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Rapid dehydration of grape berries dampens the post-ripening transcriptomic program and the metabolite profile evolution

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Horticulture Research 2020年第1期7卷 1016-1030页

作者： Sara Zenoni alessandra amato Erica D’Incà Flavia Guzzo Giovanni Battista Tornielli Department of Biotechnology University of VeronaStrada Le Grazie 1537134 VeronaItaly

The postharvest dehydration of grape berries allows the concentration of sugars and other solutes and promotes the synthesis of metabolites and aroma compounds unique to high-quality raisin wines such as the passito wines made in *** dynamic changes are dependent on environmental parameters such as temperature and relative humidity,as well as endogenous factors such as berry morphology and genotype,but the contribution of each variable is not well ***,we compared berries subjected to natural or accelerated dehydration,the latter driven by forced air *** followed the evolution of transcript and metabolite profiles and found that accelerated dehydration clearly dampened the natural transcriptomic and metabolomic programs of postharvest *** found that slow dehydration over a prolonged duration is necessary to induce gene expression and metabolite accumulation associated with the final quality traits of dehydrated *** accumulation of key metabolites(particularly stilbenoids)during postharvest dehydration is inhibited by rapid dehydration conditions that shorten the berry life time.

关键词： flow dehydration latter

Aqueous electrochemical delithiation of cathode materials as a strategy to selectively recover lithium from waste lithium-ion batteries

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Journal of Energy Chemistry 2024年第1期88卷 144-153,I0004页

作者： Pier Giorgio Schiavi Andrea Giacomo Marrani Olga Russina Ludovica D’Annibale Francesco amato Francesca Pagnanelli Pietro Altimari Department of Chemistry Sapienza University of RomePiazzale Aldo Moro n.500185 RomeItaly

Lithium recovery from end-of-life Li-ion batteries(LIBs)through pyro-and hydrometallurgical recycling processes involves several refining stages,with high consumption of reagents and energy.A competitive technological alternative is the electrochemical oxidation of the cathode materials,whereby lithium can be deintercalated and transferred to an electrolyte solution without the aid of chemical extracting *** article investigates the potential to selectively recover Li from LIB cathode materials by direct electrochemical extraction in aqueous *** process allowed to recovering up to 98%of Li from high-purity commercial cathode materials(LiMn_(2)O_(4),LiCoO_(2),and Li Ni_(1/3)Mn_(1/3)Co_(1/3)O_(2))with a faradaic efficiency of 98%and negligible co-extraction of Co,Ni,and *** process was then applied to recover Li from the real waste LIBs black mass obtained by the physical treatment of electric vehicle battery *** black mass contained graphite,conductive carbon,and metal impurities from current collectors and steel cases,which significantly influenced the evolution and performances of Li electrochemical ***,due to concomitant oxidation of impurities,lithium extraction yields and faradaic efficiencies were lower than those obtained with high-purity cathode *** oxidation was found to occur within the voltage range investigated,but it could not quantitatively explain the reduced Li extraction *** fact,a detailed investigation revealed that above 1.3 V ***/Ag Cl,conductive carbon can be oxidized,contributing to the decreased Li *** on the reported experimental results,guidelines were provided that quantitatively enable the extraction of Li from the black mass,while preventing the simultaneous oxidation of impurities and,consequently,reducing the energy consumption of the proposed Li recovery method.

关键词： Lithium recovery Lithium-ion batteries recycling Electrochemical lithium extraction Lithium selective Extraction

Experimental and Finite Element Analysis of Corroded High-Pressure Pipeline Repaired by Laminated Composite

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Computer Modeling in Engineering & Sciences 2024年第8期140卷 1783-1806页

作者： Seyed Mohammad Reza Abtahi Saeid Ansari Sadrabadi Gholam Hosein Rahimi Gaurav Singh Hamid Abyar Daniele amato Luigi Federico Faculty of Mechanical Engineering Tarbiat Modares UniversityTehran***Iran A.Leon Linton Department of Mechanical Robotics and Industrial EngineeringLawrence Technological UniversitySouthfieldMI48075USA Department of Mechanical Engineering Faculty of EngineeringMeybod UniversityYazd***Iran Department of Industrial Engineering University of SalernoVia Giovanni PaoloⅡFiscianoItaly Italian Aerospace Research Center(C.I.R.A.) Via MaioriseCapuaCE81043Italy

