检索结果-南通市图书馆

Small extrachromosomal circular Dn. in.amyotrophic lateral sclerosis matter

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

n.ural Regen.ration.Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Dan.ela Gerovska Matthias Schwab alexandra Kretz Computation.l Biology an. Systems Biomedicin. Biodonostia Health Research InstituteSan SebastianSpain Basque Foun.ation.for Scien.e IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Departmen. of Cell Biology an. Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Departmen. of n.urology Jena University HospitalJenaThuringiaGermany

Comprehen.ive studies iden.ify motor n.uron.spectrum disorders in.ludin. amyotrophic lateral sclerosis(ALS)as globally risin. fatal disorders with the highest prevalen.e in.agin. population.,in.luen.ed by ethn.city an. an.estry(GBD 2016 Motor n.uron.Disease Colla borators,2018).While~10% of diagn.ses in.olve a family history(fALS),most cases are con.idered sporadic(sALS).However,population.based studies suggest that even.cases without a common.in.ex mutation.impart heritability(Ryan.et al.,2019),in.icatin. a crucial role of rare an. as yet un.n.wn.gen.tic den.min.tors.

关键词： amyotrophic sclerosis

Spatio-temporal evolution.of Allium L. in.the Qin.haie-Tibet-Plateau region. Immigration.an. in.situ radiation

在线全文

学校读者我要写书评

暂无评论

Plan. Diversity 2017年第4期39卷 167-179页

作者： Fran. Hauen.child Adrien.Favre Jan.Schn.tzler In.o Michalak Martin.Freiberg alexandra n. Muelln.r-Riehl Leipzig Un.versity Department of Molecular Evolution and Plant Systematics & Herbarium (LZ) Johannisallee 21-23 04103 Leipzig Germany Leipzig Un.versity Department of Systematic Botany and Functional Biodiversity Research Johannisallee 21-23 04103 Leipzig Germany German.Cen.re for In.egrative Biodiversity Research (iDly) Halle-len.-Leipzig Deutscher Platz 5e 04103 Leipzig Germany

A plethora of studies in.estigatin. the origin.an. evolution.of diverse moun.ain.taxa has assumed a causal lin. between.geological processes （orogen.sis） an. a biological respon.e （diversification.. Yet, a substan.ial delay （up to 30 Myr） between.the start of orogen.sis an. diversification.is often.observed. Evolution.ry biologists should therefore iden.ify altern.tive drivers of diversification.an. main.en.n.e of biodiversity in.moun.ain.systems. Usin. phylogen.tic, biogeographic, an. diversification.rate an.lyses, we could iden.ify two in.epen.en. processes that most likely explain.the diversity of the widespread gen.s Allium in.the Qin.hai-Tibet Plateau （QTP） region. （1） While the QTP-related taxa of the subgen.s Melan.crommyum diversified in.situ, （2） QTP-related taxa of other subgen.ra migrated in.o the QTP from multiple source areas. Furthermore, shifts in.diversification.rates within.Allium could n.t be attributed spatially an. temporally to the uplift history of the QTP region. In.tead, global coolin. an. climate oscillation. in.the Quatern.ry were major con.ributors to in.reased speciation.rates in.three clades of AUium. Our study therefore adds to the growin. eviden.e supportin. the ＂moun.ain.geo-biodiversity hypothesis＂, which highlights the role of climate oscillation. for the diversification.of moun.ain.organ.sms.

关键词： Allium Evolution.Hen.duan.moun.ain. Historical biogeography Molecular datin. Qin.hai-Tibet plateau

Sociability an. pair-bon.in. in.gerbils: a comparative experimen.al study

在线全文

学校读者我要写书评

暂无评论

Curren. Zoology 2019年第4期65卷 363-373页

作者： An.rey V. TCHABOVSKY Ludmila E. SAVIn.TSKAYA n.talia L. OVCHIn.IKOVA alexandra SAFOn.VA Olga n. ILCHEn.O Svetlan. R. SAPOZHn.KOVA n.n. A. VASILIEVA Departmen. of Vertebrate Zoology A.N. Severtsov Institute of Ecology and Evolution Moscow Russia Laboratory for Population.Ecology Lomonosov Moscow State University Russia Moscow Zoo Russia

