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镫骨赝附体与砧骨长脚之间连接状态对声音传导的影响

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中国耳鼻咽喉头颈外科 2006年第4期13卷 227-231页

作者：马芙蓉 alex huber Thomas Linder Heidi Felix Anita Pollak 北京大学第三医院耳鼻咽喉科北京100083 瑞士苏黎世大学医院耳鼻咽喉头颈外科

目的探讨镫骨赝附体与砧骨长脚间连接程度对声音传导的影响,为镫骨手术寻找理论依据和更好的指导临床工作。方法17例新鲜尸体颞骨标本,在不同强度的机械刺激下,采用激光多普勒振动仪研究镫骨赝附体与砧骨长脚间不同的连接程度对声音传... 详细信息

目的探讨镫骨赝附体与砧骨长脚间连接程度对声音传导的影响,为镫骨手术寻找理论依据和更好的指导临床工作。方法17例新鲜尸体颞骨标本,在不同强度的机械刺激下,采用激光多普勒振动仪研究镫骨赝附体与砧骨长脚间不同的连接程度对声音传导的影响。结果将镫骨赝附体与砧骨长脚的连接程度,由三位医师分别对内镜和扫描电镜在颞骨标本中采集的镫骨赝附体与砧骨长脚之间连接的图像进行评分,分为紧密连接、松弛连接和未连接,三位医师的评分结果基本一致。分别对上述三种连接程度,在500mV、800mV和1200mV的机械刺激下,用激光多普勒振动仪测试砧骨长脚侧与镫骨赝附体间的振动差距,经过专门的计算机软件处理,换算为声刺激模式,发现紧密连接时,声音的传导在此连接上损失2dB,小于砧镫关节生理性的声损失3dB,松弛连接和未连接对声音的传导在此连接上的损失很大,高达28dB不等,平均为10dB。结论镫骨手术时镫骨赝附体与砧骨长脚连接紧密,声传导损失接近砧镫关节的生理性声传导损失。

关键词：镫骨假体和植入体颞骨

新鲜颞骨模型建立在中耳传声机制研究中的作用

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中国耳鼻咽喉头颈外科 2005年第6期12卷 359-361页

作者：马芙蓉 Thomas Linder alex huber Heidi Felix Anita Pollak 北京大学第三医院耳鼻咽喉科北京100083 瑞士苏黎世大学医院耳鼻咽喉头颈外科

目的探讨中耳传声机制研究中的中耳模型建立,为深入研究中耳传声机制,指导耳外科手术,尤其在听骨链重建方面建立一个接近活体情况的研究模型。方法采用17例新鲜尸体颞骨标本,利用激光多普勒振动仪,在声刺激和不同强度的机械刺激下,研究... 详细信息

目的探讨中耳传声机制研究中的中耳模型建立,为深入研究中耳传声机制,指导耳外科手术,尤其在听骨链重建方面建立一个接近活体情况的研究模型。方法采用17例新鲜尸体颞骨标本,利用激光多普勒振动仪,在声刺激和不同强度的机械刺激下,研究了鼓膜和镫骨底板的运动。结果鼓膜和镫骨底板的运动与活体测量的数据接近。结论新鲜颞骨标本可以用于不同方面中耳传声机制的研究。在鼓膜脐部的电机械刺激可以模仿声刺激。

关键词：机制研究中耳颞骨机械刺激耳外科手术听骨链重建激光多普勒研究模型新鲜尸体不同强度活体测量骨标本声刺激振动仪鼓膜运动镫骨

Conics on Barth-Bauer octics

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Science China Mathematics 2024年第7期67卷 1507-1524页

作者： alex Degtyarev Department of Mathematics Bilkent UniversityAnkara06800Turkey

We analyze the configurations of conics and lines on a special class of Kummer octic surfaces. In particular, we bound the number of conics by 176 and show that there is a unique surface with 176 conics, all irreducible: it admits a faithful action of one of the Mukai groups. Therefore, we also discuss conics and lines on Mukai surfaces: we discover a double plane(ramified at a smooth sextic curve) that contains 8,910 smooth conics.

