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Contrast-enhanced sonography versus biopsy for the differential diagnosis of thrombosis in hepatocellular carcinoma patients

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World Journal of Gastroenterology 2009年第18期15卷 2245-2251页

作者： Paolo Sorrentino Salvatore D'Angelo Luciano Tarantino Umberto Ferbo alessandra Bracigliano Raffaela Vecchione Liver Unit Clinical and Experimental HepatologyDepartment of Internal MedicineS.G.Moscati Hospital83100 AvellinoItaly Department of Biomorphological Science University of Naples Federico Ⅱ80131 NaplesItaly Hepatology and Interventional Ultrasound Unit S.Giovanni di Dio HospitalASL 380027 FrattamaggioreNaplesItaly Institute of Pathology S.G.Moscati Hospital83100 AvellinoItaly

AIM:To clarify which method has accuracy:2nd gen-eration contrast-enhanced ultrasound or biopsy of portal vein thrombus in the differential diagnosis of portal vein ***:One hundred and eighty-six patients with hepatocellular carcinoma and portal vein thrombosis underwent in blinded fashion a 2nd generation contrast-enhanced ultrasound and biopsy of portal vein thrombus;both results were examined on the basis of the follow-up of patients compared to ***:One hundred and eight patients completed the *** thrombosis on 2nd generation contrast-enhanced ultrasound was characterised by progressive hypoenhancing of the thrombus;in malignant portal vein thrombosis there was a precocious homo-geneous enhancement of the *** follow-up there were 50 of 108 patients with benign thrombosis:all were correctly diagnosed by both *** were 58 of 108 patients with malignant thrombosis:amongst these,52 were correctly diagnosed by both methods,the remainder did not present malignant cells on portal vein thrombus biopsy and showed on 2nd generation contrast-enhanced ultrasound an inho-mogeneous enhancement pattern.A new biopsy during the follow-up,guided to the area of thrombus that showed up on 2nd generation contrast-enhanced ultra-sound,demonstrated an enhancing pattern indicating malignant ***:In patients with hepatocellular carcinoma complicated by portal vein thrombosis,2nd generation contrast-enhanced ultrasound of portal vein thrombus is very useful in assessing the benign or malignant nature of the *** biopsy of thrombus is usually accurate but presents some sampling errors,so,when pathological results are required,2nd generation contrast-enhanced ultrasound could guide the sampling needle to the correct area of the thrombus.

关键词：门静脉血栓形成超声造影穿刺活检鉴别诊断肝癌患者对比增强恶性肿瘤恶性细胞

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Trends in tropospheric ozone concentrations and forest impact metrics in Europe over the time period 2000–2014

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Journal of Forestry Research 2021年第2期32卷 543-551页

作者： Chiara Proietti Maria Francesca Fornasier Pierre Sicard Alessandro Anav Elena Paoletti alessandra De Marco Italian Institute for Environmental Protection and Research(ISPRA) via Brancati 4800144 RomeItaly ARGANS 260 route du Pin Montard06410 BiotFrance Italian National Agency for New Technologies Energy and the EnvironmentC.R.Casaccia00123 RomeItaly IRET-CNR Via Madonna del Piano 10Florence50019 Sesto FiorentinoItaly

In Europe,tropospheric ozone pollution appears as a major air quality issue,and ozone concentrations remain potentially harmful to *** this study we compared the trends of two ozone metrics widely used for forests protection in Europe,the AOT40(Accumulated Ozone over Threshold of 40 ppb)which only depends on surface air ozone concentrations,and the Phytotoxic Ozone Dose which is the accumulated ozone uptake through stomata over the growing season,and above a threshold Y of uptake(PODY).By using a chemistry transport model,we found that European-averaged ground-level ozone concentrations(−2%)and AOT40 metric(−26.5%)significantly declined from 2000 to 2014,due to successful control strategies to reduce the emission of ozone precursors in Europe since the early *** contrast,the stomatal ozone uptake by forests increased from 17.5 to 26.6 mmol O3 m^(−2)despite the reduction in ozone concentrations,leading to an increase of potential ozone damage on plants in *** a climate change context,a biologically-sound stomatal flux-based standard(PODY)as new European legislative standard is needed.

关键词： Tropospheric ozone AOT40 POD Trendm Mann-Kendall test

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Hepatitis C virus micro-elimination:Where do we stand?

