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Brazilian biosafety law and the new breeding technologies

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Frontiers of Agricultural Science and Engineering 2020年第2期7卷 204-210页

作者： alexandre lima nepomuceno Renata FUGANTI-PAGLIARINI Maria Sueli Soares FELIPE Hugo Bruno Correa MOLINARI Edivaldo Domingues VELINI Eduardo Romano de Campos PINTO Maria Lucia Zaidan DAGLI Galdino ANDRADE FILHO Patricia Machado Bueno FERNANDES Embrapa Soybean Londrina 86001970Brazil Catholic University of Brasilia Brasilia 70790160Brazil Embrapa Agroenergy Biological Station ParkBrasilia 70770901Brazil Paulista State University Julio de Mesquita Filho Botucatu Faculty of Agronomic SciencesBotucatu 18610307Brazil Embrapa Biotechnology and Genetic Resources—Biological Station Park Brasilia 70770900Brazil Sao Paulo University Veterinary FacultySao Paulo 05508900Brazil Londrina State University Microbiology DepartmentUniversity CampusLondrina 86051990Brazil Espirito Santo Federal University Biotechnology Post GraduationVitoria 29040090Brazil CTNBio(National Biosafety Technical Commission) Brasilia 70610200Brazil

Globally,the area of land cultivated with genetically modified(GM)crops has increased a thousand-fold over the last two *** this technology has become important for food production,the regulatory frameworks that underpin these outcomes are based on a list of requirements for a risk assessment that differ from country to *** recent years,policymakers have had the opportunity to learn from the controversies over transgenics to create effective regulatory milestones for emerging technologies,allowing them to reach their potential for a more sustainable agriculture,ensuring food *** Brazil,Law No.11.105 of 24 March 2005 established a framework with four main organizations responsible for risk assessment and ***,most of new breeding technologies did not exist at that time and were not considered in this ***2016,Normative Resolution No.16 of the National Biosafety Technical Commission(CTNBio)was established to address this gap based on the evaluation of the products obtained through these techniques(termed Innovative Precision Improvement Techniques in the resolution),in a case-by-case consultation ***,if the product is designated to be a GM,the developer will have to go through the biosafety requirements and will be approved only after CTNBio risk *** the product is designated not to be GM(for the purposes of the legislation),then it can be registered using the existing ***,152 GM products are commercially approved in *** 2018,CTNBio assessed the first consultation on commercial release of plants generated using the new breeding technologies and has subsequently approved six *** is expected that many institutions would be able to participate in Brazilian and world markets,developing and introducing new biotechnological solutions and products through a more sustainable approach and without facing public disapproval,a common issue for GM crops.

关键词： Brazilian legislation CTNBio genetically modified crops

Monthly and seasonal streamflow forecasting of large dryland catchments in Brazil

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Journal of Arid Land 2021年第3期13卷 205-223页

作者： alexandre C COSTA Alvson B S ESTACIO Francisco de A de SOUZA FILHO Iran E lima NETO Institute of Engineering and Sustainable Development University of International Integration of the Afro-Brazilian LusophonyRedençãoCEP 62.790-970Brazil Department of Hydraulic Engineering and Environment Federal University of CearáFortalezaCEP 60.451-970Brazil

Streamflow forecasting in drylands is *** are scarce,catchments are highly humanmodified and streamflow exhibits strong nonlinear responses to *** goal of this study was to evaluate the monthly and seasonal streamflow forecasting in two large catchments in the Jaguaribe River Basin in the Brazilian semi-arid *** adopted four different lead times:one month ahead for monthly scale and two,three and four months ahead for seasonal *** gaps of the historic streamflow series were filled up by using rainfall-runoff ***,time series model techniques were applied,i.e.,the locally constant,the locally averaged,the k-nearest-neighbours algorithm(k-NN)and the autoregressive(AR)*** criterion of reliability of the validation results is that the forecast is more skillful than streamflow *** approach outperformed the streamflow climatology for all monthly *** average,the former was 25%better than the *** seasonal streamflow forecasting(SSF)was also reliable(on average,20%better than the climatology),failing slightly only for the high flow season of one catchment(6%worse than the climatology).Considering an uncertainty envelope(probabilistic forecasting),which was considerably narrower than the data standard deviation,the streamflow forecasting performance increased by about 50%at both *** forecast errors were mainly driven by the streamflow intra-seasonality at monthly scale,while they were by the forecast lead time at seasonal *** best-fit and worst-fit time series model were the k-NN approach and the AR model,*** rainfall-runoff modelling outputs played an important role in improving streamflow forecasting for one streamgauge that showed 35%of data *** developed data-driven approach is mathematical and computationally very simple,demands few resources to accomplish its operational implementation and is applicable to other dryland *** findings may be part of drou

