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Open Journal of Orthopedics 2014年第1期4卷 1-6页

作者： alexander m. wood Luke m.Ilwain Calum.H. Arthur Stuart A. Aitken Andre C. m. Keenan Phil Walm.ley Ivan Brenkel Traum. and Orthopaedics Victoria Hospital NHS Fife Kirkcaldy UK.

The PFC Sigm. Cobalt Chrom. Sigm. (PFCSCC) was introduced in 2006, and represents further developm.nt of the PFC Sigm. design aim.ng at reducing the problem.of backside wear. To ensure that there were no significant early failures following the introduction of this knee system.to our hospital in 2006, we prospectively identified all patients undergoing TKA with the PFCSCC over a one-year period. Clinical and dem.graphic patient data, Am.rican Knee Society scores, Oxford Knee scores, SF-12 scores and radiographic data were recorded preoperatively and at three-year post surgery. 233 patients underwent 249 prim.ry knee arthroplasties with the PFCSCC. Seven patients (eight TKAs) died before the last review and eight cases were lost to follow up. m.an age was 66.7 (range 34 - 80) with 47.6% m.le. m.an follow-up days were 1109 (range 741 to 1591). 5 (2.2%) were revised for infection with 1 revised for pain. The 3-year survival rate was 97.6% and 99.6% for aseptic failure. AKS 46.2 (0 - 95) was preoperatively 88.3 (17 - 100) with 3 years P 0.001. OKS 39.0 (22 - 53) was preoperatively 22.6 (12 - 53) with 3 years P 0.001. 17 of the 219 who had x-rays (8%) had radiolucent zones on x-ray. Our results dem.nstrate a good early aseptic survivorship of the PFCSCC at three years of 99.6%, com.ined with a good functional and objective im.rovem.nt in our patients in three years.

关键词： Arthroplasty Knee Outcom.s

Com.arason of Peri-Articular m.ltim.dal Drug Injection with Fem.ral and Sciatic Nerve Block after Total Knee Arthroplasty

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Open Journal of Orthopedics 2012年第4期2卷 155-158页

作者： Calum.H. C. Arthur alexander m. wood Charles Leeson-Payne Steffen J. Breusch Orthopaedic Departm.nt Royal Infirmary of Edinburgh Edinburgh UK

Good perioperative analgesia following total knee arthroplasty facilitates rehabilitation and m.y reduce hospital stay. We present the patient analgesic requirem.nts and rehabilitation of a prospective single surgeon series after the introduction of a m.ltim.dal drug injection during his total knee arthroplasty. Basic epidem.ological data as well as analgesic, antiem.tic requirem.nts and tim. to straight leg raised was collected on 27 consecutive patients (group 1) whom.received the m.ltim.dal drug injection, consisting of levobupivacaine, ketorolac and adrenaline at the tim. of their total knee arthroplasty under spinal anaesthesia. Their rehabilitation was com.ared to a retrospective review of patients who were case m.tched by age and sex (group 2n = 26), whom.had received the unit standard of spinal anaesthetic and a fem.ral and sciatic block at the tim. of their operation. Patients in group 1 had significantly lower analgesic and antiem.tic requirem.nts than group 2. Group 1 also had a significantly shorter hospital stay. We have dem.nstrated that periarticular m.ltim.dal drug injection can im.rove perioperative analgesia and m.bilisation following total knee arthroplasty as well as reducing opioid requirem.nts and side effects.

关键词： Analgesia Total Knee Replacem.nt m.ltim.dal Drug Injection Peripheral Nerve Blocks Rehabilitation

The Functional Outcom. of Total Knee Replacem.nt in Young Patients: A 10-Year m.tched Case Control Study

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Open Journal of Orthopedics 2013年第2期3卷 128-132页

作者： alexander m. wood Andre C. m. Keenan Calum.H. C. Arthur Stuart A. Aitken Phil J. Walm.ley Ivan J. Brenkel Orthopaedic Departm.nt Victoria Hospital Kirkcaldy UK.

We present the results of a prospective study on the functional outcom. from.total knee replacem.nt (TKR) in young versus old patients. Am.rican Knee Society and pain scores over ten years post TKR were com.ared using a cohort of young patients (≤55 years) and a control group of patients ≥56, m.tched for ASA, body m.ss index and preoperative condition. A total of 24 young and 24 older knees were analysed. All scores im.roved significantly over tim.. There was no statistical differences over 10 years in pain (p = 0.436) and knee perform.nce (0.618). Overall function was consistently higher in the younger group (p = 0.004). TKR in younger patients produces sim.lar outcom.s in term. of pain and function com.ared with older patients and we feel that TKR should not be withheld on account of age alone.

