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Mechanisms of pulmonary endothelial barrier dysfunction in acute lung injury and acute respiratory distress syndrome

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Chinese Medical Journal Pulmonary and Critical Care Medicine 2024年第2期2卷 80-87页

作者： Yunchao Su Rudolf Lucas David J.R.Fulton alexander D.Verin Department of Pharmacology&Toxicology Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Division of Pulmonary and Critical Care Medicine Department of MedicineMedical College of GeorgiaAugusta UniversityAugustaGA 30912USA Vascular Biology Center Medical College of GeorgiaAugusta UniversityAugustaGA 30912USA Research Service Charlie Norwood Veterans Affairs Medical CenterAugustaGA 30912USA

Endothelial cells(ECs)form a semi-permeable barrier between the interior space of blood vessels and the un-derlying *** endothelial barrier integrity is maintained through coordinated cellular processes involving receptors,signaling molecules,junctional complexes,and protein-regulated cytoskeletal *** acute lung injury(ALI)or its more severe form acute respiratory distress syndrome(ARDS),the loss of endothelial barrier integrity secondary to endothelial dysfunction caused by severe pulmonary inflamma-tion and/or infection leads to pulmonary edema and ***-inflammatory agonists such as histamine,thrombin,bradykinin,interleukin 1𝛽,tumor necrosis factor𝛼,vascular endothelial growth factor,angiopoietin-2,and platelet-activating factor,as well as bacterial toxins and reactive oxygen species,cause dynamic changes in cytoskeletal structure,adherens junction disorganization,and detachment of vascular endothelial cadherin(VE-cadherin)from the actin cytoskeleton,leading to an increase in endothelial *** interactions with leukocytes,platelets,and coagulation enhance the inflammatory ***,inflammatory infil-tration and the associated generation of pro-inflammatory cytokines during infection cause EC death,resulting in further compromise of the structural integrity of lung endothelial *** the use of potent antibiotics and aggressive intensive care support,the mortality of ALI is still high,because the mechanisms of pulmonary EC barrier disruption are not fully *** this review,we summarized recent advances in the studies of endothelial cytoskeletal reorganization,inter-endothelial junctions,endothelial inflammation,EC death,and endothelial repair in ALI and ARDS,intending to shed some light on the potential diagnostic and therapeutic targets in the clinical management of the disease.

关键词： Lung Endothelium Pulmonary edema Acute lung injury Acute respiratory distress syndrome

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N-acetylcysteine and zinc sulphate abate di-2-ethylhexyl phthalate-mediated reproductive dysfunction in rats:Focus on oxidative and sex hormone receptors mechanisms

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Asian pacific Journal of Reproduction 2024年第5期13卷 228-240页

作者： Victor Oghenekparobo Emojevwe Mega Obukohwo Oyovwi Kayode Ezekiel Adewole Peggy Ejiro Ohwin Adeniran Oluwadamilare Akinola alexander Obidike Naiho Eze Kingsley Nwangwa Victor Omo-Idonije Motunrayo Lade-Ige Benneth Ben-Azu Department of Physiology University of Medical SciencesOndo CityOndo StateNigeria Department of Physiology Delta State UniversityAbrakaDelta StateNigeria Department of Physiology Adeleke UniversityEdeOsun StateNigeria Department of Biochemistry University of Medical SciencesOndo CityOndo StateNigeria Department of Pharmacology Delta State UniversityAbrakaDelta StateNigeria

