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Verapamil and vasospastic angina： underuse in the elderly population

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Journal of Geriatric Cardiology 2017年第7期14卷 430-435页

作者： Xavier Humbert Vincent Roule Paul Milliez Joachim alexandre Department of General Medicine Medical School Caen France Department of Pharmacology CHU de Caen Caen France Normandie University UNICAEN CHU Caen Signalisation eleetrophysiologie et imagerie des lesions d'ischOmie-reperfusion myocardique Caen France Department of Cardiology CHU de Caen Caen France

The first case of Prinzmetal angina was described in 1959 by Prinzmetal, et al. Since this description, several triggering factors have been associated with vasospastic angina （VA） and included： illicit drugs such as cocaine, amphetamine or marijuana, but also bitter-orange, alcohol, butane, chemotherapy drugs, over-the-counter medication and different antibiotics. Smoking is also a major risk factor for developing VA.t21 Thus, except for smoking, many of conventional atherosclerosis risk factors do not appear to be applicable to VA.t21 However, vasospastic angina can also occur without any triggering factor.

关键词： Calcium antagonists Elderly population Prinzmetal angina Variant angina Verapamil

Genetic diversity and structure of Drimys brasiliensis in southern Brazil:insights for conservation

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Journal of Forestry Research 2020年第4期31卷 1325-1332页

作者： alexandre Mariot Tiago Montagna Maurício Sedrez dos Reis Núcleo de Pesquisas Em Florestas Tropicais Pós-Graduacāo Em Recursos Genéticos VegetaisCentro de Ciências AgráriasUniversidade Federal de Santa CatarinaRodovia Admar Gonzaga1346FlorianópolisSC 88034-000Brazil

Population genetics studies are widely recognized for generating useful knowledge for biodiversity *** date,however,little is known about the levels and distribution of genetic diversity of Drymis brasiliensis(Miers LC),a tree species from the Atlantic ***,in this study,we investigated how genetic diversity is distributed within and among populations of *** from southern Brazil using allozyme markers to genotype reproductive trees(8 populations)and seedlings(3 populations).Furthermore,in two populations,we established two permanent plots(5.1 and 1 ha)to analyze fine-scale genetic structure(FSGS).Studied populations presented low levels of genetic diversity(reproductive=0.085;seedlings=0.054)and high fixation indexes(reproductive=0.396;seedlings=0.231).Genetic divergence among populations was equal to 0.05,which is significant,signaling that few populations can conserve large portions of the species total genetic *** was only detected for one population,when reproductive individuals were separated by less than40 *** genetic diversity combined with high fixation indexes clearly signal a risk of losing ***,conservation efforts should be aimed at enhancing gene flow within the studied populations.

关键词： Atlantic Rainforest Effective population size Fine-scale genetic structure Seed collection

Comment on:local control and survival after induction chemotherapy and ablative radiation versus resection for pancreatic ductal adenocarcinoma with vascular involvement

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Hepatobiliary Surgery and Nutrition 2021年第5期10卷 672-674页

作者： Pauline Georges alexandre Doussot Department of Digestive Surgical Oncology-Liver Transplantation Unit CHU BesanconBesanconFrance

We read with interest the study from Jolissaint et *** issued in the Annals of Surgery(1).In this single center retrospective study,the authors compared oncological outcomes in patients with pancreatic ductal adenocarcinoma(PDAC)and vascular involvement who underwent pancreatectomy(n=105)*** dose ablative radiation(A-RT,n=104).All patients received induction chemotherapy first,over a recent study period[2014-2018].While the rationale for submitting patients to pancreatectomy or A-RT was not clearly stated in the Methods section,comparison between the two groups showed that patients allocated to A-RT were frailer with higher Charlson Comorbidity indexes and Eastern Cooperative Oncology Group(ECOG)scores and harbored significantly larger tumors,more often left-sided,with more arterial involvement as compared to patients in the pancreatectomy group.

关键词： involvement adenocarcinoma Surgery

National botanical gardens at the forefront of global plant conservation

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The Innovation 2023年第5期4卷 1-2页

作者： Hai Ren alexandre Antonelli South China Botanical Garden of the Chinese Academy of Sciences Guangzhou 510650China South China National Botanical Garden Guangzhou 510650China Royal Botanic Gardens KewRichmondLondonTW93AE SurreyUK Gothenburg Global Biodiversity Center Department of Biological and Environmental SciencesUniversity of GothenburgBox 46140530 GoteborgSweden|

Global changes in land use driven by demands on food,energy,and other resources in response to a rapidly increasing human population have collectively led to escalating environmental challenges,including biodiversity loss,global warming,environmental pollution,and ecosystem *** present,biodiversity is seriously threatened at global,regional,and local scales,which,in turn,threatens our own *** is a global asset of immense material and non-material value,providing us with food,medicine,building materials,fiber,and the ecological environment required for our well-being and health.

