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Role of ablation therapy in conjunction with surgical resection for neuroendocrine tumors involving the liver

World Journal of Gastrointestinal Surgery 2024年第3期16卷 768-776页

作者： alexander Ostapenko Stephanie Stroever Lud Eyasu Minha Kim Krist Aploks Xiang Da Dong Ramanathan Seshadri Department of General Surgery Danbury HospitalDanburyCT 06810United States Department of Research and Innovation Nuvance HealthDanburyCT 06810United States Division of Surgical Oncology/Hepato-Pancreato-Biliary Surgery Danbury HospitalDanburyCT 06810United States

BACKGROUND Resection of hepatic metastasis from neuroendocrine tumors(NETs)improves quality of life and prolongs 5-year *** can be utilized with surgery to achieve complete *** several studies report long-term out-comes for patients undergoing ablation,none have explored perioperative effects of ablation in patients with metastatic *** To determine if intra-operative ablation during hepatectomy increases risk of ad-verse outcomes such as surgical site infections(SSIs),bleeding,and bile *** A retrospective analysis of the hepatectomy National Surgical Quality Impro-vement Program database from 2015-2019 was performed to determine the odds of SSIs,bile leaks,or bleeding in patients undergoing intraoperative ablation when compared to hepatectomy *** Of the 966 patients included in the study,298(30.9%)underwent ablation during *** were 78(11.7%)patients with SSIs in the hepatectomy alone group and 39(13.1%)patients with a SSIs in the hepatectomy with ablation *** leak occurred in 41(6.2%)and 14(4.8%)patients in the two groups,respec-tively;bleeding occurred in 117(17.5%)and 33(11.1%),*** con-trolling for confounding variables,ablation did not increase risk of SSI(P=0.63),bile leak(P=0.34)or bleeding(P=0.07)when compared to patients undergoing resection alone on multivariate *** Intraoperative ablation with hepatic resection for NETs is safe in the perioperative period without significant increased risk of infection,bleeding,or bile *** should utilize this modality when appropriate to a-chieve optimal disease control and outcomes.

关键词： Hepatectomy Neuroendocrine tumor Ablation Bile leaks Bleeding Surgical site infections

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Elucidating elusive quaternary selenide EuCeCuSe3:Synthesis,crystal structure,properties and theoretical studies

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Journal of Rare Earths 2024年第1期42卷 163-171,I0006页

作者： Maxim V.Grigoriev Anna V.Ruseikina Maxim S.Molokeev Vladimir A.Chernyshev Aleksandr S.Aleksandrovsky alexander S.Krylov Svetlana N.Krylova Nikolai P.Shestakov Dmitriy A.Velikanov alexander A.Garmonov Alexey V.Matigorov Evgeny A.Ostapchuk Thomas Schleid Damir A.Safin Laboratory of Theory and Optimization of Chemical and Technological Processes University of TyumenVolodarskogo Str.6625003TyumenRussian Federation Kirensky Institute of Physics Federal Research Center KSC SB RASAkademgorodok 50 Bld.38660036KrasnoyarskRussian Federation Department of Physics Far Eastern State Transport UniversitySerysheva Str.47680021KrasnoyarskRussian Federation Institute of Natural Sciences and Mathematics Ural Federal University Named After the First President of Russia B.N.YeltsinMira Str.19620002EkaterinburgRussian Federation Department of Photonics and Laser Technology Siberian Federal UniversitySvobodnii Ave.79660079KrasnoyarskRussian Federation Institute of Physics and Technology University of TyumenVolodarskogo Str.6625003 TyumenRussian Federation Institute for Inorganic Chemistry University of StuttgartPfaffenwaldring 55D-70569StuttgartGermany Scientific and Educational and Innovation Center for Chemical and Pharmaceutical Technologies Ural Federal University named after the First President of Russia B.N.YeltsinMira Str.19620002 EkaterinburgRussian Federation University of Tyumen Volodarskogo Str.6625003TyumenRussian Federation

