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Brain-derived neurotrophic factor rs6265(Val66Met)single nucleotide polymorphism as a master modifier of human pathophysiology

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Neural Regeneration Research 2023年第1期18卷 102-106页

作者： Van Thuan Nguyen Braxton Hill Naiya sims Aaron Heck Marcus Negron Claire lusk Cristi lGalindo Department of Biology Western Kentucky UniversityBowling GreenKYUSA

Brain-derived neurotrophic factor is the most prevalent member of the nerve growth factor *** its discovery in 1978,this enigmatic molecule has spawned more than 27,000 publications,most of which are focused on neurological ***-derived neurotrophic factor is indispensable during embryogenesis and postnatally for the normal development and function of both the central and peripheral nervous *** is becoming increasingly clear,however,that brain-derived neurotrophic factor likewise plays crucial roles in a variety of other biological functions independently of sympathetic or parasympathetic ***-derived neurotrophic factor is also increasingly recognized as a sophisticated environmental sensor and master coordinator of whole organismal *** that point,we recently found that a common nonsynonymous(Val66→Met)single nucleotide polymorphism in the brain-derived neurotrophic factor gene(rs6265)not only substantially alters basal cardiac transcriptomics in mice but subtly influences heart gene expression and function differentially in males and *** addition to a short description of recent results from associative neuropsychiatric studies,this review provides an eclectic assortment of research reports that support a modulatory role for rs6265 including and beyond the central nervous system.

关键词： brain-derived neurotrophic factor neuropsychiatric disorders rs6265 Val66Met

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亚洲H5N1型禽流感暴发的回顾与反思

中国家禽 2007年第11期29卷 41-46页

作者： l.D.sims 吕玲

亚洲暴发的H5N1型禽流感疫情带给我们很多教训和启示。对发生疫情的国家来说,疫苗接种是一种行之有效的防控措施,但单纯使用疫苗却无法将H5N1从一个国家根除,但是疫苗接种能够显著地降低家禽对病毒的易感性并能减缓病毒扩散的速度。同时... 详细信息

亚洲暴发的H5N1型禽流感疫情带给我们很多教训和启示。对发生疫情的国家来说,疫苗接种是一种行之有效的防控措施,但单纯使用疫苗却无法将H5N1从一个国家根除,但是疫苗接种能够显著地降低家禽对病毒的易感性并能减缓病毒扩散的速度。同时,在疫区采取大规模扑杀的措施也能降低当地家禽发生病毒感染的程度。然而,对于有疫情发生的国家来说,当疫情得到控制之后,在疫区恢复饲养的家禽对H5N1病毒易感性较高,致使该地区很可能再次暴发新的疫情。因此,在H5N1禽流感的防控工作中除了做到扑杀和疫苗接种之外,还必须同时辅助采取其它措施以达到预期的防控效果。由于家鸭和大规模的活禽市场中的家禽可以感染禽流感病毒而不易被察觉,因此它们成为特定地区持续发生H5N1感染的重要原因。在与H5N1病毒的斗争中,各个国家都必须广泛交流并制定出符合各自国情的最佳防控措施。对于疫情监测数据,包括感染和发病信息在内都必须共享。各项防控措施在实施之前必须通过社会经济学和生态学评估,这一点对于贫穷的农村地区尤为重要。

关键词： H5N1型禽流感疫情亚洲疫苗接种病毒感染防控措施易感性家禽

Does orthotics use improve comfort,speed,and injury rate during running?A randomised control trial

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World Journal of Orthopedics 2023年第5期14卷 348-361页

作者： Alice E Fortune Jonathan M G sims George Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi Ltd.SouthportPR83NSUnited Kingdom School of Medicine University of LiverpoolLiverpool L693GEMerseysideUnited Kingdom

BACKGROUND Running is a hugely popular ***,running-related injury(RRI)rates are high,particularly amongst amateur and recreational *** ways to reduce RRI rates and maximise comfort and performance for runners is *** regarding whether orthotics can successfully improve these parameters is limited and *** research is required to provide runners with clearer guidance on the usefulness of *** To investigate the effect of Aetrex Orthotics on comfort,speed and RRI rates during recreational *** One hundred and six recreational runners were recruited on a voluntary basis via running clubs and social media pages and randomised into either the intervention or control *** in the intervention group ran with Aetrex l700 Speed Orthotics inserted in their usual running shoes,whilst participants in the control group ran in their usual running shoes with no *** study ran for an 8-wk *** provided data relating to running comfort,distance,and time during weeks *** provided data relating to any RRIs they sustained during all 8 *** distance and time were used to calculate running speed in miles per hour(mph).For each outcome variable,95%confidence intervals and P values were calculated to assess the statistical significance between the *** comfort and speed data,univariate multi-level analysis was performed,and for outcome variables with significant between group differences,multi-level multivariate analysis was performed to evaluate any confounding effects of gender and *** Ninety-four participants were included in the final analysis(drop-out rate=11%).Comfort and speed from 940 runs and 978 injury data reports were *** who ran with orthotics reported,on average,speeds 0.30 mph faster(P=0.20)and comfort scores 1.27 points higher(P≤0.001)than participants who ran with no *** were also 2.22 times less

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

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SWEATERS

小学生时代（大嘴英语） 2023年第11期 18-20页

作者： JUlIE ANN IVERSON BlANCHE l.sims(图) 不详

I pull down a box from my high closet *** a chair, I can reach it myself. I blow off the dust that fell for a year and get out my sweaters—Autumn is here!