Objective:To investigate the potential of N-acetylcysteine(NAC)and zinc sulphate(ZnSO_(4))in mitigating reproductive dysfunction caused by di-2-ethylhexyl phthalate(DEHP)in rats and to understand the underlying mechanisms,specifically oxidative stress and sex hormone receptor ***:Thirty-five male Wistar rats were randomly divided into five equal groups(n=7 per group).Group 1 was administered 0.5 mL of distilled water and served as the control *** 2 was given only DEHP(750 mg/kg/day),while group 3,4 and 5 were given DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day),DEHP(750 mg/kg/day)plus ZnSO_(4)(0.5 mg/kg/day),and DEHP(750 mg/kg/day)plus NAC(100 mg/kg/day)as well as ZnSO_(4)(0.5 mg/kg/day),*** treatments lasted for 21 *** were obtained after the rats were sacrificed,and hormones levels in the serum and markers of oxidative stress in the testicles were analyzed using the enzyme-linked immunosorbent *** amount of androgen receptors in the testicles was determined by immunohistochemistry,and the susceptibility of testosterone and DEHP to bind to androgen receptor and 5α-reductase was determined by molecular docking ***:DEHP decreased reproductive hormones,testicular antioxidant enzymes,increased malondialdehyde levels,and negatively impacted histology of the pituitary and *** or ZnSO_(4) treatment showed a marked improvement in testicular antioxidant status and hormone levels,as well as a positive effect on the histology of the pituitary and *** combination of both treatments appeared to be more *** affinity of DEHP to bind to androgen receptors may lead to disruption of androgen receptor signaling,which can further result in dysfunction of hormones related to ***,NAC is more likely to form stronger binding interactions with follicle stimulating hormone and luteinizing hormone receptors,as well as gonadotropin-releasing hormone receptors,when compared to ***:The pos

关键词： Di-2-ethylhexyl phthalate Testosterone Androgen receptor 5α-reductase Oestrogen Luteinizing hormone

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Effect of Variety and Plant Spacing on Growth and Yield of Groundnuts (Arachis hypogaea L.)

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Agricultural Sciences 2024年第1期15卷 54-70页

作者： Abukari Iddrisu Eric Adjei Samuel Kwesi Asomaning Kwadwo Gyasi Santo Adu Poku Isaac alexander Danson-Anokye Cocoa Health and Extension Division Huni Valley Ghana Department of Agriculture Berekum East Municipal Assembly Berekum Ghana Department of Horticulture and Crop Production School of Agriculture and Technology University of Energy and Natural Resources Sunyani Ghana Glenn High School Winston Salem USA

A field experiment was carried out to determine the effect of variety and plant spacing on yield and growth of groundnuts. The field experiment was laid in a 3 × 3 factorial experiment in a Randomized Complete Block Design (RCBD) with three (3) replications. The factor A included three (3) groundnut varieties (Nkatie Sari, Sum Nutt 22 and Yenyawoso) and Factor B was the three (3) spacing of 30 cm × 15 cm, 30 cm × 30 cm and 30 cm × 40 cm. All recommended agronomic practices were followed. Data was collected from eight (8) tagged plants. Growth data were recorded on plant height, number of branches, number of leaves, and the number of flowers while yield data were collected on the number of flowers, number of pods per plant, 100 seeds weight and the pod yield (kg/ha). The plant spacing significantly influenced (P < 0.05) the growth and yield parameters. Groundnut grown at a spacing of 30 cm × 15 cm produced the maximum plant height, whereas the maximum number of leaves, number of branches and number of flowers were produced from 30 cm × 40 cm. Yenyawoso variety with a wider plant spacing performed better vegetatively among all the varieties. The Yenyawoso variety produced the highest number of pods, 100 seeds weight and pod yield as compared to the other varieties. Also, Yenyawoso at 30 cm × 40 cm spacing and Nkatie Sari at 30 cm × 15 cm spacing produced the maximum pod yield.