关键词： Com.onent Form.tting Style Styling Insert

The olfactory system.of Pieris brassicae caterpllars:from.receptors to glom.ruli

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Insect Science 2024年第2期31卷 469-488页

作者： Qi Wang Hans m.Sm.d m.rcel Dicke alexander Haverkam. Laboratory of Entom.logy Wageningen University and ResearchWageningenthe Netherlands

Tolfactory system.of adult lepidopterans is am.ng the best described neuronal ***,com.aratively little is known about the organization of the olfactory system.in the larval stage of these ***,we explore the expression of olfactory receptors and the organization of olfactory sensory neurons in caterpillars of Pieris brassicae,a significant pest species in Europe and a well-studied species for its chem.cal *** describe the larval olfactory system.in this species,we first analyzed the head transcriptom. of third-instar larvae(L3)and identified 16 odorant receptors(ORs)including the OR coreceptor(Orco),13 ionotropic receptors(IRs),and 8 gustatory receptors(GRs).We then quantified the expression of these 16 ORs in different life stages,using qPCR,and found that the m.jority of ORs had significantly higher expression in the L4 stage than in the L3 and L5 stages,indicating that the larval olfactory system.is not static throughout caterpillar *** an Orco-specific antibody,we identified all olfactory receptor neurons(ORNs)expressing the Orco protein in L3,L4,and L5 caterpillars and found a total of 34 Orco-positive ORNs,distributed am.ng three sensilla on the *** num.er of Orco-positive ORNs did not differ am.ng the three larval ***,we used retrograde axon tracing of the antennal nerve and identified a m.an of 15 glom.ruli in the larval antennal center(LAC),suggesting that the caterpillar olfactory system.follows a sim.lar design as the adult olfactory system.although with a lower num.rical *** together,our results provide a detailed analysis of the larval olfactory neurons in P brassicae,highlighting both the differences as well as the com.onalities with the adult olfactory *** findings contribute to a better understanding of the developm.nt of the olfactory system.in insects and its life-stage-specific adaptations.

关键词： glom.ruli larvae Lepidoptera odorant receptor olfactory receptor neurons sensilla

Transcriptional reprogram.ing during hum.n osteoclast differentiation identifies regulators of osteoclast activity

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Bone Research 2024年第1期12卷 180-198页

作者： m.rten S.Hansen Kaja m.dsen m.ria Price Kent Søe Yasunori Om.ta m.rio m.Zaiss Caroline m.Gorvin m.rten Frost alexander Rauch m.lecular Endocrinology Laboratory(Km.B) Department of EndocrinologyOdense University HospitalDK-5000 Odense CDenmark Departm.nt of Clinical Research Faculty of Health SciencesUniversity of Southern DenmarkDK-5000 Odense CDenmark Clinical Cell Biology Pathology Research UnitDepartment of Clinical ResearchUniversity of Southern DenmarkDK-5000 Odense CDenmark Institute of m.tabolism.and System. Research(Im.R)and Centre for Diabetes Endocrinology and Metabolism(CEDAM)University of BirminghamBirmingham B152TTUK Centre for m.m.rane Proteins and Receptors(COm.ARE) Universities of Birmingham and NottinghamBirmingham B152TTUK Departm.nt of m.lecular m.dicine University of Southern DenmarkDK-5000 Odense CDenmark Departm.nt of Orthopedic Surgery Faculty of MedicineThe University of TokyoTokyo 113-8655Japan Departm.nt of Internal m.dicine 3 Rheumatology and ImmunologyFriedrich-Alexander-University Erlangen-Nürnberg(FAU)and Universitätsklinikum ErlangenD-91054 ErlangenGermany Deutsches Zentrum.Im.untherapie(DZI) Friedrich-Alexander-University Erlangen-Nürnberg and Universitätsklinikum ErlangenD-91054 ErlangenGermany Steno Diabetes Center Odense Odense University HospitalDK-5000 Odense CDenmark

Enhanced osteoclastogenesis and osteoclast activity contribute to the developm.nt of osteoporosis,which is characterized by increased bone resorption and inadequate bone *** novel antiosteoporotic therapeutics are needed,understanding the genetic regulation of hum.n osteoclastogenesis could help identify potential treatm.nt *** study aim.d to provide an overview of transcriptional reprogram.ing during hum.n osteoclast *** were differentiated from.CD14+m.nocytes from.eight fem.le *** sequencing during differentiation revealed 8980 differentially expressed genes grouped into eight tem.oral patterns conserved across *** patterns revealed distinct m.lecular functions associated with postm.nopausal osteoporosis susceptibility genes based on RNA from.iliac crest biopsies and bone m.neral density *** analyses revealed m.tual dependencies between tem.oral expression patterns and provided insight into subtype-specific transcriptional *** donor-specific expression patterns revealed genes at the m.nocyte stage,such as filam.n B(FLNB)and oxidized low-density lipoprotein receptor 1(OLR1,encoding LOX-1),that are predictive of the resorptive activity of m.ture *** expression of differentially expressed G-protein coupled receptors was strong during osteoclast differentiation,and these receptors are associated with bone m.neral density SNPs,suggesting that they play a pivotal role in osteoclast differentiation and *** regulatory effects of three differentially expressed G-protein coupled receptors were exem.lified by in vitro pharm.cological m.dulation of com.lem.nt 5 A receptor 1(C5AR1),som.tostatin receptor 2(SSTR2),and free fatty acid receptor 4(FFAR4/GPR120).Activating C5AR1 enhanced osteoclast form.tion,while activating SSTR2 decreased the resorptive activity of m.ture osteoclasts,and activating FFAR4 decreased both the num.er and resorptive activity of m.ture *** conclus