关键词： collective pollution seriously

To drain or not to drain after distal pancreatectomy: reflexions on the PANDORINA trial

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 675-677页

作者： Maxime Constant alexandre Doussot Department of Digestive and Surgical Oncology Liver Transplantation UnitCHU BesanconBesançonFrance

We read with great interest the PANDORINA study(1).This international multicenter(mostly from the Netherlands)randomized controlled trial aimed at determining whether omitting drainage after distal pancreatectomy(DP)was equivalent in terms of complications to systematic drainage *** primary outcome was the occurrence of severe complications at 90 days defined as Dindo-Clavien grade≥*** main secondary outcome was the occurrence of grade B–C postoperative pancreatic fistula(POPF)at 90 *** both outcomes,the non-inferiority threshold was set at 8%.Randomization was performed intraoperatively,stratified by annual center volume(high volume defined as DP≥40/year)and the risk of POPF according to the distal fistula risk score(D-FRS)combining pancreas thickness(high risk,>19 mm)and main pancreatic duct diameter(high risk,>3 mm)measured both at the isthmus(2).

关键词： Drainage distal pancreatectomy(DP) randomized controlled trial

Limit behaviour of the minimal solution of a BSDE with singular terminal condition in the non Markovian setting

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Probability, Uncertainty and Quantitative Risk 2020年第1期5卷 1-24页

作者： Dmytro Marushkevych alexandre Popier Laboratoire Manceaude Mathematiques Le Mans UniversiteAvenue Olivier Messiaen72085 Le Mans cedex 9France

We use the functional Ito calculus to prove that the solution of a BSDE with singular terminal condition verifies at the terminal time:lim inf_(t→T)Y(t)=ξ=Y(T).Hence,we extend known results for a non-Markovian termi... 详细信息

关键词： Backward stochastic differential equations Functional stochastic calculus Singularity

Liver transplantation for perihilar cholangiocarcinoma is not a provocative idea

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Hepatobiliary Surgery and Nutrition 2023年第2期12卷 232-234页

作者： alexandre Chebaro Heithem Jeddou Service de Chirurgie Hépatobiliaire et Digestive CHU RennesUniv RennesRennesFrance Inserm EHESPIrset(Institut de recherche en santéenvironnement et travail)-UMR_S 1085Univ RennesRennesFrance

This is a multicenter benchmarking study on liver transplantation(LT)for perihilar cholangiocarcinoma(PHC)after neoadjuvant chemoradiotherapy(1).The study comprises of 134 patients from 2014 to 2018 among whom the majority had underlying primary sclerosing cholangitis(PSC).Dropout rate was available from 4 out of 17 centers and was 28%,primarily for oncological reasons(tumor progression and lymph node invasion).All patients followed neo-adjuvant chemoradiotherapy according to the Mayo(88%)or Mayo-like *** grafts originated from brain-dead donors in 61.3%of cases and from living donors in 29.7%of cases.

关键词： Liver invasion patients

Coming of age for the rhizosphere microbiome transplantation

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Soil Ecology Letters 2023年第1期5卷 4-5页

作者： alexandre Jousset Seon-Woo Lee Key Laboratory of Plant Immunity Jiangsu Key Laboratory for Organic Solid Waste UtilizationNational Engineering Research Center for Organic-based FertilizersNanjing Agricultural UniversityNanjing 210095China Department of Applied Bioscience Dong-A UniversityBusan 49315Korea

Microbiome transplants have the potential to disrupt agriculture and medicine by transferring the microbial genetic pool(and hence capabilities)from one host to ***,for this technology to become reality,we need to understand the drivers shaping the success of microbiome *** highlight here recent findings by *** Jiang and *** disease suppression as a model function,they highlight the microbiome characteristics making a successful transplant *** see this study is a seminal work making microbiome transplant an informed process that will replace the current error-prone trial *** anticipate that the insights may catalyse a paradigm shift in microbiome management in agriculture and medicine.

关键词： Microbiome transplant Coalescence Ralstonia Biodiversity Crop health

Directional H^(2) Compression Algorithm: Optimisations and Application to a Discontinuous Galerkin BEM for the Helmholtz Equation

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Communications in Computational Physics 2022年第5期31卷 1585-1635页

作者： Nadir-alexandre Messaï Sebastien Pernet Abdesselam Bouguerra ONERA/DTIS Universitéfédérale de Toulouse F-31000 Toulouse France Laboratoire de Physique de la Matière et du Rayonnement(LPMR) Département de Sciences de la MatièreUniversitéde Souk-AhrasBP 155341000 Souk-AhrasAlgeria

This study aimed to specialise a directional H^(2)(DH^(2))compression to matrices arising from the discontinuous Galerkin(DG)discretisation of the hypersingular equation in *** significantfinding is an algorithm that takes a DG stiffness matrix andfinds a near-optimal DH^(2) approximation for low and high-frequency *** introduced the necessary special optimisations to make this algorithm more efficient in the case of a DG stiffness ***,an automatic parameter tuning strategy makes it easy to use and *** comparisons with a classical Boundary Element Method(BEM)show that a DG scheme combined with a DH^(2) gives better computational efficiency than a classical BEM in the case of high-order finite elements and hp heterogeneous *** results indicate that DG is suitable for an auto-adaptive context in integral equations.

关键词： Integral equation boundary element method Helmholtz equation discontinuous Galerkin directional H^(2)-matrix low-rank approximation all frequency compression algorithm