We report on the novel heterometallic quaternary selenide EuCeCuSe3,the fabrication of which has been a challenge until this *** structure of the reported selenide was elucidated from the powder X-ray diffraction data,which revealed the formation of EuCeCuSe3with excellent yield(96.7%)accompanied with a minor fraction of CeSe2(3.3%),and was best solved in orthorhombic space group Pnma with the BaLaCuS3structural ***,the crystal structure of the title compound completes the row of the heterometallic quaternary selenides EuRECuSe3(RE=La,Pr,Nd,Sm,Eu,Gd,Tb,Dy,Ho,Er,Tm,Yb,Lu,Y),of which the cerium-based derivative exclusively belongs to the BaLaCuS3structural *** distortion of the CuSe4polyhedron was compared for the whole series of EuRECuSe3compounds using theτ4-descriptor for four coordinated ions,which revealed the highest degree of distortion for the Ce3+-containing selenide,followed by the La3+-based ***,the crystallographic and geometrical parameters of the reported selenide were discussed in comparison to the Ce3+-based sulfides SrCeCuS3and *** initio calculations of the crystal structure,a phonon spectrum and elastic constants for the crystal of EuCeCuSe3were also *** types and wavenumbers of fundame ntal modes were determined and the involvement of ions participating in the phonon modes was *** experimental IR spectrum of the reported selenide was interpreted and found to be in agreement with the calculated *** experimental direct band gap of EuCeCuSe3was measured to be 1.36 eV that is consistent with the concept of its origin due to interband transitions between orbitals emerging mainly from 4f(valence band)and 5d(conduction band)levels of the Eu2+*** dependence of the Young’s modulus on the direction demonstrates the anisotropy of the elastic properties,while the Vickers hardness for EuCeCuSe3was calculated to be 5.2 ***,the title compound is paramagnetic above 4 K.

关键词： Quaternary selenide Synthesis Crystal structure Ab initio calculations Magnetic measurements Spectroscopy

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Stretchable on-skin touchless screen sensor enabled by ionic hydrogel

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Nano Research 2024年第5期17卷 4462-4470页

作者： Tianxing Feng Dan Ling Chaoyue Li Wentao Zheng Shichuan Zhang Chang Li Artem Emel’yanov alexander S.Pozdnyakov Lijun Lu Yanchao Mao Key Laboratory of Materials Physics of Ministry of Education School of Physics and MicroelectronicsZhengzhou UniversityZhengzhou 450001China A.E.Favorsky Irkutsk Institute of Chemistry Siberian Branch of the Russian Academy of SciencesIrkutsk 664033Russian Federation

Screen sensors are the most commonly used human-machine interfaces in our everyday life,which have been extensively applied in personal electronics like *** screen sensors are attracting growing interest due to their distinct advantages of high interaction freedom,comfortability,and hand ***,the material compositions of current touchless screen sensors are rigid and fragile,hardly meeting the needs of wearable and stretchable on-skin electronics ***,these touchless screen sensors are also restricted by high power consumption,limited gesture types of recognition,and the requirement of light ***,we report a stretchable on-skin touchless screen sensor(OTSS)enabled by an ionic hydrogel-based triboelectric nanogenerator(TENG).Compared with current touchless screen sensors,the OTSS is stretchable,self-powered,and competent to recognize diverse gestures by making use of charges naturally carried on fingers without the need of sufficient light *** on-skin noncontact screen operating system is further demonstrated on the basis of the OTSS,which could unlock a cellphone interface in touchless operation mode on the human *** work for the first time introduces the on-skin touchless concept to screen sensors and offers a direction to develop new-generation screen sensors for future cellphones and personal electronics.

