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Use of endoscopic ultrasound-guided gallbladder drainage as a rescue approach in cases of unsuccessful biliary drainage

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World Journal of Gastroenterology 2024年第1期30卷 70-78页

作者： alessandro Fugazza Kareem Khalaf Katarzyna M Pawlak Marco Spadaccini Matteo Colombo Marta Andreozzi Marco Giacchetto Silvia Carrara Chiara Ferrari Cecilia Binda Benedetto Mangiavillano Andrea Anderloni alessandro Repici Division of Gastroenterology and Digestive Endoscopy Humanitas Research Hospital-IRCCSRozzano 20089MilanoItaly Division of Gastroenterology St.Michael’s HospitalUniversity of TorontoToronto M5B 1W8ONCanada Department of Anesthesia Humanitas Research Hospital-IRCCSRozzano 20089MilanoItaly Gastroenterology and Digestive Endoscopy Unit Forlì-Cesena HospitalsRomagna 47121Italy Gastrointestinal Endoscopy Unit Humanitas Mater DominiCastellanza 21100Italy Gastroenterology and Digestive Endoscopy Unit Fondazione IRCCS Policlinico San MatteoPavia 27100Italy

This narrative review provides an overview of the utilization of endoscopic ultrasound-guided gallbladder drainage(EUS-GBD)as a salvage approach in cases of unsuccessful conventional ***-GBD is a minimally invasive and effective technique for drainage in patients with acute cholecystitis with high risk of *** procedure has demonstrated impressive technical and clinical success rates with low rates of adverse events,making it a safe and effective option for appropriate ***,EUS-GBD can also serve as a rescue option for patients who have failed endoscopic retrograde cholangiopancreatography or EUS biliary drainage for relief of jaundice in malignant biliary ***,patient selection is critical for the success of EUS-GBD,and proper patient selection and risk assessment are important to ensure the safety and efficacy of the *** the field continues to evolve and mature,ongoing research will further refine our understanding of the benefits and limitations of EUS-GBD,ultimately leading to improved outcomes for patients.

关键词： Endoscopic ultrasound-guided gallbladder drainage Gallbladder drainage Acute cholecystitis Malignant obstruction Interventional endoscopic ultrasound Lumen-apposing metal stents

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Thermo-hydro-poro-mechanical responses of a reservoir-induced landslide tracked by high-resolution fiber optic sensing nerves

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第3期16卷 1018-1032页

作者： Xiao Ye Hong-Hu Zhu Gang Cheng Hua-Fu Pei Bin Shi Luca Schenato alessandro Pasuto School of Earth Sciences and Engineering Nanjing UniversityNanjing210023China School of Computer Science North China Institute of Science and Technology(National Safety Training Center of Coal Mines)Beijing101601China State Key Lab of Coastal and Offshore Engineering Department of Geotechnical EngineeringDalian University of TechnologyDalian116024China National Research Council-Research Institute for Geo-Hydrological Protection(CNR-IRPI) Padova35127Italy Department of Information Engineering University of PadovaPadova35131Italy

Thermo-poro-mechanical responses along sliding zone/surface have been extensively ***,it has not been recognized that the potential contribution of other crucial engineering geological interfaces beyond the slip surface to progressive ***,we aim to investigate the subsurface multiphysics of reservoir landslides under two extreme hydrologic conditions(*** and dry),particularly within sliding *** on ultra-weak fiber Bragg grating(UWFBG)technology,we employ specialpurpose fiber optic sensing cables that can be implanted into boreholes as“nerves of the Earth”to collect data on soil temperature,water content,pore water pressure,and *** Xinpu landslide in the middle reach of the Three Gorges Reservoir Area in China was selected as a case study to establish a paradigm for in situ thermo-hydro-poro-mechanical *** UWFBG-based sensing cables were vertically buried in a 31 m-deep borehole at the foot of the landslide,with a resolution of 1 m except for the pressure *** reported field measurements covering the period 2021 and 2022 and produced the spatiotemporal profiles throughout the *** show that wet years are more likely to motivate landslide motions than dry *** annual thermally active layer of the landslide has a critical depth of roughly 9 m and might move downward in warmer *** dynamic groundwater table is located at depths of 9e15 m,where the peaked strain undergoes a periodical response of leap and withdrawal to annual hydrometeorological *** interface behaviors may support the interpretation of the contribution of reservoir regulation to slope stability,allowing us to correlate them to local damage events and potential global *** paper also offers a natural framework for interpreting thermo-hydro-poro-mechanical signatures from creeping reservoir bank slopes,which may form the basis for a landslide monitoring and early warning system.

