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Horticulture Research 2020年第1期7卷 1016-1030页

作者： Sara Zenoni alessandra amato Erica D’Incà Flavia Guzzo Giovanni Battista Tornielli Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly

The postharvest dehydration of grape berries allows the concentration of sugars and other solutes and promotes the synthesis of metabolites and aroma compounds unique to high-quality raisin wines such as the passito wines made in *** dynamic changes are dependent on environmental parameters such as temperature and relative humidity,as well as endogenous factors such as berry morphology and genotype,but the contribution of each variable is not well ***,we compared berries subjected to natural or accelerated dehydration,the latter driven by forced air *** followed the evolution of transcript and metabolite profiles and found that accelerated dehydration clearly dampened the natural transcriptomic and metabolomic programs of postharvest *** found that slow dehydration over a prolonged duration is necessary to induce gene expression and metabolite accumulation associated with the final quality traits of dehydrated *** accumulation of key metabolites(particularly stilbenoids)during postharvest dehydration is inhibited by rapid dehydration conditions that shorten the berry life time.

关键词： flow dehydration latter

A molecular phenology scale of grape berry development

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Horticulture Research 2023年第5期10卷 72-84页

作者： Giovanni Battista Tornielli Marco Sandri Marianna Fasoli alessandra amato Mario Pezzotti Paola Zuccolotto Sara Zenoni Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly Big&Open Data Innovation Laboratory University of BresciaC.da S.Chiara 5025122 BresciaItaly

Fruit growth and development consist of a continuous succession of physical,biochemical,and physiological changes driven by a genetic program that dynamically responds to environmental *** recognizable stages over the whole fruit lifetime represents a fundamental requirement for research and fruit crop *** is especially relevant in perennial crops like grapevine(Vitis vinifera L.)to scale the development of its fruit across genotypes and growing *** this work,molecular-based information from several grape berry transcriptomic datasets was exploited to build a molecular phenology scale(MPhS)and to map the ontogenic development of the *** proposed statistical pipeline consisted of an unsupervised learning procedure yielding an innovative combination of semiparametric,smoothing,and dimensionality reduction *** transcriptomic distance between fruit samples was precisely quantified by means of the MPhS that also enabled to highlight the complex dynamics of the transcriptional program over berry development through the calculation of the rate of variation of MPhS stages by *** MPhS allowed the alignment of time-series fruit samples proving to be a complementary method for mapping the progression of grape berry development with higher detail compared to classic time-or phenotype-based approaches.

关键词： crops yielding lifetime

Carbon dioxide:Global warning for nephrologists

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World Journal of Nephrology 2016年第5期5卷 429-436页

作者： Marco Marano Anna D'amato, alessandra Cantone Hemodialysis Unit Maria Rosaria ClinicPompeii80045 NaplesItaly Bayview Physicians Group SuffolkVA 23462United States

The large prevalence of respiratory acid-base disordersoverlapping metabolic acidosis in hemodialysis popu-lation should prompt nephrologists to deal with the partial pressure of carbon dioxide （pCO2） complying with the reduced bicarbonate concentration. What the most suitable formula to compute pCO2 is reviewed. Then, the neglected issue of CO2 content in the dialysis fluid is under the spotlight. In fact, a considerable amount of CO2 comes to patients’ bloodstream every hemodialysis treatment and “acidosis by dialysate” may occur if lungs do not properly clear away this burden of CO2. Moreover, vascular access recirculation may be easy diagnosed by detecting CO2 in the arterial line of extracorporeal circuit if CO2-enriched blood from the flter reenters arterial needle.

关键词： Acid-base assessment Bicarbonate Carbon dioxide Hemodialysis Metabolic acidosis Mixed disorders Ventilatory response Expected pressure of carbon dioxide Vascular access recirculation

Non-toxic, high selectivity process for the extraction of precious metals from waste printed circuit boards

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Frontiers of Environmental Science & Engineering 2023年第10期17卷 65-74页

作者： Giulia Merli Alessandro Becci Alessia amato Francesca Beolchini Department of Life and Environmental Sciences Polytechnic University of MarcheAncona 60131Italy

The work presented here focused on the extraction of gold (Au), silver (Ag) and palladium (Pd) from electronic waste using a solution of ammonium thiosulfate. Thiosulfate was used as a valid alternative to cyanide for precious metal extractions, due to its non-toxicity and high selectivity. The interactions between sodium thiosulfate, total ammonia/ammonium, precious metal concentrations and the particle size of the waste printed circuit boards (WPCBs) were studied by the response surface methodology (RSM) and the principal component analysis (PCA) to maximize precious metal mobilization. Au extraction reached a high efficiency with a granulometry of less than 0.25 mm, but the consumption of reagents was high. On the other hand, Ag extraction depended neither on thiosulfate/ammonia concentration nor granulometry of WPCBs and it showed efficiency of 90% also with the biggest particle size (0.50 < Ø < 1.00 mm). Pd extraction, similarly to Au, showed the best efficiency with the smallest and the medium WPCB sizes, but required less reagents compared to Au. The results showed that precious metal leaching is a complex process (mainly for Au, which requires more severe conditions in order to achieve high extraction efficiencies) correlated with reagent concentrations, precious metal concentrations and WPCB particle sizes. These results have great potentiality, suggesting the possibility of a more selective recovery of precious metals based on the different granulometry of the WPCBs. Furthermore, the high extraction efficiencies obtained for all the metals bode well in the perspective of large-scale applications.

