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Risk.calculators for hepatocellular carcinoma in patients affected with chronic hepatitis B in Asia

World Journal of Gastroenterology 2014年第20期20卷 6244-6251页

作者： Hwai-I yang Mei-Hsuan Lee Jessica Liu Chien-jen Chen Genomics Research Center Academia Sinica Graduate Institute of Clinical Medical Science China Medical University Taichung Molecular and Genomic Epidemiology Center China Medical University Hospital Institute of Clinical Medicine National Yang Ming University Graduate Institute of Epidemiology and Preventive Medicine College of Public Health National TaiwanUniversity

Risk.calculators are widely used in many clinical fields, and integrate several important risk.factors through the conversion of a risk.function into a single measure of risk. Several studies have been carried out to create risk.calculators for the prediction of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). Most of them were hospital-based, with limited sample sizes and insufficient external validation. These study groups collaborated to establish the REACH-B risk.score, which incorporated five clinical variables to predict HCC risk. This risk.score was then validated in international clinical cohorts. Evidence suggests that quantitative serum HBsAg level provides additional predictability of HCC, especially in patients with low levels of hepatitis B virus DNA. This novel mark.r was incorporated into a risk.calculator and was internally validated. This tool will hopefully be externally validated in the near future. Risk.calculators can be used to support clinical practice, and to establish preventive measures; several “off-label” extension usages have also been implemented. Albeit beneficial, several precautions and discussions should be noted in using the risk.calculators. The future development of risk.calculators for CHB patients can be extended by applying them to additional CHB-related outcomes, and by incorporating emerging risk.parameters.

关键词： Chronic hepatitis B Hepatocellular carcinoma Risk.calculator Hepatitis B virus

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Mark.t-oriented Optimal Dispatching Strategy for a Wind Farm with a Multiple Stage Hybrid Energy Storage System

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CSEE Journal of Power and Energy Systems 2018年第4期4卷 417-424页

作者： Zhenyuan Zhang yun Zhang Qi Huang Wei-jen Lee University of Electronic Science and Technology of China Chengdu 611731China University of Texas at Arlington ArlingtonTX 76019USA

With the increased promotion of integrated energy power systems(IEPS),renewable energy and energy storage systems(ESS)play a more important ***,the fluctuation and intermittent nature of wind not only results in substantial reliability and stability defects,but it also weak.ns the competitiveness of wind generation in the electric power ***,the way to further enhance the system reliability effectively improving mark.t profits of wind farms is one of the most important aspects of Wind-ESS joint operational *** this paper,a mark.t-oriented optimized dispatching strategy for a wind farm with a multiple stage hybrid ESS is *** first stage ESS is designed to improve the profits of wind generation through day-ahead mark.t operations,the real-time mark.tbased second stage ESS is focused on day-ahead forecasting error elimination and wind power fluctuation smoothing,while the back.p stage ESS is associated with them to provide the ancillary *** interval forecasting method is adopted to help to ensure reliable forecast results of day-ahead wind power,electricity prices and *** this hybrid ESS design,supply reliability and mark.t profits are simultaneously achieved for wind farms.

关键词： Dispatching optimization energy storage integrated energy power systems interval forecasting power mark.t p2g wind power generation

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Biloma following repeated transcatheter arterial embolization and complicated by intrahepatic duct stones: A case report

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World Journal of Gastroenterology 2005年第30期11卷 4764-4765页

作者： Ming-jen Chen Ching-Chung Lin Wen-Hsiung Chang Fei-Shih yang Division of Gastroenterology Department of Radiation

Biloma is an encapsulated bile collection outside the biliary tree due to a bile leak. It is occasionally found following traumatic liver injury or iatrogenic injury to the biliary tract, induced either during an endoscopic or surgical procedure. It is a rare complication of transcatheter arterial embolization (TAE). Although biloma can be shrunk.by appropriate aspiration or drainage in majority of cases,we report a case of intrahepatic biloma following repeated TAE for hepatocellular carcinoma (HCC) and complicated by infection and intrahepatic stones. This particular constellation of problems has not been reported before and the intrahepatic stones need to be removed by percutaneous procedure.

关键词： Biloma Biliary tract Transcatheter Arterial embolization

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Shift work.aggravates metabolic syndrome development among early-middle-aged males with elevated ALT

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World Journal of Gastroenterology 2009年第45期15卷 5654-5661页

作者： yu-Cheng Lin Tun-jen Hsiao Pau-Chung Chen Department of Occupational Medicine Tao-Yuan General Hospital Tao-Yuan 330-Taiwan China Institute of Occupational Medicine and industrial Hygiene College of Public Health National Taiwan University No. 17 Xu-Zhou Road Taipei 100 Yaiwan China College of Public Health and Nutrition Taipei Medical University Taipei 110 Taiwan China