关键词： shelf ERS and

Does orthotics use improve comfort,speed and injury rate during running?Preliminary analysis of a randomised control trial

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World Journal of Orthopedics 2022年第7期13卷 652-661页

作者： Alice E Fortune Jonathan M G sims Samantha J Rhodes George Ampat School of Medicine University of LiverpoolLiverpool L693GEUnited Kingdom Research Unit Talita Cumi LtdSouthport PR83NSUnited Kingdom

BACKGROUND Evidence regarding the effectiveness of using orthotics in improving comfort,increasing running speed and helping to reduce injury rate during running is limited and *** the increasing popularity of running is the increasing rate of running-related injuries(RRIs).Further research into whether orthotics could be used to help reduce RRIs would be highly beneficial for those ***,there is a need to clarify whether orthotics use increases comfort during running and helps improve running *** To investigate whether running with Aetrex Orthotics improves comfort and performance and reduces injury whilst *** Runners were recruited on a voluntary basis if they were 18 or older with no serious health conditions,ongoing foot pain or deformity,previous foot surgery in their lifetime or any surgery in the past 6 *** were randomly assigned to either an intervention group or a control *** participants were asked to complete runs and provide quantitative data regarding comfort during running,running time and distance,and any RRIs over an 8-wk study *** in the intervention group ran with Aetrex l700 Speed Orthotics,whilst participants in the control group ran without *** than the addition of orthotics for participants in the intervention group,all participants were asked to run as they usually *** report presents preliminary data from the first 47 participants recruited for this *** speed was calculated from running distance and time and given in miles per *** each outcome variable,the mean for each group,effect size and 95%confidence interval were calculated,and a t-test was performed to determine if between-group differences were statistically *** Data for all three primary outcomes was provided from a total of 254 runs by the 23 participants in the intervention group and a total of 289 runs by the 24 participants in the control ***

关键词： Running Foot orthoses Running related injuries Pain Patient comfort Athletic performance

基于跨模态注意力和门控单元融合网络的多模态情感分析方法

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数据分析与知识发现 2024年第7期8卷 67-76页

作者：陈岩松张乐张雷瀚吕学强北京信息科技大学网络文化与数字传播北京市重点实验室北京100101 北京信息科技大学计算机学院北京100101 北京邮电大学经济管理学院北京100876

【目的】针对当前多模态情感分析中模态融合与交互不充分、多模态特征提取不完全的问题,提出一种基于跨模态注意力和门控单元融合网络的多模态情感分析方法。【方法】在多模态特征提取方面,增加视频模态中人物微笑程度特征和人物头部姿... 详细信息

【目的】针对当前多模态情感分析中模态融合与交互不充分、多模态特征提取不完全的问题,提出一种基于跨模态注意力和门控单元融合网络的多模态情感分析方法。【方法】在多模态特征提取方面,增加视频模态中人物微笑程度特征和人物头部姿势特征,丰富了多模态数据的底层特征;在模态融合方面,利用跨模态注意力机制使模态内部以及模态之间的信息进行更充分的交互,利用门控单元融合网络去除冗余信息,并通过自注意力机制分配注意力权重;最后,通过全连接层输出最终情感分类结果。【结果】在中文公开数据集CH-sims上与先进的Self-MM模型进行对比,实验结果表明,本文提出的方法在二分类准确率、三分类准确率和F1值上分别提升2.22、2.04和1.49个百分点。【局限】视频中人物的肢体动作在不断变化,不同的肢体动作蕴含不同的情感信息,模型没有考虑到人物在视频中的肢体动作信息。【结论】本文丰富了多模态数据的底层特征,有效实现模态融合,提升了情感分析的效果。

关键词：多模态情感分析注意力机制门控机制特征融合

Use of orthotics with orthotic sandals versus the sole use of orthotics for plantar fasciitis:Randomised controlled trial

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世界骨科杂志:英文版 2023年第9期14卷 707-719页

作者： Portia Amoako-Tawiah Holly love Jaida Chacko Madathilethu Jessica laCourse Alice E Fortune Jonathan M G sims George Ampat School of Medicine University of LiverpoolMerseysideLiverpool L693GEUnited Kingdom Urology Royal Stoke University HospitalStaffordshireStoke ST46QGUnited Kingdom Research Unit Talita Cumi Ltd.MerseysideSouthport PR83NSUnited Kingdom