关键词： Reservoir landslide Thermo-hydro-poro-mechanical response Ultra-weak fiber bragg grating(UWFBG) subsurface evolution Engineering geological interface Geotechnical monitoring

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On the Vacuum Hydrodynamics of Moving Bodies—The Theory of General Singularity

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 875-905页

作者： alessandro Rizzo Independent Researcher Brescia Italy

The Theory of General Singularity is presented, unifying quantum field theory, general relativity, and the standard model. This theory posits phonons as fundamental excitations in a quantum vacuum, modeled as a Bose-Einstein condensate. Through key equations, the role of phonons as intermediaries between matter, energy, and spacetime geometry is demonstrated. The theory expands Einsteins field equations to differentiate between visible and dark matter, and revises the standard model by incorporating phonons. It addresses dark matter, dark energy, gravity, and phase transitions, while making testable predictions. The theory proposes that singularities, the essence of particles and black holes, are quantum entities ubiquitous in nature, constituting the very essence of elementary particles, seen as micro black holes or quantum fractal structures of spacetime. As the theory is refined with increasing mathematical rigor, it builds upon the foundation of initial physical intuition, connecting the spacetime continuum of general relativity with the hydrodynamics of the quantum vacuum. Inspired by the insights of Tesla and Majorana, who believed that physical intuition justifies the infringement of mathematical rigor in the early stages of theory development, this work aims to advance the understanding of the fundamental laws of the universe and the perception of reality.

关键词： Planck Mass Gravity Light Phonons Phononic Field Vacuum Hydrodynamics Bose-Einstein Condensate Phonons Quantum Vacuum Unification Gravity Dark Matter Dark Energy Theory of General Singularity

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On a Heuristic Viewpoint Concerning the Conversion and Transformation of Sound into Light

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第1期10卷 363-385页

作者： alessandro Rizzo Brescia Italy

In the study of Terrestrial Gamma-ray Flashes (TGFs) and Sonoluminescence, we observe parallels with larger cosmic events. Specifically, sonoluminescence involves the rapid collapse of bubbles, which closely resembles gravitational collapse in space. This observation suggests the potential formation of low-density quantum black holes. These entities, which might be related to dark matter, are thought to experience a kind of transient evaporation similar to Hawking radiation seen in cosmic black holes. Consequently, sonoluminescence could be a valuable tool for investigating phenomena typically linked to cosmic scale events. Furthermore, the role of the Higgs boson is considered in this context, possibly connecting it to both TGFs and sonoluminescence. This research could enhance our understanding of the quantum mechanics of black holes and their relation to dark matter on Earth.

关键词： Planck Mass Gravity Light Phonons Phononic Field Vacuum Hydrodynamics Sonoluminescence Hawking Radiation Quantum Black Holes Theory of General Singularity

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Legendre-Jacobi’s Elliptic Integrals Shed Light on the Luminosity Distance in Cosmology

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Journal of High Energy Physics, Gravitation and Cosmology 2024年第3期10卷 930-957页

作者： alessandro Trinchera Independent Researcher Stuttgart Germany

This article concerns the integral related to the transverse comoving distance and, in turn, to the luminosity distance both in the standard non-flat and flat cosmology. The purpose is to determine a straightforward mathematical formulation for the luminosity distance as function of the transverse comoving distance for all cosmology cases with a non-zero cosmological constant by adopting a different mindset. The applied method deals with incomplete elliptical integrals of the first kind associated with the polynomial roots admitted in the comoving distance integral according to the scientific literature. The outcome shows that the luminosity distance can be obtained by the combination of an analytical solution followed by a numerical integration in order to account for the redshift. This solution is solely compared to the current Gaussian quadrature method used as basic recognized algorithm in standard cosmology.