关键词： human-machine interface stretchable ionic hydrogel triboelectric nanogenerator self-powered sensor

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Praseodymium metal nanorods as a 5-fluorouracil carrier

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Journal of Rare Earths 2024年第7期42卷 1328-1336,I0005页

作者： Varnitha Manikantan Govindaraj Sri Varalakshmi Ujma Ashapak Tamboli Archana Sumohan Pillai Aleyamma alexander Anushka Lucas Bose Allben Akash Israel V.M.V.Enoch Centre for Nanoscience and Genomics Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia Department of Applied Chemistry Karunya Institute of Technology and Sciences(Deemed University)Coimbatore641114Tamil NaduIndia

Interest in metal nanoparticles as nanoscale drug-carrying vehicles has been *** such an aspect,lanthanide metal nanoparticles are particularly ***,we report praseodymium nanoparticles as a novel anticancer therapeutic transporting *** material was made as a composite with the supramolecular host polymer,poly-β-*** praseodymium nanorods were characterized using standard analytical techniques,including X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),and thermogravimetric analysis(TGA).In addition,they were imaged using transmission electron *** nanostructures are a long rod-shaped material with 2.0±0.1μm in length and 230±10 nm in *** material shows a saturation magnetization value above 30 emu/g with a coercivity value of 130 *** nanocarrier is freighted with the drug 5-fluorouracil,and the encapsulation efficiency is 76.09%.The drug release is continuous from the nanocarrier(polymer-containing praseodymium nanoparticles)and proceeds for above 250 *** in vitro cytotoxicities of the blank nanocarrier and the 5-fluorouracil-loaded one are deduced by testing them on MCF-7 and Vero(non-cancerous)cell *** cytotoxicity on the cancerous cell lines is observed,whereas the non-cancerous cells are *** IC_(50)values on the cell lines are reported.

关键词： Metal nanoparticles Praseodymium Poly-cyclodextrin Drug delivery Anticancer activity Rare earths

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Intelligent Transformation: General Intelligence Theory

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International Journal of Intelligence Science 2024年第3期14卷 59-70页

作者： alexander Ngu Amaya Odilon Kosso Ngu Energy Boston USA Boston University Boston USA IntelligenceDAO Boston USA

This paper aims to formalize a general definition of intelligence beyond human intelligence. We accomplish this by re-imagining the concept of equality as a fundamental abstraction for relation. We discover that the concept of equality = limits the sensitivity of our mathematics to abstract relationships. We propose a new relation principle that does not rely on the concept of equality but is consistent with existing mathematical abstractions. In essence, this paper proposes a conceptual framework for general interaction and argues that this framework is also an abstraction that satisfies the definition of Intelligence. Hence, we define intelligence as a formalization of generality, represented by the abstraction ∆∞Ο, where each symbol represents the concepts infinitesimal, infinite, and finite respectively. In essence, this paper proposes a General Language Model (GLM), where the abstraction ∆∞Ο represents the foundational relationship of the model. This relation is colloquially termed “The theory of everything”.

关键词： Intelligence Generalization Abstraction Transformation General Language Model General Intelligence Theory Theory of Everything

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Inhibition of M2 tumor-associated macrophages polarization by modulating the Wnt/β-catenin pathway as a possible liver cancer therapy method

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World Journal of Gastroenterology 2024年第40期30卷 4399-4403页

作者： Vladislav V Tsukanov Julia L Tonkikh Edward V Kasparov alexander V Vasyutin Clinical Department of the Digestive System Pathology of Adults and Children Federal Research Center“Krasnoyarsk Science Center”of the Siberian Branch of the Russian Academy of SciencesScientific Research Institute of Medical Problems of the NorthKrasnoyarsk 660022Russia

The problem of liver cancer is becoming increasingly important due to the epi-demic of metabolic diseases and persistent high alcohol *** deter-mines great attention to the development and improvement of methods for early diagnosis and treatment of liver *** et al presented a study in the World Journal of Gastroenterology,in which they showed that the use of the traditional Chinese medicine Calculus bovis(CB)can suppress tumor growth in mice by inhibiting M2 tumor-associated macrophages(TAM)through modulating the activity of the Wnt/β-catenin *** interaction of CB components with the Wnt/β-catenin pathway,M2 TAM polarization,and tumor dynamics were studied using network pharmacology,transcriptomics,and molecular *** is now generally accepted that the polarization of TAM and the differentiation of the functions of M1 and M2 phagocytes are of great importance for the progression of *** is assumed that M2 TAM promote proliferation and migration of tumor *** to medicinally influence the Wnt/β-catenin pathway in order to modulate phagocyte polarization now belong to one of the most promising areas of immunotherapy of oncological ***,the work of the Chinese authors deserves attention and further development.

