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World Journal of Diabetes 2023年第3期14卷 347-351页

作者： alexandra Papadopoulou Konstantinos I Papadopoulos Occupational and Environmental Health Services Feelgood LundLund 22363SkåneSweden Department of Research and Development THAI StemLife Co.Ltd.Bangkok 10310BangkokThailand

Type 2 diabetes mellitus(T2DM)is a lifelong condition and a grave threat to human *** efforts to relieve its detrimental effects are acutely *** sine qua non in T2DM management is consistent adherence to a prudent lifestyle and nutrition,combined with aerobic and resistance exercise regimens,together repeatedly shown to lead to complete reversal and even longterm ***-adherence to the above lifestyle adjustments condemns any treatment effort and ultimately the patient to a grim *** is thus imperative that every study evaluating the effects of innovative interventions in T2DM objectively compares the novel treatment modality to lifestyle modifications,preferably through double-blind controlled randomization,before claiming efficacy.

关键词： Type 1 diabetes mellitus Type 2 diabetes mellitus Human umbilical cord mesenchymal stem cells Diabetes remission Diabetes reversal Lifestyle modifications

Mental health of the Slovak population during COVID-19 pandemic:A cross-sectional survey

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World Journal of Clinical Cases 2022年第25期10卷 8880-8892页

作者： Maria Kralova alexandra Brazinova Veronika Sivcova Lubomira Izakova Department of Psychiatry Faculty of Medicine Comenius University and University Hospital BratislavaBratislava 81369Slovakia Institute of Epidemiology Faculty of Medicine Comenius University BratislavaBratislava 81372Slovakia

BACKGROUND Population’s mental health surveillance is essential for knowing the distribution of mental well-being and mental disorders in the *** allows for the establishment,evaluation,and revision of preventive measures and curative *** results of such monitoring should serve as a database for evidencebased mental health *** disorders are among the top ten causes of burden globally and crisis situations such as the pandemic increase the risk of mental health problems,as they cause constant fear of contagion and the implementation of restrictive *** impact of the coronavirus disease 2019(COVID-19)pandemic on the general population of the Slovak Republic has not yet been *** hypothesis was that more than one fifth of the population(women to a greater extent)will have symptoms of anxiety and *** To assess the mental health of the general Slovak population aged 15 years and older in the summer of 2021 by determining the prevalence of depressive and anxiety *** An anonymous cross-sectional survey was implemented in a sample of 1501 respondents in the summer of 2021 during the COVID-19 *** inclusion criteria were age of 15 years and older and ability to complete the survey questionnaire online or in a face-to-face *** survey assessed anxiety symptoms by the seven-item general anxiety disorder and depressive symptoms by the nine-item patient health questionnaire *** cut-off scores of 10 or greater were used for *** Anxiety symptoms were present in 19.32%and depression in 24.65%of the *** of both disorders were more common in females:15.00%of males and 24.00%of females experienced anxiety symptoms,and 19.00%of males and 30.00%of females experienced symptoms of *** of both disorders were the most common in the youngest age group(15-25 years old):One fifth of males(20.29%)and one third of females(35.32%)had symptoms of anxiety,and 2

关键词： Mental health COVID-19 pandemic Anxiety Depression Slovak Republic

Artificial intelligence as a noninvasive tool for pancreatic cancer prediction and diagnosis

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World Journal of Gastroenterology 2023年第12期29卷 1811-1823页

作者： alexandra Corina Faur Daniela Cornelia Lazar Laura Andreea Ghenciu Department of Anatomy and Embriology “Victor Babeș”University of Medicine and Pharmacy TimișoaraTimișoara 300041TimișRomania Department V of Internal Medicine I Discipline of Internal Medicine IVUniversity of Medicine and Pharmacy“Victor Babes”TimișoaraTimișoara 300041TimișRomania DepartmentⅢ Discipline of Pathophysiology“Victor Babeș”University of Medicine and PharmacyTimișoara 300041TimișRomania

