: To conduct an evaluation of commercially available molecular HPV tests in Brazilian women. Study design: Two groups were recruited: group A was composed of 511 women referred to the clinics because of a previous abnormal Pap test while group B consisted of 2464 subjects under routine screening. Cervical samples were collected using SurePath liquid cytology (LBC) device, and split into aliquots which were submitted to molecular testing by Hybrid Capture and cobas HPV. Colposcopy and biopsies were made according to the standard guidelines, directed by cytological diagnosis. Results: Prevalence of HSIL was 5.97% and 0.7% in Group A and B respectively. High-Risk HPV DNA was found in about 9% of group B women, while in group A this frequency was 24%. Having CIN3+ as the study end-point, the negative predictive values for molecular methods were above 99.8%. All “in-situ” and invasive cervical carcinomas were detected by both HPV nucleic acid assays. Conclusion: Use of HPV DNA testing was feasible and highly sensitive in cancer screening settings of Brazil.

关键词： High-Risk HPV Test HPV-DNA Cervical Cancer Screening

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Topology optimization and seismic collapse assessment of shape memory alloy(SmA)-braced frames:Effectiveness of Fe-based SmAs

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Frontiers of Structural and Civil Engineering 2022年第3期16卷 281-301页

作者： Aydin HASSANZADEH saber mORADI Department of Civil Engineering Ryerson UniversityToronto M5B 2K3Canada

This paper presents a seismic topology optimization study of steel braced frames with shape memory alloy(SmA)*** SmA-braced frames(SmA-BFs)with either Fe-based SmA or NiTi braces are determined in a performance-based seismic design *** topology optimization is performed on 5-and 10-story SmA-BFs considering the placement,length,and cross-sectional area of SmA bracing ***,strength,and performance-based design constraints are considered in the *** seismic response and collapse safety of topologically optimal SmA-BFs are assessed according to the FEmA P695 methodology.A comparative study on the optimal SmA-BFs is also presented in terms of total relative cost,collapse capacity,and peak and residual story *** results demonstrate that Fe-based SmA-BFs exhibit higher collapse capacity and more uniform distribution of lateral displacement over the frame height while being more cost-effective than NiTi braced *** addition to a lower unit price compared to NiTi,Fe-based SmAs reduce SmA material *** frames with Fe-based SmA braces,the SmA usage is reduced by up to 80%.The results highlight the need for using SmAs with larger recoverable strains.

关键词： topology optimization shape memory alloy Fe-based SmA steel braced frames performance-based seismic design collapse assessment

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metaheuristic Optimization Algorithm for Signals Classification of Electroencephalography Channels

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Computers, materials & Continua 2022年第6期71卷 4627-4641页

作者： marwa m.Eid Fawaz Alassery abdelhameed Ibrahim mohamed saber Department of Communications and Electronics Delta Higher Institute of Engineering and TechnologyMansoura35111Egypt Department of Computer Engineering College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Computer Engineering and Control Systems Department Faculty of EngineeringMansoura UniversityMansoura35516Egypt Department of Electronics and Communications Engineering Faculty of EngineeringDelta University for Science and TechnologyMansoura11152Egypt

Digital signal processing of electroencephalography(EEG)data is now widely utilized in various applications,including motor imagery classification,seizure detection and prediction,emotion classification,mental task classification,drug impact identification and sleep state *** the increasing number of recorded EEG channels,it has become clear that effective channel selection algorithms are required for various *** Whale Optimization method(Guided WOA),a suggested feature selection algorithm based on Stochastic Fractal Search(SFS)technique,evaluates the chosen subset of *** may be used to select the optimum EEG channels for use in Brain-Computer Interfaces(BCIs),the method for identifying essential and irrelevant characteristics in a dataset,and the complexity to be *** enables(SFS-Guided WOA)algorithm to choose the most appropriate EEG channels while assisting machine learning classification in its tasks and training the classifier with the ***(SFSGuided WOA)algorithm is superior in performance metrics,and statistical tests such as ANOVA and Wilcoxon rank-sum are used to demonstrate this.

关键词： Signals metaheuristics optimization feature selection multilayer perceptron support vector machines

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modified Differential Evolution Algorithm for Solving Dynamic Optimization with Existence of Infeasible Environments

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Computers, materials & Continua 2023年第1期74卷 1-17页

作者： mohamed A.meselhi saber m.Elsayed Daryl L.Essam Ruhul A.Sarker School of Engineering and Information Technology University of New South Wales Canberra Australia

Dynamic constrained optimization is a challenging research topic in which the objective function and/or constraints change over *** such problems,it is commonly assumed that all problem instances are *** reality some instances can be infeasible due to various practical issues,such as a sudden change in resource requirements or a big change in the availability of ***-makers have to determine whether a particular instance is feasible or not,as infeasible instances cannot be solved as there are no solutions to *** this case,locating the nearest feasible solution would be valuable information for the *** this paper,a differential evolution algorithm is proposed for solving dynamic constrained problems that learns from past environments and transfers important knowledge from them to use in solving the current instance and includes a mechanism for suggesting a good feasible solution when an instance is *** judge the performance of the proposed algorithm,13 well-known dynamic test problems were *** results indicate that the proposed algorithm outperforms existing recent algorithms with a margin of 79.40%over all the environments and it can also find a good,but infeasible solution,when an instance is infeasible.

