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New perspectives on biology,disease progression,and therapy response of head and neck cancer gained from single cell RNA sequencing and spatial transcriptomics

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Oncology Research 2024年第1期32卷 1-17页

作者： GERWIN HELLER THORSTEN FUEREDER alexander MICHAEL GRANDITS ROTRAUD WIESER Division of Oncology Department of Medicine IMedical University of ViennaVienna1090Austria Ludwig Boltzmann Institute for Hematology and Oncology Medical University of ViennaVienna1090Austria

Head and neck squamous cell carcinoma(HNSCC)is one of the most frequent cancers *** main risk factors are consumption of tobacco products and alcohol,as well as infection with human papilloma *** therapeutic options comprise surgery,radiation,chemotherapy,targeted therapy through epidermal growth factor receptor inhibition,and immunotherapy,but outcome has remained unsatisfactory due to recurrence rates of~50%and the frequent occurrence of second *** availability of the human genome sequence at the beginning of the millennium heralded the omics era,in which rapid technological progress has advanced our knowledge of the molecular biology of malignant diseases,including HNSCC,at an unprecedented ***,microarray-based methods,followed by approaches based on next-generation sequencing,were applied to study the genetics,epigenetics,and gene expression patterns of bulk *** recently,the advent of single-cell RNA sequencing(scRNAseq)and spatial transcriptomics methods has facilitated the investigation of the heterogeneity between and within different cell populations in the tumor microenvironment(e.g.,cancer cells,fibroblasts,immune cells,endothelial cells),led to the discovery of novel cell types,and advanced the discovery of cell-cell communication within *** review provides an overview of scRNAseq,spatial transcriptomics,and the associated bioinformatics methods,and summarizes how their application has promoted our understanding of the emergence,composition,progression,and therapy responsiveness of,and intercellular signaling within,HNSCC.

关键词： Head and neck squamous cell carcinoma Tumor microenvironment Immunotherapy Gene expression Omics

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SmartMicro Grid Energy System Management Based on Optimum Running Cost for Rural Communities in Rwanda

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Energy Engineering 2024年第7期121卷 1805-1821页

作者： Fabien Mukundufite Jean Marie Vianney Bikorimana alexander Kyaruzi Lugatona Electrical and Electronic Engineering Department University of RwandaKigaliRwanda Electrical Engineering Department University of Dar es SalaamDar es SalaamTanzania

The governmental electric utility and the private sector are joining hands to meet the target of electrifying all households by ***,the aforementioned goal is challenged by households that are scattered in remote *** far,Solar Home Systems(SHS)have mostly been applied to increase electricity access in rural *** have continuous constraints to meet electricity demands and cannot run income-generating *** current research presents the feasibility study of electrifying Remera village with the smart microgrid as a case *** renewable energy resources available in Remera are the key sources of electricity in that *** generation capacity is estimated based on the load *** microgrid configurations are simulated with HOMER,and the genetic algorithm is used to analyze the optimum *** analyzing the impact of operation and maintenance costs,the results show that the absence of subsidies increases the levelized cost of electricity(COE)five times greater than the electricity price from the public *** microgrid made up of PV,diesel generator,and batteries proved to be the most viable solution and ensured continuous power supply to *** considering the subsidies,COE reaches 0.186$/kWh,a competitive price with electricity from public utilities in Rwanda.

关键词： Load demand load profile optimum running cost power demand satisfaction smart meters and smart micro grid

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Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

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Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg alexander Becker Sebastian Keppler Guillaume Duchateau Stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing alexander Kessler Franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensities<10^(16)W/cm^(2).Single-shot near-infrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

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Understanding the eff ect of recreational drug use on bone health and musculoskeletal disease in the establishment of pain regimens

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World Journal of Emergency Medicine 2024年第5期15卷 356-364页

作者： Ariella Gartenberg alexander Petrie Winston Yen Woojn Cho Emergency Medicine Department Montefi ore Medical Center and Jacobi Medical CenterNew York 10461USA Emergency Medicine Department Jacobi Medical Center and North Central BronxNew York 10461USA Touro College of Osteopathic Medicine Touro UniversityNew York 10027USA