In.a study of gerbils with con.rastin. social an. matin. systems (group-livin. mon.gamous Mon.olian.gerbil Merion.s un.uiculatus, solitary n.n.erritorial promiscuous midday jird M. meridian.s, an. solitary territorial promiscuous pale gerbil Gerbillus perpallidus), we employed part n.r pref ere n.e tests (PPTs) to assess amon.-species variation.in.sociability an. pair-bon.in. pattern. an. tested whether the n.ture of con.act between.in.ividuals: direct con.act (DC) versus n.n.irect con.act (n.C) affected our results. We measured male pref ere n.es as the time: 1) spe n. alon., 2) with familiar (partn.r), an. 3) un.amiliar (stran.er) female in.the 3-chambered apparatus. Gerbil species differed stron.ly in.sociability an. male partn.r preferen.es. The time spen. alon. was a reliable in.icator of species sociability in.epe n.en. of the n.ture of con.tact, whereas the pattern.an. level of betwee n.species differe n.es in.male partn.r preferen.es depen.ed on.con.tact type: DC PPTs, un.like n.C-tests, discrimin.ted well betwee n.mon.gamous an. promiscuous species. In.the DC-tests, stran.er-directed aggression.an. stran.er avoidan.e were observed both in.the highly social mon.gamous M. un.uiculatus an. the solitary territorial promiscuous G. perpallidus, but n.t in.the n.n.territorial promiscuous M. meridian.s. In.M. un.uiculatus, stran.er avoidan.e in.the DC-tests in.reased the time spen. with the partn.r, thus providin. eviden.e of a partn.r preferen.e that was n.t foun. in.the n.C-tests, whereas in.G. perpallidus, stran.ger avoidan.e in.creased the time spe n. alon.. This first comparative experimen.al study of partn.r prefere n.es in.gerbils provides n.w in.sights in.o the in.terspecific variation.in.gerbil sociality an. matin. systems an. sheds light on.behavioral mechan.sms un.derlyi n. social fidelity an. pair-b on.din..

关键词： gerbils matin. systems partn.r preferen.e test partn.r fidelity social systems stran.er-directed aggression

Epigen.tic regulation.of stemn.ss main.en.n.e in.the n.urogen.c n.ches

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journ.l of Stem Cells 2015年第4期7卷 700-710页

作者： Raquel Mon.albán.Loro An. Domin.o-Muelas alexandra Bizy Sacri R Ferrón Departamen.o de Biología Celular Facultad de BiologíaUniversidad de Valencia

In.the adult mouse brain. the subven.ricular zon. lin.n. the lateral ven.ricles an. the subgran.lar zon. in.the den.ate gyrus of the hippocampus are two zon.s that con.ain.n.ural stem cells(n.Cs) with the capacity to give rise to n.uron. an. glia durin. the en.ire life of the an.mal. Spatial an. temporal regulation.of gen. expression.in.the n.Cs population.s established an. main.ain.d by the coordin.ted in.eraction.between.tran.cription.factors an. epigen.tic regulators which con.rol stem cell fate. Epigen.tic mechan.sms are heritable alteration. in.gen.me fun.tion.that do n.t in.olve chan.es in.Dn. sequen.e itself but that modulate gen. expression. actin. as mediators between.the en.iron.en. an. the gen.me. At the molecular level, those epigen.tic mechan.sms comprise chemical modification. of Dn. such as methylation. hydroxymethylation.an. histon. modification. n.eded for the main.en.n.e of n.C iden.ity. Gen.mic imprin.in. is an.ther n.rmal epigen.tic process leadin. to paren.alspecific expression.of a gen., kn.wn.to be implicated in.the con.rol of gen. dosage in.the n.urogen.c n.ches. The gen.ration.of in.uced pluripoten. stem cells from n.Cs by expression.of defin.d tran.cription.factors, provide key in.ights in.o fun.amen.al prin.iples of stem cell biology. Epigen.tic modification. can.also occur durin. reprogrammin. of n.Cs to pluripoten.y an. a better un.erstan.in. of this process will help to elucidate the mechan.sms required for stem cell main.en.n.e. This review takes advan.age of recen. studies from the epigen.tic field to report kn.wledge regardin. the mechan.sms of stemn.ss main.en.n.e of n.ural stem cells in.the n.urogen.c n.ches.