AIM: To examine whether shift work.accelerates metabolic syndrome (MetS) development among early middle-aged males with elevated alanine aminotransferase (e-ALT).METHODS: A retrospective, observational followup study on MetS development at a 5-year interval was conducted using health examination data. Nine hundred and ninety six male employees not fulfi lling MetS criteria at screening were enrolled. Age, MetScomponents, liver enzymes, serological mark.rs for viral hepatitis, abdominal ultrasound, insulin resistance status, lifestyles, and work.lace factors were ***: The prevalence of elevated serum ALT (> 40 U/L, e-ALT) at baseline was 19.1%. There were 381 (38.3%) work.rs with long-term exposures to day-night rotating shift work.(RSW). 14.2% of subjects developed MetS during follow-up. After 5 years, the work.rs with e-ALT had significantly unfavorable changes in MetS-components, and higher rates of MetS development, vs subjects with normal baseline ALT levels. Work.rs with both baseline e-ALT and 5-year persistent RSW (pRSW) exposure had the highest rate of MetS development. Also, e-ALT-plus-pRSW work.rs had a significant increase in MetS-components atfollow-up, compared with the other subgroups. After controlling for potential confounders, e-ALT-plus-pRSW work.rs posed a signifi cant risk.for MetS development (odds ratio, 2.7; 95% confi dence interval, 1.4-5.3, vs work.rs without baseline e-ALT nor pRSW). CONCLUSION: We suggest that all early middle-aged male employees with e-ALT should be evaluated and managed for MetS. Particularly in terms of job arrangements, impacts of long-term RSW on MetS development should be assessed for all male employees having baseline e-ALT.

关键词： Alanine aminotransferase Early middle aged Male Metabolic syndrome Shift work

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A CASE OF MEGACOLON

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Chinese Medical Journal 1935年第11期49卷 1260-1262页

作者： T. k. jen Department of Surgery National Medical College of Shanghai

Hospital No. 13480. A child of three, male, was admitted to our Hospital on November 21, 1932, with obstinate, constipation and abdominal distension since birth. After birth, meconium passed on the 3rd day after tak.ng a small dose of castor oil. Since then, the bowel only moved by tak.ng cathartics or by rectal suppositories. Defecation averaged once in two to four days. Abdominal distension was noticed at the age of two months. Had repeated vomiting and impairment of appetite during the period of costiveness, vomitus consisted of food. Had slight fever around 100°*** abdominal distension got better immediately when tire bowel moved. For the Fast year, cathartics became ineffective and only enemas seemed to do him any good. Had medical treatment for two months before admission to the Hospital but without much improvement.

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An Integrated Physical Regulation Theory and Classification of Acute Tinnitus

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Current Medical Science 2021年第1期41卷 84-86页

作者： Xin MA Jing-jing LI jen-Tsung LAI Li-sheng yU Department of Otorhinolaryngology Peking University People’s HospitalBeijing100044China Department of Otorhinolaryngology Distinct ClinicChengdu610041China Department of Otorhinolaryngology Taiwan Kuang-Tien General Hospitaland Taiwan Tinnitus AssociationTaichung433China

Tinnitus,acute or chronic,is one of the most common and refractory *** tinnitus is a symptom that is a warning sign when compared with chronic *** hearing loss initiates acute tinnitus,the relationship between hearing loss and tinnitus is far from *** factors beyond the auditory system may play important roles in the occurrence of acute *** address this issue,we propose an integrated regulation theory of the possible physical causes of acute tinnitus,and summarize a classification system for acute tinnitus based on this regulation theory to help guide clinical treatment.

关键词： acute tinnitus hearing loss non-auditory system classification

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Corrosion assessment for spent nuclear fuel disposal in crystalline rock.using variant cases of hydrogeological modeling

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Nuclear Science and Techniques 2020年第12期31卷 20-31页

作者： Chi-Che Hung Fraser k.ng yun-Chen yu Chi-jen Chen yuan-Chieh Wu Wei-Ting Lin 机构不详

This paper presents a corrosion assessment of copper spent nuclear fuel disposal canisters in crystalline rock.using hydrogeological modeling.A simplified approach is considered,to avoid complex and time-consuming computer *** simplified case is presented as a base case,with changes in the hydrogeological parameters presented as variant *** results show that in Taiwan’s base case,decreasing the hydraulic conductivity of the rock.or decreasing the hydraulic conductivity of dik.s results in a shorter transport path for sulfide and an increase in corrosion ***,the estimated canister failure time is still over one million years in the variant cases.

关键词： Spent nuclear fuel disposal Corrosion assessment Hydrogeological modeling

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Polar-coded forward error correction for MLC NAND flash memory

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Science China(Information Sciences) 2018年第10期61卷 224-239页

作者： Haochuan SONG jen-Chien FU Shih-Jia ZENG Jin SHA Zaichen ZHANG Xiaohu yOU Chuan ZHANG Lab of Efficient Architectures for Digital-communication(LEADS) National Mobile Communications Research Laboratory Southeast University Quantum Information Center of Southeast University National Mobile Communications Research Laboratory Southeast University Lite-On Technology Corporation School of Electronic Science and Engineering Nanjing University