关键词： Thiosulfate Printed circuit boards Precious metals Leaching Hydrometallurgy

Protective potential of glucagon like peptide 2(GLP-2) against the neurodegeneration

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Neural Regeneration Research 2019年第11期14卷 1901-1902页

作者： Antonella amato Flavia Mulè Dipartimento di Scienze e Tecnologie Biologiche Chimiche e Farmaceutiche (STEBICEF) Università di Palermo

Neurodegeneration consists in loss of neuron specific types, pattern and distribution, leading to progressive dysfunctions of the central nervous system. Neurodegenerative diseases include diverse pathological conditions, among which Alzheimer’s and Parkinson’s diseases are the most prevalent ones. Alzheimer’s disease is known as a growing dementia, characterized by progressive language, memory, and cognitive loss, while Parkinson’s disease is primarily characterized as a motor disorder. Senile plaques, caused by amyloid β peptide, hyperphosphorylated taubased neurofibrillary tangles and synapse loss, are the principal pathological hallmarks of Alzheimer’s disease.

关键词： Protective potential glucagon like peptide 2(GLP-2) neurodegeneration

Dihydropyrimidine dehydrogenase polymorphisms in patients with gastrointestinal malignancies and their impact on fluoropyrimidine tolerability: Experience from a single Italian institution

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 101-109页

作者： Mariarosaria D'amato Gennaro Iengo Nicola Massa Chiara Carlomagno Department of Oncology Ospedale San Rocco ASL CasertaSessa Aurunca 81037CampaniaItaly Department of Clinical Medicine and Surgery University of Naples Federico IINaples 80131CampaniaItaly

BACKGROUND Fluoropyrimidines are metabolized in the liver by the enzyme dihydropyrimidine dehydrogenase(DPD),encoded by the DPYD *** 7%of the European population is a carrier of DPYD gene polymorphisms associated with reduced DPD enzyme *** To assess the prevalence of DPYD polymorphisms and their impact on fluoropyrimidine tolerability in Italian patients with gastrointestinal *** A total of 300 consecutive patients with a diagnosis of gastrointestinal malignancy and treated with a fluoropyrimidine-based regimen were included in the analysis and divided into two cohorts:(1)149 patients who started fluoropyrimidines after DPYD testing;and(2)151 patients treated without DPYD *** the patients in cohort A,15%tested only the DPYD2A polymorphism,19%tested four polymorphisms(DPYD2A,HapB3,c.2846A>T,and DPYD13),and 66%tested five polymorphisms including *** Overall,14.8%of patients were found to be carriers of a DPYD variant,the most common being DPYD6(12.1%).Patients in cohort A reported≥G3 toxicities(P=0.00098),particularly fewer nonhematological toxicities(P=0.0028)compared with cohort B,whereas there was no statistically significant difference between the two cohorts in hematological toxicities(P=0.6944).Significantly fewer chemotherapy dose reductions(P=0.00002)were observed in cohort A compared to cohort B,whereas there was no statistically significant differences in chemotherapy *** Although this study had a limited sample size,it provides additional information on the prevalence of DPYD polymorphisms in the Italian population and highlights the role of pharmacogenetic testing to prevent severe toxicity.

关键词： Dihydropyrimidine dehydrogenase DPYD polymorphisms Fluoropyrimidine Caucasian population Gastrointestinal cancers

Kinetics of defect formation in chemically vapor deposited （CVD） graphene during laser irradiation： The case of Raman investigation

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Nano Research 2015年第12期8卷 3972-3981页

作者： Giampiero amato Gianluca Milano Umberto Vignolo Ettore Vittone Quantum Research Laboratory INRIM Strada delle Cacce 91 Torino Italy Department of Physics NIS Research Center University of Torino via Pietro Giuria 1 10125 Torino Italy

The effect of laser irradiation on chemically vapor deposited （CVD） graphene was studied by analyzing the temporal evolution of Raman spectra acquired under various illumination conditions. The spectra showed that the normalized intensity of the defect-related peak increases with the square root of the exposure time and varies almost linearly with the laser power density. Furthermore, the hardness of graphene to radiation damage depends on its intrinsic structural quality. The results suggest that, contrary to the common belief, micro-Raman spectroscopy cannot be considered a noninvasive tool for the characterization of graphene. The experimental observations are compatible with a model that we derived from the interpretative approach of the Staebler-Wronski effect in hydrogenated amorphous silicon; this approach assumes that the recombination of photoexcited carriers induces the breaking of weak C-C bonds.

