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Faujasite zeolite decorated with cobalt ferrite nanoparticles for improving removal and reuse in Pb^2+ions adsorption

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1884-1890页

作者： Elaine C.Paris João O.D.Malafatti Henrique C.Musetti Alexandra Manzoli alessandra Zenatti Márcia T.Escote Nanotechnology National Laboratory for Agriculture(LNNA) Embrapa InstrumentaçãoXV de Novembro St.145213560-970 São CarlosSPBrazil Department of Chemistry Federal University of São CarlosRod.Washington Luizkm 23513565-905 São CarlosSPBrazil Regional Integrated University of High Uruguay and Missions(URI) Sete de Setembro Ave.162199709-910ErechimRSBrazil Federal University of ABC(UFABC) Avenida dos Estados5001Santo AndréSPBrazil

Water pollution caused by heavy metals ions has been gaining attention in recent years,increasing the interest in the development of methodologies for their efficient removal focusing on the adsorption process for these *** current challenge faced by adsorption processes is the adequate adsorbent immobilization for removal and ***,the present work aimed at producing a faujasite zeolite nanocomposite decorated with cobalt ferrite nanoparticles for Pb^2+ions adsorption in an aqueous medium improving magnetic removal and *** a result,a high surface area(434.4 m^2·g^-1)for the nanocomposite and an 18.93 emu·g^-1 saturation magnetization value were obtained,indicating magnetic removal in a promising material for adsorption *** nanocomposite regeneration capacity evaluated by magnetic recovery after 24 h suspension presented a high Pb^2+ion adsorptive capacity(98.4%)in the first *** 98%of the Pb^2+ions were adsorbed in the second *** this way,the synthesized faujasite:cobalt ferrite nanocomposite reveals itself as a promising alternative in adsorption processes,aiming at a synergic effect of FAU zeolite high adsorptive activity and the cobalt ferrite nanoparticles magnetic activity,allowing for adsorbent recovery from the aqueous medium via magnetic force and successive adsorptive cycles.

关键词： Faujasite zeolite Adsorption Cobalt ferrite Nanoparticles Magnetic nanocomposite

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Cell fusion in the liver, revisited

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World Journal of Hepatology 2018年第2期10卷 213-221页

作者： Michela Lizier alessandra Castelli Cristina Montagna Franco Lucchini Paolo Vezzoni Francesca Faggioli Istituto di Ricerca Genetica e Biomedica CNR Human Genome Laboratory Humanitas Clinical and Research Center IRCCS Department of Genetics and Pathology Genetics Albert Einstein College of Medicine Centro Ricerche Biotecnologiche Università Cattolica del Sacro Cuore

There is wide agreement that cell fusion is a physiological process in cells in mammalian bone, muscle and placenta. In other organs, such as the cerebellum, cell fusion is controversial. The liver contains a considerable number of polyploid cells: They are commonly believed to originate by genome endoreplication, although the contribution of cell fusion to polyploidization has not been excluded. Here, we address the topic of cell fusion in the liver from a historical point of view. We discuss experimental evidence clearly supporting the hypothesis that cell fusion occurs in the liver, specifically when bone marrow cells were injected into mice and shown to rescue genetic hepatic degenerative defects. Those experiments-carried out in the latter half of the last century-were initially interpreted to show "transdifferentiation", but are now believed to demonstrate fusion between donor macrophages and host hepatocytes, raising the possibility that physiologically polyploid cells, such as hepatocytes, could originate, at least partially, through homotypic cell fusion. In support of the homotypic cell fusion hypothesis, we present new data generated using a chimera-based model, a much simpler model than those previously used. Cell fusion as a road to polyploidization in the liver has not been extensively investigated, and its contribution to a variety of conditions, such as viral infections, carcinogenesis and aging, remains unclear.