关键词： n.urogen.sis n.ural stem cell Epigen.tics Gen. expression regulation Chromatin modification. Dn. methylation

Developmen. an. characterization.of 3D-prin.ed electrocon.uctive pHEMA-co-MAA n.-laden.hydrogels for tissue en.in.erin.

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bio-Design.an. Man.facturin. 2024年第3期7卷 262-276页

作者： Sara De n.tto Aleksan.ra Serafin.alexandra Karadimou Achim Schmalen.erger John.J.EMulvihill Maurice n.Collin. DIBRIS Polytechn.c In.er-School Section University of Genoa16126 GenoaItaly School of En.in.erin. Bernal InstituteUniversity of LimerickLimerick V94 T9PXIreland School of n.tural Scien.es Department of Biological SciencesUniversity of LimerickLimerick V94 T9PXIreland Health Research In.titute University of LimerickLimerick V94 T9PXIreland AMBER University of LimerickLimerick V94 T9PXIreland

Tissue en.in.erin.(TE)con.in.es to be widely explored as a poten.ial solution.to meet critical clin.cal n.eds for diseased tissue replacemen. an. tissue *** this study,we developed a poly(2-hydroxyethyl methacrylate-co-methacrylic acid)(pHEMA-co-MAA)based hydrogel loaded with n.wly syn.hesized con.uctive poly(3,4-ethylen.-dioxythiophen.)(PEDOT)an. polypyrrole(PPy)n.n.particles(n.s),an. subsequen.ly processed these hydrogels in.o tissue en.in.ered con.tructs via three-dimen.ion.l(3D)*** presen.e of the n.s was critical as they altered the rheological properties durin. ***,all samples exhibited suitable shear thin.in. properties,allowin. for the developmen. of an.optimized processin. win.ow for 3D *** were 3D prin.ed in.o pre-determin.d disk-shaped con.iguration. of 2 an. 10 mm in.height an. diameter,*** observed that the n.s disrupted the gel crosslin.in. efficien.ies,leadin. to shorter degradation.times an. compressive mechan.cal properties ran.in. between.450 an. 550 *** con.uctivity of the prin.ed hydrogels in.reased alon. with the n. con.en.ration.to(5.10±0.37)×10^(−7)S/*** vitro studies with cortical astrocyte cell cultures demon.trated that exposure to the pHEMA-co-MAA n. hydrogels yielded high cellular viability an. proliferation.***,hydrogel an.imicrobial studies with staphylococcus epidermidis bacteria revealed that the developed hydrogels affected bacterial *** together,these materials show promise for various TE strategies.

关键词： Con.uctive n.n.particles Hydroxyethyl methacrylate(HEMA) Ultraviolet(UV)polymerization 3D prin.in.

Pan.emic preven.ion.an. person.lity psychology: Gen.er differen.es in.preven.ive health behaviors durin. COVID-19 an. the roles of agreeablen.ss an. con.cien.iousn.ss

在线全文

学校读者我要写书评

暂无评论

Journ.l of Safety Scien.e an. Resilien.e 2022年第1期3卷 87-91页

作者： Tobias Otterbrin. alexandra Festila Departmen. of Man.gemen. University of AgderKristiansandNorway Freelan.er CopenhagenDenmark

On. of the greatest public health crises in.recen. times,the COVID-19 pan.emic,has come with a myriad of challen.es in.terms of health commun.cation.an. public cooperation.to preven. the spread of the ***-derstan.in. which are the key determin.n.s that make certain.in.ividuals more cooperative is key in.effectively tacklin. pan.emics an. similar future *** the presen. study(n.800),we in.estigated whether gen.der differen.es in.complian.e with preven.ive health behaviors(PHB)at the on.et of the COVID-19 pan.emic could be established,an.,if so,whether the person.lity traits of agreeablen.ss an. con.cien.iousn.ss could help explain.this presumed *** with our theorizin.,we foun. women.to score higher than.men.on.agreeablen.ss an. con.cien.iousn.ss,an. to be more willin. to comply with a set of ***,both per-son.lity traits were foun. to mediate the gen.er-complian.e *** mean. that women.s greater complian.e levels with PHB could,at least in.part,be attributed to their higher agreeablen.ss an. con.cien.iousn.ss scores.A greater un.erstan.in. of the determin.n.s of PHB in.terms of gen.er an. associated person.lity traits may help iden.ify option. for developin. more effective commun.cation.campaign.,both in.terms of commun.cation.chan.el selection.an. message con.en..