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World Journal of Gastroenterology 2021年第16期27卷 1728-1737页

作者： alessandra Mangia Rosa Cotugno Giovanna Cocomazzi Maria Maddalena Squillante Valeria Piazzolla Liver Unit Department of Medical SciencesIRCCS Casa Sollievo della SofferenzaSan Giovanni Rotondo 71013FgItaly

Hepatitis C virus (HCV) elimination by 2030, using direct-acting antiviraltreatments, has been promoted by the World Health Organization. Thisachievement is not attainable, however, particularly after the 2020 pandemic ofthe coronavirus disease 2019. Consequently, the more realistic objective ofeliminating HCV from population segments for which targeted strategies ofprevention and treatment are easily attained has been promoted in Europe, as avalid alternative. The underlying idea is that micro-elimination will ultimatelylead to macro-elimination. The micro-elimination strategy may target differentspecific populations and at-risk groups. Different settings, including prisons andhospitals, have also been identified as micro-elimination scenarios. In addition,dedicated micro-elimination strategies have been designed that are tailored at thegeographical level according to HCV epidemiology and individual country’sincome. The main elements of a valid and successful micro-elimination project arereliable epidemiological data and active involvement of all the *** involvement represents another essential component for a successfulprogram.

关键词： Hepatitis C virus antibodies Hepatitis C virus elimination Hepatitis C virus epidemiology Hepatitis C virus RNA Hepatitis C virus diagnosis Hepatitis C virus infection

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Rapid dehydration of grape berries dampens the post-ripening transcriptomic program and the metabolite profile evolution

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Horticulture Research 2020年第1期7卷 1016-1030页

作者： Sara Zenoni alessandra Amato Erica D’Incà Flavia Guzzo Giovanni Battista Tornielli Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly

The postharvest dehydration of grape berries allows the concentration of sugars and other solutes and promotes the synthesis of metabolites and aroma compounds unique to high-quality raisin wines such as the passito wines made in *** dynamic changes are dependent on environmental parameters such as temperature and relative humidity,as well as endogenous factors such as berry morphology and genotype,but the contribution of each variable is not well ***,we compared berries subjected to natural or accelerated dehydration,the latter driven by forced air *** followed the evolution of transcript and metabolite profiles and found that accelerated dehydration clearly dampened the natural transcriptomic and metabolomic programs of postharvest *** found that slow dehydration over a prolonged duration is necessary to induce gene expression and metabolite accumulation associated with the final quality traits of dehydrated *** accumulation of key metabolites(particularly stilbenoids)during postharvest dehydration is inhibited by rapid dehydration conditions that shorten the berry life time.

关键词： flow dehydration latter

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Multi-stage rodingitization of ophiolitic bodies from Northern Apennines(Italy): Constraints from petrography, geochemistry and thermodynamic modelling

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Geoscience Frontiers 2020年第6期11卷 2103-2125页

作者： Emma Salvioli-Mariani Tiziano Boschetti Lorenzo Toscani alessandra Montanini Jasmine Rita Petriglieri Danilo Bersani Department of Chemistry Life Sciences and Environmental SustainabilityUniversity of ParmaParco Area delle Scienze 157/A43124ParmaItaly Department of Chemistry University of TorinoVia Pietro Giuria10125TorinoItaly Institute of Exact and Applied Sciences Universitéde la Nouvelle CalédonieCampus de NouvilleBP R4-98851 Nouméa CedexNew CaledoniaFrance Department of Mathematical Physical and Computer SciencesUniversity of ParmaParco Area delle Scienze 7/A43124ParmaItaly

The investigated mantle bodies from the External Ligurians(Groppo di Gorro and ***)show evidences of a complex evolution determined by an early high temperature metasomatism,due to percolating melts of asthenospheric origin,and a later metasomatism at relatively high temperature by hydrothermal fluids,with formation of *** Groppo di Gorro,the serpentinization and chloritization processes obliterated totally the pyroxenite protolith,whereas at *** relics of peridotite and pyroxenite protoliths were preserved from *** rodingite parageneses consist of diopside+vesuvianite+garnet+calcite+chlorite at Groppo di Gorro and garnet+diopside+serpentine±vesuvianite±prehnite±chlorite±pumpellyite at *** inclusion measurements show that rodingitization occurred at relatively high temperatures(264-334℃ at 500 bar and 300-380℃ at 1 kbar).Garnet,the first phase of rodingite to form,consists of abundant hydrogarnet component at Groppo di Gorro,whereas it is mainly composed of grossular and andradite at *** last stage of rodingitization is characterized by the vesuvianite *** nucleation requires high Ca and low silica fluids,whereas the formation of vesuvianite does not need CO2-poor *** formation of calcite at Groppo di Gorro points to mildly oxidizing conditions compatible with hydrothermal fluids;the presence of andradite associated with serpentine and magnetite at *** suggests Fe^3+-bearing fluids with fO2 slightly higher than iron-magnetite *** propose that the formation of the studied rodingite could be related to different pulses of hydrothermal fluids mainly occurring in an oceancontinent transitional setting and,locally,in an accretionary prism associated with intra-oceanic subduction.