关键词： nonlinear time series analysis probabilistic streamflow forecasting reconstructed streamflow data dryland hydrology rainfall-runoff modelling stochastic dynamical systems

Multi-generational SIR modeling: Determination of parameters, epidemiological forecasting and age-dependent vaccination policies

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Infectious Disease Modelling 2021年第1期6卷 751-765页

作者： Eduardo lima Campos Rubens Penha Cysne alexandre L.Madureira Gelcio L.Q.Mendes EPGE Brazilian School of Economics and Finance(FGV EPGE) Rio de JaneiroRJBrazil ENCE-Escola Nacional de Ci^encias Estatísticas(ENCE/IBGE) Rio de JaneiroRJBrazil Laboratorio Nacional de Computaç~ao Científica PetropolisRJBrazil INCA-Brazilian National Cancer Institute Coordination of AssistanceRio de JaneiroRJBrazil

We use an age-dependent SIR system of equations to model the evolution of the *** that measure the amount of interaction in different locations(home,work,school,other)are approximated from in-sample data using a random optimization scheme,and indicate changes in social distancing along the course of the *** allows the estimation of the time evolution of classical and age-dependent reproduction *** those parameters we predict the disease dynamics,and compare our results with out-of-sample data from the City of Rio de ***,we provide a numerical investigation regarding age-based vaccination policies,shedding some light on whether is preferable to vaccinate those at most risk(the elderly)or those who spread the disease the most(the youngest).There is no clear upshot,as the results depend on the age of those immunized,contagious parameters,vaccination schedules and efficiency.

关键词： COVID-19 Epidemiology Vaccination Compartmental modeling SIR

NiWO4 powders prepared via polymeric precursor method for application as ceramic luminescent pigments

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Journal of Advanced Ceramics 2020年第1期9卷 55-63页

作者： Naiara A.lima Lorena D.S.ALENCAR Máximo SIU-LI Carlos A.C.FEITOSA alexandre MESQUITA Jean-Claude M’PEKO Maria I.B.BERNARDI Instituto de Física de Sao Carlos Universidade de Sao Paulo13560-970 Sao CarlosSPBrazil Instituto Federal de Mato Grosso do Sul IFMS79200-000 AquidauanaMSBrazil Departamento de Física Centro de Ciências Exatas e TecnologiaUniversidade Federal do MaranhaoUFMA65080-805Sao LuisMABrazil Instituto de Geociências e Ciências Exatas Departamento de FísicaUniversidade Estadual Paulista13506-900Rio ClaroSPBrazil

Ni WO4 was prepared using the polymeric precursor method and studied in terms of physical and chemical properties to verify its stability for industrial applications as *** characterization was accomplished using thermal analyses,X-ray diffraction(XRD),scanning electron microscopy(SEM),photoluminescence(PL)and UV–Vis spectroscopies,colorimetric coordinates,and Raman *** the temperature,successive exothermic reactions were observed and they are related with thermal decomposition of the organic *** stability was reached at^700℃.The material is verified to become completely free of second phase at^800℃.The end Ni WO4 powders showed an intense charge transfer(CT)-related tail centered in the ultraviolet region,resulting in a yellow *** addition,the powders exhibited broad excitation band and broad deep blue–green emission band,which were enhanced with increasing powders’crystallinity.