BACKGROUND Plantar fasciitis(PF)affects around 10%of the *** orthotics with arch support has been shown to provide symptom relief in PF by decreasing the repetitive stress sustained by the plantar ***,prefabricated orthotics are only effective when shoes are worn,meaning the foot may be left unsupported when it is impractical to wear *** orthotic sandals in conjunction with prefabricated orthotics may increase PF symptom relief,as they can be worn inside the home,extending the period in which the foot is *** To compare the combined use of prefabricated orthotics and orthotic sandals vs the sole use of prefabricated orthotics in the treatment of *** 98 participants with PF were randomised into two *** intervention group received the Aetrex l420 Compete orthotics and the Aetrex l3000 Maui Flips(orthotic sandals),whilst the control group received the Aetrex l420 Compete orthotics *** pain was assessed both by the numerical rating scale(NRS)and the pain sub-scale of the foot health status questionnaire(FHSQ).Foot functionality was measured using the function sub-scale of the *** change was measured using the global rating of change scale(GROC).RESUlTS Foot pain scores measured both by NRS and FHSQ pain sub-scale showed statistically significant reductions in foot pain in both groups(Plso reported statistically significant improvements(Ple and improvement of symptoms as measured by the GROC ***-group analysis showed that the intervention group with the combined use of orthotics and orthotic sandals scored better on all four outcome measures as compared to the control group with the sole use of ***,the between-group analysis only reached statistical significance on the NRS pain score(PlUSION Combined use of prefabricated orthotics and orthotic sandals provides a greater d

关键词： Plantar fasciitis Foot diseases Musculoskeletal pain Foot orthoses

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施肥法对白肋烟生长、产量及化学成分的影响

中国烟草科学 1986年第3期 42-44页

作者： J.l.sims 黄培昌

化肥的带状施放或撒施对大多数主要作物及其营养元素的影响,已有广泛的研究。一般,接近种子或植株带施磷钾肥可比其他施肥方法获得较高的产量,并能获得较大的肥效。但接近种子大量施肥,尤其是氮钾肥常对幼苗产生伤害作用。这是由于可溶... 详细信息

化肥的带状施放或撒施对大多数主要作物及其营养元素的影响,已有广泛的研究。一般,接近种子或植株带施磷钾肥可比其他施肥方法获得较高的产量,并能获得较大的肥效。但接近种子大量施肥,尤其是氮钾肥常对幼苗产生伤害作用。这是由于可溶性盐分含量高或受氨及亚硝酸盐的毒害所致。早在1936年即有在烟行边作带状施肥促进烟叶生长的报道。在烟行下带状施肥,存活的

关键词：白肋烟偏回归系数 pH 小区烟叶产量烟株土壤电导率施肥法带状施肥行内

樓蘭所出未釋早期粟特文古信札(斯坦因收集品l.M.Ⅱ.ii.09)

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中古中国研究 2020年第1期3卷 21-35页

作者： Nicholas sims-Williams SOAS University of london

在斯坦因收集品中,有一件編號爲l.M.Ⅱ.ii.09(現編號爲Or.8212/1823)的粟特文文書,這件文書是斯坦因在樓蘭遺址西南50公里處的一個古代垃圾堆中發現的,由於破損嚴重,迄今爲止還未得到釋讀。通過將其與早期粟特陶器和石刻銘文進行對比,... 详细信息

在斯坦因收集品中,有一件編號爲l.M.Ⅱ.ii.09(現編號爲Or.8212/1823)的粟特文文書,這件文書是斯坦因在樓蘭遺址西南50公里處的一個古代垃圾堆中發現的,由於破損嚴重,迄今爲止還未得到釋讀。通過將其與早期粟特陶器和石刻銘文進行對比,可以對這件文書的内容進行釋讀。與著名的粟特文古信札一樣,這件文書也出現了"匈奴"一詞,據此可以將文書的年代確定在公元4世紀,即粟特文古信札的年代。在粟特文古信札中,l1和l3號文書是一位被丈夫抛棄的婦女Miwnay寫給母親和丈夫的信。無獨有偶,l.M.Ⅱ.ii.09文書也是一封妻子Mayavanuk寫給丈夫的信,像Miwnay一樣,Mayavanuk也抱怨丈夫不給她回信。這件文書的發現地點位於樓蘭,雖然發現地可能是收信人的住址,但根據文書第16—18行提到的Mayavanuk不確定是否有機會寄出這封信,發現信的地方也有可能是寫信的地方。無論是哪一種情況,都可以説明在4世紀的樓蘭有粟特人活動,這正好可以與樓蘭發現的漢文文書中提到的"粟特胡"對應,而且也能説明當時的樓蘭地區還未完全干涸。

关键词：斯坦因信札粟特人文書收信人粟特文