关键词： Cell fusion Hepatocytes TdTomato Lineage tracing Chimeras Extracellular vesicles

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The Rise and Fall of the Secular Trend in Body Height in Sardinia:An Age-Period-Cohort Analysis

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Biomedical and Environmental Sciences 2020年第3期33卷 183-190页

作者： Giovanni Mario PES Roberta SALIS alessandra ERRIGO Marco SATURNO Stefano BIBBO’ Bianca Maria QUARTA COLOSSO Nunzio Pio LONGO Maria Pina DORE Department of Medical Surgical and Experimental SciencesUniversity of SassariI-07100 SassariItaly

Objective Over the last century, a progressive rise in stature, known as the ‘secular trend’, was documented worldwide, and especially in Sardinia, it has reached a peak in Europe. However, this situation recently ceased in several populations. In this study, we tested the hypothesis that the stature secular trend has significantly leveled off in the Sardinian younger *** Height measurements were retrieved from a database of patients undergoing digestive endoscopy, spanning generations between 1920 and 1990. Sex-specific principal component regression models were fitted to decompose stature variation into the contribution of age, period, and birth *** A steady increase in stature was observed in generations born after 1920, with an upward surge in those born after 1950. However, a significant leveling off was observed among cohorts born after 1970 among both sexes, as mean heights stabilized at 171.1 cm with a standard error(SE) of 0.9 cm among men and a mean of 160.1 cm(SE = 0.9 cm) among *** Our findings support a significant slowdown in the secular trend of stature among the latest Sardinian generations. Several factors, including the consumption of low-quality food, lack of physical activity, and late motherhood, among others, may explain the decline in the secular trend.

关键词： Body height Secular trend Socioeconomic status Sardinia

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Viral infections in inflammatory bowel disease:Tips and tricks for correct management

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World Journal of Gastroenterology 2021年第27期27卷 4276-4297页

作者： Vincenzo Craviotto Federica Furfaro Laura Loy alessandra Zilli Laurent Peyrin-Biroulet Gionata Fiorino Silvio Danese Mariangela Allocca Humanitas Clinical and Research Center IRCCSRozzano 20089MilanoItaly Department of Hepato-Gastroenterology and Inserm U954 University Hospital of NancyLorraine UniversityNancy 54511France Department of Biomedical Sciences Humanitas UniversityPieve Emanuele 20090MilanoItaly

Over the past decades,the treatment of inflammatory bowel diseases(IBD)has become more targeted,anticipating the use of immune-modifying therapies at an earlier *** top-down approach has been correlated with favorable short and long-term outcomes,but it has also brought with it concerns regarding potential infectious *** large IBD population treated with immunemodifying therapies,especially if combined,has an increased risk of severe infections,including opportunistic infections that are sustained by viral,bacterial,parasitic,and fungal *** infections have emerged as a focal safety concern in patients with IBD,representing a challenge for the clinician:they are often difficult to diagnose and are associated with significant morbidity and *** first step is to improve effective preventive strategies,such as applying vaccination protocols,adopt adequate prophylaxis and educate patients about potential risk *** viral infections in immunosuppressed patients may present atypical signs and symptoms,the challenges for the gastroenterologist are to suspect,recognize and diagnose such *** treatment of common viral infections allows us to minimize their impact on disease outcomes and patients’*** practical review supports this standard of care to improve knowledge in this subject area.

关键词： Inflammatory bowel diseases Viral infections Opportunistic infections Standard of care Crohn’s disease Ulcerative colitis

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Comparative analysis of the antioxidant capacity and lipid and protein oxidation of soy and oats beverages

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Food Production, Processing and Nutrition 2021年第1期3卷 1-10页

作者： Laura Moretto Federica Tonolo alessandra Folda Valeria Scalcon Alberto Bindoli Marco Bellamio Emiliano Felle Maria Pia Rigobello Department of Biomedical Sciences University of Padovavia Ugo Bassi 58/b35131 PadovaItaly Institute of Neuroscience(CNR) viale G.Colombo 335131 PadovaItaly Centrale del Latte di Vicenza s.p.a via A.Faedo 60.36100 VicenzaItaly