关键词： Rodingite Hydrothermal alteration Raman spectroscopy Thermodynamic modelling Ligurian ophiolite Northern Apennines

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A molecular phenology scale of grape berry development

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Horticulture Research 2023年第5期10卷 72-84页

作者： Giovanni Battista Tornielli Marco Sandri Marianna Fasoli alessandra Amato Mario Pezzotti Paola Zuccolotto Sara Zenoni Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly Big&Open Data Innovation Laboratory University of BresciaC.da S.Chiara 5025122 BresciaItaly

Fruit growth and development consist of a continuous succession of physical,biochemical,and physiological changes driven by a genetic program that dynamically responds to environmental *** recognizable stages over the whole fruit lifetime represents a fundamental requirement for research and fruit crop *** is especially relevant in perennial crops like grapevine(Vitis vinifera L.)to scale the development of its fruit across genotypes and growing *** this work,molecular-based information from several grape berry transcriptomic datasets was exploited to build a molecular phenology scale(MPhS)and to map the ontogenic development of the *** proposed statistical pipeline consisted of an unsupervised learning procedure yielding an innovative combination of semiparametric,smoothing,and dimensionality reduction *** transcriptomic distance between fruit samples was precisely quantified by means of the MPhS that also enabled to highlight the complex dynamics of the transcriptional program over berry development through the calculation of the rate of variation of MPhS stages by *** MPhS allowed the alignment of time-series fruit samples proving to be a complementary method for mapping the progression of grape berry development with higher detail compared to classic time-or phenotype-based approaches.

关键词： crops yielding lifetime

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Chikungunya virus,epidemiology,clinics and phylogenesis:A review

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Asian Pacific Journal of Tropical Medicine 2014年第12期7卷 925-932页

作者： alessandra Lo Presti Alessia Lai Eleonora Cella Gianguglielmo Zehender Massimo Ciccozzi Department of Infectious Parasitic and Immunomediated Diseases Epidemiology UnitReference Centre on Phytogeny Molecular Epidemiology and Microbial Evolution(FEMEM).Istituto Superiore di Sanita RomeItaly Department of Biomedical and Clinical Sciences L Sacco HospitalUniversity of MilanMilanItaly University Campus-Biomedico RomeItaly

Chikungunva virus is a mosquito-transmitted alphavirus that causes chikungunva fever,a febrile illness associated with severe arthralgia and *** virus is transmitted by culicine mosquitoes:Chikungunya virus replicates in the skin,disseminates to liver,muscle,*** tissue and brain,presumably through the *** studies showed that the Indian Ocean and the Indian subcontinent epidemics were caused by two different introductions of distinct strains of East/Central/South African genotype of *** paraphyletic grouping of African CHIK viruses supports the historical evidence that the virus was introduced into Asia from *** analysis divided Chikungunva virus isolates into three distinct genotypes based on geographical origins:the first,the West Africa genotype,consisted of isolates from Senegal and Nigeria;the second contained strains from East/Central/South African genotype,while the third contained solely *** most recent common ancestor for the recent epidemic,which ravaged Indian Ocean islands and Indian subcontinent in 2004- *** found to date in *** lineage dated about 1952 and exhibits similar spread patterns of the recent Indian Ocean outbreak lineage,with successive epidemics detected along an eastward *** group splitted into two clades:an Indian lineage and a south east *** of Chikungunya virus fever in Asia have not been associated necessarily with outbreaks in *** tools can reconstruct geographic spread of Chikungunva virus during the epidemics *** good management of patients with acute Chikungunva virus infection is essential for public health in susceptible areas with current Aedes spp activity.

关键词： CHIKV Epidemiology Phylogeny

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Human bocavirus in children hospitalized for acute respiratory tract infection in Rome

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World Journal of Pediatrics 2020年第3期16卷 293-298页

作者： Laura Petrarca Raffaella Nenna Antonella Frassanito alessandra Pierangeli Greta Di Mattia Carolina Scagnolari Fabio Midulla Maternal-Infantile and Urological Science Department "Sapienza"University of RomeRomeItaly Virology Laboratory Department of Molecular Medicine"Sapienza"University of RomeRomeItaly