BACKGROUND:The widespread use of recreational drugs has raised concerns regarding their eff ects on various organ *** use of cannabis and opioids in chronic pain management increases their prevalence among patients with musculoskeletal conditions whose bone health may already be *** article aims to review the pathophysiology and toxic eff ects of recreational drug use on musculoskeletal health to establish appropriate pain regimens for patients with substance ***:Medical literature published from 1970 until 2022 was identifi ed utilizing MEDLINE/PubMed and the Cochrane *** addition to the databases,references were obtained through the use of reference lists of published articles identifi ed by the aforementioned *** initial search terms included opioids,inhalants,hallucinogens,cannabis,stimulants,and bone *** were no methodological limitations in relation to the initial acquisition and analysis of ***:A total of 55 research articles were included in this ***,stimulants,opioids,and inhalants impact bone maintenance,specifically osteoblast and osteoclast activity,as well as impede hormone *** substances inhibit bone remodeling and development,manifesting as lower bone mineral density and increased fracture risk in chronic ***:Although the current literature suggests a deleterious effect of recreational drugs on bone health and musculoskeletal disease,further research is warranted to evaluate the clinical effects of long-term substance *** evaluation of such effects will aid in establishing appropriate pain regimens,as well as appropriate screening and treatment plans for recreational drug users.

关键词： Musculoskeletal disorders Bone health Cannabis Opioids Stimulants

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On the two-layer high-level Green-Naghdi model in a general form

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Journal of Hydrodynamics 2024年第1期36卷 78-86页

作者： Bin-bin Zhao Tian-yu Zhang Zhan Wang Wen-yang Duan alexander Chesnokov Natalia Shmakova College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China Qingdao Innovation and Development Center of Harbin Engineering University Qingdao266000China Lavrentyev Institute of Hydrodynamics NovosibirskRussia

The traditional high-level Green-Naghdi(HLGN)model,which uses the polynomial as the shape function to approximate the variation of the horizontal-and vertical-velocity components along the vertical direction for each-fluid layer,can accurately describe the large-amplitude internal waves in a two-layer system for the shallow configuration(h_(2)/λ■1,h_(1)/λ■1).However,for the cases of the deep configuration(h_(2)/λ■1,h_(1)/λ=O(1)),higher-order polynomial is needed to approximate the variation of the velocity components along the vertical direction for the lower-fluid ***,however,introduces additional unknowns,leading to a significant increase in computational *** paper,for the first time,derives a general form of the HLGN model for a two-layer fluid system,where the general form of the shape function is used during the *** obtaining the general form of the two-layer HLGN equations,corresponding solutions can be obtained by determining the reasonable shape ***-amplitude internal solitary waves in a deep configuration are studied by use of two different HLGN *** of the two HLGN models shows that the polynomial as the shape function for the upper-fluid layer and the production of exponential and polynomial as the shape function for the lower-fluid layer is a good *** comparing with Euler’s solutions and the laboratory measurements,the accuracy of the two-layer HLGN model is verified.

关键词： High-level Green-Naghdi(HLGN)model general form internal waves deep configuration

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Long-term Speckle Interferometric Monitoring of Binary Systems:2007–2023Positional Measurements and Orbits of Seven Objects

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Research in Astronomy and Astrophysics 2024年第9期24卷 147-155页

作者： Arina Mitrofanova Vladimir Dyachenko Anatoly Beskakotov Yuri Balega alexander Maksimov Denis Rastegaev Special Astrophysical Observatory 369167 Nizhnij ArkhyzRussia

The results of seventeen years of speckle interferometric monitoring of seven objects(Chara 122Aa,GJ 3010,HIP1987,GJ 3076,HIP 11253,HIP 11352,and HIP 14929)are *** data were obtained at the 6 m Big Telescope Alt-azimuthal Special Astrophysical Observatory of the Russian Academy of Science(BTA SAO RAS)from 2007 to the *** of previously published and new measurements made it possible to construct completely new orbits for Chara 122Aa,HIP 11253,and HIP *** orbit of GJ 3076 cannot be constructed accurately due to the large influence of the weights assigned to the *** resulting orbital solutions are classified based on a grading scheme suggested by ***,*** and ***;most orbits are“definitive”(Grade 1).The mass sums and masses of components calculated by two independent methods using Hipparcos and Gaia DR2 and DR3 parallaxes were compared for the objects under study.