Soy(Glycine max)and oats(Avena sativa)are plant sources used in milk-alternative ***,protein and lipid constituents of these food matrices can undergo alterations during the *** this work,a commercial formulation of soy and oat-based beverages were comparatively *** the 12 months of shelf life and two following months,their phenolic content,antioxidant capacity,lipid peroxidation,protein carbonyl formation and protein breakdown were *** phenolic content and antioxidant capacity of soy and oat-based beverages were maintained during the entire period of 14 *** beverages did not show any increase in spontaneous lipid peroxidation beyond the basal level,however,due to the different content of unsaturated fats,when lipid peroxidation was stimulated,soy exhibited a major peroxidizability with respect to oat *** alteration of proteins,estimated as carbonyl group formation,presented no increase with respect to the basal levels both in soy and oat beverages for all 14 ***,soy proteins showed a gradual increase of proteolytic activity up until half of the shelf life,while oat did not show significant changes in protein *** conclusion,both soy and oat beverages resulted oxidatively stable throughout their *** suggest that phytochemicals might guarantee the oxidative stability of the product,possibly in combination with antioxidant bioactive peptides,which already have well-known benefits on human health.

关键词： Soy Oats Plant-based beverages Oxidation Antioxidants Shelf life

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An eighteen-month follow-up study on the effects of Intravitreal Dexamethasone Implant in diabetic macular edema refractory to anti-VEGF therapy

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1427-1432页

作者： Fernanda Pacella Maria Rosaria Romano Paolo Turchetti Giovanna Tarquini Anna Carnovale Antonella Mollicone alessandra Mastromatteo Elena Pacella Department of Sense Organs Faculty of Medicine and DentistrySapienza University of Rome IRCCS NeuromedPozzilli National Institute for Health MigrationPoverty(INMP/NIHMP) Department of Internal Medicine and Clinical Specialities Sapienza University of Rome

AIM： To evaluate the long-term efficacy and safety of dexamethasone implants in subjects affected by diabetic macular edema（DME） resistant to anti-vascular endothelial growth factor（VEGF） ***： Thirty-two DME patients were enrolled.A700 microgram slow release Intravitreal Dexamethasone Implant（Ozurdex~） was placed in the vitreous *** patients were followed for 18 ***-corrected visual acuity（BCVA） measured with Early Treatment Diabetic Retinopathy Study（ETDRS） and central macular thickness（CMT） exams were carried out at baseline（T0）and after 1（T1）,3（T3）,4（T4）,6（T6）,9（T9）,12（T12）,15（T15）,and 18mo（T18） post injection. RESULTS： Repeated measures ANOVA showed an effect of treatment on ETDRS（P〈0.0001）.Post hoc analyses revealed that ETDRS values were significantly increased at T1,T3,T4,T9,and T15（P 〈0.001） as compared to baseline value（T0）.At T6,T12,and T18,ETDRS values were still statistically higher than baseline（P〈0.001 vs T0）.However,at these time points,we observed a trend to return to baseline *** also showed an effect of treatment（P 〈0.0001）.CMT decreased significantly at T1,T3,T4,T9,and T15（P〈0.001）.At T6（P〈0.01）,T12 and T18（P〈0.001） CMT was also significantly lower than T0 although a trend to return to the baseline conditions was also ***： Our findings demonstrate that Intravitreal Dexamethasone Implant is a good option to improveBCVA and CMT in DME patients resistant to anti-VEGF *** data also show that the use of drugs administered directly into the vitreous allows achieving appropriate and long-lasting concentration at the site of disease without systemic side effects.