关键词： Groundnut Variety Yield Spacing Plant Height

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The Oral Health Status of Person with Special Needs in Kumasi

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Open Journal of Stomatology 2024年第1期14卷 14-31页

作者： Ama Agyeibea Amuasi alexander Oti-Acheampong Victoria N. A. Boadu Lord J. J. Gowans The Department Child Oral Health & Orthodontics School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Oral & Maxillofacial Sciences School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana The Department of Community Dentistry School of Medicine and Dentistry College of Health Sciences Kwame Nkrumah University of Science and Technology Kumasi Ghana

Background: The most prevalent non-communicable disease worldwide is oral health-related disease, with dental caries and periodontal conditions being common. Oral health status significantly impacts overall health and quality of life. Barriers to dental care affect children with special needs. This study evaluates the oral health status and treatment requirements of people with special needs. Methodology: This descriptive cross-sectional study in Kumasi, Ghana examined oral health status among people, 121 children with special needs over two months, in June-July 2022. Dental caries, periodontal changes, malocclusion, and trauma were assessed. The data was analyzed using SPSS 20.0. Results: The oral health status among people with special needs in this study was generally moderate, with a range from very good to very poor. The prevalence of dental caries was 37%, with a mean DMFT score of 2.82. Periodontal health showed unsatisfactory indicators such as mobile teeth, poor gingival health, high plaque scores, and the presence of halitosis. Conclusion: This descriptive study aimed to provide baseline data on the oral health status of special needs students in Kumasi, addressing the lack of knowledge in this area. It highlighted the importance of dental care in maintaining good oral health and overall well-being in individuals with special needs. Coordinated efforts by dental professionals are needed to provide dental health education and preventive interventions for these children.

关键词： Special Needs Oral Health Dental Caries Periodontal Diseases Malocclusion

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Erratum to:Testing and modelling of transient adhesion phenomena in rolling-sliding contacts

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Friction 2024年第7期12卷 1622-1622页

作者： Daniel KVARDA alexander MEIERHOFER Klaus SIX Faculty of Mechanical Engineering Brno University of TechnologyBrno 61669Czech Republic Virtual Vehicle Research GmbH Graz 8010Austria

Erratum to Daniel Kvarda,alexander Meierhofer,Klaus *** and modelling of transient adhesion phenomena in rolling–sliding *** 12(5):1016–1027(2024).https://***/10.1007/s40544-023-0825-8 The authors regret that there was an inadvertent error in author biographies after checking the *** is important to note that the change does not impact the main conclusion of the *** accurate version of biographies of alexander MEIERHOFER and Klaus SIX on pages 1026 and 1027 are provided as below.

关键词： Friction transient conclusion

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Circular polarization-selective optical,photothermal,and optofluidic effects in chiral metasurfaces

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Photonics Research 2024年第2期12卷 331-340页

作者： CUIPING MA PENG YU ZHIMIN JING YISONG ZHU PEIHANG LI WENHAO WANG HONGXING XU YANNING ZHANG LIANG PAN TAE-YOUL CHOI ARUP NEOGI alexander OGOVOROV ZHIMING WANG Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu 610054China Division of Physics and Applied Physics School of Physical and Mathematical SciencesNanyang Technological UniversitySingapore 637371Singapore School of Physics and Technology Center for Nanoscience and NanotechnologyWuhan UniversityWuhan 430072China Department of Mechanical Engineering University of North TexasDentonTexas 76207USA Department of Physics and Astronomy and Nanoscale and Quantum Phenomena Institute Ohio UniversityAthensOhio 45701USA

Circular dichroism (CD) is extensively used in various material systems for applications including biological detection,enantioselective catalysis,and chiral *** paper introduces a chiral absorptive metasurface that exhibits a circular polarization-selective effect in dual bands-positive and negative CD peaks at short wavelengths and long wavelengths,***,we uncover that this phenomenon extends beyond the far-field optical response,as it is also observed in the photothermal effect and the dynamics of thermally induced fluid *** carefully engineering the metasurface design,we achieve two distinct CD signals with high g factors (1) at the wavelengths of 877 nm and 1045 nm,*** findings presented in this study advance our comprehension of CD and offer promising prospects for enhancing chiral light–matter interactions in the domains of nanophotonics and optofluidics.

