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Preventive treatment of alveolar pulmonary edema of cardiogenic origin

Journal of Geriatric Cardiology 2012年第4期9卷 321-327页

作者： Gideon Charach Michael Shochat alexander rabinovich Oded Ayzenberg Jacob George Lior Charach Pavel rabinovich Department of Internal Medicine 'C' Tel Aviv Sourasky Medical Center 6 Weizman Street Tel Aviv 64239 Israel Department of Cardiology Hillel Yaffe Medical Center Hadera P.O. Box 169 Hadera 38100 Israel Department of Geriatrics Tel Aviv Sourasky Medical Center 6 Weizman Street Tel Aviv 64239 Israel Department of Cardiology Kaplan Medical Center Pasternak Street P.O. Box 1 Rehovot 76100 Israel

Objective To evaluate the efficacy of preventive treatment (PT) on alveolar pulmonary edema (APE) of cardiogenic origin using a monitor based on principles of internal thoracic impedance (ITI) *** We conducted blinded clinical trials on patients with ST-elevation myocardial infarction (STEMI) and monitored whether the condition would progress to APE. ITI was measured noninvasively by the Edema Guard Monitor (EGM, model RS-207) every 30 min. The measurement threshold for the diagnosis of APE was fixed at > 12% decrease in ITI from baseline as described in our methodology. The patients were divided into one group that received standard treatment after the appearance of clinical signs of APE without considering the prediction of APE by EGM devise (Group 1), and another group of asymptomatic patients in whom development of APE was predicted by using only EGM measurements (Group 2). The latter participants’PT consisted of furosemide, intravenous nitroglycerine and supplemental oxygen. Results One-hundred and fifty patients with acute STEMI were enrolled into this study. Group 1 included 100 patients (53% males, age 64.1 ±12.6 years). Treatment was started after the clinical appearance of overt signs of APE. Group 2 included 50 patients (54% males, age 65.2 ±11.9 years) who received PT based on EGMmeasurements. Group 2 had significantly fewer cases of APE (n = 4, 8%) than Group 1 (n = 100, 100%) (P > 0.001). While APE was lethal in six (6%) Group 1 patients, PT resulted in prompt resolution of APE in all four (8%) Group 2 patients. Conclusion ITI is a usefulmodality for early diagnosis and PT of pulmonary edema of cardiogenic origin.

关键词： Cardiogenic pulmonary edema Early prediction Preventive treatment Monitoring cardiac patients Internal thoracic impedance

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Anti-oxidized low-density lipoprotein antibodies in chronic heart failure

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World Journal of Cardiology 2012年第11期4卷 302-308页

作者： Gideon Charach alexander rabinovich Ori Argov Moshe Weintraub Lior Charach Oded Ayzenberg Jacob George Departments of Internal Medicine 'C' Tel Aviv Sourasky Medical Center6 Weizman StreetTel Aviv 64239Israel Departments of Cardiology Kaplan Medical CenterRehovot 76100Israel

Oxidative stress may play a significant role in the pathogenesis of heart failure(HF).Antibodies to oxidized low-density lipoprotein(oxLDL Abs) reflect an immune response to LDL over a prolonged period and may represent long-term oxidative stress in *** oxLDL plasma level is a useful predictor of mortality in HF patients,and measurement of the oxLDL Abs level may allow better management of those *** to oxLDL also significantly correlate with the New York Heart Association ***,smoking,hypertension,and obesity are risk factors for atherosclerotic coronary heart disease(CHD) leading to HF,but these factors account for only onehalf of all cases,and understanding of the pathologic process underlying HF remains *** with antioxidant properties can reduce the susceptibility of LDL to *** therapy may be an adjunct to lipid-lowering,angiotensin converting enzyme inhibition and metformin(in diabetes) therapy for the greatest impact on CHD and *** data suggest a protective effect of antioxidant supple-mentation on the incidence of *** review summarizes the data on oxLDL Abs as a predictor of morbidity and mortality in HF patients.