关键词： osteoclast program.ing identif

Praseodym.um.m.tal nanorods as a 5-fluorouracil carrier

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Journal of Rare Earths 2024年第7期42卷 1328-1336,I0005页

作者： Varnitha m.nikantan Govindaraj Sri Varalakshm. Ujm. Ashapak Tam.oli Archana Sum.han Pillai Aleyam.a alexander Anushka Lucas Bose Allben Akash Israel V.m.V.Enoch Centre for Nanoscience and Genom.cs Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia Departm.nt of Applied Chem.stry Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia

Interest in m.tal nanoparticles as nanoscale drug-carrying vehicles has been *** such an aspect,lanthanide m.tal nanoparticles are particularly ***,we report praseodym.um.nanoparticles as a novel anticancer therapeutic transporting *** m.terial was m.de as a com.osite with the supram.lecular host polym.r,poly-β-*** praseodym.um.nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and therm.gravim.tric analysis(TGA).In addition,they were im.ged using transm.ssion electron *** nanostructures are a long rod-shaped m.terial with 2.0±0.1μm.in length and 230±10 nm.in *** m.terial shows a saturation m.gnetization value above 30 em./g with a coercivity value of 130 *** nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from.the nanocarrier(polym.r-containing praseodym.um.nanoparticles)and proceeds for above 250 *** in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them.on m.F-7 and Vero(non-cancerous)cell *** cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are *** IC_(50)values on the cell lines are reported.

关键词： m.tal nanoparticles Praseodym.um Poly-cyclodextrin Drug delivery Anticancer activity Rare earths

New Opportunities for Neutrons in Environm.ntal and Biological Sciences

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Frontiers of Environm.ntal Science & Engineering 2024年第7期18卷 179-186页

作者： alexander Johs Shuo Qian Leighton Coates Brian H.Davison Jam.s G.Elkins Xin Gu Jennifer m.rrell-Falvey Hugh O'Neill Jeffrey m.Warren Eric m.Pierce Kenneth Herwig Oak Ridge National Laboratory Oak RidgeTN37831USA

The use of neutron m.thods in environm.ntal and biological sciences is rapidly em.rging and accelerating with the developm.nt of new instrum.nts at neutron user *** article,based on a workshop held at Oak Ridge National Laboratory(ORNL),offers insights into the application of neutron techniques in environm.ntal and biological *** highlight recent advances and identify key challenges and potential future research *** include soil and rhizosphere processes,root water dynam.cs,plant-m.crobe interactions,structure and dynam.cs of biological system.,applications in synthetic biology and enzym. engineering,next-generation bioproducts,biom.terials and bioenergy,nanoscale structure,and fluid dynam.cs of porous m.terials in *** provide an outlook on em.rging opportunities with an em.hasis on new capabilities that will be enabled at the Spallation Neutron Source Second Target Station currently under design at *** m.ssion of scientific neutron user facilities worldwide is to enable science using state-of-the-art neutron *** aim.to encourage researchers in the environm.ntal and biological research com.unity to explore the unique capability afforded by neutrons at these facilities.

关键词： Neutrons Environm.nt Biology Neutron im.ging Neutron scattering Second Target Station(STS)

Effects of site preparation m.thods on soil physical properties and outplanting success of coniferous seedlings in boreal forests

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Journal of Forestry Research 2024年第2期35卷 70-80页

作者： Aleksey S.Ilintsev Elena N.Nakvasina alexander P.Bogdanov Northern Research Institute of Forestry 13 Nikitova Str.Arkhangelsk 163062Russian Federation Departm.nt of Silviculture and Forest m.nagem.nt Northern(Arctic)Federal University Named After M.V.LomonosovSevernoy Dviny Emb.17Arkhangelsk 163002Russian Federation

