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Multifaceted superoxide dismutase 1 expression in amyotrophic lateral sclerosis patients:a rare occurrence?

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Neural Regeneration Research 2025年第1期20卷 130-138页

作者： Ilaria Martinelli Jessica Mandrioli Andrea Ghezzi Elisabetta zucchi Giulia Gianferrari Cecilia Simonini Francesco Cavallieri Franco Valzania Department of Neurosciences Azienda Ospedaliero Universitaria di ModenaModenaItaly Clinical and Experimental Medicine Ph.D.Program University of Modena and Reggio EmiliaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Neurology Unit Neuromotor&Rehabilitation DepartmentAzienda USL-IRCCS di Reggio EmiliaReggio EmiliaItaly

Amyotrophic lateral sclerosis(ALS)is a neuromuscular condition resulting from the progressive degeneration of motor neurons in the cortex,brainstem,and spinal *** the typical clinical phenotype of ALS involves both upper and lower motor neurons,human and animal studies over the years have highlighted the potential spread to other motor and non-motor regions,expanding the phenotype of *** superoxide dismutase 1(SOD1)mutations represent a minority of ALS cases,the SOD1 gene remains a milestone in ALS research as it represents the first genetic target for personalized *** numerous single case reports or case series exhibiting extramotor symptoms in patients with ALS mutations in SOD1(SOD1-ALS),no studies have comprehensively explored the full spectrum of extramotor neurological manifestations in this *** this narrative review,we analyze and discuss the available literature on extrapyramidal and non-motor features during *** multifaceted expression of SOD1 could deepen our understanding of the pathogenic mechanisms,pointing towards a multidisciplinary approach for affected patients in light of new therapeutic strategies for SOD1-ALS.

关键词： amyotrophic lateral sclerosis(ALS) autonomic extramotor genotype-phenotype multisystem involvement Parkinson’s disease sensory SOD1 superoxide dismutase 1 urinary vocal cord palsy

Identification of Soybean Genes Involved in Circadian Clock Mechanism and Photoperiodic Control of Flowering Time by In Silico Analyses

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Journal of Integrative Plant Biology 2007年第11期49卷 1640-1653页

作者： VeraQuecini MariaI.zucchi JoséBaldin NatalA.Vello InstitutoAgron mico de Campinas Centro de Pesquisa e Desenvolvimento de Recursos GenéticosCampinasSP 13075-630Brazil Departamento de Genética ESALQUniversidade de Sāo PauloPiracicabaSP 13400-970Brazil

Glycine max is a photoperiodic short-day plant and the practical consequence of the response is latitude and sowing period limitations to commercial crops. Genetic and physiological studies using the model plants Arabidopsis thaliana and rice （Oryza sativa） have uncovered several genes and genetic pathways controlling the process, however information about the corresponding pathways in legumes is scarce. Data mining prediction methodologies, including multiple sequence alignment, phylogeneUc analysis, bioinformaUcs expression and sequence motif pattern identification, were used to identify soybean genes involved in day length perception and photoperiodic flowering induction. We have investigated approximately 330 000 sequences from open-access databases and have identified all bona fide central oscillator genes and circadian photoreceptors from A. thaliana in soybean sequence databases. We propose a working model for the photoperiodic control of flowering time in G. max, based on the identified key components. These results demonstrate the power of comparative genomics between model systems and crop species to elucidate the several aspects of plant physiology and metabolism.

关键词： circadian clock cryptochrome data mining flowering photoperiod phytochrome.

The landscape of cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis

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Neural Regeneration Research 2023年第7期18卷 1427-1433页

作者： Ilaria Martinelli Elisabetta zucchi Cecilia Simonini Giulia Gianferrari Giovanna Zamboni Marcello Pinti Jessica Mandrioli Clinical and Experimental Medicine PhD Program University of Modena and Reggio EmiliaModenaItaly Department of Neurosciences Azienda Ospedaliero-Universitaria di ModenaModenaItaly Department of Biomedical Metabolic and Neural SciencesUniversity of Modena and Reggio EmiliaModenaItaly Department of Life Sciences University of Modena and Reggio EmiliaModenaItaly

