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Optical probing of ultrafast laser-induced solid-to-overdense-plasma transitions

Light(Science & Applications) 2024年第5期13卷 973-984页

作者： Yasmina Azamoum Georg alexander Becker Sebastian Keppler Guillaume Duchateau Stefan Skupin Mickael Grech Fabrice Catoire Sebastian Hell Issa Tamer Marco Hornung Marco Hellwing alexander kessler Franck Schorcht Malte Christoph Kaluza GSI Helmholtzzentrum für Schwerionenforschung Planckstr.164291 DarmstadtGermany. Helmholtz Institute Jena Fröbelstieg 307743 JenaGermany. Institute of Optics and Quantum Electronics Friedrich-SchillerUniversität JenaMax-Wien-Platz 107743 JenaGermany. CEA-CESTA 15 Avenue des SablièresCS6000133116 Le BarpCedexFrance Institut Lumière Matière UMR 5306-CNRSUniversitéde Lyon 169622 VilleurbanneFrance. LULI CNRSCEASorbonne UniversitéInstitut Polytechnique de ParisPalaiseauFrance. Universitéde Bordeaux-CNRS-CEA CELIAUMR 5107 TalenceFrance

Understanding the solid target dynamics resulting from the interaction with an ultrashort laser pulse is a challenging fundamental multi-physics problem involving atomic and solid-state physics,plasma physics,and laser *** of the initial interplay of the underlying processes is essential to many applications ranging from lowpower laser regimes like laser-induced ablation to high-power laser regimes like laser-driven ion *** the properties of the so-called pre-plasma formed as the laser pulse’s rising edge ionizes the target is complicated from the theoretical and experimental point of view,and many aspects of this laser-induced transition from solid to overdense plasma over picosecond timescales are still open *** the one hand,laser-driven ion acceleration requires precise control of the pre-plasma because the efficiency of the acceleration process crucially depends on the target properties at the arrival of the relativistic intensity peak of the *** the other hand,efficient laser ablation requires,for example,preventing the so-called“plasma shielding”.By capturing the dynamics of the initial stage of the interaction,we report on a detailed visualization of the pre-plasma formation and ***-thin diamond-like carbon foils are shown to transition from solid to plasma during the laser rising edge with intensities<10^(16)W/cm^(2).Single-shot near-infrared probe transmission measurements evidence sub-picosecond dynamics of an expanding plasma with densities above 10^(23)cm^(−3)(about 100 times the critical plasma density).The complementarity of a solid-state interaction model and kinetic plasma description provides deep insight into the interplay of initial ionization,collisions,and expansion.

关键词： laser acceleration solid

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The all-diode-pumped laser system POLARIS——an experimentalist's tool generating ultra-high contrast pulses with high energy

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High Power Laser Science and Engineering 2014年第3期2卷 5-11页

作者： Marco Hornung Hartmut Liebetrau Andreas Seidel Sebastian Keppler alexander kessler Jrg Krner Marco Hellwing Frank Schorcht Diethard Klpfel Ajay K.Arunachalam Georg A.Becker alexander Svert Jens Polz Joachim Hein Malte C.Kaluza Helmholtz-Institute Jena Germany Institute of Optics and Quantum Electronics JenaGermany

The development,the underlying technology and the current status of the fully diode-pumped solid-state laser system POLARIS is ***,the POLARIS system delivers 4 J energy,144 fs long laser pulses with an ultra-high temporal contrast of 5 × 1012 for the ASE,which is achieved using a so-called double chirped-pulse amplification scheme and cross-polarized wave generation pulse *** tightly focusing,the peak intensity exceeds 3.5 × 1020 W *** parameters predestine POLARIS as a scientific tool well suited for sophisticated experiments,as exemplified by presenting measurements of accelerated proton ***,an additional amplifier has been added to the laser *** the ramp-up phase,pulses from this amplifier are not yet compressed and have not yet reached the anticipated ***,an output energy of 16.6 J has been achieved so far.