This study assessed the effect of patch scarification and m.unding on the physical properties of the root layer and the success of tree planting in various types of *** study was conducted on 12 forest sites in taiga forests of the European part of Russia.A total of 54 plots were set up to assess seedling survival;root collar diam.ter,height,and heigh increm.nt were m.asured for 240 seedlings to assess *** the rooting layer,240 soil sam.les were taken to determ.ne physical *** study showed that soil treatm.nt m.thods had no effect on bulk density and total porosity in Cladina ***,reduced soil m.isture was noted,particularly in m.unds,resulting in increased *** m.rtillus sites,there were increased bulk density,reduced soil m.isture,and total porosity in the *** treatm.nt in Polytrichum.sites resulted in reduced soil m.isture and increased aeration *** the m.rtillus and Polytrichum.sites,patch scarification had no effects on physical *** Polytrichum.sites,survival rates,heights,and heigh increm.nts of bareroot Norway spruce seedlings in m.unds were higher than in patches;however,the sam. did not apply to *** Cladina and m.rtillus sites,there was no difference in growth for bareroot and containerised seedlings with different soil *** conditions and soil types should be considered when applying different soil treatm.nt m.thods to ensure high survival rates and successful seedling growth.

关键词： Boreal forests m.chanical site preparation Patch scarification m.unding Soil properties Containerised seedlings Bareroot seedlings

Effect of sodium.nitroprusside on the m.crorheological properties of red blood cells in di®erent m.dia

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Journal of Innovative Optical Health Sciences 2024年第5期17卷 23-31页

作者： Petr Erm.linskiy m.tvey m.ksim.v Andrei Lugovtsov Alexey m.ravyov Irina Tikhom.rova alexander Priezzhev Faculty of Physics M.V.Lomonosov Moscow State University Moscow 119991Russia Faculty of Physical Education K.D.Ushinsky Yaroslavl State Pedagogical University Yaroslavl 150000 Russia Faculty of Natural Sciences K.D.Ushinsky Yaroslavl State Pedagogical University Yaroslavl 150000 Russia

Red blood cell(RBC)aggregation as well as their deform.tion signi¯cantly affects blood *** processes depend on various factors,one of which is concentration of the nitric oxide,one of the m.in signaling m.lecule in the *** purpose of this study was to investigate the effect of nitric oxide on the m.crorheological properties of red blood cells(RBCs)in RBC sam.les of various m.dia after the addition of nitric oxide donor sodium.nitroprusside in *** properties were m.asured using laser aggregom.ter and ektacytom.ter based on diffuse light scattering and diffraction of laser light on a suspension of RBCs,*** study found that heparin-stabilized blood showed increased RBC aggregation and deform.tion with sodium.nitroprusside concentrations of 100,and 200m.while EDTA-stabilized blood showed slightly decreased aggregation and unchanged *** washed RBCs in dextran solution,the addition of sodium.nitroprusside(in the concentrations of 100,and 200m.resulted in decreased aggregation and increased ***-ndings aid in our understanding of nitric oxide's effect on RBC m.crorheological properties.

关键词： Sodium.nitroprusside nitric oxide red blood cells RBC aggregation diffuse light scattering laser diffractom.ter

A Statistical Study of m.gnetic Flux Em.rgence in Solar Active Regions Prior to Strongest Flares

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Research in Astronom. and Astrophysics 2024年第4期24卷 147-160页

作者： alexander S.Kutsenko Valentina I.Abram.nko Andrei A.Plotnikov Crim.an Astrophysical Observatory p/o NauchnyCrimea298409Russia

Using the data on m.gnetic field m.ps and continuum.intensity for Solar Cycles 23 and 24,we explored 100 active regions(ARs)that produced m..0 or stronger *** focus on the presence/absence of the em.rgence of m.gnetic flux in these ARs 2-3 days before the strong flare *** found that 29 ARs in the sam.le em.rged m.notonically am.dst quiet-Sun.A m.jor em.rgence of a new m.gnetic flux within a pre-existing AR yielding the form.tion of a com.lex flare-productive configuration was observed in another 24 *** 30 ARs,an insignificant(in term. of the total m.gnetic flux of pre-existing AR)em.rgence of a new m.gnetic flux within the pre-existing m.gnetic configuration was observed;for som. of them.the em.rgence resulted in a form.tion of a configuration with a sm.ll δ-sunspot;11 out of 100 ARs exhibited no signatures of m.gnetic flux em.rgence during the entire interval of *** six cases the em.rgence was in progress when the AR appeared on the Eastern lim.,so that the classification and tim.ng of em.rgence were not *** conclude that the recent flux em.rgence is not a necessary and/or sufficient condition for strong flaring of an *** flux em.rgence rate of flare-productive ARs analyzed here was com.ared with that of flare-quiet ARs analyzed in our previous *** revealed that the flare-productive ARs tend to display faster em.rgence than the flare-quiet ones do.

关键词： Sun:activity Sun:flares Sun:m.gnetic fields