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Development of efficient and accurate sk.letal mechanisms for hydrocarbon fuels and k.rosene surrogate

Acta Mechanica Sinica 2015年第5期31卷 732-740页

作者： Fengquan Zhong Sugang Ma Xinyu Zhang Chih-jen Sung k.le E.Niemeyer State k.y Laboratory of High Temperature Gas Dynamics Institute of MechanicsChinese Academy of Sciences Department of Mechanical Engineering University of Connecticut School of Mechanical Industrialand Manufacturing EngineeringOregon State University

In this paper,the methodology of the directed relation graph with error propagation and sensitivity analysis（DRGEPSA）,proposed by Niemeyer et al.（Combust Flame 157：1760-1770.2010）.and its differences to the original directed relation graph method are *** DRGEPSA,the detailed mechanism of ethylene containing 71 species and 395 reaction steps is reduced to several sk.letal mechanisms with different error *** 25-species and 131-step mechanism and the 24-species and115-step mechanism are found to be accurate for the predictions of ignition delay time and laminar flame *** further reduction leads to a smaller sk.letal mechanism with 19 species and 68 steps,it is no longer able to represent the correct reaction *** the DRGEPSA method,a detailed mechanism for n-dodecane considering low-temperature chemistry and containing 2115 species and8157 steps is reduced to a much smaller mechanism with249 species and 910 steps while retaining good *** considering only high-temperature（higher than 1000 k.applications,the detailed mechanism can be simplified to even smaller mechanisms with 65 species and 340 steps or48 species and 220 ***,a detailed mechanism for a k.rosene surrogate having 207 species and 1592 steps is reduced with various error thresholds and the results show that the 72-species and 429-step mechanism and the66-species and 392-step mechanism are capable of predicting correct combustion properties compared to those of the detailed *** is well recognized that k.netic mechanisms can be effectively used in computations only after they are reduced to an acceptable size level for computation capacity and at the same time retaining ***,the sk.letal mechanisms generated from the present work.are expected to be useful for the application of k.netic mechanisms of hydrocarbons to numerical simulations of turbulent or supersonic combustion.

关键词： Reduced chemistry Hydrocarbons Directed relation graph Ignition delay time

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Effects of forward mask.ng on the responses of the inferior collicular neurons in the big brown bats, Eptesicus fuscus

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Chinese Science Bulletin 2003年第16期48卷 1748-1752页

作者： LUANRuihong WUFeijian P.H.S.jen SUNXinde CollegeofLifeSciences EastChinaNormalUniversityShanghai200062China CollegeofLifeSciences CentralChinaNormalUniversityWuhan430079China DivisionofBiologicalSciences UMCMO65211USA

The present study explores the forward mask.ing of the two-tone stimuli in sequence that evok.d responses in the inferior colliculus (IC) of the echolocating bats. The results indicate that forward mask.ng is obvious in the acoustic responses of the IC neurons to the two-tone stimuli. Meanwhile the intensity sensitivity of the neurons respond-ing to the probe increases with the inter-tone interval de-creasing. The effects of forward mask.ng are correlated with the relative intensity and the interval between the mask.r and probe. That is, the effects of forward mask.ng are re-duced with the mask.r intensity decreasing and enhanced with the probe intensity decreasing and the inter-tone inter-val shortened. The present study suggests that there is a cor-relation between the characteristics of the response to the probe and the dynamic conditions of the postsynaptic cur-rents in the IC neurons.

关键词：神经元回音声音间隔声音探测器前掩蔽 IC 回声定位生理学多突触传递

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Simultaneous bilateral floating k.ee:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10172-10179页

作者： Chi-Ming Wu Hung-En Liao Shou-jen Lan Department of Orthopaedic Jen-Ai HospitalTaichung 42481Taiwan Department of Orthopaedic National Defense Medical CenterTaipei 11490Taiwan Department of Healthcare Administration Asia UniversityTaichung 41354Taiwan Department of Medical Research China Medical University HospitalChina Medical UniversityTaichung 40402Taiwan School of Medical Science Putian UniversityPutian 351100Fujian ProvinceChina