关键词： Dynamic optimization constrained optimization disruption differential evolution

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Features on Very Peripheral Collisions of 16O-Em at 3.7A GeV

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Chinese Physics Letters 2018年第3期35卷 14-17页

作者： m.S.El-Nagdy A.abdelsalam B.m.Badawy P.I.Zarubin A.m.abdalla A.saber Physics Department Faculty of ScienceHelwan UniversityHelwanEgypt Physics Department Faculty of ScienceCairo UniversityGizaEgypt Reactor Physics Department Atomic Energy AuthorityEgypt Joint Institute for Nuclear Research DubnaMoscowRussia Department of mathematical and Physical Engineering Faculty of Engineering in ShoubraBenha UniversityCairoEgypt

From 1540 inelastic interactions of 3. 7A GeV 160 projectile with emulsion nuclei, we select samples of 87 and 61 events carefully due to interactions of neutron （n） and singly charged particles （Z = 1）, respectively. New results concerning the topology of such events are investigated. The average multiplicities of secondary relativistic particles that appear as shower tracks for n and Z = 1 stay more or less constant when compared with analogous data on p-Em at similar energy. The multiplicity distributions and the average values of the various secondary charged particles are studied and compared with the corresponding predictions by the cascade evaporation model. The results assume that the n or Z = 1 from 16O collide peripherally with an emulsion target and are considered as an expansion to the N-N collisions.

关键词： Features on Very Peripheral Collisions of O-Em at 3.7 A GeV

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DTLm-DBP:Deep Transfer Learning models for DNA Binding Proteins Identification

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Computers, materials & Continua 2021年第9期68卷 3563-3576页

作者： Sara saber Uswah Khairuddin Rubiyah Yusof Ahmed madani Department of Computer Engineering Faculty of EngineeringArab Academy of Science and TechnologyEgypt Centre for Artificial Intelligence&Robotics Malaysia-Japan International Institute of TechnologyUniversiti Teknologi Malaysia

The identification of DNA binding proteins(DNabPs)is considered a major challenge in genome annotation because they are linked to several important applied and research applications of cellular functions e.g.,in the study of the biological,biophysical,and biochemical effects of antibiotics,drugs,and steroids on *** paper presents an efficient approach for DNabPs identification based on deep transfer learning,named“DTLm-DBP.”Two transfer learning methods are used in the identification *** first is based on the pre-trained deep learning model as a feature’s extractor and *** different pre-trained Convolutional Neural Networks(CNN),AlexNet 8 and VGG 16,are tested and *** second method uses the deep learning model as a feature’s extractor only and two different classifiers for the identification *** classifiers,Support Vector machine(SVm)and Random Forest(RF),are tested and *** proposed approach is tested using different DNA proteins *** performance of the identification process is evaluated in terms of identification accuracy,sensitivity,specificity and mCC,with four available DNA proteins datasets:PDB1075,PDB186,PDNA-543,and *** results show that the RF classifier,with VGG-Net pre-trained deep transfer learning features,gives the highest ***-DBP was compared with other published methods and it provides a considerable improvement in the performance of DNabPs identification.

关键词： DNabPs deep transfer learning AlexNet 8 VGG 16 SVm RF

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Hysteresis Loops and Phase Diagrams of the Spin-1 Ising model in a Transverse Crystal Field

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Chinese Physics Letters 2012年第1期29卷 194-197页

作者： S.Bouhou I.Essaoudi A.Ainane m.saber J.J.de miguel m.Kerouad Laboratoire de Physique des materiaux et modelisations des Systemes Unite Associee au CNRST-URAC 08Department of PhysicsFaculty of SciencesUniversity of Moulay IsmailB.P.11201MeknesMorocco max-Planck-Institut fur Physik Complexer Systeme Nohnitzer Str.38D-01187 DresdenGermany Dpto.Fisica de la materia Condensada C-3 and Institut of Materials Sciences“Nicolas Cabrera”Univ.AutonomaCantoblanco E-28049-MadridSpain

Within the framework of the effective-field theory with a probability distribution technique,which accounts for the self-spin correlation functions,the ferromagnetic spin-1 Ising model with a transverse crystal field on honeycomb,square and simple cubic lattices is *** have investigated the effect of the transverse crystal field on the phase diagrams,magnetization,hysteresis loops and χ_(z,h) of the system.A number of interesting phenomena of the system are discussed.