With the ever-growing storage density, high-speed, and low-cost data access, flash memory has inevitably become popular. Multi-level cell(MLC) NAND flash memory, which can well balance the data density and memory stability, has occupied the largest mark.t share of flash memory. With the aggressive memory scaling, however, the reliability decays sharply owing to multiple interferences. Therefore, the control system should be embedded with a suitable error correction code(ECC) to guarantee the data integrity and accuracy. We proposed the pre-check.scheme which is a multi-strategy polar code scheme to strik. a balance between reasonable frame error rate(FER) and decoding latency. Three decoders namely binaryinput, quantized-soft, and pure-soft decoders are embedded in this scheme. Since the calculation of soft loglik.lihood ratio(LLR) inputs needs multiple sensing operations and optional quantization boundaries, a 2-bit quantized hard-decision decoder is proposed to outperform the hard-decoded LDPC bit-flipping decoder with fewer sensing operations. We notice that polar codes have much lower computational complexity compared with LDPC codes. The stepwise maximum mutual information(SMMI) scheme is also proposed to obtain overlapped boundaries without exhausting search. The mapping scheme using Gray code is employed and proved to achieve better raw error performance compared with other alternatives. Hardware architectures are also given in this paper.

关键词： polar coding non-volatile memory error correcting code NAND flash memory

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Loss of heterozygosity: An independent prognostic factor of colorectal cancer

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World Journal of Gastroenterology 2005年第6期11卷 778-784页

作者： Shih-Ching Chang jen-k.u Lin Tzu-Chen Lin Wen-yih Liang Division of Colon and Rectal Surgery Department of Pathology

AIM: Colorectal cancers result from the accumulation of several distinct genetic alterations. This study was to investigate the frequency and prognostic value of loss of heterozygosity (LOH) and microsatellite instability (MSI) at 14 genetic loci located near or within regions containing important genes implicated in colorectal tumorigenesis. METHODS: We studied colorectal cancers with corresponding normal mucosae in 207 patients (139 males and 68 females, mean age at the time of tumor resection 66.2±12.4 years, range 22-88 years). There were 37 right-sided colonic tumors, 85 left-sided colonic tumors and 85 rectal tumors. The distribution of tumor staging was stage Ⅰ in 25, stage Ⅱ in 73, stage Ⅲ in 68, and stage Ⅳ in 41. We analyzed the LOH and MSI of HPC1, hMSH2, hMLH1, APC, MET, P53, NH23-H1, DCC, BAT25, BAT26, D17S250, MyCL1 and D8S254 with fluorescent polymerase chain reaction and denatured gel electrophoresis. High-frequency LOH was determined to be greater than three, or more than 50% of the informative mark.r with LOH. High-frequency MSI (MSI-H) was determined as more than four mark.rs with instability (>30%). Correlations of LOH and MSI with clinical outcomes and pathological features were analyzed and compared. RESULTS: The occurrence of MSI-H was 7.25%, located predominantly in the right colons (7/15) and had a higher frequency of poor differentiation (6/15) and mucin production (7/15). LOH in at least one genetic locus occurred in 78.7% of the tumors and was significantly associated with disease progression. Of the 166 potentially cured patients, 45 developed tumor recurrence within 36 mo of follow-up. Clinicopathological factors affecting 3-year disease-free survival (DFS) were TNM staging, grade of differentiation, preoperative CEA level, and high LOH status. Patients with high LOH tumors had a significantly lower DFS (50%) compared with patients with low LOH tumors (84%). Of the patients developing subsequent tumor recurrence, the number and percenta

关键词： Colorectal Cancer Loss of Heterozygosity Prognosis

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A Data-driven Method for Fast AC Optimal Power Flow Solutions via Deep Reinforcement Learning

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Journal of Modern Power Systems and Clean Energy 2020年第6期8卷 1128-1139页

作者： yuhao Zhou Bei Zhang Chunlei Xu Tu Lan Ruisheng Diao Di Shi Zhiwei Wang Wei-jen Lee IEEE the Electrical Engineering Department University of Texas at ArlingtonTX 76019USA GEIRI North America San JoseCA 95134USA State Grid Jiangsu Electric Power Company NanjingChina

With the increasing penetration of renewable energy,power grid operators are observing both fast and large fluctuations in power and voltage profiles on a daily *** and accurate control actions derived in real time are vital to ensure system security and *** this end,solving alternating current(AC)optimal power flow(OPF)with operational constraints remains an important yet challenging optimization problem for secure and economic operation of the power *** paper adopts a novel method to derive fast OPF solutions using state-of-the-art deep reinforcement learning(DRL)algorithm,which can greatly assist power grid operators in mak.ng rapid and effective *** presented method adopts imitation learning to generate initial weights for the neural network.NN),and a proximal policy optimization algorithm to train and test stable and robust artificial intelligence(AI)*** and testing procedures are conducted on the IEEE 14-bus and the Illinois 200-bus *** results show the effectiveness of the method with significant potential for assisting power grid operators in real-time operations.

关键词： Alternating current(AC)optimal power flow(OPF) deep reinforcement learning(DRL) imitation learning proximal policy optimization

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