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An ontological modelling of multi-attribute criticality analysis to guide Prognostics and Health Management program development

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Autonomous Intelligent Systems 2022年第1期2卷 16-31页

作者： Adalberto Polenghi Irene Roda Marco Macchi alessandro Pozzetti Department of Management Economics and Industrial EngineeringPolitecnico di MilanoP.zza Leonardo da Vinci 3320133 MilanItaly

Digital technologies are becoming more pervasive and industrial companies are exploiting them to enhance the potentialities related to Prognostics and Health Management(PHM).Indeed,PHM allows to evaluate the health state of the physical assets as well as to predict their future *** be effective in developing PHM programs,the most critical assets should be identified so to direct modelling *** techniques could be adopted to evaluate asset criticality;in industrial practice,criticality analysis is amongst the most *** the advancement of artificial intelligence for data analysis and predictions,the criticality analysis,which is built upon both quantitative and qualitative data,has not been improved *** is the goal of this work to propose an ontological formalisation of a multi-attribute criticality analysis in order to i)fix the semantics behind the terms involved in the analysis,ii)standardize and uniform the way criticality analysis is performed,and iii)take advantage of the reasoning capabilities to automatically evaluate asset criticality and associate a suitable maintenance *** developed ontology,called MOCA,is tested in a food company featuring a global *** application shows that MOCA can accomplish the prefixed goals;specifically,high priority assets towards which direct PHM programs are *** the long run,ontologies could serve as a unique knowledge base that integrate multiple data and information across facilities in a consistent *** such,they will enable advanced analytics to take place,allowing to move towards cognitive Cyber Physical Systems that enhance business performance for companies spread worldwide.

关键词： Criticality analysis Ontology Artificial intelligence Prognostics and Health Management PHM Maintenance

Prophylactic drains in totally laparoscopic distal gastrectomy:are they always necessary?

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World Journal of Gastroenterology 2022年第3期28卷 399-401页

作者： Tommaso Maria Manzia alessandro Parente Roberta Angelico HPB and Transplant Unit Department of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy Queen Elizabeth Hospital Liver UnitUniversity of BirminghamBirmingham UK and HPB and Transplant UnitDepartment of Surgery ScienceUniversity of Rome Tor VergataRome 00133Italy

Prophylactic drains have always been a useful tool to detect early complications and prevent postoperative fluid collections,particularly in gastrointestinal ***,the utilization of such drains has been debated,due to mounting evidence that they could be harmful rather than *** on recent published articles,Liu et al reported that the routine use of prophylactic drains in total laparoscopic distal gastrectomy might not be necessary for all ***,we express our opinion regarding this interesting publication.

关键词： Gastric cancer Prophylactic drainage Totally laparoscopic gastrectomy Enhanced recovery after surgery Minimally invasive surgery Early gastric cancer

A Tabu-search-based Algorithm for Distribution Network Restoration to Improve Reliability and Resiliency

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Journal of Modern Power Systems and Clean Energy 2023年第1期11卷 302-311页

作者： alessandro Bosisio Alberto Berizzi Daniele Lupis Andrea Morotti Gaetano Iannarelli Bartolomeo Greco Energy Department of Politecnico di Milano MilanItaly E-distribuzione MonzaItaly Unareti Electrical Network Planning Department MilanItaly Department of Astronautics Electrical and Energy Engineering of the Sapienza UniversityRomeItaly Technological Development Department of the DSO Unareti MilanItaly Unareti Market Development and Special Projects Department MilanItaly IEEE

Fault restoration techniques have always been crucial for distribution system operators(DSOs).In the last decade,it started to gain more and more importance due to the introduction of output-based regulations where DSO performances are evaluated according to frequency and duration of energy supply *** paper presents a tabu-searchbased algorithm able to assist distribution network operational engineers in identifying solutions to restore the energy supply after permanent *** to the network property,two objective functions are considered to optimize either reliability or *** mathematical formulation includes the traditional feeders,number of switching operation limit,and radiality *** to the DSO of Milan,Unareti,the proposed algorithm has been tested on a real distribution network to investigate its effectiveness.