关键词： transverse Ising crystal

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Predictors and Effects of Persistent Hypertension after Successful Treatment of Coarctation of the Aorta

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Congenital Heart Disease 2022年第3期17卷 325-333页

作者： mohamed saber Hafez Alaa Roushdy Dina Ezzeldin Ain Shams University CairoEgypt

Background:Coarctation of the aorta is a congenital heart disease that sometimes remains clinically silent until adulthood,usually presenting with arterial *** is well known that after coarctation treatment,many patients remain hypertensive despite successful *** this study we approached the predictors and effects of residual hypertension after successful coarctation ***:It was a cross sectional observational study involving 50 patients who underwent Coarctation repair/angioplasty in Ain Shams university *** divided the patients into two groups(hypertensive and normotensive)and we studied their demographic data(e.g.,age,gender,age at first repair,follow up period,etc.)to conclude the possible predictors of persistent hypertension in such *** also performed full echocardiographic assessment including 3D speckle tracking echocardiography to detect subtle changes in left ventricular systolic ***:Hypertensive patients had significantly higher BmI(29.1 kg/m^(2))as compared to normotensives(24 kg/m^(2)),pmeasures(Global area strain,global circumferential strain and global longitudinal strain).The incidence of bicuspid aortic valve was significantly higher in the hypertensive group,yet it was not an independent predictor of persistent ***:The predictors for residual hypertension post successful CoA repair were late intervention and higher *** aortic valve was more common in the hypertensive *** the effects of such disease domain,treated CoA patients with persistent hypertension tended to have higher LV mass index and lower values of LV deformation.

关键词： Coarctation arterial hypertension speckle tracking left ventricular strain

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Reliability-aware swarm based multi-objective optimization for controller placement in distributed SDN architecture

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Digital Communications and Networks 2024年第5期10卷 1245-1257页

作者： abeer A.Z.Ibrahim Fazirulhisyam Hashim Aduwati Sali Nor K.Noordin Keivan Navaie saber m.E.Fadul Department of Computer and Communication Systems Engineering Faculty of Engineering Universiti Putra Malaysia Wireless and Photonics Networks Research Centre (WiPNET) Faculty of Engineering Universiti Putra Malaysia Department of Communication and Computer Engineering College of Engineering and Medical Sciences School of Computing and Communications Lancaster University Department of Electrical and Electronics Engineering Faculty of Engineering Universiti Putra Malaysia

The deployment of distributed multi-controllers for Software-Defined Networking(SDN) architecture is an emerging solution to improve network scalability and ***,the network control failure affects the dynamic resource allocation in distributed networks resulting in network disruption and low ***,we consider the control plane fault tolerance for cost-effective and accurate controller location models during control plane *** fault-tolerance strategy has been applied to distributed SDN control architecture,which allows each switch to migrate to next controller to enhance network *** this paper,the Reliable and Dynamic mapping-based Controller Placement(RDmCP) problem in distributed architecture is framed as an optimization problem to improve the system reliability,quality,and *** considering the bound constraints,a heuristic state-of-the-art Controller Placement Problem(CPP) algorithm is used to address the optimal assignment and reassignment of switches to nearby controllers other than their regular *** algorithm identifies the optimal controller location,minimum number of controllers,and the expected assignment costs after failure at the lowest effective cost.A metaheuristic Particle Swarm Optimization(PSO)algorithm was combined with RDmCP to form a hybrid approach that improves objective function optimization in terms of reliability and *** effectiveness of our hybrid RDmCP-PSO was then evaluated using extensive experiments and compared with other baseline *** findings demonstrate that the proposed hybrid technique significantly increases the network performance regarding the controller number and load balancing of the standalone heuristic CPP algorithm.

关键词： Software defined networking Dynamic mapping Particle swarm optimization Reliability multi-objective optimization Evolutionary

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Two Bioinspired mobile manipulators with Rolling Locomotion

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Journal of Bionic Engineering 2016年第1期13卷 48-58页

作者： saber mahboubi Heydarabad mir masoud Seyyed Fakhrabadi Steve Davis Samia Nefti-meziani School of Computing Science & Engineering University of Salford Manchester The Crescent M5 4WT UK School of mechanical Engineering College of Engineering University of Tehran Tehran Iran

This paper deals with two novel structures for mobile robots. The original inspiration of the robots comes from a sala- mander and a specific kind of spiders. Our robots have some especial moving capabilities causing to increase the robot ma- neuverability. Indeed, the capability of rolling motion is added to ordinary quadruped robots. This capability causes increment in maneuvering of the robots. manipulators can be embedded into the robots to add the ability of transferring materials into the shell and conducting some tasks such as repairing. In this paper, after analysis of motion principles of the rolling robots, their dynanlic equations are derived. Different simulations of two bioinspired mobile robots are presented in order to scrutinize various capabilities of the proposed designs. Walking capabilities of the robots and their advantages are discussed in detail. The comprehensive simulation results of the robots in various motion modes are presented. Finally the first prototype is introduced to verify the motion mechanisms.

关键词： bionics rolling robot quadruped robot Lagrange equations

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