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World Journal of Gastroenterology 2012年第43期18卷 6206-6215页

作者： Gianluca Ianiro Giovanni Cammarota luca Valerio Brigida Eleonora Annicchiarico alessandro Milani Massimo Siciliano Antonio Gasbarrini Gastroenterology Unit A. Gemelli University Hospital Catholic University of Sacred Heart 00168 Rome Italy Institute of Public Health A. Gemelli University Hospital Catholic University of Sacred Heart 00168 Rome Italy

Microscopic colitis may be defined as a clinical syndrome, of unknown etiology, consisting of chronic watery diarrhea, with no alterations in the large bowel at the endoscopic and radiologic evaluation. Therefore, a definitive diagnosis is only possible by histological analysis. The epidemiological impact of this disease has become increasingly clear in the last years, with most data coming from Western countries. Microscopic colitis includes two histological subtypes [collagenous colitis (CC) and lymphocytic colitis (LC)] with no differences in clinical presentation and management. Collagenous colitis is characterized by a thickening of the subepithelial collagen layer that is absent in LC. The main feature of LC is an increase of the density of intra-epithelial lymphocytes in the surface epithelium. A number of pathogenetic theories have been proposed over the years, involving the role of luminal agents, autoimmunity, eosinophils, genetics (human leukocyte antigen), biliary acids, infections, alterations of pericryptal fibroblasts, and drug intake; drugs like ticlopidine, carbamazepine or ranitidine are especially associated with the development of LC, while CC is more frequently linked to cimetidine, non-steroidal antiinflammatory drugs and lansoprazole. Microscopic colitis typically presents as chronic or intermittent watery diarrhea, that may be accompanied by symptoms such as abdominal pain, weight loss and incontinence. Recent evidence has added new pharmacological options for the treatment of microscopic colitis:the role of steroidal therapy, especially oral budesonide, has gained relevance, as well as immunosuppressive agents such as azathioprine and 6-mercaptopurine. The use of anti-tumor necrosis factoragents, infliximab and adalimumab, constitutes a new, interesting tool for the treatment of microscopic colitis, but larger, adequately designed studies are needed to confirm existing data.

关键词： Microscopic colitis Lymphocytic colitis Collagenous colitis Watery diarrhea Immunosuppressive agents Anti-tumor necrosis factoragentsThe requested resource could not be loaded. libcurl returned the error:

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Helicobacter pylori-negative Russell body gastritis:Case report

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World Journal of Gastroenterology 2011年第9期17卷 1234-1236页

作者： alessandro Del Gobbo luca Elli Paola Braidotti Franca Di Nuovo Silvano Bosari Solange Romagnoli Department of Medicine Surgery and DentistryDivision of PathologyA.O.San Paolo and Fondazione IRCCS Cà-Granda Ospedale Maggiore PoliclinicoUniversity of Milan Medical School Center for Prevention and Diagnosis of Celiac Disease Fondazione IRCCS Cà-Granda Ospedale Maggiore PoliclinicoUniversity of Milan Pathology Unit A.O.G.Salvini20024 Garbagnate MilaneseItaly

Russell body gastritis is an unusual form of chronic gastritis characterized by the permeation of lamina propria by numerous plasma cells with eosinophilic cytoplasmic *** few cases have been reported in the literature;the majority of which have shown Helicobacter Pylori(***)infection,thus suggesting a correlation between plasma cell presence and antigenic stimulation by *** present a case of Russell body gastritis in a 78-year-old woman who was undergoing esophagogastroduodenoscopy for epigastric *** biopsy of the gastroesophageal junction showed the presence of cells with periodic acid-Schiff-positive hyaline pink *** staining for *** infection was nega-tive,as well as immunohistochemical *** cells with eosinophilic inclusions stained positive for CD138,CD79a,andκand lambda light chains,which confirmed plasma cell *** particular,κand lambda light chains showed a polyclonal origin and the patient was negative for immunological *** histological observations were confirmed by ultrastructural *** cases reported in the literature associated with *** infection have shown regression of plasma cells after eradication of *** is known about the progression of ***-negative *** unusual morphological appearance of this type of chronic gastritis should not be misinterpreted during routine examination,and it should be distinguished from other common forms of chronic *** is mandatory to exclude neoplastic diseases such as gastric carcinoma, lymphoma and plasmocytoma by immunohistochemistry and electron microscopy,which can help with differential *** long-term effects of plasma cells hyperactivation are still unknown,because cases of gastric tumor that originated in patients affected by Russell body gastritis have not been described in the *** are of the opinion that these patients should be scheduled for endoscopic surveillance.