关键词： chemically vapor deposited (CVD) graphene Raman spectroscopy defect kinetics laser irradiation

Variable retention harvesting in Great Lakes mixed-pine forests: emulating a natural model in managed ecosystems

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Ecological Processes 2019年第1期8卷 210-224页

作者： Brian J.Palik Anthony W.D’amato USDA Forest Service Northern Research StationGrand RapidsMN 55744USA Rubenstein School of Environment and Natural Resources University of VermontBurlingtonVT 05095USA.

Variable retention harvesting(VRH)systems have gained wide use in many different forest types across the globe,but largely have been implemented in forests characterized by severe,infrequent disturbance *** has been less attention given to developing VRH approaches in forests that are characterized as having a mixed-severity disturbance regime that often results in only partial mortality of canopy trees in spatially heterogeneous *** example of such a forest type is red pine(Pinus resinosa Ait.)-dominated ecosystem of the western Great Lakes region of North *** purpose of this review is to provide a conceptual foundation for developing VRH approaches in red pine ecosystems that are based on a mixed-severity disturbance *** contention is that red pine forests managed following a natural model are more resilient to disturbances and external threats such as climate *** the red pine ecosystem,VRH application should reflect the often severe,but partial canopy removal from natural disturbance that is characteristic of this ecosystem and that results in more than trivial numbers of surviving overstory trees across a range of spatial configurations in regenerating *** live trees should span a range of diameters,but favor the larger end of the diameter distribution,as this reflects the likely pattern of survival after natural disturbance and is often a key structural element lacking from managed *** should be applied in ways that vary the spatial pattern of legacy trees in and among stands,but largely in ways that reflect the pattern of spatially patchy canopy structure,with large openings surrounded by a less disturbed matrix,as occurs with a natural disturbance *** trees and deadwood structures should reflect the composition of the pre-disturbance forest,including species in addition to dominant red ***,retained structures should be viewed as dynamic entities that grow,die,and decay and that need

关键词： Red pine Mixed-severity Variable retention Natural disturbance

Concentrated suspensions of Brownian beads in water: dynamic heterogeneities through a simple experimental technique

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Science China(Physics,Mechanics & Astronomy) 2019年第10期62卷 33-44页

作者： Raffaele Pastore Marco Caggioni Domenico Larobina Luigi Santamaria amato Francesco Greco Department of Chemical Materials and Production EngineeringUniversity of Naples FedericoⅡNapoli 80125Italy Corporate Engineering The Procter&Gamble CompanyCincinnatiWest Chester OH 45069USA Institute for Polymers Composites and BiomaterialsNational Research Council of ItalyNapoli 80055Italy ASI Agenzia Spaziale ItalianaCentro di Geodesia SpazialeMatera 75100Italy

Concentrated suspensions of Brownian hard-spheres in water are an epitome for understanding the glassy dynamics of both soft materials and supercooled molecular liquids. From an experimental point of view, such systems are especially suited to perform particle tracking easily, and, therefore, are a benchmark for novel optical techniques, applicable when primary particles cannot be resolved. Differential variance analysis（DVA） is one such novel technique that simplifies significantly the characterization of structural relaxation processes of soft glassy materials, since it is directly applicable to digital image sequences of the sample. DVA succeeds in monitoring not only the average dynamics, but also its spatio-temporal fluctuations, known as dynamic heterogeneities. In this work, we study the dynamics of dense suspensions of Brownian beads in water, imaged through digital video-microscopy, by using both DVA and single-particle tracking. We focus on two commonly used signatures of dynamic heterogeneities: the dynamic susceptibility, χ4, and the non-Gaussian parameter, α2. By direct comparison of these two quantities,we are able to highlight similarities and differences. We do confirm that χ4 and α2 provide qualitatively similar information, but we find quantitative discrepancies in the scalings of characteristic time and length scale on approaching the glass transition.

关键词： glass transition structural relaxation dynamic heterogeneities colloidal glasses

PERFORMANCE EVALUATION OF THREE DIFFERENT FAÇADE MODELS FOR SUSTAINABLE OFFICE BUILDINGS

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Journal of Green Building 2006年第4期1卷 91-103页

作者： Matthias Haase Alex amato Hong Kong University Department of ArchitecturePokfulam RoadHong Kong

Sustainable development issues are currently the driving forces of many building *** building façade is critical for the architectural expression and has a large affect upon large parts of the building’s environmental *** study investigates the advantages of using multidimensional computer aided modeling and simulation to produce a sustainable façade design.A first step towards green building design is to establish a list of parameters which can then be used as design criteria,*** performance,thermal visual and acoustic comfort,*** simulation and an analysis of recent projects in Hong Kong can help to determine the performance according to these design parameters whilst environmental impacts due to energy consumption are considered to be an important design parameter,it is also important for comfort criteria to be considered.

关键词： OFFICE computer architectural