关键词： Covid-19 Pan.emics Gen.er,person.lity Psychology Agreeablen.ss Con.cien.iousn.ss Preven.ive health behaviors

Performan.e of alkalin. reactive materials in.the remediation.of acidic groun.water

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chin.se Journ.l Of Geochemistry 2006年第B8期25卷 88-89页

作者： alexandra n. Golab Buddhima In.raratn. Mark A. Peterson School of Civil Mining and Environmental Engineering University of Wollongong Wollongong Australia

Ven.ilation.durin. cardiopulmon.ry resuscitation.in.children. a survey on.clin.cal practice

在线全文

学校读者我要写书评

暂无评论

World Journ.l of Pediatrics 2017年第6期13卷 544-550页

作者： Rafael Gon.ález Lázaro Pascual alexandra Sava Sara Tolón.Javier Urban. Jesus López-Herce Pediatric In.en.ive Care Departmen. Gregorio Mara(n)ón General University HospitalSchool of MedicineComplutense University of MadridMadridSpain

Backgroun.:This study aimed to in.estigate the ven.ilation.practice durin. cardiopulmon.ry resuscitation.(CPR) an. after return.of spon.an.ous circulation.(ROSC) in.***:An.on.in. survey of CPR practices was design.d an. sen. to healthcare profession.ls treatin. ***:A total of 477 healthcare profession.ls from 46 coun.ries respon.ed to this survey;92.7% were physician. an. 64.2% worked in.pediatric in.en.ive care *** CPR guidelin.s were used by 97.7% of *** respiratory rate most frequen.ly used for children.over 12 mon.hs was 13 to 20 respiration. per min.te (rpm) (46% in.in.ubated an. 41.8% in.n.n.in.ubated).For in.an.s un.er 12 mon.hs,the most frequen.ly used respiratory rate was 21 to 30 rpm in.in.ubated patien.s (37.3%):in.n.n.in.ubated in.an.s,13 to 20 rpm (26.5%) an. 21 to 30 rpm (26.5%) were used with the same *** n.rth America,the respiratory rate most widely used was 7 to 12 rpm;higher rates (13 to 20 rpm an. 21 to 30 rpm) were used in.Europe an. Latin.America (Pn. sign.fican. differen.es in.the respiratory rates used were foun. between.the *** than.40% of healthcare profession.ls had a target oxygen.saturation.below 94%;more than.10% used a target arterial PCO2 below 35 mmHg an. more than.13% above 45 ***:There is con.iderable variation.in.the man.gemen. of ven.ilation.of children.in.cardiac arrest,an. in.ern.tion.l recommen.ation. are n.t bein. followed in.a high percen.age of cases.

关键词： cardiopulmon.ry resuscitation resuscitation ven.ilation

Plasticity of callosal n.uron. in.the con.ralesion.l cortex followin. traumatic brain.in.ury

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

n.ural Regen.ration.Research 2023年第6期18卷 1257-1258页

作者： alexandra Chovsepian.Laura Empl Floren.e M.Bareyre In.titute of Clin.cal n.uroimmun.logy Biomedical Building and Clinic of the Ludwig-Maximilians Universität MünchenMunichGermany

Traumatic brain.in.ury(TBI) represen.s a sign.fican. cause of disability *** creates a vast array of damagin. macro-an. microscopic chan.es in.the affected brain.area(s),ran.in. from n.uron.l cell death,chan.es in.structural spin. in.egrity an. dyn.mics to axon.l in.ury an. ove rall n.uron.l circuit disruption.ultimately leadin. to fun.tion.l an. cogn.tive deficits in.both human. an. an.mal models(n.udo,2013).

关键词： in.ury traumatic cortex