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Thermogenic protein UCP1 and UCP3 expression in non- small cell lung cancer： relation with glycolysis and anaerobic metabolism

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Cancer Biology & Medicine 2017年第4期14卷 396-404页

作者： alexandra giatromanolaki Konstantina Balaska Dimitra Kalamida Christos Kakouratos Efthimios Sivridis Michael I. Koukourakis Department of Pathology Department of Radiotherapy/Oncology Democritus University of Thrace University Hospital ofAlexandroupolis Alexandroupolis 68100 Greece

Uncoupling protein 1(UCP1)is a proton transporter/channel residing on the inner mitochondrial membrane and is involved in cellular heat *** immunohistochemistry,we investigated the expression of UCP1 and UCP3 in a series of 98 patients with non-small cell lung cancer(NSCLC)treated with *** patterns were correlated with histopathological variables,prognosis,and the expression of enzymes/proteins related to cell *** epithelium did not express UCP1 or UCP3,while alveolar cells strongly expressed *** tumors,strong expression of UCP1 and UCP3 was recorded in43/98(43.8%)and 27/98(27.6%)cases,***1 was significantly associated with squamous cell histology(P=0.05),whilst UCP3 was more frequently overexpressed in large cell carcinomas(P=0.08),and was inversely related to necrosis(P=0.009).In linear regression analysis,UCP1 was directly related to markers of glycolysis[hexokinase(HXKII)and phosphofructokinase(PFK1)]and anaerobic glucose metabolism[pyruvate dehydrogenase kinase(PDK1)and lactate dehydrogenase(LDH5)].UCP3 was directly linked with a glucose transporter(GLUT2),monocarboxylate transporter(MCT2),glycolysis markers(PFK1 and aldolase),and with the phosphorylation of pyruvate dehydrogenase(p PDH).Kaplan-Meier survival analysis showed that UCP3 was significantly related to poor prognosis in squamous cell carcinomas(P=0.04).UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption,intensified glycolysis,and anaerobic glucose *** UCPs are targets for therapeutic interventions in lung cancer is a hypothesis that demands further investigation.

关键词： Lung cancer thermogenesis UCP1 UCP3 glycolysis anaerobic metabolism

Autophagic flux response and glioblastoma sensitivity to radiation

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Cancer Biology & Medicine 2018年第3期15卷 260-274页

作者： Achilleas G.Mitrakas Dimitra Kalamida alexandra giatromanolaki Stamatia Pouliliou Avgi Tsolou Rafail Kyranas Michael I.Koukourakis Department of Radiotherapy/Oncology democritus university of thraceand university general hospital of alexandroupolisAlexandroupolis 68200Greece Department of Pathology Democritus University of Thraceand University General Hospital of AlexandroupolisAlexandroupolis 68200Greece

Objective:Glioblastoma is the most common primary brain tumor in adults and one of the most lethal human *** constitutes a unique non-metastasizing human tumor model with high resistance to radiotherapy and *** current study investigates the association between autophagic flux and glioblastoma cell ***:The expression kinetics of autophagy-and lysosome-related proteins following exposure of two glioblastoma cell lines(T98 and U87)to clinically relevant radiation doses was ***,the response of cells resistant to radiotherapy and chemotherapy was investigated after silencing of LC3A,LC3B,and TFEB genes in vitro and in ***:Following irradiation with 4 Gy,the relatively radioresistant T98 cells exhibited enhanced autophagic *** more radiosensitive U87 cell line suffered a blockage of autophagic *** of LC3A,LC3B,and TFEB genes in vitro,significantly sensitized cells to radiotherapy and temozolomide(U87:P<0.01 and<0.05,respectively;T98:P<0.01 and<0.01,respectively).Silencing of the LC3A gene sensitized mouse xenografts to ***:Autophagy in cancer cells may be a key factor of radio-resistance and chemo-resistance in glioblastoma *** autophagy may improve the efficacy of radiochemotherapy for glioblastoma patients.

关键词： Glioblastoma autophagy radiation temozolomide TFEB

Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter

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Neural Regeneration Research 2025年第5期20卷 1411-1413页

作者： Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab alexandra Kretz Computational Biology and Systems Biomedicine Biodonostia Health Research InstituteSan SebastianSpain Basque Foundation for Science IKERBASQUEBilbaoSpainMax Planck Institute for Molecular BiomedicineComputational Biology and Bioinformatics GroupMünsterNorth Rhine-WestphaliaGermany Department of Cell Biology and Histology Faculty of Medicine and NursingUniversity of Basque Country(UPV/EHU)LeioaSpain Department of Neurology Jena University HospitalJenaThuringiaGermany

Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关键词： amyotrophic sclerosis

Fever without source in infants aged 22–60 days:how laboratory tests perform at identifying bacterial infections and predicting the need for a lumbar puncture?

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World Journal of Emergency Medicine 2025年第1期16卷 74-77页

作者： Keven Vachon Geneviève Gravel Samuel Leduc alexandra Larouche Myriam Mallet David Simonyan Mahukpe Narcisse Ulrich Singbo Julie Ouellet-Pelletier Simon Berthelot Centre de Recherche du CHU de Québec-UniversitéLaval Population Health and Optimal Health Practices AxisQuébec G1V 4G2Canada Faculty of Medicine UniversitéLavalQuébec G1V 0A6Canada Centre Hospitalier de l’UniversitéLaval(CHUL) Québec G1V 4G2Canada

Febrile infants are at greater risk of invasive bacterial infections (IBI),which include bacterial meningitis and *** bacterial meningitis is uncommon,^([1-2])it remains a concern for clinicians treating infants younger than 90 *** for investigating fever without a source(meaning without an apparent source of infection,or of nonobvious origin) are numerous around the world but remain conflicting,particularly on whether to perform a lumbar puncture for cerebrospinal fluid (CSF) analysis in infants older than 22 d and hence at lower risk than younger infants.

