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A new perspective on intervertebral disc calcification—from bench to bedside

Bone research 2024年第1期12卷 50-61页

作者： Emanuel J.Novais rajkishen Narayanan Jose A.Canseco Koen van de Wetering Christopher K.Kepler Alan S.Hilibrand alexander r.vaccaro Makarand V.risbud Department of Orthopaedic Surgery Sidney Kimmel Medical CollegeThomas Jefferson UniversityPhiladelphiaPAUSA Unidade Local de Saúde do Litoral Alentejano Orthopedic DepartmentSantiago do CacémPortugal rothman Orthopedic Institute at Thomas Jefferson University PhiladelphiaPAUSA

Disc degeneration primarily contributes to chronic low back and neck ***,there is an urgent need to understand the spectrum of disc degeneration phenotypes such as fibrosis,ectopic calcification,herniation,or mixed *** these phenotypes,disc calcification is the least *** calcification,by definition,is the pathological mineralization of soft tissues,widely studied in the context of conditions that afflict vasculature,skin,and ***,disc calcification is associated with poor surgical outcomes and back pain refractory to conservative *** is frequently seen as a consequence of disc aging and progressive degeneration but exhibits unique molecular and morphological characteristics:hypertrophic chondrocyte-like cell differentiation;TNAP,ENPP1,and ANK upregulation;cell death;altered Pi and PPi homeostasis;and local *** studies in mouse models have provided a better understanding of the mechanisms underlying this *** is essential to recognize that the presentation and nature of mineralization differ between AF,NP,and EP ***,the combination of anatomic location,genetics,and environmental stressors,such as aging or trauma,govern the predisposition to ***,the systemic regulation of calcium and Pi metabolism is less important than the local activity of PPi modulated by the ANK-ENPP1 axis,along with disc cell death and differentiation *** there is limited understanding of this phenotype,understanding the molecular pathways governing local intervertebral disc calcification may lead to developing disease-modifying drugs and better clinical management of degeneration-related pathologies.

关键词： degeneration metabolism intervertebral

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reasons for delayed spinal cord decompression in individuals with traumatic spinal cord injuries in Iran:A qualitative study from the perspective of neurosurgeons

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Chinese Journal of Traumatology 2021年第6期24卷 356-359页

作者： Masoud SohrabiAsl Zahra Ghodsi roya Habibi Arejan Zahra Azadmanjir Mahdi Sharif-Alhoseini Moein Khormali Maryam Shojaei Abbas rahimiforoushani Alireza Khoshnevisan alexander r.vaccaro Michael G.Fehlings Vafa rahimi-Movaghar Sina Trauma and Surgery research Center Tehran University of Medical SciencesTehranIran rehabilitation Office State Welfare Organization of IranTehranIran Health Information Management Department Tehran University of Medical Sciences Department of Epidemiology and Biostatistics School of Public HealthTehran University of Medical SciencesTehranIran Department of Neurosurgery Shariati HospitalTehran University of Medical SciencesTehran Iran Department of Orthopaedics and Neurosurgery Thomas Jefferson University and the Rothman InstitutePhiladelphiaPAUSA Department of Surgery University of TorontoSenior Scientist Krembil Brain Institute and McEwen Centre for Regenerative MedicineToronto Western HospitalUniversity Health NetworkCanada Universal Scientific Education and research Network(USErN) TehranIran Institute of Biochemistry and Biophysics University of TehranTehranIran Visiting Professor Spine ProgramUniversity of TorontoTorontoCanada Brain and Spinal Cord Injury research Center Neuroscience InstituteTehran University of Medical SciencesTehranIran

Purpose:The median time from the event leading to the spinal cord injury(SCI)to the time of decompressive surgery is estimated to be 6.9 days in Iran,which is much longer than the proposed ideal time(less than 24 h)in published *** current qualitative study aimed to determine the reasons for the observed decompression surgery delay in Iran from the perspective of ***:This qualitative study is designed to perform content analysis on the gathered data from face-to-face semi-structured interviews with 12 Iranian ***:The findings of the current study suggest that patient-related factors constitute more than half of the codes extracted from the ***,the type of injury,presence of polytrauma,and surgeons’’wrong attitude are the main factors causing delayed spinal cord decompression in Iranian patients from the perspective of *** notable factors include delay in transferring patients to the trauma center,delay in availability of necessary equipment,and scarce medical ***:In the perspective of neurosurgeons,the type of injury,presence of polytrauma,and surgeons’’wrong attitude are the leading reasons for delayed decompressive surgery of individuals with SCI in Iran.