关键词： Heart failure Oxidized low-density lipoproteins Antibodies Antioxidants

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Seasonal changes in blood pressure:Cardiac and cerebrovascular morbidity and mortality

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World Journal of Hypertension 2013年第1期3卷 1-8页

作者： Gideon Charach Michael Shochat Ori Argov Moshe Weintraub Lior Charach alexander rabinovich Oded Ayzenberg Jacob George Department of Internal Medicine "C" Sourasky Medical CenterTel Aviv UniversityTel?Aviv 64239Israel Heart Institute Hillel Yaffe Medical CenterHadera 38100 Israel Geriatric Medicine Sourasky Medical Center Tel Aviv 64239 Israel Department of Cardiology Kaplan Medical CenterRehovot 76100 Israel

Cold is a seasonal and circadian risk factor for cardioand cerebrovascular morbidity and mortality. Colder temperatures have been associated with higher blood pressure(BP), based on studies which show that BP levels measured during the summer months are generally lower than those measured during the winter months. Residents in geographic areas which have greater seasonal temperature differences show greater fluctuation in BP. Surprisingly, atmospheric pressure, rainfall, and humidity were not related to BP levels. The increased sympathetic nervous activity due to cold, as evidenced by elevated BP and by plasma and urinary catecholamines, has been proposed as being the underlying etiology. Patients with heart failure may experience, in cold conditions, endothelial dysfunction and produce fewer endogenous vasodilators(e.g., nitric oxide, prostaglandins) and more endogenous vasoconstrictors(e.g., endothelin), thus increasing afterload. Arterial stiffness is also related to seasonal BP changes. Increased BP, arterial stiffness and endothelial dysfunction could predispose to increased coronary and cerebrovascular events. Improved protection against lower temperatures or increased doses of existing medications or the addition of newer medications could lead to a reduction in increased cardiovascular mortality in winter. Here, we briefly review findings from existing literature and provide an update on seasonal long-term variation in BP along with the related complications.

关键词： Seasonal variations Circadian variations Outdoor temperature Seasonal effects Blood pressure Hypertension

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Gushing metal chain

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Frontiers of Mechanical Engineering 2016年第1期11卷 95-100页

作者： alexander BELYAEV alexander SUKHANOV alexander TSVETKOV Institute of Applied Mathematics and Mechanics Saint-Petersburg Polytechnic University St. Petersburg 195251 Russia

This article addresses the problem in which a chain falls from a glass from some height. This phenomenon demonstrates a paradoxical rise of the chain over the glass. To explain this effect, an initial hypothesis and an appropriate theory are proposed for calculating the steady fall parameters of the chain. For this purpose, the modified Cayley ＇s problem of falling chain given its rise due to the centrifugal force of upward inertia is solved. Results show that the lift caused by an increase in linear density at the part of chain where it is being bent （the upper part） is due to the convergence of the chain balls to one another. The experiments confirm the obtained estimates of the lifting chain.

关键词： chain fountain Meshchersky equation,Cayley's problem

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Computer study of the formation of water-ammonia clusters and their dielectric properties

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Chinese Physics B 2013年第7期22卷 167-172页

作者： alexander Galashev Institute of Industrial Ecology Ural BranchRussian Academy of Sciences

The absorption of one to six ammonia molecules by the （H2O）50 cluster is studied by the molecular dynamics method under near-atmospheric conditions. The capture of NH 3 molecules by a water cluster produces an increase in the integrated intensity of IR absorbance, substantially decreases emission power in the frequency range of 0≤ω≤3500cm-1,and transforms a continuous reflectance spectrum into a banded one. Adsorption of ammonia molecules by water clusters greatly diminishes the number of electrons that are active with respect to electromagnetic radiation. The present results are also compared with the experimental findings wherever available.