Pancreatic cancer(PC)has a low incidence rate but a high mortality,with patients often in the advanced stage of the disease at the time of the first *** detected,early neoplastic lesions are ideal for surgery,offering the best *** lesions of the pancreas include pancreatic intraepithelial neoplasia and mucinous cystic neoplasms,with intraductal papillary mucinous neoplasms being the most commonly *** study focused on predicting PC by identifying early signs using noninvasive techniques and artificial intelligence(AI).A systematic English literature search was conducted on the PubMed electronic database and other *** obtained a total of 97 studies on the subject of pancreatic *** final number of articles included in our study was 44,34 of which focused on the use of AI algorithms in the early diagnosis and prediction of pancreatic *** algorithms can facilitate diagnosis by analyzing massive amounts of data in a short period of *** can be made through AI algorithms by expanding image and electronic medical records databases,which can later be used as part of a screening program for the general ***-based screening models should involve a combination of biomarkers and medical and imaging data from different *** requires large numbers of resources,collaboration between medical practitioners,and investment in medical infrastructures.

关键词： Pancreatic cancer Early pancreatic lesions Pancreatic neoplasia Artificial intelligence Deep learning Machine learning Radiomics Diagnosis Pancreas

Monitoring and Prediction of Indoor Air Quality for Enhanced Occupational Health

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Intelligent Automation & Soft Computing 2023年第1期35卷 925-940页

作者： Adela POP(Puscasiu) alexandra Fanca Dan Ioan Gota Honoriu Valean Technical University of Cluj Napoca Cluj NapocaRomania

The amount of moisture in the air is represented by relative humidity(RH);an ideal level of humidity in the interior environment is between 40%and 60%at temperatures between 18°and 20°*** the RH falls below this level,the environment becomes dry,which can cause skin dryness,irritation,and discomfort at low *** the humidity level rises above 60%,a wet atmosphere develops,which encourages the growth of mold and *** and allergy symptoms may occur as a *** health is harmed by excessive humidity or a lack *** can be used to provide an optimal level of humidity and a stable and pleasant atmosphere;certain models disinfect and purify the water,reducing the spread of *** design and implementation of a client-server indoor and outdoor air quality monitoring application are presented in this *** Netatmo station was used to acquire the data needed in the *** client is an Android application that allows the user to monitor air quality over a period of their *** a good monitoring process,the Netatmo modules were used to collect data from both environments(indoor:temperature(T),RH,carbon dioxide(CO_(2)),atmospheric pressure(Pa),noise and outdoor:T and RH).The data is stored in a database,using *** Android application allows the user to view the evolution of the measured parameters in the form of ***,the paper presents a prediction model of RH using Azure Machine Learning Studio(Azure ML Studio).The model is evaluated using metrics:Mean Absolute Error(MAE),Root Mean Squared Error(RMSE),Relative Absolute Error(RAE),Relative Squared Error(RSE)and Coefficient of Determination(CoD).

关键词： Machine learning indoor air quality humidity carbon dioxide relative humidity

Acute hepatitis of unknown etiology in an adult female:A case report

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World Journal of Clinical Cases 2023年第22期11卷 5288-5295页

作者： Lucinda Dass alexandra Marie Malabanan Pacia Mahgol Hamidi Department of Clinical Studies St.George's UniversityTrue Blue 00000Grenada Department of Internal Medicine Jersey City Medical CenterJersey CityNew Jersey 07307United States