BACk.ROUND The phrase “floating k.ee is a flail k.ee joint,” referring to ipsilateral femoral and tibial fractures,was first used by Blak. and Mc Bryde in *** condition is often caused by a high-energy trauma with often extensive injury to the soft tissues,and is accompanied by life-threatening systemic complications,including head,chest or abdominal injuries and a high incidence of fat *** k.ee is a severe and uncommon injury *** SUMMARy A 27-year-old man sustained multiple injuries when the electric motorcycle he was riding was hit by a *** injuries included traumatic hypovolemic shock.comminuted and open type II fractures of the left femoral shaft,fracture of the right femoral shaft,comminuted fracture of the bilateral tibial and fibular shaft,and multiple lacerations and abrasions on his forehead,lower lip,neck.and *** diagnosis was simultaneous bilateral floating k.ee complicated with soft tissue *** emergency treatment and the exclusion of life-threating complications,open reduction and internal fixation were successfully performed using plates and screws in the bilateral femoral and tibial *** Simultaneous bilateral floating k.ee is a rare and severe injury *** treatment is challenging,and *** present a case report of a young adult who suffered from bilateral floating k.ees during road traffic *** also offer our treatment experience of this complex injury and review past literature.

关键词： Floating k.ee Femoral and tibial fractures High-energy trauma Life-threatening complications Fat embolism syndrome Case report

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miR-222 targets ACOX1, promotes triglyceride accumulation in hepatocytes

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 360-365页

作者： Jing-Jie Wang yi-Tong Zhang yu jen Tseng Jun Zhang Department of Digestive Diseases Huashan Hospital Fudan University

Back.round:Non-alcoholic fatty liver disease(NAFLD)is one of the most prevalent chronic liver ***,the exact pathogenesis of NAFLD remains to be *** the association with tumors and cardiovascular diseases,the role of miR-222 in NAFLD remains *** present study was to investigate the role of miR-222 in ***:Wild-type C57BL/6 mice were fed a high-fat diet for 12 week. to induce *** human liver cell line(L02)was cultured with free fatty acid(FFA)-containing medium to stimulate cell *** mRNA levels of miR-222 and acyl Coenzyme A xidase 1(ACOX1)were detected by quantitative-PCR(Q-PCR).The prediction of ACOX1 as the target gene for miR-222 was conducted via *** overexpression or inhibition of miR-222 was mediated by miR-222 mimics or antagomir,and intracellular triglyceride levels were measured using a triglyceride *** reporter assays verified ACOX1 as the target gene for ***:miR-222 was significantly elevated in both the in vivo and in vitro NAFLD *** of miR-222 significantly increased triglyceride content in the L02 cells,while inhibition of miR-222 expression restricted the accumulation of *** of miR-222 significantly inhibited ACOX1 *** transfection assays verified that ACOX1 3-UTR luciferase reporter activity could be inhibited by miR-222 ***:The present study suggested that miR-222 promotes the accumulation of triglycerides by inhibiting ACOX1.

关键词： ACOX1 Hepatocyte steatosis miR-222 NAFLD β-hydroxybutyrate

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Entrepreneurship and Growth in Emerging Mini-dragon Economies： A South-East Asia Perspective

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Chinese Business Review 2013年第1期12卷 48-61页

作者： alex Maritz Viet Le Simon Masli Anton de Waal Bert Verhoeven Shieh, Chich jen Swinbume University of Technology Melbourne Australia Chang Jung University Tainan Taiwan

Entrepreneurship and growth are driving forces in the development of emerging economic systems. In this exploratory study we discuss emerging economies within a South-East Asia context. In particular, we expand on a previous study on the East Asian Tiger economies, and introduce the mini-dragon economies of Indonesia, Malaysia, Thailand, and Philippines. We explore the role of various economic indicators and indices entrepreneurship and SMEs as drivers of growth in these emerging economies. Growth factors unique to the region are also identified, and institutional and government interventions are recommended. Furthermore, we elaborate on the interdependence of the entire region on each of the mini-dragon economies. Since we have highlighted only a few of the emerging economies in the region, opportunities exist to expand the base for further study

关键词： entrepreneurship growth SMEs mini-dragon economies

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CO_2 sequestration utilizing basic-oxygen furnace slag:Controlling factors,reaction mechanisms and V–Cr concerns

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Journal of Environmental Sciences 2016年第3期28卷 99-111页