关键词： ammonia water cluster infrared absorption spectra molecular dynamics

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Chargino Production via Z^0-Boson Decay in a Strong Electromagnetic Field

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Chinese Physics Letters 2016年第3期33卷 17-19页

作者： alexander Kurilin Moscow Technological Institute on leave from Moscow State Open Pedagogical University

In the framework of MSSM the probability of Z0-boson decay to chaxginos in a strong electromagnetic field, Z X＋X-, is analyzed. The method of calculations employs exact solutions of relativistic wave equations for charginos in a crossed electromagnetic field. Analytic expression for the decay width is obtained at an arbitrary value of the parameter which characterizes the external-field strength Fμv and Z%boson momentum qv. The process Z0→ X＋X- is forbidden in a vacuum for the case of relatively heavy charginos： Mx±mz/2. However, in an intense electromagnetic background this reaction could take place in the region of superstrong fields （x〉1）.

关键词： of on is in Chargino Production via Z~0-Boson Decay in a Strong Electromagnetic Field for

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Use of GIS technology and cellular automata for modeling multiple socio-economic scenarios of regional spatial development and inter-regional cooperation

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Geo-Spatial Information Science 2023年第1期26卷 71-93页

作者： Igor Musikhin alexander Karpik Department of Photogrammetry and Remote Sensing Siberian State University of Geosystems and TechnologiesNovosibirskRussia Department of Space and Physical Geodesy Siberian State University of Geosystems and TechnologiesNovosibirskRussia

The advancement of effective spatial planning to support sustainable development and interregional cooperation has become an issue of serious concern for regional *** planning research helps to identify economic clusters and analyze their changing spatial patterns,which is important for understanding regional economic space dynamics and poten-tial inter-regional *** support decision-makers in the development of efficient plans of spatial development encompassing the identification of the best-suited territories,a combined Geographic Information System(GIS)based approach to interpret qualitatively expressed multiple socio-economic scenarios in quantitative map-based terms of graded suitability,and a formalized approach to the socio-economic evaluation of the territory is *** on GIS technology coupled with integrated cellular automata decision analysis techniques,the study provides a method that performs socio-economic assessment of the study area according to the generated scenarios of regional spatial and socio-economic *** proposed method is applied to Primorsky and Khabarovsk Krais,located in the Russian Far ***-economic scenarios of spatial development initiated by investors and regional authorities were assessed and *** generated socio-economic scenar-ios illustrate how the unified set of spatial and socio-economic variables can be linked and used to gain insights into inter-regional socio-economic and spatial *** application results demonstrate the advantage of the proposed method in identifying the best-suited unit areas for targeted regional development.

关键词： Geographic Information System(GIS) spatial development socioeconomic scenarios interregional cooperation open source software Cellular Automata(CA)

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Volcanic Ash in the Atmosphere and Risks for Civil Aviation:A Study in European Crisis Management

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International Journal of Disaster Risk Science 2013年第1期4卷 9-19页

作者： David alexander Institute for Risk and Disaster Reduction University College London London WC1E 6BT United Kingdom

This paper uses the eruption of the Icelandic volcano Eyjafjallaj?kull in April and May 2010 as a case study of disruption to civil aviation by airborne ash, with emphasis on risk management aspects. Severe curtailment of flights over much of Europe took place during the crisis, which lasted for slightly more than one week. More than 8.5 million passengers were stranded and commerce was profoundly affected. The United Kingdom was one of the worst impacted countries and took the lead in managing the crisis. The paper considers elements of the decision-making process that formed the basis of the UK Government’s emergency response. It examines the relations between science, governance, and economi c imperatives. Physical thresholds guiding decisions to restrict airspace were defined somewhat arbitrarily, which may have increased disruption. A damaging form of risk aversion prevailed at certain points in the crisis. Lack of preexisting procedures and planning meant that the response to dynamically changing meteorological conditions had to be improvised. At the same time, lack of integration between different modes in the European transportation system meant that had the crisis continued any longer there would have been severe problems in moving stranded people and commodities, as well as soaring economic losses. Eruptions similar to or more serious than that of Eyjafjallaj?kull are perfectly possible in Europe in the not-too-distant future.

关键词： Atmosphere aviation meteorological

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