关键词： Spinal cord injuries Decompression Surgical Neurosurgeons Iran Qualitative research

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脊柱关节成形术运动保留

脊柱关节成形术运动保留

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2009年

作者： alexander r.vaccaro Stephen Papadopoulos Vincent C.Traynelis regis W.Haid rick C.Sasso

全书共21章，回顾了脊柱外科技术的发展历史；介绍了脊柱融合技术的发展，并与非融合技术进行了对比，融合术后相邻节段的退变问题；基础应用解剖与生物力学等最新技术。

关键词：脊柱关节成形术

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National Spinal Cord Injury registry of Iran(NSCIr-Ir)-a critical appraisal of its strengths and weaknesses

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Chinese Journal of Traumatology 2019年第5期22卷 300-303页

作者： Mahdi Sharif-Alhoseini Zahra Azadmanjir Mohsen Sadeghi-Naini Zahra Ghodsi Khatereh Naghdi Mahdi Mohammadzadeh Amir AzarHomayoun Kazem Zendehdel Moein Khormali Farideh Sadeghian Seyed Behzad Jazayeri Mojtaba Sehat Habibollah Pirnejad Edward C.Benzel Gerard O'reilly Michael G.Fehlings alexander r.vaccaro Vafa rahimi-Movaghar Sina Trauma and Surgery research Center Tehran University of Medical SciencesTehranIran Toronto Western Hospital University Health NetworkTorontoOntarioCanada Department of Orthopaedic Surgery The Rothman InstituteThomas Jefferson UniversityPhiladelphiaUSA Brain and Spinal Cord Injury research Center Neuroscience InstituteTehran University of Medical SciencesTehranIran Department of Health Information Management School of Allied Medical SciencesTehran University of Medical SciencesTehranIran Trauma research Center Kashan University of Medical SciencesKashanIran Cancer research Center Cancer InstituteTehran University of Medical SciencesTehranIran Students'Scientific research Center Tehran University of Medical SciencesTehranIran Center for Health related Social and Behavioral Sciences research Shahroud University of Medical SciencesShahroudIran Department of Health Information Technology Urmia University of Medical SciencesUrmiaIran Cleveland Clinic Foundation Department of NeurosurgeryClevelandOHUSA Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash UniversityMelbourneAustralia

The National Spinal Cord Injury registry of Iran(NSCIr-Ir)is a not-for-profit,hospital-based,and prospective observational registry that appraises the quality of care,long-term outcomes and the personal and psychological burden of traumatic spinal cord injury in *** validity in every registry includes rigorous attention to data *** quality assurance is essential for any registry to make sure that correct patients are being enrolled and that the data being collected are *** reviewed strengths and weaknesses of the NSCIr-Ir while considering the methodological guidelines and recommendations for efficient and rational governance of patient *** summary,the steering committee,funded and maintained by the Ministry of Health and Medical Education of Iran,the international collaborations,continued staff training,suitable data quality,and the ethical approval are considered to be the strengths of the registry,while limited human and financial resources,poor interoperability with other health systems,and time-consuming processes are among its main weaknesses.

关键词： Spinal cord injuries Injury registries Data accuracy Iran

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Testing and modelling of transient adhesion phenomena in rolling-sliding contacts

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Friction 2024年第5期12卷 1016-1027页

作者： Daniel KVArDA alexander MEIErHOFEr Klaus SIX Faculty of Mechanical Engineering Brno University of TechnologyBrno61669Czech Republic Virtual Vehicle research GmbH Graz8010Austria

Transient adhesion effects in rolling–sliding contacts influence all aspects of train–track *** is of high importance specifically when these effects result in critically low adhesion,which poses a risk to traction and braking of railway *** study presents a model that can replicate the transient changes of the coefficient of adhesion with tested water and solid particle *** experimental data for the model are measured using a commercial ball-on-disc *** experimental results showed a liquid reservoir in front of the contact area that slowly reduces in *** observation was used in the modelling approach to divide the calculation into two stages where the reservoir is present and when it *** model was able to reproduce the occurrence of low adhesion region seen in experimental results with different particle concentrations.