关键词： Distribution system operators(DSOs) heuristic algorithms power system reliability power system restoration resiliency

Climate warming induced a stretch of the breeding season and an increase of second clutches in a passerine breeding at its altitudinal limits

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Current Zoology 2022年第1期68卷 9-17页

作者： Toni MINGOZZI Pierpaolo STORINO Giampalmo VENUTO alessandro MASSOLO Giacomo TAVECCHIA Department of Biology Ecology and Earth Sciences(DiBEST)University of CalabriaVia P.BucciRende 87036Italy Department of Biology Ethology UnitUniversity of PisaVia L.Ghini13Pisa 56126Italy UMR CNRS 6249 Chrono-environnement UniversiteBourgogne Franche-Comte16 Route de GrayBesanc¸on 25030France Animal Demography and Ecology Unit(GEDA-IMEDEA CSIC-UIB)C.M.MarquesEsporles 07190Spain

The increase in the average air temperature due to global warming has produced an early onset of the reproduction in many migratory birds of the Paleartic *** to the“mismatch hypothesis”this response can lead to a decrease in the breeding output when the conditions that trigger the departure from the wintering areas do not match the availability of food resources in the breeding *** used 653 brooding events registered during the period 1991–2013 to investigate the link between climatic variables and individual breeding performance of a partially migratory passerine,the Rock Sparrow Petronia petronia,breeding at the altitude limit of its *** laying date(LD)of the earliest first clutch was associated with local spring(minimum)temperatures but did not show a significant trend during the period *** LD of the latest first clutch had a positive and statistically significant trend,unrelated to local covariates and resulting in a longer breeding season(1.5 days/year).A longer breeding season allowed birds to produce more second clutches,which proportion increased from 0.14 to *** average breeding success was also positively correlated with the average temperature in July and with the duration of the breeding *** to expectations,the most important climate-dependent effect was a stretch of the breeding season due to a significant increase of the LD of the latest first-clutches rather than an earlier breeding *** show how climate changes act on bird populations through multiple paths and stress the need to assess the link between climatic variables and several aspects of the breeding cycle.

关键词： breeding phenology climate warming long-term study Petronia petronia reproductive success

Correlative CD4 and CD8 T-cell immunodominance in humans and mice:Implications for preclinical testing

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Cellular & Molecular Immunology 2023年第11期20卷 1328-1338页

作者： Tertuliano Alves Pereira Neto John Sidney Alba Grifoni alessandro Sette Center for Infectious Disease and Vaccine Research La Jolla Institute for Immunology(LJI)La JollaCA92037USA Department of Medicine Division of Infectious Diseases and Global Public HealthUniversity of CaliforniaSan DiegoLa JollaCA92037USA

Antigen-specific T-cell recognition is restricted by Major Histocompatibility Complex(MHC)molecules,and differences between CD4 and CD8 immunogenicity in humans and animal species used in preclinical vaccine testing are yet to be fully *** this study,we addressed this matter by analyzing experimentally identified epitopes based on published data curated in the Immune Epitopes DataBase(IEDB)*** first analyzed SARS-CoV-2 spike(S)and nucleoprotein(N),which are two common targets of the immune response and well studied in both human and mouse *** observed a weak but statistically significant correlation between human and H-2^(b)mouse T-cell responses(CD8 S specific(r=0.206,p=1.37×10^(−13));CD4 S specific(r=0.118,p=2.63×10^(−5))and N specific(r=0.179,p=2.55×10^(−4))).Due to intrinsic differences in MHC molecules across species,we also investigated the association between the immunodominance of common Human Leukocyte Antigen(HLA)alleles for which HLA transgenic mice are available,namely,A*02:01,B*07:02,DRB1*01:01,and DRB1*04:01,and found higher significant correlations for both CD8 and CD4(maximum r=0.702,p=1.36×10^(−31)and r=0.594,p=3.04−122,respectively).Our results further indicated that some regions are commonly immunogenic between humans and mice(either H-2^(b)or HLA transgenic)but that others are human ***,we noted a significant correlation between CD8 and CD4 S-(r=0.258,p=7.33×10^(21))and N-specific(r=0.369,p=2.43×10^(14))responses,suggesting that discrete protein subregions can be simultaneously recognized by T *** findings were confirmed in other viral systems,providing general guidance for the use of murine models to test T-cell immunogenicity of viral antigens destined for human use.

关键词： T cells SARS-CoV-2 Vaccine Animal testing HLA

Dissecting the effect of soil on plant phenology and berry transcriptional plasticity in two Italian grapevine varieties (Vitis vinifera L.).