作者： Tung-Hsin Su Huai-jen yang yen-Hong Shau Eiichi Tak.zawa yu-Chen Lee Department of Earth Sciences National Cheng-Kung UniversityTainan 70101Taiwan Department of Marine Biotechnology and Resources National Sun Yat-Sen UniversityKaohsiung 80424Taiwan Department of Geology Niigata University8050Ikarashi 2-no-choNishi-kuNiigata 950-2182Japan China Steel Corporation 1Chung-Kang Rd.Kaohsiung 81233Taiwan

Basic-oxygen furnace slag（BOF-slag） contains 〉35%CaO,a potential component for CO_*** this study,slag-water-CO_2 reaction experiments were conducted with the longest reaction duration extending to 96 hr under high CO_2 pressures of 100-300 k./cm2 to optimize BOF-slag carbonation conditions,to address carbonation mechanisms,and to evaluate the extents of V and Cr release from slag *** slag carbonation degree generally reached the maximum values after 24 hr slag-water-CO_2 reaction and was controlled by slag particle size and reaction *** maximum carbonation degree of 71%was produced from the experiment using fine slag of〈0.5 mm under 100℃and a CO_2 pressure of 250 k./cm^2 with a water/slag ratio of *** release from the slag to water was significantly enhanced（generally 〉2 orders） by slag *** contrast,slag carbonation did not promote chromium release until the reaction duration exceeded 24 ***,the water chromium content was generally at least an order lower than the vanadium concentration,which decreased when the reaction duration exceeded 24 ***,long reaction durations of 48-96 hr are proposed to reduce environmental impacts while k.eping high carbonation *** textures and water compositions indicated that Mg-wustite,in addition to CaO-containing minerals,can also be ***,the conventional expression that only considered carbonation of the CaO-containing minerals undervalued the CO_2 sequestration capability of the BOF-slag by^20%.Therefore,the BOF-slag is a better CO_2 storage medium than that previously recognized.

关键词： Mineral CO_2 sequestration BOF-slag Carbonation

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Chest pain in a heart transplant recipient:A case report

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World Journal of Clinical Cases 2021年第16期9卷 3966-3970页

作者： yu-jen Chen Chien-Sung Tsai Tsai-Wang Huang Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Cardiovascular Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 11490Taiwan

BACk.ROUND Heart transplantation is recommended for the treatment of patients with refractory heart *** pain after heart transplantation is usually considered noncardiac owing to the denervated ***,data from case reports on tacrolimus-induced achalasia after heart transplantation are *** aimed to present a case of tacrolimus-induced achalasia that developed after heart tran-splantation,which was successfully relieved by laparoscopic Heller *** SUMMARy A 67-year-old man with a history of Type 2 diabetes mellitus,hyperlipidemia,and dilated cardiomyopathy had congestive heart failure following orthotopic heart transplantation with tacrolimus treatment 12 years *** the 10-year follow-up after the heart transplantation,the patient presented with persistent cough,dysphagia,heartburn,and retrosternal chest pain lasting for 2 *** endoscopy revealed no specific *** years later,the patient experienced the same symptoms,including chest pain lasting for 4 *** and manometry confirmed the presence of *** reports showed that discontinuing calcineurin inhibitor(CNI)treatment and endoscopic botulinum toxin injection could treat CNI-induced *** to the risk.of rejection of the transplanted heart and considering the temporary benefits of botulinum toxin injection in achalasia,the patient underwent laparoscopic Heller *** was relieved without *** months later,he had no signs of recurrence of the *** In transplant patients with chest pain and gastrointestinal symptoms, CNIinducedachalasia may be one of the differential diagnoses. Esophagogram/manometry is useful for diagnosis.

关键词： Heart transplantation Refractory heart failure Chest pain Achalasia Esophagogram Case report

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Application of Proteomics in the Study of Tumor Metastasis

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Genomics, Proteomics & Bioinformatics 2004年第3期2卷 152-166页

作者： Zhen Cai jen-Fu Chiu Qing-yu He Department of Surgery The University of Hong KongHong KongChina Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis The University of Hong KongHong KongChina Institute of Molecular Biology The University of Hong KongHong KongChina Department of Chemistry The University of Hong KongHong KongChina

Tumor metastasis is the dominant cause of death in cancer patients. However, the molecular and cellular mechanisms underlying tumor metastasis are still elusive. The identi?cation of protein molecules with their expressions correlated to the metastatic process would help to understand the metastatic mechanisms and thus facilitate the development of strategies for the therapeutic interventions and clini- cal management of cancer. Proteomics is a systematic research approach aiming to provide the global characterization of protein expression and function under given conditions. Proteomic technology has been widely used in biomark.r discovery and pathogenetic studies including tumor metastasis. This article provides a brief review of the application of proteomics in identifying molecular factors in tumor metastasis process. The combination of proteomics with other experimental ap- proaches in biochemistry, cell biology, molecular genetics and chemistry, together with the development of new technologies and improvements in existing method- ologies will continue to extend its application in studying cancer metastasis.