关键词： coefficient of adhesion tribology transient effects wheel-rail contact

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Competitive resource Allocation Among Urban Congestion Areas in a Modern Big City

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Journal of the Operations research Society of China 2024年第1期12卷 133-153页

作者： alexander Krylatov Anastasiya raevskaya Institute of Applied Mathematical research of the Karelian research Centre of the russian Academy of Sciences Petrozavodsk185910Russia Saint Petersburg State University Saint Petersburg199034Russia

The continuing growth of modern big cities leads to their spatial expansion and the emergence of new road connections and urban *** where large transportation flows of pedestrians,passengers,and drivers come together create demand points,which attract business companies that strive to allocate their resources in the most sought-after ***,the law of supply and demand restrains companies from allocating all their resources solely in the most popular congestion areas since the more valuable an urban area,the higher the cost to be paid for a resource unit allocation *** a result,companies act in a non-cooperative manner and try to minimize their own overall costs when allocating resources across available commercial areas in a big ***-cooperative behavior of companies leads to the problem of Nash equilibrium search in the game of competing *** this paper,we study the corresponding resource allocation game under affine cost functions and obtain Nash equilibrium strategies in explicit *** findings allow us to develop a simple procedure for computing Nash equilibria in the game of companies allocating their resources among urban congestion *** computational study demonstrates the dependence of the average price for resource allocation on the number of players and their resource *** outcome of the paper contributes to flow theory and seems to be fresh and useful for managers.

关键词： resource allocation Nash equilibrium Affine costs

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A Converse Theorem for Split SO_(2l) over Finite Fields

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Acta Mathematica Sinica,English Series 2024年第3期40卷 731-771页

作者： alexander HAZELTINE Bai Ying LIU Department of Mathematics Purdue University150 N.University St.West LafayetteIN 47907USA E-mail:ahazelti@purdue.edu liu2053@purdue.edu

We prove a converse theorem for split even special orthogonal groups over finite *** is the only case left on converse theorems of classical groups and the difficulty is the existence of the outer automorphism. In thi... 详细信息

关键词： Converse theorems generic cuspidal representations even special orthogonal groups

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Architecture of Graphics System with 3D Acceleration Support for Embedded Operating Systems

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Tsinghua Science and Technology 2024年第3期29卷 863-873页

作者： alexander Giatsintov Kirill Mamrosenko Pavel Bazhenov Center of Visualization and Sattelite Information Technologies Scientific Research Institute for System Analysis of the Russian Academy of Sciences(SRISA RAS)Moscow 117218Russia

An increasing number of tasks now require the use of hardware accelerators to reduce the time required for computation and display the computational *** paper presents a new graphics system architecture for operating systems(OSs)with microkernel architecture,including real-time *** proposed system architecture provides capabilities for displaying graphical images on various information display devices and for accelerating graphical operations on *** architecture of the graphics system uses a concept of allocators to manage system and video memory,provides an abstraction of memory operations with a single interface for video memory management,and simplifies memory handling where incorrect operation is the cause of many failures.A comparison between the performance of a real-time OS and Linux OS implementing the graphics system using the example of a glmark2 benchmark is presented,thereby the superiority of the proposed architecture in several scenarios is demonstrated.

关键词： real-time operating system(rTOS) graphics system rendering system architecture operatingsystem visualization system programming

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Unveiling the atomic-scale transition between light harvesting and photoprotective states in plant photosynthesis

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Science China Chemistry 2024年第5期67卷 1375-1377页

作者： alexander V.ruban School of Biological and Behavioural Sciences Queen Mary University of LondonLondon E14NSUK

Non-photochemical chlorophyll fluorescence quenching(NPQ) stands as a cornerstone in the realm of photosynthesis research, attracting generations of dedicated scientists in their quest to unravel its mysteries. This mechanism, crucial for safeguarding photosynthesis, plays a pivotal role in regulating light harvesting, particularly in oxygenic photosynthesis where the oxygen-evolving photosystem II (PSII)is susceptible to photodamage [1].

关键词： harvesting protective attracting

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Prediction of ball-on-plate friction and wear by ANN with data-driven optimization

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Friction 2024年第6期12卷 1235-1249页

作者： alexander KOVALEV Yu TIAN Yonggang MENG State Key Laboratory of Tribology in Advanced Equipment Tsinghua UniversityBeijing 100084China

For training artificial neural network(ANN),big data either generated by machine or measured from experiments are used as input to"learn"the unspecified functions defining the *** experimental data are fed directly into the optimizer allowing training to be performed according to a predefined loss *** predict sliding friction and wear at mixed lubrication conditions,in this study a specific ANN structure was so designed that deep learning algorithms and data-driven optimization models can be *** ball-on-plate friction and wear data were analyzed using the specific training procedure to optimize the weights and biases incorporated into the neural layers of the ANN,and only two independent experimental data sets were used during the ANN optimization *** the training procedure,the ANN is capable to predict the contact and hydrodynamic pressure by adapting the output data according to the tribological condition implemented in the optimization algorithm.

关键词： machine learning deep learning artificial neural network mixed lubrication

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