关键词： puncture infections lumbar

纽约首座“被动式建筑”学校市中心高密度开发的典范

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商业周刊(中文版) 2025年第3期 36-39页

作者： alexandra Lange 程奎(翻译) 不详

在城市中建造学校,向来是一项极具挑战性的任务。不同于拥有广阔用地的郊区学校,城市学校必须在有限的空间内,巧妙地平衡休闲区域与课堂教学的需求,既要确保学生能够高效地在校园内流动,拥有足够的活动空间,又要兼顾敞开怀抱的校门与安... 详细信息

在城市中建造学校,向来是一项极具挑战性的任务。不同于拥有广阔用地的郊区学校,城市学校必须在有限的空间内,巧妙地平衡休闲区域与课堂教学的需求,既要确保学生能够高效地在校园内流动,拥有足够的活动空间,又要兼顾敞开怀抱的校门与安全设施。

关键词：安全设施课堂教学市中心校园内挑战性

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精疲力竭的父母需要更好的公共空间

商业周刊(中文版) 2025年第2期 38-40页

作者： alexandra Lange 程玺(译) 不详

生儿育女从来都不容易。而近期,美国医务总监(US Surgeon General)宣称养育子女的重担已然引发一场公共卫生危机,这再度掀起了有关家庭如何挣脱无休止的期望枷锁的讨论热潮。鲜少被提及的-点是,住房、交通以及公共空间在物理设计层面的... 详细信息

生儿育女从来都不容易。而近期,美国医务总监(US Surgeon General)宣称养育子女的重担已然引发一场公共卫生危机,这再度掀起了有关家庭如何挣脱无休止的期望枷锁的讨论热潮。鲜少被提及的-点是,住房、交通以及公共空间在物理设计层面的弊端,导致通勤时长增加、公共游乐场地缩减、儿童活动受阻,令曰常生活愈发艰难。

关键词：公共卫生危机公共空间儿童活动养育子女游乐场

Pressure-induced structural changes cause large enhancement of photoluminescence in halide perovskites: a quantitative relationship

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National Science Review 2021年第9期8卷 13-14页

作者： alexandra Navrotsky Center for Materials of the Universe Arizona State University

Halide perovskites containing both organic and inorganic cations are receiving extensive attention for their promising optoelectronic properties, including photoluminescence (PL)[1,2]. Tuning these properties for specific applications and designing and synthesizing perovskites with optimized properties are major goals of materials science. These goals will be achieved faster and more economically by harnessing a fundamental understanding of structure–property relations, rather than by random searches for better materials. Chemical composition,temperature and pressure are the major‘knobs’ one can turn to adjust properties such as conductivity and bandgap[1,3]. Each of these variables has the potential to change interatomic distances,

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“Pachyostosis” in aquatic amniotes: a review

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Integrative Zoology 2009年第4期4卷 325-340页

作者： alexandra HOUSSAYE Department of Earth History Museum of Natural HistoryParisFrance

During the course of amniote evolution,numerous taxa secondarily adapted to an aquatic *** appears that many of these taxa primitively display“pachyostosis,”an osseous specialization characterized by an increase in bone compactness and/or *** term“pachyostosis”is used in morphological and histological descriptions to describe what in fact corresponds to different *** aim of this paper is to present the current state of knowledge relative to this adaptation among aquatic *** the taxa that have returned to an aquatic environ-ment are ***,their degree of adaptation to the marine environment,their life environment,and the nature of their“pachyostotic”pattern,when present,are *** inventory enables the evaluation of the current quality of the data relative to this specialization and provides an indication of the work that remains to be *** functional consequences of“pachyostosis,”and notably its importance for buoyancy control in the context of hydrostatic regulation of the body trim,are discussed and opposed to the requirement of improved swimming abilities in the case of a hydrodynamic mode of trim *** are posed about the significa-tion of the polymorphism displayed by this specialization between different taxa,different specimens of the same taxon and different bones of the same specimen,and the problem of quantification of pachyostosis is discussed.

关键词： buoyancy control life environment locomotion “pachyostosis”sensu lato polymorphism.

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日粮中添加酵母提取物有益于猪只生长

猪业科学 2025年第1期42卷 18-19页

作者：张振玲(编译) 徐州生物工程职业技术学院动物工程学院江苏徐州221006

0引言众所周知,饲料中有较高水平的霉菌毒素就会影响猪只的健康及其生长性能,从而影响猪场经济效益。现在越来越多的研究表明,即使饲料中霉菌毒素含量水平较低,(长期摄食的话)也会对猪只产生不良影响,因此也不能轻视。霉菌毒素是世界各... 详细信息

0引言众所周知,饲料中有较高水平的霉菌毒素就会影响猪只的健康及其生长性能,从而影响猪场经济效益。现在越来越多的研究表明,即使饲料中霉菌毒素含量水平较低,(长期摄食的话)也会对猪只产生不良影响,因此也不能轻视。霉菌毒素是世界各地猪饲料中常见的污染物,一旦摄入霉菌毒素,就会对猪只造成不利的影响。日粮中添加酵母细胞壁提取物对猪只的生长及健康有益,它可有效应对猪饲粮中的霉菌毒素问题。

关键词：酵母提取物霉菌毒素酵母细胞壁猪饲粮生长性能有效应对含量水平猪饲料

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