关键词： Russell body Gastritis Helicobacter Pylori Plasma cells Crystalline inclusions

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Dynamical learning of a photonics quantum-state engineering process

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Advanced Photonics 2021年第6期3卷 48-58页

作者： Alessia Suprano Danilo Zia Emanuele Polino Taira Giordani luca Innocenti alessandro Ferraro Mauro Paternostro Nicolo Spagnolo Fabio Sciarrino Sapienza Universitàdi Roma Dipartimento di FisicaRomaItaly Palacky University Department of OpticsOlomoucCzech Republic Queen’s University Belfast School of Mathematics and PhysicsCentre for Theoretical AtomicMolecularand Optical PhysicsBelfastUnited Kingdom Universita degli Studi di Palermo Dipartimento di Fisica e Chimica-Emilio SegrePalermoItaly

Experimental engineering of high-dimensional quantum states is a crucial task for several quantum information ***,a high degree of precision in the characterization of the noisy experimental apparatus is required to apply existing quantum-state engineering *** is often lacking in practical scenarios,affecting the quality of the engineered *** implement,experimentally,an automated adaptive optimization protocol to engineer photonic orbital angular momentum(OAM)*** protocol,given a target output state,performs an online estimation of the quality of the currently produced states,relying on output measurement statistics,and determines how to tune the experimental parameters to optimize the state *** achieve this,the algorithm does not need to be imbued with a description of the generation apparatus ***,it operates in a fully black-box scenario,making the scheme applicable in a wide variety of *** handles controlled by the algorithm are the rotation angles of a series of waveplates and can be used to probabilistically generate arbitrary four-dimensional OAM *** showcase our scheme on different target states both in classical and quantum regimes and prove its robustness to external perturbations on the control *** approach represents a powerful tool for automated optimizations of noisy experimental tasks for quantum information protocols and technologies.

关键词： orbital angular momentum state engineering black-box optimization algorithm quantum walk

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Physical activity support or weight loss counseling for nonalcoholic fatty liver disease?

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World Journal of Gastroenterology 2014年第29期20卷 10128-10136页

作者： luca Montesi Chiara Caselli Elena Centis Chiara Nuccitelli Simona Moscatiello alessandro Suppini Giulio Marchesini Unit of Metabolic Diseases and Clinical Dietetics "Alma Mater Studiorum" University S. Orsola-Malpighi Hospital

AIM: To determine the clinical effectiveness of intense psychological support to physical activity (PA) in nonalcoholic fatty liver disease (NAFLD), compared with cognitive-behavioral treatment (CBT).

关键词： Nonalcoholic fatty liver disease Behavior treatment Physical activity Physical fitness Weight loss liver fat Liver enzymes

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Sustained virologic response to direct-acting antiviral agents predicts better outcomes in hepatitis C virus-infected patients: A retrospective study

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World Journal of Gastroenterology 2019年第40期25卷 6094-6106页

作者： Gian luca Colussi Debora Donnini Rosario Francesco Brizzi Silvia Maier luca Valenti Cristiana Catena alessandro Cavarape Leonardo Alberto Sechi Giorgio Soardo Department of Medicine University of Udine

BACKGROUND Direct-acting antiviral agents(DAAs)are extremely effective in eradicating hepatitis C virus(HCV)in chronically infected ***,the protective role of the sustained virologic response(SVR)achieved by second-and thirdgeneration DAAs against the onset of hepatocellular carcinoma(HCC)and mortality is less well *** To examine the occurrence of HCC or death from any cause in a retrospectiveprospective study of patients treated with *** Patients were enrolled from a tertiary academic hospital center for liver disease management that collects subject data mainly from northeastern *** study was conducted in 380 patients(age:60±13 years,224 males,32%with cirrhosis)treated with DAAs with or without SVR(95/5%),with a median follow up of 58 wk(interquartile range:38-117).The baseline anthropometric features,HCV viral load,severity of liver disease,presence of extra-hepatic complications,coinfection with HIV and/or HBV,alcohol consumption,previous interferon use,alphafetoprotein levels,and renal function were considered to be *** The incidence rate of HCC in patients with and without SVR was 1.3 and 59 per 100 person-years,respectively(incidence rate ratio:44,95%CI:15-136,P<0.001).Considering the combined endpoint of HCC or death from any cause,the hazard ratio(HR)for the SVR patients was 0.070(95%CI:0.025-0.194,P<0.001).Other independent predictors of HCC or death were low HCV viremia(HR:0.808,P=0.030),low platelet count(HR:0.910,P=0.041),and presence of mixed cryoglobulinemia(HR:3.460,P=0.044).Considering SVR in a multi-state model,the independent predictors of SVR achievement were absence of cirrhosis(HR:0.521,P<0.001)and high platelet count(HR:1.019,P=0.026).Mixed cryoglobulinemia predicted the combined endpoint in patients with and without SVR(HR:5.982,P=0.028 and HR:5.633,P=0.047,respectively).CONCLUSION DAA treatment is effective in inducing SVR and protecting against HCC or death.A residual risk of HCC persi