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Horticulture Research 2023年第5期10卷 178-192页

作者： alessandro Vannozzi Corrado Perin Fabio Palumbo Marco Sandri Paola Zuccolotto Sara Zenoni Silvia Farinati Gianni Barcaccia Massimo Pindo Paolo Sonego alessandro Cestaro Margherita Lucchin Department of Agronomy FoodNatural resourcesAnimals and Environment(DAFNAE)University of Padova Agripolis35020 LegnaroItaly Department of biotechnology University of VeronaI-37034VeronaItaly Big&Open Data Innovation Laboratory University of Brescia25122 BresciaItaly Research and Innovation Centre Fondazione Edmund Machvia E.Mach 138010San Michele all’AdigeItaly

Grapevine embodies a fascinating species as regards phenotypic plasticity and genotype-per-environment *** terroir,namely the set of agri-environmental factors to which a variety is subjected,can influence the phenotype at the physiological,molecular,and biochemical level,representing an important phenomenon connected to the typicality of *** investigated the determinants of plasticity by conducting a field-experiment where all terroir variables,except soil,were kept as constant as *** isolated the effect of soils collected from different areas,on phenology,physiology,and transcriptional responses of skin and flesh of a red and a white variety of great economic value:Corvina and *** results,together with physio-phenological parameters,suggest a specific effect of soil on grapevine plastic response,highlighting a higher transcriptional plasticity of Glera in respect to Corvina and a marked response of skin compared to *** a novel statistical approach,we identified clusters of plastic genes subjected to the specific influence of *** findings could represent an issue of applicative value,posing the basis for targeted agricultural practices to enhance the desired characteristics for any soil/cultivar combination,to improve vineyards management for a better resource usage and to valorize vineyards uniqueness maximizing the terroir-effect.

关键词： soil plasticity effect

Assessment of advanced age candidates for liver transplantation warrants more caution

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World Journal of Transplantation 2022年第2期12卷 24-26页

作者： alessandro Parente Vincenzo Ronca Liver Unit Queen Elizabeth Hospital University Hospital Birmingham NHS Foundation TrustBirmingham B152THUnited Kingdom Centre for Liver and Gastrointestinal Research Institute of Immunology and Immunotherapy University of BirminghamBirmingham B152TTUnited Kingdom

For patients with fulminant liver failure and end-stage liver disease,liver transplantation remains the only effective *** the years,as a result of the ageing population,the average age of liver transplant donors and recipients has increased and currently about one quarter of patients receiving transplantation in the United States are above the age of ***,a study reported that patients aged 65 years or older had lower one-year survival compared to a younger ***,we express our opinion about this interesting publication.

关键词： Liver transplantation Elderly patients Age in liver transplantation Frailty Transplant assessment Liver transplant outcomes

Unfolding the structural stability of nanoalloys via symmetry-constrained genetic algorithm and neural network potential

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npj Computational Materials 2022年第1期8卷 1135-1145页

作者： Shuang Han Giovanni Barcaro alessandro Fortunelli Steen Lysgaard Tejs Vegge Heine Anton Hansen Department of Energy Conversion and Storage Technical University of DenmarkFysikvej2800Kgs.LyngbyDenmark CNR-ICCOM&IPCF Consiglio Nazionale delle Ricerchevia G.Moruzzi 156124PisaItaly

The structural stability of nanoalloys is a challenging research subject due to the complexity of size,shape,composition,and chemical *** genetic algorithm is a popular global optimization method that can efficiently search for the ground-state nanoalloy ***,the algorithm suffers from three significant limitations:the efficiency and accuracy of the energy evaluator and the algorithm’s *** we describe the construction of a neural network potential intended for rapid and accurate energy predictions of Pt-Ni nanoalloys of various sizes,shapes,and *** further introduce a symmetry-constrained genetic algorithm that significantly improves the efficiency and viability of the algorithm for realistic size *** combination of the two allows us to explore the space of homotops and compositions of Pt-Ni nanoalloys consisting of up to 4033 atoms and quantitatively report the interplay of shape,size,and composition on the dominant chemical ordering patterns.

关键词： structure symmetry constrained

Glucose-lowering agents and reduced risk of incident non-alcoholic fatty liver disease:new insights

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 156-160页

作者： alessandro Mantovani Rosa Lombardi Andrea Dalbeni Section of Endocrinology Diabetes and MetabolismDepartment of MedicineUniversity and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly Unit of Internal Medicine and Metabolic Disease Fondazione IRCCS Ca’Granda Ospedale Maggiore PoliclinicoMilanItaly Department of Pathophysiology and Transplantation Universitàdegli Studi di MilanoMilanItaly Section of General Medicine C and Liver Unit University and Azienda Ospedaliera Universitaria Integrata of VeronaVeronaItaly

Non-alcoholic fatty liver disease(NAFLD)is classically defined as the hepatic manifestation of metabolic syndrome(1).Histologically,NAFLD covers a range of conditions,spanning from simple steatosis to non-alcoholic steatohepatitis(NASH)and cirrhosis(2).At present,NAFLD is the most frequent chronic liver disease seen in clinical practice in high-income countries,as it affects nearly 30%of adults in the general population,up to 70%of patients with type 2 diabetes(T2DM)and almost all patients with obesity(2).

关键词： NAFLD liver hepatic