BACKGROUND Acute liver injury(ALI)refers to inflammation of the hepatic parenchyma without hepatic encephalopathy that lasts less than 6 *** the etiology is unknown,Acute Hepatitis of Unknown Origin(AHUO)can present as a diagnostic and treatment *** in the adult population is unusual and poorly *** has an incidence between 11%and 75%.Currently,no treatment guidelines *** no identified cause,treatment is often blind,and the wrong treatment plan may have unintended *** SUMMARY We present the case of a 58-year-old woman who presented to the emergency room for elevated liver function tests(LFTs).Her symptoms started 10 d prior to admission and included nausea,vomiting,jaundice,decreased appetite,weight loss of 10 lbs,and dark *** denied drinking alcohol or taking any hepatotoxic agents,including acetaminophen,statins,vitamins,or *** was admitted to the hospital,and an etiologic work-up was carried *** initial bloodwork revealed elevated liver enzymes(alanine aminotransferase 2500 U/L,aspartate aminotransferase 3159 U/L,and alkaline phosphatase 714 U/L)and elevated total bilirubin of 6.4 mg/*** tested negative for common infectious etiologies such as hepatotropic viruses A,B,C,and *** infective work-up revealed negative serology for cytomegalovirus,Epstein-Barr virus,herpes simplex virus 1&2,and human immunodeficiency *** autoanti-body test results were negative,including anti-smooth muscle antibody,anti-mitochondrial antibody,and anti-liver kidney microsome 1 *** resonance cholangiopancreatography ruled out biliary causes of elevated LFTs,and her core liver biopsy proved *** the course of her hospital stay,the patient's LFTs improved with supportive care and without *** Idiopathic hepatitis makes treatment *** can leave patients feeling confused and ***,educating the patient thoroughly for shared decision-making and manag

关键词： Acute hepatitis Acute liver injury Idiopathic hepatitis Acute hepatitis of unknown etiology Case report

INF-γ and IL-2 Profile as Therapeutic Markers in Tuberculosis Patients at the Jamot Hospital of Yaounde-Cameroon

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Journal of Tuberculosis Research 2024年第2期12卷 119-128页

作者： alexandra Emmanuelle Membangbi Jacky Njiki-Bikoï Esther Del-Florence Moni Ndedi Donatien Serge Mbaga Elsa Nguiffo Makue André Chris Mikangue Mbongue Koko-Ta Ladiff Sharonne Martha Mesembe Justin Olivier Essindi Aïcha Ngoutane Arnaud Franck Elang Sabine Aimée Touangnou-Chamda George Ikomey Mondinde Eric Walter Perfura-Yone Marie Joseph Nkodo Mindimi Sara Honorine Riwom Essama Department of Microbiology The University of Yaound 1 Yaound Cameroon Center for the Study and Control of Communicable Diseases (CSCCD) Yaound Cameroon The Institute for Medical Research and Medicinal Plants Studies Yaound Cameroon Faculty of Medicine and Biomedical Sciences The University of Yaound I Yaound Cameroon The Pneumology Department Jamot Hospital of Yaound Yaound Cameroon

Background: Tuberculosis (TB) is one of the top lethal infectious diseases worldwide. In recent years, interferon-γ (INF-γ) release assays (IGRAs) have been established as routine tests for diagnosing TB infection. However, produced INF-γ assessment cannot permit to distinguish active ATB from latent TB infection (LTBI), especially in TB epidemic areas. In addition to IFN-γ, interleukin-2 (IL-2), secreted by activated T cells, is involved in immune response against Mycobacterium tuberculosis. This could be involved in the follow up of treatment response. The aim of our study was to determine IFN-γ and IL2 cytokines profiles of patients under antituberculosis treatment. Materials and Methods: A six months’ cross-sectional study was conducted at the Jamot Hospital of Yaoundé, from May to August 2021. Sociodemographic and clinical data as well as 5 mL of blood were collected from each participant. INF-γ and IL-2 were determined using indirect Enzyme linked Immuno-Sorbent Assay (ELISA) according to the manufacturer’s recommendations and spectrum exam in combination with radiography and GeneXpert were used as standard. P-values Results: The results showed that men were more infected 14/61 (31.8%) with a high presence in active and resistant TB groups. The mean age was 41.3 ± 13.1 years with a 95% CI = [38.2 - 44.7], the age group with the highest infection rate was ranged between 31 and 40 years. The IL-2 and INF-γ means were respectively 327.6 ± 160.6 pg/mL and 26.6 ± 13.0 pg/mL in ATB patients, 251.1 ± 30.9 pg/mL and 21.4 ± 9.2 pg/mL in patients with resistant tuberculosis, while it was 149.3 ± 93.3 pg/mL and 17.9 ± 9.4 pg/mL in cured patients, 15.1 ± 8.4 pg/mL and 5.3 ± 2.6 pg/mL in participants presumed healthy (p γ and IL-2rates were observed between the different groups. Conclusion: Monitoring the serum levels of INF-γ and IL-2 would be useful for the follow-up of anti-tuberculosis patients, particularly in the both cytokines association case.