Background The role of human bocavirus (HBoV) as a respiratory pathogen has not been fulfilled *** aimed to describe clinical and serological characteristics of children with HBoV hospitalized for acute respiratory tract infection and to evaluate whether differences occur between HBoV alone and in *** We retrospectively reviewed data from 60 children (median age of 6.2 months,range 0.6-70.9) hospitalized for acute respiratory symptoms,with HBoV detected from a respiratory sample,using a reverse transcriptase-PCR for 14 respiratory viruses (including respiratory syncytial virus (RSV),influenza virus A and B,human coronavirus OC43,229E,NL-63 and HUK1,adenovirus,rhinovirus,parainfluenza virus 1-3,and human metapneumovirus).Results HBoV was detected alone in 29 (48.3%) patients,while in co-infection with other viruses in 31 patients (51.7%),with a peak between December and *** the 60 patients,34 were bronchiolitis,19 wheezing,3 pneumonia,2 upper respiratory tract infection,and 2 whooping *** children (11.6%) required admission to the paediatric intensive care unit (PICU) for respiratory *** differences was observed in age,family history for atopy and/or asthma,clinical presentations,chest X-ray,or laboratory findings in children with HBoV alone *** viral *** was the most frequently co-detected virus (61.3%).When compared with HBoV detection alone,the co-detection of RSV and HBoV was associated with male sex (P=0.013),younger age (P=0.01),and lower blood neutrophil count (P=0.032).Conclusions HBoV can be detected alone and in co-infection respiratory samples of children with an acute respiratory tract infection.A cause-effect relationship between HBoV and respiratory infection is not clear,so further studies are needed to clarify this point.

关键词： Human bocavirus Pediatrics Respiratory tract infection Viral infection

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Postmortem Nasopharyngeal Swabs Performed during the COVID-19 Infection:Analysis of Preliminary Clinical Records by the Genoa Institute of Legal Medicine(North-West Italy)

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Journal of Forensic Science and Medicine 2022年第1期8卷 24-31页

作者： Martina Drommi Rosario Barranco Arianna Bal bo Stefano Errico Francesca Maria Elena Frigiolini Manuela Mangioni Giulia Molinari alessandra Zappi Patrizia Caligiuri Francesco De Stefano Francesco Ventura Department of Forensic and Legal Medicine University of GenovaGenovaItaly Department of Health Sciences University of GenovaGenoaItaly Department of Hygiene San Martino Polyclinic HospitalGenovaItaly

COVID-19,the disease caused by the SARS-CoV-2 virus,is highly *** persistence of the virus after infected individuals die remains *** article reports the findings taken from postmortem nasopharyngeal swabs performed to investigate the presence of SARS-CoV-2 in the corpses transferred to the Genoa District Mortuary from the outset of the Italian lockdown(March 9)to the end of the first emergency phase(July 13).One hundred and eighty swabs were carried out:13 corpses resulted positive for the virus,with the diagnosis being reached only after *** were male and 6 female with an average age of 73.5 years *** most frequent comorbidities recorded were arterial hypertension,diabetes,Alzheimer 5s,and pulmonary *** two cases,the swab tested positive at a distance of 125 h and 165 h from actual *** nasopharyngeal swab results a useful way to screen corpses for COVID-19 and to handle bodies in Legal Medicine Centers where safe autoptic rooms are not *** are also a means of safeguarding forensic pathologists,identifying the presence of breeding grounds in the community and providing information for the Public Prosecutor's Office in legal *** are able to produce reliable results up to at least 7 days following death,provided that the corpse is correctly preserved.

关键词： Autopsy forensic pathology legal medicine managing of the corpses naso-pharyngeal swab SARS-CoV-2

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The phylogenetic and evolutionary history of Kokobera virus

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Asian Pacific Journal of Tropical Medicine 2016年第10期9卷 945-950页

作者： Aletheia Blasi alessandra Lo Presti Eleonora Cella Silvia Angeletti Massimo Ciccozzi Unit of Clinical Pathology and Microbiology University Campus Bio-Medico of Rome Department of Infectious Parasitic and Immunomediated Diseases Istituto Superiore di Sanità Public Health and Infectious Diseases Sapienza University

Objective: To estimate the genetic diversity of Kokobera virus, the date of origin and the spread among different viruses in the endemic regions of Australia. Methods: Two datasets were built. The first consisting of 29 sequences of the NS5/3' UTR region of Kokobera group downloaded from Gen Bank, the second including only 24 sequences of Kokobera viruses, focus is on this group. Results: Bayesian time analysis revealed two different entries in Australia of Kokobera virus in the 50 s years with the dated ancestor in 1861 year. Clade A and B showed a clear separation of the Kokobera sequences according to the geographic region. Conclusions: Data from the study showed as Kokobera virus, despite of its ancient origin and its circulation before the European colonization, remained limited to the Australian Country and nowadays limited mostly to the regions were Australian marsupials are mostly found.

关键词： Kokobera virus Phylogeny Date of origin Evolution

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