Although mutations in the superoxide dismutase 1 gene account for only a minority of total amyotrophic lateral sclerosis cases,the discovery of this gene has been crucial for amyotrophic lateral sclerosis *** the identification of superoxide dismutase 1 in 1993,the field of amyotrophic lateral sclerosis genetics has considerably widened,improving our understanding of the diverse pathogenic basis of amyotrophic lateral *** this review,we focus on cognitive impairment in superoxide dismutase 1-amyotrophic lateral sclerosis *** has mostly reported that cognition remains intact in superoxide dismutase 1-amyotrophic lateral sclerosis patients,but recent reports highlight frontal lobe function frailty in patients carrying different superoxide dismutase 1-amyotrophic lateral sclerosis *** thoroughly reviewed all the various mutations reported in the literature to contribute to a comprehensive database of superoxide dismutase 1-amyotrophic lateral sclerosis genotype-phenotype *** a resource could ultimately improve our mechanistic understanding of amyotrophic lateral sclerosis,enabling a more robust assessment of how the amyotrophic lateral sclerosis phenotype responds to different variants across genes,which is important for the therapeutic strategy targeting genetic *** in superoxide dismutase 1-amyotrophic lateral sclerosis deserves further longitudinal research since this peculiar frailty in patients with similar mutations can be conditioned by external factors,including environment and other unidentified agents including modifier genes.

关键词： amyotrophic lateral sclerosis cognitive impairment genotype-phenotype correlation superoxide dismutase 1

Corporoplasty with small soft axial prostheses （VIRILIS ） and bovine pericardial graft （HYDRIX） in Peyronie＇s disease

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Asian Journal of Andrology 2013年第2期15卷 275-279,I0009页

作者： Alessandro zucchi Mauro Silvani Stefano Pecoraro Department of Urology and Andrology University of Perugia 06100 Perugia Italy Department of Urology Ospedale Degli Infermi Biella Italy private Clinic Malzoni Urologic Section Avellino Italy

The surgical techniques used by Austoni and Egydio in the treatment of Peyronie＇s disease are based on geometric principles. The aim of this paper is to report our multicentric experience and technical changes to Austoni＇s original technique, focusing on several tips and tricks to make this technique easy to perform, even by less experienced practitioners. We performed operations in three different Italian institutions. We implanted a small soft Virilis I~ axial prostheses （Ф 7 Fr.）, using a bovine pericardium collagen matrix patch （Hydrix） to cover the defect in the tunica albuginea. Sixty patients with a mean age of 58 years （range 44-76 years） underwent surgery between September 2005 and January 2010. After surgery, mean lengthening of the shaft was 2 cm （range 1.2-2.3 cm） with complete correction of penile recurvatum. Thirty-nine patients resumed sexual activity 60 days later, 14 after 90 days and 7 after 120 days. The international index of erectile function （IIEF） score was 15.5 before surgery and it improved to 23 at 12 and 24 months after surgery. Furthermore, the visual analogue scale （VAS） showed good results in terms of the recovery of natural sexual intercourse （over 80% of couples） and of the original length and girth of the penis. The soft implant we used takes advantage of erection that occurs spontaneously, using the residual erection of the spared cavernous tissue. The method is easy to learn and reproducible, and the use of pericardium speeds up the operation, while also covering large defects of the tunica albuginea that result from complex recurvatum.

关键词： implants penis pericardial graft Peyronie's disease prostheses

CONTRIBUTO ALLA CONOSCENZA DELLA FLORA BRESCIANA Ⅰ.Flora vascolare della valle del fiume Oglio nell'Orceano

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Natural Disaster Reduction in China 1978年第1期 139-168页

作者： COSTANZA zucchi

INTRODUZIONEIl presente catalogo riguarda principalmente il tratto planiziale allasinistra del fiume *** tratto è denominato *** a diredi *** comune della bassa bresciana confinante con la pro-vincia di *** maggior parte dell’Orceano è occupato dai campicoltivati,che spesso si spingono fino al fiume,tultavia alcune parti sonoancora relativamente intatle:la presente indagine si è concentrata sulla fa-

关键词： Miller 一弓 110 Flora vascolare della valle del fiume Oglio nell’Orceano CONTRIBUTO ALLA CONOSCENZA DELLA FLORA BRESCIANA 李一 Ca