关键词： Direct-acting antiviral agents Hepatitis C virus Mixed cryoglobulinemia Sustained virologic response Cirrhosis Survival analysis

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Impact of laser chirp on the polarization of terahertz from two-color plasma

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Photonics Research 2023年第6期11卷 978-985页

作者： SEN MOU luca TOMARCHIO ANNALISA D’ARCO MARTA DI FABRIZIO SALVATORE MACIS alessandro CURCIO LUIGI PALUMBO STEFANO LUPI MASSIMO PETRARCA INFN-Roma1 and Physics Department University of Rome“La Sapienza”00185 RomeItaly Physics Department University of Rome“La Sapienza”00185 RomeItaly SBAI Department of Basic and Applied Sciences for EngineeringUniversity of Rome“La Sapienza”00161 RomeItaly Centro de Laseres Pulsados(CLPU) 37185 VillamayorSalamancaSpain INFN-LNF 00044 FrascatiItaly

Two-color plasma,induced by two lasers of different colors,can radiate ultra-broadband and intense terahertz(THz)pulses,which is desirable in many technological and scientific *** was found that the polarization of the emitted THz depends on the phase difference between the fundamental laser wave and its second *** investigation suggests that chirp-induced change of pulse overlap plays an important role in the THz yield from two-color ***,the effect of laser chirp on THz polarization remains ***,we investigate the impact of laser chirp on THz *** is unveiled that the chirp-induced phase difference affects THz ***,positive and negative chirps have opposite effects on the variation of the THz polarization versus the phase *** polarization of THz generated by a positively chirped pump laser rotates clockwise with an increasing phase difference,while it rotates anticlockwise when generated by a negatively chirped pump laser.

关键词： polarization laser pump

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The Intra-Pontide ophiolites in Northern Turkey revisited:From birth to death of a Neotethyan oceanic domain

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Geoscience Frontiers 2020年第1期11卷 129-149页

作者： Michele Marroni M.Cemal Goncüoglu Chiara Frassi Kaan Sayit luca Pandolfi alessandro Ellero Giuseppe Ottria Dipartimento di Scienze della Terra Universita di Pisavia S.Maria 5356126PisaItaly Istituto di Geoscienze e Georisorse-CNR Via G.Moruzzi 156124PisaItaly Department of Geological Engineering Middle East Technical University06531 AnkaraTurkey

The Anatolian peninsula is a key location to study the central portion of the Neotethys Ocean(s)and to understand how its western and eastern branches were *** of the lesser known branches of the Mesozoic ocean(s)is preserved in the northern ophiolite suture zone exposed in Turkey,namely,the Intra-Pontide suture *** is located between the Sakarya terrane and the Eurasian margin(i.e.,Istanbul-Zonguldak terrane)and consists of several metamorphic and non-metamorphic units containing ophiolites produced in supra-subduction settings from the Late Triassic to the Early *** preserved in the metamorphic units recorded pervasive deformations and peak metamorphic conditions ranging from blueschist to eclogite *** the nonmetamorphic units,the complete oceanic crust sequence is preserved in tectonic units or as olistoliths in sedimentary ***,structural,metamorphic and geochronological investigations performed on ophiolite-bearing units allowed the formulation of a new geodynamic model of the entire"life"of the IntraPontide oceanic basin(s).The reconstruction starts with the opening of the Intra-Pontide oceanic basins during the Late Triassic between the Sakarya and Istanbul-Zonguldak continental microplates and ends with its closure caused by two different subductions events that occurred during the upper Early Jurassic and Middle *** continental collision between the Sakarya continental microplate and the Eurasian margin developed from the upper Early Cretaceous to the *** presented reconstruction is an alternative model to explain the complex and articulate geodynamic evolution that characterizes the southern margin of Eurasia during the Mesozoic era.