关键词： Liver cancer Treatment Calculus bovis Tumor-associated macrophages M2 tumor Macrophage polarization Wnt/β-catenin pathway

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Determination of Thermal Properties of Unsmooth Si Nanowires

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Chinese Physics Letters 2024年第1期41卷 51-56页

作者：刘世贤 alexander A.Barinov 訚菲 Vladimir I.Khvesyuk Department of Thermophysics Bauman Moscow State Technical UniversityMoscow 105005Russian Federation

We estimate the thermal properties of unsmooth Si nanowires,considering key factors such as size(diameter),surface texture(roughness)and quantum size effects(phonon states)at different *** nanowires with a diameter of less than 20 nm,we highlight the importance of quantum size effects in heat capacity calculations,using dispersion relations derived from the modified frequency equation for the elasticity of a *** thermal conductivities of nanowires with diameters of 37,56,and 115nm are predicted using the Fuchs–Sondheimer model and Soffer’s specular ***,the roughness parameters are chosen to reflect the technological characteristics of the real *** findings reveal that surface texture plays a significant role in thermal conductivity,particularly in the realm of ballistic heat transfer within *** study provides practical recommendations for developing new thermal management materials.

关键词： nanowires roughness size

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A new implementation of FLEXPART with Enviro-HIRLAM meteorological input,and a case study during a heavy air pollution event

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Big Earth Data 2024年第2期8卷 397-434页

作者： Benjamin Foreback alexander Mahura Petri Clusius Carlton Xavier Metin Baykara Putian Zhou Tuomo Nieminen Victoria Sinclair Veli-Matti Kerminen Tom V.Kokkonen Simo Hakala Diego Aliaga Risto Makkonen alexander Baklanov Roman Nuterman Men Xia Chenjie Hua Yongchun Liu Markku Kulmala Pauli Paasonen Michael Boy Aerosol and Haze Laboratory Beijing Advanced Innovation Center for Soft Matter Science and EngineeringBeijing University of Chemical TechnologyBeijingChina Institute for Atmospheric and Earth System Research/Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland Division of Nuclear Physics Department of PhysicsLund UniversityLundSweden Swedish Meteorological and Hydrological Institute(SMHI) Research DepartmentUnit of Meteorology/Environment and ClimateNorrköpingSweden Climate and Marine Sciences Department Eurasia Institute of Earth SciencesIstanbul Technical UniversityIstanbulTurkey Department of Physics Faculty of ScienceUniversity of HelsinkiHelsinkiFinland Department of Meteorology(MISU)and Bolin Centre for Climate Research Stockholm UniversityStockholmSweden Climate System Research Unit Finnish Meteorological InstituteHelsinkiFinland Science and Innovation Department World Meteorological Organization(WMO)GenevaSwitzerland Niels Bohr Institute University of CopenhagenCopenhagenDenmark Joint International Research Laboratory of Atmospheric and Earth System Sciences School of Atmospheric SciencesNanjing UniversityNanjingChina School of Engineering Science Lappeenranta-Lahti University of Technology(LUT)LappeenrantaFinland Atmospheric Modelling Centre Lahti Lahti University CampusLahtiFinland

We integrated Enviro-HIRLAM(Environment-High Resolution Limited Area Model)meteorological output into FLEXPART(FLEXible PARTicle dispersion model).A FLEXPART simulation requires meteorological input from a numerical weather prediction(NWP)*** publicly available version of FLEXPART can utilize either ECMWF(European Centre for Medium-range Weather Forecasts)Integrated Forecast System(IFS)forecast or reanalysis NWP data,or NCEP(*** Center for Environmental Prediction)Global Forecast System(GFS)forecast or reanalysis NWP *** primary benefits of using Enviro-HIRLAM are that it runs at a higher resolution and accounts for aerosol effects in meteorological *** compared backward trajectories gener-ated with FLEXPART using Enviro-HIRLAM(both with and without aerosol effects)to trajectories generated using NCEP GFS and ECMWF IFS meteorological inputs,for a case study of a heavy haze event which occurred in Beijing,China in November *** found that results from FLEXPART were considerably different when using different meteorological *** aerosol effects were included in the NWP,there was a small but noticeable differ-ence in calculated ***,when looking at potential emission sensitivity instead of simply expressing trajectories as lines,additional information,which may have been missed when looking only at trajectories as lines,can be inferred.