Pelvic muscle floor rehabilitation as a therapeutic option in lifelong premature ejaculation： long-term outcomes

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Asian Journal of Andrology 2018年第6期20卷 572-575页

作者： Antonio Luigi Pastore Giovanni Palleschi Andrea Fuschi Yazan AI Salhi Alessandro zucchi Giorgio Bozzini Ester IUiano Elisabetta Costantini Antonio Carbone Uroiogy Unit Department of Medico-Surgical Sciences and Biotechnologies ICOT Faculty of Pharmacy and Medicine 'Sapienza' University of Rome Latina (LT) 04100 Italy Uroresearch Nonprofit Association for Research in Urology Latina 04100 Italy Department of Urology and Andrology University of Perugia Perugia 05156 Italy Department of Urology MATER DOMINI Humanitas Castellanza (VA) 21053 Italy

The aim of the study was to evaluate the long-term outcomes of pelvic floor muscle （PFM） rehabilitation in males with lifelong premature ejaculation （PE）, using intravaginal ejaculatory latency time （IELT） and the self-report Premature Ejaculation Diagnostic Tool （PEDT） as primary outcomes. A total of 154 participants were retrospectively reviewed in this study, with 122 completing the training protocol. At baseline, all participants had an IELT 〈60 s and PEDT score 〉11. Participants completed a 12-week program of PFM rehabilitation, including physio-kinesiotherapy treatment, electrostimulation, and biofeedback, with three sessions per week, with 20 min for each component completed at each session. The effectiveness of intervention was evaluated by comparing the change in the geometric mean of IELT and PEDT values, from baseline, at 3, 6, and 12 months during the intervention, and at 24 and 36 months postintervention, using a paired sample 2-tailed t-test, including the associated 95% confidence intervals. Of the 122 participants who completed PFM rehabilitation, 111 gained control of their ejaculation reflex, with a mean IELT of 161.6 s and PEDT score of 2.3 at the 12-week endpoint of the intervention, representing an increase from baseline of 40.4 s and 17.0 scores, respectively, for IELT and PEDT （P 〈 0.0001）. Of the 95 participants who completed the 36-month follow-up, 64% and 56% maintained satisfactory eiaculation control at 24 and 36 months oostintervention, respectively.

关键词： biofeedback electrostimulation intravaginal ejaculatory latency time pelvic floor rehabilitation premature ejaculation premature ejaculation diagnostic tool

Long-term results of the surgical treatment of Peyronie＇s disease with Egydio＇s technique： a European multicentre study

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Asian Journal of Andrology 2011年第6期13卷 842-845页

作者： Salvatore Sansalone Giulio Garaffa Rados Djinovic Stefano Pecoraro Mauro Silvani Guido Barbagli Alessandro zucchi Giuseppe Vespasiani Carla Loreto Department of Urology School of Medicine Tor Vergata University of Rome Rome 00133 italy St Peter＇s Andrology University College London Hospitals London WIG 6BJ UK Department of Urology School of Medicine Serbian Academy of Science and Arts University of Belgrade Belgrade 11000 Serbia Department of Nephro-Urology Malzoni Medical Center Avellino Avellino 83100 Italy Department of Urology General Hospital Biella 13900 Italy Center for Reconstructive Urethral Surgery Arezzo 52100 Italy Department of Urology and Andrology University of Perugia Perugia 06123 Italy Department of Bio-Medical Sciences Anatomy Section University of Catania Catania 95100 Italy

The long-term outcomes of 157 patients affected by Peyronie＇s disease （PD） who underwent penile straightening with Egydio＇s technique between January 2004 and December 2008 are reported. Only patients with PD who were stable for at least 6-12 months prior to surgery were enrolled in this study. Preoperative assessment included a dynamic echo colour Doppler ultrasound scan to evaluate the degree of penile deformity and the peak systolic velocity in the cavernosal arteries and an assessment of erectile function with the administration of the International Index of Erectile Function 5 （IIEF-5） questionnaire. Stretched penile length was recorded pre- and postoperatively. Surgical complications, cosmesis and sexual function, patient satisfaction and postoperative erectile function were assessed postoperatively at 3 months, I year and 2 years, respectively. After a median follow-up period of 20 months （range： 12-24 months）, we found that mild residual curvature （12%） and glans hypoesthesia （3%） were the only causes of partial dissatisfaction. No rejection of the graft was observed. All patients recovered their ability to penetrate with no difficulty. In addition, an intraoperative average increase of 2.5 cm （range： 1.7-4.1 cm） in stretched penile length was recorded, with all patients engaging in penetrative sexual intercourse. In conclusion, this procedure represents a safe and reproducible technique for the correction of penile curvature resulting from PD and yields excellent cosmetic and functional results.