关键词： Intra-Pontide suture zone Central Pontides Northern Turkey Ophiolites Neotethys Ocean Geodynamics

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Branching patterns of the left portal vein and consequent implications in liver surgery:The left anterior sector

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Hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 399-402页

作者： Mattia Garancini Mauro alessandro Scotti luca Gianotti Antonio Rovere Fabio Uggeri Marco Braga Fabrizio Romano Unit of Hepatobiliary Pancreatic Surgery Department of General Surgery 1ASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 3320900 MonzaMBItaly Unit of Interventional Radiology Department of RadiologyASST-MonzaSan Gerardo HospitalMilano-Bicocca Universityvia Pergolesi 3320900 MonzaMBItaly

To the Editor: There are still some open issues about the systematization of the knowledge of the branching of the left portal vein(LPV) and the division in anatomo-functional units within the left liver. The first controversial topic concerns the division of S4 in subsegments. The Brisbane 20 0 0 system of Nomenclature of Hepatic Anatomy and Resections(B20 0 0) [1] does not mention such subdivision, but in literature this is still a matter of discussion.

关键词： branching portal discussion

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Bicruciate-retaining total knee arthroplasty: What’s new?

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World Journal of Orthopedics 2021年第10期12卷 732-742页

作者： Luigi Sabatini luca Barberis Daniele Camazzola Michele Centola Marcello Capella alessandro Bistolfi Marco Schiraldi alessandro Massè Orthopaedics and Traumatology Department Presidio CTOTorino 10126Italy Orthopaedics and Traumatology Department CTO HospitalTorino 10126Italy Orthopedics and Traumaology Department Michele e Pietro Ferrero HospitalVerduno 12060Italy

Primary total knee arthroplasty(TKA)is a widespread procedure to address end stage osteoarthritis with good results,clinical outcomes,and long-term *** it is frequently performed in elderly,an increased demand in young and active people is expected in the next ***,a considerable dissatisfaction rate has been reported by highly demanding patients due to the intrinsic limitations provided by the ***-retaining(BCR)TKA was developed to mimic knee biomechanics,through anterior cruciate ligament ***-generation BCR TKA has not gained popularity due to its being a challenging technique and having poor survival *** to implant design improvement and surgeon-friendly instrumentation,secondgeneration BCR TKA has seen renewed *** review will focus on surgical indications,kinematical basis,clinical results and latest developments of secondgeneration BCR TKA.

关键词： Total knee arthroplasty Anterior cruciate ligament Bicruciate retaining Knee kinematics Second generation design Knee osteoarthritis treatment

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Anterolateral complex of the knee: State of the art

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World Journal of Orthopedics 2022年第8期13卷 679-692页

作者： Luigi Sabatini Marcello Capella Daniele Vezza luca Barberis Daniele Camazzola Salvatore Risitano luca Drocco alessandro Massè Department of Orthopaedics and Traumatology Universitàdegli Studi di TorinoTorino 10126Italy

Rotatory instability of the knee represents the main reason for failure and poor clinical outcomes regarding anterior cruciate ligament(ACL)reconstruction *** is now clear that the anterolateral complex(ALC)of the knee possesses a fundamental role,in association with the ACL,in controlling internal *** the past decade,ever since the anterolateral ligament has been identified and described as a distinct structure,there has been a renewed interest in the scientific community about the whole ALC:Lateral extra-articular tenodesis have made a comeback in association with ACL reconstructions to improve functional outcomes,reducing the risks of graft failure and associated *** ACL reconstruction surgery must therefore investigate residual instability and proceed,when necessary,to extra-articular techniques,whether functional tenodesis or anatomical *** review aims to investigate the latest anatomical and histological descriptions,and the role in rotational control and knee biomechanics of the ALC and its *** diagnostic tools for its identification,different reconstruction techniques,and possible surgical indications are described..In addition,clinical and functional results available in the literature are reported.

关键词： Knee Knee dislocation Anterior cruciate ligament reconstruction Fascia lata Tenodesis Joint instability

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