关键词： Tuberculosis Antituberculosis Treatment INF-γ IL-2 ELISA

Bayesian modeling of dynamic behavioral change during an epidemic

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Infectious Disease Modelling 2023年第4期8卷 947-963页

作者： Caitlin Ward Rob Deardon alexandra M.Schmidt Division of Biostatistics University of MinnesotaMinneapolisMNUSA Faculty of Veterinary Medicine University of CalgaryCalgaryABCanada Department of Mathematics and Statistics University of CalgaryCalgaryABCanada Department of Epidemiology Biostatisticsand Occupational HealthMontrealQCCanada

For many infectious disease outbreaks,the at-risk population changes their behavior in response to the outbreak severity,causing the transmission dynamics to change in *** change is often ignored in epidemic modeling efforts,making these models less useful than they could *** address this by introducing a novel class of datadriven epidemic models which characterize and accurately estimate behavioral *** proposed model allows time-varying transmission to be captured by the level of“alarm”in the population,with alarm specified as a function of the past epidemic *** investigate the estimability of the population alarm across a wide range of scenarios,applying both parametric functions and non-parametric functions using splines and Gaussian *** model is set in the data-augmented Bayesian framework to allow estimation on partially observed epidemic *** benefit and utility of the proposed approach is illustrated through applications to data from real epidemics.

关键词： Bayesian inference Compartmental model SIR SEIR Transmission modeling

MicroRNA-155 mediates endogenous angiotensin II type 1 receptor regulation:implications for innovative type 2 diabetes mellitus management

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世界糖尿病杂志:英文版(电子版) 2023年第9期14卷 1334-1340页

作者： Konstantinos I Papadopoulos alexandra Papadopoulou Tar-Choon Aw Department of R&D THAI StemLifeBangkok 10310Thailand Occupational and Environmental Health Services Feelgood LundLund 223-63SkåneSweden Department of Laboratory Medicine Changi General HospitalSingapore 529889SingaporeSingapore Department of Medicine National University of SingaporeSingapore 119228SingaporeSingapore

Type 2 diabetes mellitus(T2DM)is a lifelong condition and a threat to human *** understanding of its pathogenesis is acutely needed in order to devise innovative,preventative,and potentially curative pharmacological ***(miRNA),are small,non-coding,one-stranded RNA molecules,that can target and silence around 60%of all human genes through translational ***-155 is an ancient,evolutionarily well-conserved miRNA,with distinct expression profiles and multifunctionality,and a target repertoire of over 241 genes involved in numerous physiological and pathological processes including hematopoietic lineage differentiation,immunity,inflammation,viral infections,cancer,cardiovascular conditions,and particularly diabetes ***-155 Levels are progressively reduced in aging,obesity,sarcopenia,and ***,the loss of coordinated repression of multiple miR-155 targets acting as negative regulators,such as C/EBPβ,HDAC4,and SOCS1 impacts insulin signaling,deteriorating glucose homeostasis,and causing insulin resistance(IR).Moreover,deranged regulation of the renin angiotensin aldosterone system(RAAS)through loss of Angiotensin II Type 1 receptor downregulation,and negated repression of ETS-1,results in unopposed detrimental Angiotensin II effects,further promoting ***,loss of BACH1 and SOCS1 repression abolishes cytoprotective,anti-oxidant,anti-apoptotic,and anti-inflam matory cellular pathways,and promotesβ-cell *** contrast to RAAS inhibitor treatments that further decrease already reduced miR-155 Levels,strategies to increase an ailing miR-155 production in T2DM,e.g.,the use of metformin,mineralocorticoid receptor blockers(spironolactone,eplerenone,finerenone),and verapamil,alone or in various combinations,represent current treatment *** the future,direct tissue delivery of miRNA analogs is likely.