关键词： techniques:high angular resolution (stars:)binaries:visual stars:fundamental parameters stars:low-mass stars:solar-type

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Structural and chemical transformations of CuZn alloy nanoparticles under reactive redox atmospheres:An in situ TEM study

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Nano Research 2024年第7期17卷 6265-6273页

作者： Shengnan Yue Qian Li Chaobin Zeng alexander Klyushin Ramzi Farra Marc-Georg Willinger Xing Huang College of Chemistry Fuzhou UniversityFuzhou 350108China Qingyuan Innovation Laboratory Quanzhou 362801China Hitachi High-Tech Scientific Solutions(Beijing)Co. Ltd.Beijing 100015China MAX IV Laboratory Lund UniversityBox 11822100 LundSweden Department of Inorganic Chemistry Fritz-Haber Institute of Max Planck SocietyBerlin 14195Germany Department of Chemistry Technical University of MunichGarching 85748Germany

Alloying metals to form intermetallics has been proven effective in tuning the chemical properties of metal-based ***,intermetallic alloys can undergo structural and chemical transformations under reactive conditions,leading to changes in their catalytic *** and understanding these transformations are crucial for establishing relevant structureperformance relationships and for the rational design of alloy-based *** this work,we used CuZn alloy nanoparticles(NPs)as a model material system and employed in situ transmission electron microscopy(TEM)to investigate the structural and chemical changes of CuZn NPs under H_(2),O_(2)and their *** results show how CuZn NPs undergo sequential transformations in the gas mixture at elevated temperatures,starting with gradual leaching and segregation of Zn,followed by oxidation at the NP *** remaining copper at the core of particles can then engage in dynamic behavior,eventually freeing itself from the zinc oxide *** structural dynamics arises from an oscillatory phase transition between Cu and Cu_(2)O and is correlated with the catalytic water formation,as confirmed by in situ mass spectrometry(MS).Under pure H_(2)or O_(2)atmosphere,we observe different structural evolution pathways and final chemical states of CuZn NPs compared to those in the gas *** results clearly demonstrate that the chemical state of alloy NPs can vary considerably under reactive redox atmospheres,particularly for those containing elements with distinct redox properties,necessitating the use of in situ or detailed ex situ characterizations to gain relevant insights into the states of intermetallic alloy-based catalysts and structure-activity relationships.

关键词： In situ transmission electron microscopy(TEM) CuZn alloy structural and chemical transformations redox atmosphere

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Photonic properties and applications of multi-functional organo-lanthanide complexes:Recent advances

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Journal of Rare Earths 2024年第1期42卷 16-27,I0001页

作者： Virender Archana Chauhan Ashwani Kumar Gurjaspreet Singh alexander A.Solovev Jichuan Xiong Xuefeng Liu Brij Mohan Department of Chemistry Kurukshetra University KurukshetraKurukshetra136119India Aggarwal College Ballabhgarh121004Department of Higher EducationHaryanaIndia Department of Chemistry&Centre for Advanced Studies in Chemistry Panjab UniversityChandigarh160014India Department of Materials Science Fudan UniversityShanghai200433China School of Electronic and Optical Engineering Nanjing University of Science and TechnologyNanjing210094China College of Ocean Food and Biological Engineering Jimei UniversityXiamen361021China

Lanthanides(Ln(Ⅲ))based compounds as light-emitting materials have emerged as successful agents in high-performance defense and lighting systems,magnets,bio-markers,and ***,they have recently gained much attention as energy-saving and cost-effective luminescent materials and their applications in analyte *** present review summarizes powerful features and recent developments of organo-lanthanide complexes in lighting applications with a particular focus on visible light emitters,including Eu(Ⅲ),Tb(Ⅲ),Sm(Ⅲ),and Dy(Ⅲ)*** addition,this review discusses the most relevant aspects of photosensitization,such as the structure,property,functionalization of primary and secondary ligands,and molecular *** addition,coordination sites of organo-lanthanide complexes and their applications collectively contribute to the improved performance of innovative luminescent ***,the current challenges and key recommendations for advancing organolanthanides in material science are provided.