关键词： Cosmology Distance Luminosity Transverse Comoving Distance Incomplete Elliptic Integrals

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漂浮的柯里公园广场

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现代装饰 2017年第3期 120-123页

作者： Carlo Ratti Associati Carlo Ratti Andrea Galanti Emma Greer Chiara Borghi Valentina Grasso Ohver Kazimir alessandro tassinari Alberto Bottero Gary di Silvio 姜敏华

总部位于都灵的创新型设计公司Carlo Ratti Associati提出了一个关于漂浮广场的总体规划,计划通过利用水下船舶施工技术来设计坐落于佛罗里达州西棕榈滩的新柯里滨水公园的一部分,打造一个独一无二的漂浮广场。该方案提出将在Worth Lag... 详细信息

总部位于都灵的创新型设计公司Carlo Ratti Associati提出了一个关于漂浮广场的总体规划,计划通过利用水下船舶施工技术来设计坐落于佛罗里达州西棕榈滩的新柯里滨水公园的一部分,打造一个独一无二的漂浮广场。该方案提出将在Worth Lagoon湖边的海岸上改造一块占地面积19公顷的空地,以一条狭长的海上通道划分西棕榈滩和棕榈滩,打造一个以居住、零售和休闲设施为特色的新的多功能综合体。

关键词：广场漂浮公园佛罗里达州施工技术占地面积休闲设施创新型

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Long-term normothermic machine perfusion of fatty livers:towards transplanting untransplantable livers?

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 681-685页

作者： Damiano Patrono Nicola De Stefano Elena Vissio alessandro Gambella Renato Romagnoli General Surgery 2U–Liver Transplant Unit Azienda Ospedaliero Universitaria Cittàdella Salute e della Scienza di TorinoTurinItaly Pathology Unit Azienda Ospedaliero Universitaria Cittàdella Salute e della Scienza di TorinoTurinItaly Department of Medical Sciences University of TurinTurinItaly

Since the very early days of clinical liver transplantation(LT),transplant surgeons and professionals have been confronted with the increased risk of failure associated with the use of fatty liver grafts(1).Notwithstanding the wide variability in steatosis assessment across different centers and pathologists(2),utilization of livers with moderate(≥30%)or severe(≥60%)macrovesicular steatosis has been consistently associated with an increased risk of primary non-function,early allograft dysfunction,acute kidney injury,as well as inferior graft and patient survival(3).The mechanisms behind the increased susceptibility of steatotic livers to ischemia-reperfusion injury(IRI)are multiple,including disturbances to microcirculation due to sinusoidal narrowing,increased oxidative stress upon reperfusion and enhanced lipid peroxidation,leading to an increased release of inflammatory mediators like IL6,IL1βand so-called damage associated molecular patterns(DAMP),like cell-free DNA and mitochondrial ***,this is reflected by hepatocyte death by necrosis rather than apoptosis,pseudopeliotic steatosis(i.e.,the expulsion of lipid droplets into the extracellular space)and lately,by tissue remodelling and fibrosis(4,5).

关键词： Liver transplantation(LT) steatosis macrovesicular steatosis large droplet fat normothermic machine perfusion

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A Few Important and Original Aspects of Carlo Cattaneo’s Philosophical-Linguistic Ideas

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Philosophy Study 2024年第2期14卷 66-72页

作者： alessandro Prato University of Siena SienaItaly

The essay has two main *** first is a general reconstruction of Cattaneo’s linguistic thought,highlighting the most important aspects of both his reflections on the connection between language and the community of speakers,and his study of the functions and properties of *** latter includes an analysis of the influence Cattaneo’s philosophy had on the sphere of Italian linguistics at the turn of the 20th century.