关键词： Angiotensin II Angiotensin II type 1 receptor Arginase 2 L-type calcium channel Mineralocorticoid receptor MiRNA-155 Renin-angiotensin aldosterone system Type 1/2 diabetes mellitus Verapamil

Multiple forest structural elements are needed to promote beetle biomass, diversity and abundance

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Forest Ecosystems 2022年第5期9卷 585-595页

作者： Nolan J.Rappa Michael Staab Julian Frey Nathalie Winiger alexandra-Maria Klein Nature Conservation and Landscape Ecology University of FreiburgTennenbacherstrasse 479106Freiburg im BreisgauGermany Ecological Networks Technical University DarmstadtSchnittspahnstrasse 364287DarmstadtGermany Forest Growth and Dendroecology University of FreiburgTennenbacherstrasse 479106Freiburg im BreisgauGermany Wildlife Ecology and Management University of FreiburgTennenbacherstrasse 479106Freiburg im BreisgauGermany

Background:Retention forestry is a management strategy aiming to mitigate biodiversity loss by retaining structural elements such as dead trees that would otherwise be *** we analyze the biomass,diversity and abundance among forest beetles collected using window traps on 1281-ha forest sites reflecting gradients in the amount of structural elements in southwestern ***:We found that beetle biomass increased with mean diameter at breast height(a measure of tree size),and decreased with stand structural *** of individual feeding guilds responded differently to forest structural elements,namely lying deadwood,understory complexity,tree basal area and stand structural *** family diversity increased with the effective number of layers,i.e.1-m forest strata occupied by vegetation assessed via terrestrial laser *** of feeding guilds responded to only elevation and share of deciduous *** composition in terms of biomass was structured by forest elements similar to biomass of individual feeding guilds,with the addition of lying *** differed from community composition in terms of abundance of feeding guilds,which was structured by primarily standing deadwood volume and share of deciduous ***:Our results show that biomass,diversity and abundance respond differently to forest structural *** suggests that the concurrent prioritization of multiple forest elements is needed to promote forest beetles,with more focus placed on the differing resource needs among feeding *** addition,retention strategies should also consider the varying responses of beetle biodiversity metrics when assessing the importance of forest structural elements.

关键词： Allometry Biodiversity Coleoptera Forest management Terrestrial laser scanning Window trap

Compressibility characteristics of bio-cemented calcareous sand treated through the bio-stimulation approach

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Journal of Rock Mechanics and Geotechnical Engineering 2023年第2期15卷 510-522页

作者： Yijie Wang Ningjun Jiang alexandra Clarà Saracho Ogul Doygun Yanjun Du Xiaole Han Institute of Geotechnical Engineering Southeast UniversityNanjingChina Department of Civil and Environmental Engineering University of Hawaii at ManoaHonoluluUSA Department of Engineering Cambridge UniversityCambridgeUK Geosyntec Consultants Inc.Huntington BeachUSA

Calcareous sand is widely present in coastal areas around the world and is usually considered as a weak and unstable material due to its high compressibility and low ***-induced calcium carbonate precipitation(MICP)is a promising technique for soil ***,the commonly adopted bio-augmented MICP approach is in general less compatible with the natural soil ***,this study focuses on the bio-stimulated MICP approach,which is likely to enhance the dominance of ureolytic bacteria for longer period and thus is deemed more *** main objective of this paper is to investigate the compressibility of calcareous sand treated by bio-stimulated MICP *** the current study,a series of one-dimension compression tests was conducted on bio-cemented sand pre-pared via bio-stimulation with different initial relative densities(D r).Based on the obtained compression curves and particle size distribution(PSD)curves,the parameters including cementation content,the coefficient of compressibility(a v),PSD,relative breakage(B r),and relative agglomeration(A r)were *** results showed that a v decreased with the increasing cementation *** bio-cemented sand prepared with higher initial D r had smaller(approximately 20%e70%)a v values than that with lower initial D *** specimen with higher initial D r and higher cementation content resulted in smaller B r but larger A ***,a conceptual framework featuring multiple contact and damage modes was proposed.

关键词： Calcareous sand Bio-cementation Bio-stimulation Compressibility