关键词： diabetic macular edema Intravitreal Dexamethasone Implant anti-vascular endothelial growth factor therapy

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Health care service usage and costs for high-needs elderly patients with heart failure

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Journal of Geriatric Cardiology 2020年第9期17卷 580-584页

作者： alessandra Buja Riccardo Caberlotto Carlo Pinato Giulia Grotto Maria Chiara Corti Francesco Avossa Elena Schievano Vincenzo Baldo Department of Cardiologic Vascular and Thoracic Sciencesand Public HealthUniversity of PaduaPadovaItaly School of Specialization in Hygiene Preventive Medicine and Public HealthUniversity of PaduaPadovaItaly Azienda Zero UnitàOperativa Complessa“Servizio Epidemiologico Regionale e Registri”Italy

Heart failure(HF)has been defined as global disease of pandemic proportions,since it affects around 26 million people worldwide.[1]According to a recent study,age is the most important factor influencing the prevalence of HF,as it is for most other chronic conditions.[2]This means that,with the predicted aging of the population(the proportion of the world’s population aged 60 years and over will nearly double from 2015 to 2050),[3]there will be a growth in the total burden of HF,and a rise in the number of comorbidities in HF *** to a recent study,almost 86%of adults with HF have two or more comorbid conditions.[4]Comorbidity,defined as the co-existence of one or more additional conditions in individuals with a specified index medical condition,[5]adds to the complexity of treating elderly patients with HF.

关键词： Heart failure Healthcare service costs Healthcare service usage Multimorbidity

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Alternate Wetting and Drying of Rice Reduced CH4 Emissions but Triggered N2O Peaks in a Clayey Soil of Central Italy

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Pedosphere 2016年第4期26卷 533-548页

作者： alessandra LAGOMARSINO Alessandro Elio AGNELLI Bruce LINQUIST Maria Arlene ADVIENTO-BORBE Alberto AGNELLI Giacomo GAVINA Stefano RAVAGLIA Rossana Monica FERRARA Consiglio per la Ricerca in agricoltura e l'analisi dell'Economia Agraria centro di ricerca per l'Agro Biologia e la Pedologia 50121 Firenze Department of Plant Sciences University of California Davis CA 95616 Dipartimento di Scienze Agrarie Alimentari e Ambientali Universita di Perugia 06123 Perugia Societa Italiana Sementi S. Lazzaro di Savena 40068 Bologna Consiglio per la Ricerca in agricoltura e l'analisi dell'Economia Agraria Research Unit for Cropping Systems in Dry Environments70125 Bari

Reducing CH4 and N20 emissions from rice cropping systems while sustaining production levels with less water requires a better understanding of the key processes involved. Alternate wetting and drying （AWD） irrigation is one promising practice that has been shown to reduce CH4 emissions. However, little is known about the impact of this practice on N20 emissions, in particular under Mediterranean climate. To close this knowledge gap, we assessed how AWD influenced grain yield, fluxes and annual budgets of CH4 and N20 emissions, and global warming potential （GWP） in Italian rice systems over a 2-year period. Overall, a larger GWP was observed under AWD, as a result of high N20 emissions which offset reductions in CH4 emissions. In the first year, with 70% water reduction, the yields were reduced by 33%, CH4 emissions decreased by 97%, while N20 emissions increased by more than 5-fold under AWD as compared to PF; in the second year, with a 40% water saving, the reductions of rice yields and CH4 emissions （13% and 11%, respectively） were not significant, but N20 fluxes more than doubled. The transition from anaerobic to aerobic soil conditions resulted in the highest N20 fluxes under AWD. The duration of flooding, transition to aerobic conditions, water level above the soil surface, and the relative timing between fertilization and flooding were the main drivers affecting greenhouse gas mitigation potential under AWD and should be carefully planned through site-specific management options.