关键词： proteomics metastasis tumor mechanism protein identification MALDI-TOF SELDI-ProteinChip

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Polymorphisms of uridine-diphosphoglucuronosyltransferase 1A7 gene in Taiwan Chinese

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World Journal of Gastroenterology 2005年第6期11卷 797-802页

作者： May.jen Huang Sien-Sing yang Min-Shung Lin Ching-Shan Huang Department of Laboratory Medicine Department of Liver Unit Department of Family Medicine School of Medicine and Health Sciences

AIM: Single nucleotide polymorphisms (SNPs) of uridinediphosphoglucuro -nosyltransferase 1A7 (UGT1A7) gene are associated with the development of orolaryngeal cancer, hepatocellular carcinoma, and colorectal cancer. We performed this research to establish the techniques for determining UGT1A7 gene and basic data of this gene for Taiwan Chinese. METHODS: We collected blood samples from 112 healthy adults and 505 subjects carrying different genotypes of UGT1A1, and determined the promoter area and the entire sequence of UGT1A7 exon 1 by polymerase chain reaction. We designed appropriate primers and restriction enzymes to detect variant UGT1A7 genotypes found in the study subjects. RESULTS: Six SNPs at nucleotides 33, 387, 391, 392, 622, and 756 within the coding region of UGT1A7 exon 1 were found. The incidence of UGT1A7*l/*2 (N129R131W208/ k.29k.31W208) was predominant (35.7%) while that of UGT1A7 *3/*3 (k.29k.31R208/k.29k.31R208) was the least (2.7%). The allele frequency of UGT1A7*3, which exists in a considerable proportion of Caucasians (0.361) and Japanese (0.255), was identified only to be 0.152 in our study subjects. A novel variation at nucleotide -57 in the upstream was found, which was associated with SNPs at nucleotides 33, 387, 391, 392, and 622 in one of the variant haplotypes. The nucleotide changes at positions 387, 391, 392 and 756 were in link.ge in another variant haplotype. The allele frequency of UGT1A7*3 was 0.018, 0.158, 0.242, 0.433, and 0.920 in subjects carrying wild, A(TA)6TAA/A(TA)7TAA, A(TA)7TAA/A(TA)7TAA, 211G/211A, and 211A/211A variants of UGT1A1 gene, respectively. By using natural or mutagenesis primers, we successfully detected the variations at nucleotides -57, 33, 387, and 622 with the restriction enzymes HpyCH4 Ⅳ, TaqⅠ, AflⅡ, and Rsa Ⅰ, respectively. CONCLUSION: The results indicate that the allele frequencies of UGT1A7 gene in Taiwan Chinese are different from those in Caucasians and Japanese. Carriage of the nucleotide 211- vari

关键词： UGT1A7 gene Single nudeotide polymorphisms Genotype Taiwan Chinese

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Inflation and Economic Growth in China:An Empirical Analysis

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China & World Economy 2011年第5期19卷 67-84页

作者： jen- Te Hwang Ming-Jia Wu Department of Bank.ng and Finance Kainan University Taoyuan Taiwan Department of Economics National Chengchi University Taipei Taiwan

Using official provincial data for gross provincial product, consumer price index and other explanatory variables from 1986 to 2006, the present paper investigates the nonlinear effects of inflation on economic growth in China. The main finding of the study is that the inflation threshold effect is highly significant and robust in China. Above the 2.50percent threshold, every 1-percentage point increase in the inflation rate impedes economic growth by O. 61percent; below this threshold, every 1-percentage point increase in the inflation rate stimulates growth by 0.53 percent. This indicates that high inflation harms economic growth, whereas moderate inflation benefits growth. We suggest that China should maintain a moderate inflation rate for long-run growth.

关键词： China growth inflation nonlinearity threshold effect

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