关键词： nickel tungstate yellow pigment colorimetric coordinate optical property structural characterization

Understanding the corrosion of Mg alloys in in vitro urinary tract conditions: A step forward towards a biodegradable metallic ureteral stent

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Journal of Magnesium and Alloys 2023年第11期11卷 4301-4324页

作者： Margarida Pacheco Ivo M.Aroso Joana M.Silva Sviatlana V.Lamaka Jan Bohlen Maria Nienaber Dietmar Letzig Estêvão lima alexandre A.Barros Rui L.Reis 3B’s Research Group-Research Institute on Biomaterials Biodegradables and BiomimeticsUniversity of MinhoGuimarãesPortugal ICVS/3B’s-PT Government Associate Laboratory Braga/GuimarãesPortugal Institute of Surface Science Helmholtz-Zentrum hereon GmbHGermany Institute of Material and Process Design Helmholtz-Zentrum hereon GmbHGermany School of Health Sciences Life and Health Sciences Research Institute(ICVS)University of MinhoBragaPortugal

Ureteral stents play a fundamental role in modern time urology. However, following the deployment, stent-related symptoms are frequent and affect patient health and quality of life. Using biodegradable metals as ureteral stent materials have emerged as a promising strategy, mainly due to the improved radial force and slower degradation rate expected. Therefore, this study aimed to characterize different biodegradable metals in urinary tract environment to understand their propensity for future utilization as base materials for ureteral stents. The corrosion of 5 Mg alloys - AZ31, Mg-1Zn, Mg-1Y, pure Mg, and Mg-4Ag - under simulated urinary tract conditions was accessed. The corrosion layer of the different alloys presented common elements, such as Mg(OH)_(2), MgO, and phosphate-containing products, but slight variations in their chemical compositions were detected. The corrosion rate of the different metals varied, which was expected given the differences in the corrosion layers. On top of this, the findings of this study highlighted the significant differences in the samples' corrosion and corrosion layers when in stagnant and flowing conditions. With the results of this study, we concluded that Mg-1Zn and Mg-4Ag presented a higher propensity for localized corrosion, probably due to a less protective corrosion layer;Mg-4Ag corroded faster than all the other four alloys,and Mg-1Y stood out due to its distinct corrosion pattern, that showed to be more homogeneous than all the other four samples, making this one more attractive for the future studies on biodegradable metals.

关键词： Biodegradable metals Magnesium alloys Localized corrosion Biodegradable metallic ureteral stent

Effects of a Carbonated Soft Drink on Epitheial Tumor Incidence in Drosophila melanogaster

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Journal of Pharmacy and Pharmacology 2018年第3期6卷 240-247页

作者： Paula Marynella Alves Pereira lima Priscila Capelari Orsoli Thaise Gongalves Araujo Douglas Brandao Cardoso Julio Cesar nepomuceno Laboratory of Genetics and Biotechnology Institute of Biotechnology Federal University of Uberlandia Patos de Minas 38700-000 Brazil Laboratory of Cytogenetic and Mutagenesis University Center of Patos de Minas Patos de Minas 38700-000 Brazil

Diet represents an important risk factor for tumor development and numerous food dyes have been tested for their carcinogenic potential. Caramel IV colorant and its byproduct, the 4-methylimidazole （4-MI）, are part of the composition of cola soft drinks, although in undefined concentration. Considering that this concentration depends on the manufacturing place, we aimed to evaluate the potential carcinogenic activity of cola soft drinks from Brazil, Canada, Egypt and Netherlands, through the test for detection of epithelial tumor clones （warts） in somatic cells of Drosophila melanogaster. We used 72-hour larvae resulting from the crossing of wts/TM3, Sb^1 virgin females and mwh/mwh males. Larvae were exposed to the media containing the cola soft drinks for 48 hours and the analysis was performed in adults after transformation. Cola soft drinks from Brazil significantly induced epithelial tumor in D. melanogaster, while those from Canada, Egypt and Netherlands did not. In fact, the concentration of 4-MI is higher in cola soft drink commercialized in Brazil. Our results highlight the importance of investigating the toxic potential of current drinks, which may correlate with the rising incidence of malignant diseases.

关键词： Carcinogenic effect Drosophila melanogaster caramel IV warts

Challenges in the chemotherapy of Chagas disease: Looking for possibilities related to the differences and similarities between the parasite and host

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World Journal of Biological Chemistry 2017年第1期8卷 57-80页

作者： Vitor Sueth-Santiago Debora Decote-Ricardo alexandre Morrot Celio Geraldo Freire-de-lima Marco Edilson Freire lima Instituto Federal de Educacao Ciência e Tecnologia do Rio de JaneiroCampus Sao Goncalo Universidade Federal Rural do Rio de Janeiro Instituto de Ciências ExatasDepartamento de Química Universidade Federal Rural do Rio de Janeiro Instituto de VeterináriaDepartamento de Microbiologia e Imunologia Veterinária Universidade Federal do Rio de Janeiro

Almost 110 years after the first studies by Dr. Carlos Chagas describing an infectious disease that was named for him, Chagas disease remains a neglected illness and a death sentence for infected people in poor countries. This short review highlights the enormous need for new studies aimed at the development of novel and more specific drugs to treat chagasic patients. The primary tool for facing this challenge is deep knowledge about the similarities and differences between the parasite and its human host.