关键词： chiral catalysis circular

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Increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.Solovуeva Shaza S.Issa Aysilu I.Mullagulova Angelina A.Titova Yana O.Mukhamedshina Anna V.Timofeeva alexander M.Aimaletdinov Islam R.Nigmetzyanov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(HexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of HexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-HEXA-HEXB express the functionally active HexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

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Surgical Treatment of Nephroblastoma in a 4-Year Male Child: A Case Report and Literature Review

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Case Reports in Clinical Medicine 2024年第2期13卷 43-51页

作者： alexander Kofi Egote Samuel Kolonziah Blay Constance Amuzuah Egote Cardinal Kofi Newton Albert Afriyie Akowuah Emmanuel Nana Bosoma Urology Unit Sunyani Teaching Hospital Sunyani Ghana

Herein we report a patient with nephroblastoma which was successfully removed at the Sunyani Teaching Hospital CJ Oppong theatre in Ghana in sub-Saharan Africa by extended below umbilical incision. Our patient had a family history of Wilms tumour predisposing him to the disease. His main symptoms were haematuria and abdominal mass which was noticed later. Examination and investigation were suggestive of a late-stage unilateral Nephroblastoma resulting in the need for nephrectomy. To reduce the need for such radical surgeries among children at an early stage, there is the need for early screening of children for Wilms tumours especially, those with family predisposition as in our case study. The case report presented here constitutes a rare case of nephroblastoma in the literature.

关键词： Nephroblastoma Wilms Tumour Nephrectomy Screening

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Lateral femoral neck stress fractures: A case report

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World Journal of Orthopedics 2024年第9期15卷 891-901页

作者： Christiaan AJ Oudmaijer Nuno R Paulino Pereira David Visser alexander M Wakker Wout S Veltman Robbart van Linschoten Department of Surgery Division of Hepatobiliary and Transplantation SurgeryErasmus MC Transplant InstituteRotterdam 3015 GDZuid-HollandNetherlands Princess Maxima Center for Pediatric Oncology Utrecht 3584 CSNetherlands Orthopaedics and Sports Medicine Erasmus MCErasmus University Medical Center RotterdamRotterdam 3015 GDZuid-HollandNetherlands Department of Surgery Division of Trauma SurgeryErasmus MCErasmus University Medical Center RotterdamRotterdam 3015 GDZuid-HollandNetherlands

BACKGROUND Sport-induced injuries particularly affect young,healthy,and active ***,a popular and accessible sport,can cause a wide range of injuries,including stress *** fractures can occur during high-intensity training or competitions,especially among well-trained amateurs and professional *** diagnosis can be complicated by the typically young age,unremarkable medical history,and vital condition of the *** fractures present insidiously,and this is specifically the case with stress fractures of the femoral *** intervention is crucial to prevent progressive displacement,as this can damage the blood supply to the femoral *** SUMMARY A 30-year-old male runner presented to our outpatient clinic with persistent pain 3 weeks after running a marathon.X-ray showed a complete lateral fracture of the left femoral neck,which was treated surgically with a dynamic hip *** It is essential for healthcare providers to be vigilant for the subtle symptoms of stress fractures to ensure timely *** recognition prevents com-plication and leads to a better prognosis.

关键词： Stress fractures Atypical Femoral Neck Marathon Diagnosis Case report

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新奥尔良当代艺术中心共享办公室美国新奥尔良

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世界建筑导报 2024年第1期39卷 74-78页

作者：无 Neil alexander(摄影) Sara Essex Bradley(摄影) EDR建筑事务所不详

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮... 详细信息

The Shop是一个综合的联合办公项目,位于新奥尔良市中心,坐落在新奥尔良市当代艺术中心(CAC)的三层和四层。面向科技、艺术和文化事业,The Shop成为发展中的创新工业的创业者中心。这座历史悠久的建筑之前被用做K&B的总部和一个杂货冷饮店,70年代中期被用作当代艺术中心。顶部两层在过去40年中一直没有被充分利用,The Shop的开发标志着对这一空间的第一次大规模整修。

关键词：联合办公当代艺术中心新奥尔良市美国新奥尔良 Shop 冷饮店办公室杂货

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