关键词： K3-surface octic surface Kummer surface conic Mukai group

In situ characterization of particle formation in spray flame synthesis using wide-angle light scattering

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Particuology 2024年第3期86卷 304-312页

作者： Simon Aβmann Franz J.T.huber Stefan Will Lehrstuhl für Technische Thermodynamik(LTT) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91058Germany Erlangen Graduate Schoolin Advanced Optical Technologies(SAOT) Friedrich-Alexander-Universitat Erlangen-Nurnberg(FAU)Erlangen91052Germany Competence Unit Engineering of Advanced Materials(EAM) Friedrich-Alexander-Universitat Erlangen-Nürnberg(FAU)Erlangen91052Germany

Wide-angle light scattering(WALS)was used for in situ measurements of droplet and nanoparticle size distributions during the synthesis of titania and iron oxide particles from liquid precursor solutions in the standardized SpraySyn burner for spray flame *** was synthesized from titanium tetraisopropoxide(TTIP)and iron oxide from iron(II)nitrate nonahydrate(INN)using ethanol(EtOH)as *** images were taken at heights up to 120 mm above the burner surface and classified into droplet and particle *** size distributions were derived from a sequential analysis of scattering data containing the oscillating Mie pattern,the lognormal size distribution parameters for spherical and fractal particle fractions from a multivariate approach on averaged particle scattering *** results show that the precursor addition leads to altered evaporation behavior and even droplet disruption probably induced by puffing or micro-explosions compared to pure *** the case of TTIP(a hygroscopic alkoxide),the synthesis of a large fraction of spheres was observed,while the nitrate INN leads to the formation of mostly fractal aggregates.

关键词： Spray flame synthesis Metal oxide particles Elastic light scattering Droplet size distribution Nanoparticle morphology Particle size distribution

Methyltransferase-like 3(METTL3)inhibition potentiates anti-tumor immunity:a novel strategy for improving anti-PD1 therapy

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Signal Transduction and Targeted Therapy 2024年第1期9卷 10-11页

作者： Anna Brichkina Roman Suezov Magdalena huber Institute of Systems Immunology Member of the German Center for Lung Research(DZL)Philipps University of Marburg35043 MarburgGermany

In a recent article published in Cancer Discovery,Guirguis et *** that enzymatic inhibitors of the m6 A methyltransferase METTL3 induced a formation of immunostimulatory doublestranded mRNAs(dsRNAs)in cancer cells,which triggered a profound tumor-cell-intrinsic interferon response leading to an enhanced antigen presentation and thereby increased killing of tumor cells by cytotoxic CD8+*** inhibition of METTL3 synergized with anti-PD1 immunotherapy,highlighting its potential for improving cancer treatment.

关键词： PD1 immunity

Developing the new soil science——Advice for early-career soil scientists

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Pedosphere 2024年第1期34卷 3-4页

作者： alex McBRATNEY Sydney Institute of Agriculture&School of Life and Environmental Sciences The University of SydneySydney NSW 2006Australia

Confucius said,“To know what you know and what you do not know, that is true knowledge.”Hartemink (2006) edited a prescient book on the future of soil science, the contents of which are worthy of consideration today. Since then, there has been a growing emphasis on soil carbon, soil health, and soil security, as well as increased capability of technology related to machine leaning and soil sensing and *** KNOWLEDGE DISCOVERY CATEGORISATION Based on the above ancient aphorism attributed to Confucius, the author writing in Hartemink (2006) classified soil knowledge and knowledge discovery into 4 categories. An updated version is given in Fig. 1.