关键词： Lanthanides Organometallic Luminescent Lifetime OLED Rare earths

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Effect of autologous serum after amniotic membrane transplantation for persistent corneal ulcers

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1639-1644页

作者： Rozaliya Hristova Petya Yankova Georgi Markov alexander Oscar Yani Zdravkov Department of Ophthalmology Medical University SofiaUniversity Hospital AlexandrovskaSofia 1431Bulgaria Department of Clinical Immunology Medical University SofiaUniversity Hospital AlexandrovskaSofia 1431Bulgaria

AIM:To investigate the effect of adding autologous serum eye drops to the postoperative regime after amniotic membrane transplantation for severe persistent corneal ***:Forty eyes of 40 patients with persistent corneal ulcers were randomly assigned to artificial tears(sodium hyaluronate 0.2%,ATs group,n=20)or autologous serum eye drops(ASEDs,n=20)following treatment with amniotic membrane *** slit lamp images were acquired from all patients before and 30d post *** area with fibrovascular tissue was calculated using Image *** corneal sensitivity was assessed by Cochet-Bonnet aesthesiometry before and one month after *** tissue transparency was assessed with a novel optical ***:Mean age of patients was 61.65±16.47y and 57.3±19.11y in the ATs group and ASEDs group,***-two male and 18 female patients were included in the *** improvement in visual acuity was significantly greater in the ASEDs group(0.14±0.04)than the ATs(0.08±0.04;P=0.00046).Cochet-Bonnet aesthesiometry improved significantly after treatment with a similar rate between *** were no statistically significant differences in the area of postoperative fibrovascular tissue between the two groups(P=0.082).The success rate in the two groups was *** difference in densitometry between the ATs and ASEDs group was statistically significant(P=0.042)with greater reduction from baseline in the ASEDS ***:Autologous serum eye drops can lead to better visual acuity,more stable results and improved densitometry and should be considered in the postoperative care following amniotic membrane transplantation.

关键词： autologous serum amniotic membrane ocular surface persistent corneal ulcer

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High-speed performance self-powered short wave ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3)

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Journal of Semiconductors 2024年第4期45卷 56-62页

作者： Aleksei Almaev alexander Tsymbalov Bogdan Kushnarev Vladimir Nikolaev Alexei Pechnikov Mikhail Scheglov Andrei Chikiryaka Petr Korusenko Research and Development Center for Advanced Technologies in Microelectronics National Research Tomsk State UniversityTomsk 634050Russia Fokon LLC Kaluga 248035Russia Department of Semiconductor Electronics and Physics of Semiconductors National University of Science and Technology MISISMoscow 119049Russia Perfect Crystals LLC Saint Petersburg 194223Russia Department of Solid-State Electronics Saint Petersburg State UniversitySaint Petersburg 199034Russia Department of Physics Omsk State Technical UniversityOmsk 644050Russia

High-speed solar-blind short wavelength ultraviolet radiation detectors based onκ(ε)-Ga_(2)O_(3)layers with Pt contacts were demonstrated and their properties were studied in ***κ(ε)-Ga_(2)O_(3)layers were deposited by the halide vapor phase epitaxy on patterned GaN templates with sapphire *** spectral dependencies of the photoelectric properties of struc-tures were analyzed in the wavelength interval 200-370 *** maximum photo to dark current ratio,responsivity,detectiv-ity and external quantum efficiency of structures were determined as:180.86 ***.,3.57 A/W,1.78×10^(12) Hz^(0.5)∙cm·W^(-1) and 2193.6%,respectively,at a wavelength of 200 nm and an applied voltage of 1 *** enhancement of the photoresponse was caused by the decrease in the Schottky barrier at the Pt/κ(ε)-Ga_(2)O_(3)interface under ultraviolet *** detectors demon-strated could functionalize in self-powered mode due to built-in electric field at the Pt/κ(ε)-Ga_(2)O_(3)*** responsivity and external quantum efficiency of the structures at a wavelength of 254 nm and zero applied voltage were 0.9 mA/W and 0.46%,*** rise and decay times in self-powered mode did not exceed 100 ms.

关键词： κ(ε)-gallium oxide solar-blind shortwave ultraviolet radiation detectors self-powered operation mode

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