关键词： design high power laser laser amplifiers laser plasmas interaction laser systems modelling optimization ultra-intense ultrashort pulse laser interaction with matter

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Microglia:a promising therapeutic target in spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 454-463页

作者： Xiaowei Zha Guoli Zheng Thomas Skutella Karl Kiening Andreas Unterberg alexander Younsi Department of Neurosurgery Heidelberg University HospitalHeidelbergGermany Department of Neuroanatomy Institute for Anatomy and Cell BiologyHeidelberg UniversityHeidelbergGermany

Microglia are present throughout the central nervous system and are vital in neural repair,nutrition,phagocytosis,immunological regulation,and maintaining neuronal *** a healthy spinal cord,microglia are accountable for immune surveillance,however,when a spinal cord injury occurs,the microenvironment drastically changes,leading to glial scars and failed axonal *** this context,microglia vary their gene and protein expression during activation,and proliferation in reaction to the injury,influencing injury responses both favorably and unfavorably.A dynamic and multifaceted injury response is mediated by microglia,which interact directly with neurons,astrocytes,oligodendrocytes,and neural stem/progenitor *** a clear understanding of their essential nature and origin,the mechanisms of action and new functions of microglia in spinal cord injury require extensive *** review summarizes current studies on microglial genesis,physiological function,and pathological state,highlights their crucial roles in spinal cord injury,and proposes microglia as a therapeutic target.

关键词： astrocytes cytokines functional recovery immune regulation M1/M2 activation macrophages microglia neuroinflammation spinal cord injury therapy

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Short-term results of incremental penile girth enhancement using liquid injectable silicone： words of praise for a change

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Asian Journal of Andrology 2007年第3期9卷 408-413页

作者： YacovYacobi alexander Tsivian Roman Grinberg Oded kessler Department of Urologic Surgery E. Wolfson Medical Center Holon 58100 Israel Theomim Clinic Ramat-Gan 52511 Israel

Aim： To report our experience with penile girth augmentation using liquid injectable silicone. Methods： Between August 2003 and July 2006, 324 men （mean age 35 years, range 19-65 years） received a series of liquid silicone subcutaneous injections between the penile skin and the corpora cavernosa on the dorsal and lateral aspects of the penile shaft, under local anesthesia. Digital photographs taken pre- and post-procedure （n = 324）, and penile contour measurements （n = 30） yielded objective results. Subjective results were derived from patient and partner testimony of satisfaction. Follow-up averaged 20 months （range 1-36 months）. Results： Three hundred and twenty-four procedures were primary augmentations. Most men （61%） were married, 7% were accompanied by their partners, and 93% were circumcised. The mean measured penile circumference was 9.5 cm （7.5-11.5 cm） pretreatment and 12.1 cm （10.3-15.3 cm） post-treatment （mean increase of 27% in circumference and 0.84 cm in diameter）. Patient and partner satisfaction was already expressed after the first two treatments. Sexual activity could be resumed after 8 h. Complications （mild bruising） were easily resolved. Conclusion： Penile girth augmentation using liquid injectable silicone yields very satisfactory short-term results with no immediate or short-term complications.

关键词： injectable silicone penile girth augmentation penile contouring

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Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera alexander J.P.Goldschmidt Damien D.Pearse W.Dalton Dietrich Allan D.Levi James D.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

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Gushing metal chain

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Frontiers of Mechanical Engineering 2016年第1期11卷 95-100页

作者： alexander BELYAEV alexander SUKHANOV alexander TSVETKOV Institute of Applied Mathematics and Mechanics Saint-Petersburg Polytechnic University St. Petersburg 195251 Russia

This article addresses the problem in which a chain falls from a glass from some height. This phenomenon demonstrates a paradoxical rise of the chain over the glass. To explain this effect, an initial hypothesis and an appropriate theory are proposed for calculating the steady fall parameters of the chain. For this purpose, the modified Cayley ＇s problem of falling chain given its rise due to the centrifugal force of upward inertia is solved. Results show that the lift caused by an increase in linear density at the part of chain where it is being bent （the upper part） is due to the convergence of the chain balls to one another. The experiments confirm the obtained estimates of the lifting chain.

关键词： chain fountain Meshchersky equation,Cayley's problem

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Computer study of the formation of water-ammonia clusters and their dielectric properties

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Chinese Physics B 2013年第7期22卷 167-172页

作者： alexander Galashev Institute of Industrial Ecology Ural BranchRussian Academy of Sciences

The absorption of one to six ammonia molecules by the （H2O）50 cluster is studied by the molecular dynamics method under near-atmospheric conditions. The capture of NH 3 molecules by a water cluster produces an increase in the integrated intensity of IR absorbance, substantially decreases emission power in the frequency range of 0≤ω≤3500cm-1,and transforms a continuous reflectance spectrum into a banded one. Adsorption of ammonia molecules by water clusters greatly diminishes the number of electrons that are active with respect to electromagnetic radiation. The present results are also compared with the experimental findings wherever available.