关键词： aerobic soil conditions fertilization global warming potential greenhouse gas mitigation potential water saving

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Molecular memory of Flavescence dorée phytoplasma in recovering grapevines

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Horticulture Research 2020年第1期7卷 1185-1199页

作者： Chiara Pagliarani Giorgio Gambino alessandra Ferrandino Walter Chitarra Urska Vrhovsek Dario Cantu Sabrina Palmano Cristina Marzachì Andrea Schubert Institute for Sustainable Plant Protection National Research Council(IPSPCNR)Strada delle Cacce 7310135 TurinItaly PlantStressLab Department of AgriculturalForestry and Food SciencesUniversity of TurinLargo Paolo Braccini 210095 GrugliascoTOItaly Research Centre for Viticulture and Enology Council for Agricultural Research and Economics(CREA-VE)Via XXVIII Aprile 2631015 ConeglianoTVItaly Fondazione Edmund Mach Via Edmund Mach 138010 San Michele all’AdigeTNItaly Department of Viticulture and Enology University of CaliforniaOne Shields AvenueDavisCA 95616USA

Flavescence dorée(FD)is a destructive phytoplasma disease of European *** and cultivardependent recovery(REC)may occur in the field in FD-infected vines starting the year following the first ***,the biological underpinnings of this process are still largely *** this study,transcriptome sequencing(RNAseq),whole-genome bisulphite sequencing(WGBS)and metabolite analysis were combined to dissect molecular and metabolic changes associated to FD and REC in leaf veins collected in the field from healthy(H),FD and REC plants of the highly susceptible Vitis vinifera‘Barbera’.Genes involved in flavonoid biosynthesis,carbohydrate metabolism and stress responses were overexpressed in FD conditions,whereas transcripts linked to hormone and stilbene metabolisms were upregulated in REC *** patterns of abscisic acid and stilbenoid compounds analysed in the same samples confirmed the RNAseq *** recovery conditions,we also observed the persistence of some FD-induced expression changes concerning inhibition of photosynthetic processes and stress *** differentially expressed genes tied to those pathways also underwent post-transcriptional regulation by microRNAs,as outlined by merging our transcriptomic data set with a previously conducted smallRNAseq *** by WGBS analysis also revealed different DNA methylation marks between REC and H leaves,occurring within the promoters of genes tied to photosynthesis and secondary *** results allowed us to advance the existence of a“molecular memory”of FDp infection,involving alterations in the DNA methylation status of REC plants potentially related to transcriptional reprogramming events,in turn triggering changes in hormonal and secondary metabolite profiles.

关键词： metabolism alterations starting

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Environmental licensing of new transmission systems in brazil: framing criteria by environmental agency

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Global Energy Interconnection 2020年第5期3卷 423-429页

作者： Ricardo Abranches Felix Cardoso Junior alessandra Schwertner Hoffmann Lillian Monteath Carolina Vasconcellos Salcedo Benoit Lagore Bruno Busato Rocha Agriculture and Environmental Engineering Department-Engineering School.Universidade Federal Fluminense.R.Passo da Pátria 156-237-São DomingosNiteróiRJ24210-240Brazil Water Resources and Environmental Engineering Department-Engineering School.Universidade Federal Fluminense.R.Passo da Pátria 156-209-São DomingosNiteróiRJ24210-240Brazil Electric Sector Study Group-Federal University of Rio de Janeiro(UFRJ)-Institute of Economics Red Beach Campus Av.Pasteur 250-UrcaRio de JaneiroRJ22290-240Brazil

The growing demand for electricity in large Brazilian cities and the distance to the region with the largest energy production have encouraged the construction of transmission lines thousands of kilometers long, crossing several states of the federation. Therefore, the heterogeneity of requirements in federal, state and district environmental laws tend to lead to uncertainty for the investor regarding procedures and investments necessary for the completion of the project, as well as the time that the requirements will take to be fulfilled. In the present study, we identify and compare the criteria used by the various environmental licensing agencies for classifying transmission system projects in the different procedures(simplified and ordinary) of environmental licensing. It was possible to expose the differences and demonstrate some inconsistencies in the legislation of some Brazilian states. In particular, we note an absence of proportionality between the licensing requirements and the expected environmental impacts for projects on the physical, biological and social environments. Additionally, it was identified subjectivity in the requirement for social participation through public hearings, demanded by the legislation for the projects classified in the ordinary procedure.

关键词： environmental licensing environmental permitting transmission lines Brazil

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