关键词： soil measurement. leaning

Pathogenic and therapeutic role of exosomes in neurodegenerative disorders

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Neural Regeneration Research 2024年第1期19卷 75-79页

作者： Christa C.huber Hongmin Wang Division of Basic Biomedical Sciences Sanford School of MedicineUniversity of South DakotaVermillionSDUSA

Neurodegenerative disorders affect millions of people worldwide,and the prevalence of these disorders is only projected to rise as the number of people over 65 will drastically increase in the coming *** therapies exist to aid in symptomatic relief,effective treatments that can stop or reve rse the progress of each neurodegenerative disease are ***,research on the role of extracellular vesicles as disease markers and therapeutics has been intensively ***,30-150 nm in diameter,are one type of extracellular vesicles facilitating cell-to-cell *** are thought to play a role in disease propagation in a variety of neurodegenerative diseases,such as Alzheimer's disease,Parkinson s disease,and amyotrophic lateral ***,the exosomes derived from the patients are an invaluable source of disease *** the other hand,exosomes,especially those derived from stem cells,could serve as a therapeutic for these disorders,as seen by a rapid increase in clinical trials investigating the therapeutic efficacy of exosomes in different neurological *** review summarizes the pathological burden and therapeutic approach of exosomes in neurodegenerative *** also highlight how heat shock increases the yield of exosomes while still maintaining their therapeutic ***,this review concludes with outstanding questions that remain to be addressed in exosomal research.

关键词： aging Alzheimer's disease biomarker drug exosome extracellular vesicle neurodegenerative disease Parkinson's disease therapy

Blast waveform tailoring using controlled venting in blast simulators and shock tubes

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Defence Technology（防务技术） 2024年第7期37卷 14-26页

作者： Edward Chern Jinn Gan alex Remennikov David Ritzel Faculty of Engineering and Information Sciences University of WollongongWollongongNSW2522Australia Dyn-FX Consulting Ltd 19 Laird Ave NorthAmherstburgONN9V 2T5Canada

A critical challenge of any blast simulation facility is in producing the widest possible pressure-impulse range for matching against equivalent high-explosive *** tubes and blast simulators are often constrained with the lack of effective ways to control blast wave profiles and as a result have a limited performance *** wave shaping techniques employed in some facilities are reviewed but often necessitate extensive geometric modifications,inadvertently cause flow anomalies,and/or are only applicable under very specific *** paper investigates controlled venting as an expedient way for waveforms to be tuned without requiring extensive modifications to the driver or existing geometry and could be widely applied by existing and future blast simulation and shock tube *** use of controlled venting is demonstrated experimentally using the Advanced Blast Simulator(shock tube)at the Australian National Facility of Physical Blast Simulation and via numerical flow simulations with Computational Fluid *** venting is determined as an effective method for mitigating the impact of re-reflected waves within the blast *** control method also allows for the adjustment of parameters such as tuning the peak overpressure,the positive phase duration,and modifying the magnitude of the negative phase and the secondary shock of the blast *** paper is concluded with an illustration of the potential expanded performance range of the Australian blast simulation facility when controlled venting for blast waveform tailoring as presented in this paper is applied.

关键词： Advanced blast simulator Shock wave propagation Far-field explosion Blast loads Blast waves Computational fluid dynamics

No evidence of predator odor avoidance in a North American bird community

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Avian Research 2024年第1期15卷 133-138页

作者： Austin Dotta Batur Yaman alex Van Huynh Department of Biology DeSales University2755 Station AvenueCenter ValleyPAUSA

Recent advances in our understanding of avian chemical communication have highlighted the importance of olfaction in many aspects of avian *** studies investigating predator avoidance behaviors in response to predator odor cues have produced mixed results across species and *** we assess if a community of birds in eastern Pennsylvania displays avoidance behaviors towards predator odor cues in a natural foraging *** use clay caterpillars to measure foraging activity by birds in the presence of predator(bobcat)urine,non-predator(rabbit)urine,and water controls in two different environmental contexts(field ***).Although we detected a weak trend for birds to forage less at predator urine-treated sites,we found no significant difference in avian foraging between the site *** did find that foraging rates between environmental contexts changed significantly over the course of the experiment,with forest sites showing decreasing foraging rates and field sites showing increasing foraging *** results reinforce the published literature that avoidance of predator odors by birds may not be ubiquitous across contexts and species.

关键词： Foraging Odor Olfaction Predation Predator-avoidance