关键词： ammonia water cluster infrared absorption spectra molecular dynamics

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Chargino Production via Z^0-Boson Decay in a Strong Electromagnetic Field

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Chinese Physics Letters 2016年第3期33卷 17-19页

作者： alexander Kurilin Moscow Technological Institute on leave from Moscow State Open Pedagogical University

In the framework of MSSM the probability of Z0-boson decay to chaxginos in a strong electromagnetic field, Z X＋X-, is analyzed. The method of calculations employs exact solutions of relativistic wave equations for charginos in a crossed electromagnetic field. Analytic expression for the decay width is obtained at an arbitrary value of the parameter which characterizes the external-field strength Fμv and Z%boson momentum qv. The process Z0→ X＋X- is forbidden in a vacuum for the case of relatively heavy charginos： Mx±mz/2. However, in an intense electromagnetic background this reaction could take place in the region of superstrong fields （x〉1）.

关键词： of on is in Chargino Production via Z~0-Boson Decay in a Strong Electromagnetic Field for

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Use of GIS technology and cellular automata for modeling multiple socio-economic scenarios of regional spatial development and inter-regional cooperation

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Geo-Spatial Information Science 2023年第1期26卷 71-93页

作者： Igor Musikhin alexander Karpik Department of Photogrammetry and Remote Sensing Siberian State University of Geosystems and TechnologiesNovosibirskRussia Department of Space and Physical Geodesy Siberian State University of Geosystems and TechnologiesNovosibirskRussia

The advancement of effective spatial planning to support sustainable development and interregional cooperation has become an issue of serious concern for regional *** planning research helps to identify economic clusters and analyze their changing spatial patterns,which is important for understanding regional economic space dynamics and poten-tial inter-regional *** support decision-makers in the development of efficient plans of spatial development encompassing the identification of the best-suited territories,a combined Geographic Information System(GIS)based approach to interpret qualitatively expressed multiple socio-economic scenarios in quantitative map-based terms of graded suitability,and a formalized approach to the socio-economic evaluation of the territory is *** on GIS technology coupled with integrated cellular automata decision analysis techniques,the study provides a method that performs socio-economic assessment of the study area according to the generated scenarios of regional spatial and socio-economic *** proposed method is applied to Primorsky and Khabarovsk Krais,located in the Russian Far ***-economic scenarios of spatial development initiated by investors and regional authorities were assessed and *** generated socio-economic scenar-ios illustrate how the unified set of spatial and socio-economic variables can be linked and used to gain insights into inter-regional socio-economic and spatial *** application results demonstrate the advantage of the proposed method in identifying the best-suited unit areas for targeted regional development.

关键词： Geographic Information System(GIS) spatial development socioeconomic scenarios interregional cooperation open source software Cellular Automata(CA)

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Volcanic Ash in the Atmosphere and Risks for Civil Aviation:A Study in European Crisis Management

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International Journal of Disaster Risk Science 2013年第1期4卷 9-19页

作者： David alexander Institute for Risk and Disaster Reduction University College London London WC1E 6BT United Kingdom

This paper uses the eruption of the Icelandic volcano Eyjafjallaj?kull in April and May 2010 as a case study of disruption to civil aviation by airborne ash, with emphasis on risk management aspects. Severe curtailment of flights over much of Europe took place during the crisis, which lasted for slightly more than one week. More than 8.5 million passengers were stranded and commerce was profoundly affected. The United Kingdom was one of the worst impacted countries and took the lead in managing the crisis. The paper considers elements of the decision-making process that formed the basis of the UK Government’s emergency response. It examines the relations between science, governance, and economi c imperatives. Physical thresholds guiding decisions to restrict airspace were defined somewhat arbitrarily, which may have increased disruption. A damaging form of risk aversion prevailed at certain points in the crisis. Lack of preexisting procedures and planning meant that the response to dynamically changing meteorological conditions had to be improvised. At the same time, lack of integration between different modes in the European transportation system meant that had the crisis continued any longer there would have been severe problems in moving stranded people and commodities, as well as soaring economic losses. Eruptions similar to or more serious than that of Eyjafjallaj?kull are perfectly possible in Europe in the not-too-distant future.

关键词： Atmosphere aviation meteorological

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