关键词： linguistics philosophy of language connection between language and nation linguistics and anthropology

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Role of glioma stem cells in promoting tumor chemo- and radioresistance: A systematic review of potential targeted treatments

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World Journal of Stem Cells 2024年第5期16卷 604-614页

作者： Edoardo Agosti Marco Zeppieri Mattia Ghidoni Tamara Ius alessandro Tel Marco Maria Fontanella Pier Paolo Panciani Division of Neurosurgery Department of Medical and Surgical SpecialtiesRadiological Sciences and Public HealthUniversity of BresciaBrescia 25123Italy Department of Ophthalmology University Hospital of UdineUdine 33100Italy Neurosurgery Unit Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy Clinic of Maxillofacial Surgery Department of Head-Neck and NeuroScienceUniversity Hospital of UdineUdine 33100Italy

BACKGROUND Gliomas pose a significant challenge to effective treatment despite advancements in chemotherapy and *** stem cells(GSCs),a subset within tumors,contribute to resistance,tumor heterogeneity,and *** studies reveal GSCs’role in therapeutic resistance,driven by DNA repair mechanisms and dynamic transitions between cellular *** mechanisms can involve different cellular pathways,most of which have been recently reported in the *** progress,targeted therapeutic approaches lack consensus due to GSCs’high *** To analyze targeted therapies against GSC-mediated resistance to radio-and chemotherapy in gliomas,focusing on underlying *** A systematic search was conducted across major medical databases(PubMed,Embase,and Cochrane Library)up to September 30,*** search strategy utilized relevant Medical Subject Heading terms and keywords related to including“glioma stem cells”,“radiotherapy”,“chemotherapy”,“resistance”,and“targeted therapies”.Studies included in this review were publications focusing on targeted therapies against the molecular mechanism of GSC-mediated re-sistance to radiotherapy resistance(RTR).RESULTS In a comprehensive review of 66 studies on stem cell therapies for SCI,452 papers were initially identified,with 203 chosen for full-text *** them,201 were deemed eligible after excluding 168 for various *** temporal breakdown of studies illustrates this trend:2005-2010(33.3%),2011-2015(36.4%),and 2016-2022(30.3%).Key GSC models,particularly U87(33.3%),U251(15.2%),and T98G(15.2%),emerge as significant in research,reflecting their representativeness of glioma *** analysis indicates a focus on phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin(mTOR)(27.3%)and Notch(12.1%)pathways,suggesting their crucial roles in resistance *** molecules with mTOR(18.2%),CHK1/2(15.2%),and ATP binding cassette

关键词： Glioma stem cells Chemoresistance Radioresistance Molecular pathways Targeted therapies Systematic review

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Development of deep-learning-based autonomous agents for low-speed maneuvering in Unity

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第3期7卷 229-244页

作者： Riccardo Berta Luca Lazzaroni Alessio Capello Marianna Cossu Luca Forneris alessandro Pighetti Francesco Bellotti Electrical Electronics and Telecommunication Engineering and Naval Architecture Department(DITEN)University of GenoaGenoa 16145Italy

This study provides a systematic analysis of the resource-consuming training of deep reinforcement-learning (DRL) agents for simulated low-speed automated driving (AD). In Unity, this study established two case studies: garage parking and navigating an obstacle-dense area. Our analysis involves training a path-planning agent with real-time-only sensor information. This study addresses research questions insufficiently covered in the literature, exploring curriculum learning (CL), agent generalization (knowledge transfer), computation distribution (CPU vs. GPU), and mapless navigation. CL proved necessary for the garage scenario and beneficial for obstacle avoidance. It involved adjustments at different stages, including terminal conditions, environment complexity, and reward function hyperparameters, guided by their evolution in multiple training attempts. Fine-tuning the simulation tick and decision period parameters was crucial for effective training. The abstraction of high-level concepts (e.g., obstacle avoidance) necessitates training the agent in sufficiently complex environments in terms of the number of obstacles. While blogs and forums discuss training machine learning models in Unity, a lack of scientific articles on DRL agents for AD persists. However, since agent development requires considerable training time and difficult procedures, there is a growing need to support such research through scientific means. In addition to our findings, we contribute to the R&D community by providing our environment with open sources.

关键词： automated driving autonomous agents deep reinforcement learning curriculum learning modeling and simulation

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