关键词： Trypanosoma cruzi Trans-sialidase Trypanothione reductase CYP51 Cruzipain Tubulin

Embryonal rhabdomyosarcoma in the maxillary sinus with orbital involvement in a pediatric patient:Case report

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World Journal of Clinical Cases 2017年第12期5卷 440-445页

作者： Ana Carolina Rodrigues de Melo Tácio Candeia Lyra Isabella lima Arrais Ribeiro alexandre Rolim da Paz Paulo Rogério Ferreti Bonan Ricardo Dias de Castro Ana Maria Gondim Valen?a Department of Clinical and Social Dentistry Federal University of Paraíba Department of Pathology Hospital Napole?o Laureano Department of Restorative Dentistry Federal University of Paraíba

This report presents a case of embryonal rhabdomyosarcoma(e RMS) located in the left maxillary sinus and invading the orbital cavity in a ten-year-old male patient who was treated at a referral *** images provided from the computed tomography showed a heterogeneous mass with soft-tissue density,occupying part of the left half of the face inside the maxillary sinus,and infiltrating and destroying the bone structure of the maxillary sinus,left orbit,ethmoidal cells,nasal cavity,and sphenoid *** analysis of the histological sections revealed an undifferentiated malignant neoplasm infiltrating the skeletal muscle *** immunohistochemical analysis was positive for the antigens:MyoD 1,myogenin,desmin,and Ki67(100% positivity in neoplastic cells),allowing the identification of the tumour as an eR *** treatment protocol included initial chemotherapy followed by radiotherapy and finally *** total time of the treatment was nine months,and in 18-mo of follow-up period did not show no local recurrences and a lack of visual impairment.

关键词： Oncology Embryonal rhabdomyosarcoma Pediatrics Maxillary sinus Chemotherapy

Experimental Acoustic Determination of the Void Fraction in Two-Phase Flow in Horizontal Pipelines

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Journal of Mechanics Engineering and Automation 2014年第8期4卷 625-631页

作者： Fernando Augusto de Noronha Castro Pinto Thiago de Campos Negrelly alexandre Silva de lima Mechanical Engineering Department UFRJ (Universidade Federal do Rio de Janeiro) Rio de Janeiro 21941-972 Brasil Mechanical Engineering Department CEFET/RJ (Centro Federal de Educag6o Tecnologica Celso Suckow da Fonseca) Rio deJaneiro 20271-110 Brasil

In multi-phase flows, the phases can flow and arranged in different spatial configurations in the pipe, which called flow patterns. This type of flow is found in the oil, chemical and nuclear industries. For example, in the production and transport of oil and gas, the identification of the flow patterns are essential for answering those questions which are related to the economic return of the field, such as, measuring the volumetric flow, determining the pressure drop along the flow lines, production management and supervision. In offshore production, these factors are very important. This paper presents a new method for measuring the void fraction in horizontal pipelines, taking the air as gas in water-air two-phase flow. Through acoustic analysis of the frequency response of the pipe, the method gets the parameters to changes in runoff regime, in an experimental arrangement constructed on a small scale. The main advantages are the non-intrusive characteristic and easy to implement. The paper is composed of a qualitative experimental evaluation and transducers （microphone） which are used to analyze variations in the response accompanying variations in void and flow pattern changes. Changes are imposed and controlled by a two-phase flow experimental simulation rig, including a measurement cell constituted of an external casing that can isolate the measurement from the environmental background noise fitted with acoustic pressure transducers radially arranged, and the impact of a monitored excitation mechanism. The signals which captured by the microphones are processed and analyzed by checking their frequency contents changes according to the amount of air in the mixture.

关键词： Experimental method two-phase flow determination of void fraction horizontal pipelines.