关键词： Atmospheric and chemical transport modelling trajectory and particle dispersion modelling severe air pollution episode FLEXPART Enviro-HIRLAM

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Understanding rhabdomyolysis induced acute kidney injury in patients with COVID-19

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World Journal of Virology 2024年第4期13卷 139-142页

作者： alexander Ikanović Karan Varshney School of Medicine Deakin UniversityWaurn PondsVIC 3216Australia School of Public Health and Preventive Medicine Monash UniversityMelbourneVIC 3004Australia

This work comments on an article published in the recent issue of the World Journal of *** is a complex condition with symptoms such as myalgia,changes to urination,and *** the potential for substantial kidney impairment,it has also been shown to be a severe complication of coronavirus disease 2019(COVID-19).To date,various theoretical explanations exist for the development of rhabdomyolysis induced acute kidney injury(RIAKI)in COVID-19 infection,including the accumulation of released striated muscle myoglobin in the urine(myoglobinuria).In their article,they(2024)demonstrate in a retrospective study that RIAKI in COVID-19 patients tended to have elevated levels of C-reactive protein,ferritin,and *** patients also had poorer overall prognoses when compared to COVID-19 patients who have acute kidney injury(AKI)due to other *** is clear from these findings that clinicians must closely monitor and assess for the presence of rhabdomyolysis in COVID-19 patients who have developed ***,additional research is required to further understand the mechanisms behind the development of RIAKI in COVID-19 patients in order to better inform treatment guidelines and protocols.

关键词： COVID-19 Rhabdomyolysis Acute kidney injury Mortality Complication

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Enhancing 3D Reconstruction Accuracy of FIB Tomography Data Using Multi‑voltage Images and Multimodal Machine Learning

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Nanomanufacturing and Metrology 2024年第1期7卷 48-60页

作者： Trushal Sardhara alexander Shkurmanov Yong Li Lukas Riedel Shan Shi Christian J.Cyron Roland C.Aydin Martin Ritter Institute for Continuum and Material Mechanics Hamburg University of TechnologyHamburgGermany Electron Microscopy Unit Hamburg University of TechnologyHamburgGermany Institute of Materials Physics and Technology Hamburg University of TechnologyHamburgGermany Institute of Materials Mechanics Helmholtz-Zentrum HereonGeesthachtGermany Research Group of Integrated Metallic Nanomaterials Systems Hamburg University of TechnologyHamburgGermany Institute of Material Systems Modeling Helmholtz-Zentrum HereonGeesthachtGermany

FIB-SEM tomography is a powerful technique that integrates a focused ion beam(FIB)and a scanning electron microscope(SEM)to capture high-resolution imaging data of *** approach involves collecting in-plane SEM imagesand using FIB to remove material layers for imaging subsequent planes,thereby producing image ***,theseimage stacks in FIB-SEM tomography are subject to the shine-through effect,which makes structures visible from theposterior regions of the current *** artifact introduces an ambiguity between image intensity and structures in thecurrent plane,making conventional segmentation methods such as thresholding or the k-means algorithm *** study,we propose a multimodal machine learning approach that combines intensity information obtained at differentelectron beam accelerating voltages to improve the three-dimensional(3D)reconstruction of *** treatingthe increased shine-through effect at higher accelerating voltages as a form of additional information,the proposed methodsignificantly improves segmentation accuracy and leads to more precise 3D reconstructions for real FIB tomography data.

关键词： Multimodal machine learning Multi-voltage images FIB-SEM Overdeterministic systems 3D reconstruction FIB tomography

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