关键词： Egydio's technique erectile dysfunction graft Peyronie's disease

Araucaria angustifolia Aboveground Roots Presented High Arbuscular Mycorrhizal Fungal Colonization and Diversity in the Brazilian Atlantic Forest

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Pedosphere 2016年第4期26卷 561-566页

作者： Milene MOREIRA Maria I. zucchi Jose E. GOMES Siu M. TSAI Alessandro ALVES-PEREIRA Elke J. B. N. CARDOSO Sao Paulo State Agency for Agribusiness Technology CP 28 Piracicaba 13400-970 Center for Nuclear Energy in Agriculture University of Sao Paulo Piracieaba 13416-000 Genetics Department Luiz de Queiroz College of Agriculture University of Sao Paulo Piraeieaba 13418-900 Soil Science Department Luiz de Queiroz College of Agriculture University of Sao Paulo Piracicaba 13418-900

30 different arbuscular mycorrhizal fungi （AMF） species, distributed in different genera such as Glomus, Acaulospora, Scutellospora, Entrophospora, Ambisporu, Kuklospora, Gigaspora, and Archeospora, have been identified in the root zone of Araucaria angustifolia, known as Brazil Pine. During our AMF survey in this ecosystem, our attention was called to the presence of many superficially growing Araucaria roots. Our hypothesis was that these roots were colonized with AMF because of the presence of AMF spores in organic material aboveground. Samples of these superficial roots and the organic substrate they were growing on were evaluated for their mycorrhizal status. DNA was extracted from the AMF-colonized superficial roots and submitted to polymerase chain reaction （PCR） amplification using the NS31-AM1 primer pair, followed by cloning and sequencing. We found that the root colonization percentages were between 31% and 52%, and the number of AMF spores in the substrate ranged from 27 to 164 spores per 50 g dry substrate. The phylogenetic analyses and tree construction using maximum parsimony （MP） and neighbor-joining （N J） methods identified 13 different species of the phylum Glomeromycota belonging to the genera Glomus, Funneliformis, Rhizophagus, Gigaspora, Acaulospora, and Archaeospora, and five isolates were identified only at the genus level. To our knowledge, this is the first report on Araucaria angustifolia with roots growing aboveground, producing runner roots that develop on dead tree trunks and organic material. The higher colonization of the aboveground roots than those commonly found in belowground Araucaria roots suggests that they may present active metabolic uptake of nutrients.

关键词： AMF spores fungal taxonomy mycorrhizal status nutrient uptake organic substrate root colonization superficial roots

古尔德卡海岛的琼汉斯原工业区改造,威尼斯,意大利

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世界建筑 2005年第9期 42-45页

作者： CZA Cino zucchi Architetti (Milan) CZA契诺.祖奇建筑事务所米兰

古尔德卡岛的城市布局有两种不同的尺度:岛的北边楼房林立,而另一边的工业区则远眺拉古纳海滩,且布局松散.这项工程口袋是在原工业区上进行的一种'微观手术',放弃规模较大的改造(刷新旧建筑和新建建筑),而采取了对原有建筑及空地的小规... 详细信息

古尔德卡岛的城市布局有两种不同的尺度:岛的北边楼房林立,而另一边的工业区则远眺拉古纳海滩,且布局松散.这项工程口袋是在原工业区上进行的一种'微观手术',放弃规模较大的改造(刷新旧建筑和新建建筑),而采取了对原有建筑及空地的小规模的修缮.

关键词：工业区改造古尔德威尼斯意大利海岛城市布局新旧建筑小规模海滩楼房