Repairs of corroded high-pressure pipelines are essential for fluids transportation under high *** of the methods used in their repairs is the use of layered *** composite used must have the necessary ***,the experiments and analytical solutions presented in this paper are performed according to the relevant standards and codes,including ASME PCC-2,ASME B31.8S,ASME B31.4,ISO 24817 and ASME *** addition,the experimental tests are replicated numerically using the finite element *** the strain gauges at different distances from the defect location,can reduce the nonlinear effects,deformation,and fluctuations due to the high *** direct relationship between the depth of an axial defect and the stress concentration is observed at the inner side edges of the *** reparation reduces the non-linearities related to the sharp variation of the geometry and a more reliable numerical simulation could be performed.

关键词： High-pressure pipeline composite repair ASME PCC-2 ISO 24817

Multi-disciplinary Pathways to Computing:A Scalable and Col aborative Approach to Capitalize on the Demand for Computer Science Education

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计算机教育 2024年第3期 10-12页

作者： Nancy M.amato Department of Computer Science University of Illinois at Urbana-Champaign 201 N.Goodwin Ave. UrbanaIL 61801

The number of students demanding computer science(CS)education is rapidly rising,and while faculty sizes are also growing,the traditional pipeline consisting of a CS major,a CS master’s,and then a move to industry or a *** is simply not *** address this problem,the Department of Computing at the University of Illinois has introduced a multidisciplinary approach to computing,which is a scalable and collaborative approach to capitalize on the tremendous demand for computer science *** key component of the approach is the blended major,also referred to as“CS+X”,where CS denotes computer science and X denotes a non-computing *** CS+X blended degrees enable win-win partnerships among multiple subject areas,distributing the educational responsibilities while growing the entire *** meet the demand from non-CS majors,another pathway that is offered is a graduate certificate program in addition to the traditional minor *** accommodate the large number of students,scalable teaching tools,such as automatic graders,have also been developed.

关键词： Multi-disciplinary Pathways A Scalable and Collaborative Approach Computer Science Education CS+X

Panel Discussion on“Development Trends of Computer Science in the New Era”

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计算机教育 2024年第3期 26-29页

作者： Andrew Yao Nancy M.amato Ann Copestake Sukyoung Ryu Yike Guo Yaqin Zhang Institute for Interdisciplinary Information Sciences Tsinghua UniversityBeijing100084China Department of Computing University of IllinoisUrbana61801U.S Department of Computer Science and Technology University of CambridgeCambridgeCB30FDUK Korea Advanced Institute of Science and Technology(KAIST) Yuseong-gu Daejeon34141Korea Hong Kong University of Science and Technology Hong Kong999077China Institute for AI Industry Research(AIR) Tsinghua UniversityBeijing100084China

At the panel session of the 3rd Global Forum on the Development of Computer Science,attendees had an opportunity to deliberate recent issues affecting computer science departments as a result of the recent growth in the field.6 heads of university computer science departments participated in the discussions,including the moderator,Professor Andrew *** first issue was how universities are managing the growing number of applicants in addition to swelling class *** approaches were suggested,including increasing faculty hiring,implementing scalable teaching tools,and working closer with other departments through degree programs that integrate computer science with other *** second issue was about the position and role of computer science within broader *** generally agreed that all fields are increasingly relying on computer science techniques,and that effectively disseminating these techniques to others is a key to unlocking broader scientific progress.

关键词： Development trends Computer science

Non-toxic, high selectivity process for the extraction of precious metals from waste printed circuit boards

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Frontiers of Environmental Science & Engineering 2023年第10期17卷 65-74页

作者： Giulia Merli Alessandro Becci Alessia amato Francesca Beolchini Department of Life and Environmental Sciences Polytechnic University of MarcheAncona 60131Italy

The work presented here focused on the extraction of gold (Au), silver (Ag) and palladium (Pd) from electronic waste using a solution of ammonium thiosulfate. Thiosulfate was used as a valid alternative to cyanide for precious metal extractions, due to its non-toxicity and high selectivity. The interactions between sodium thiosulfate, total ammonia/ammonium, precious metal concentrations and the particle size of the waste printed circuit boards (WPCBs) were studied by the response surface methodology (RSM) and the principal component analysis (PCA) to maximize precious metal mobilization. Au extraction reached a high efficiency with a granulometry of less than 0.25 mm, but the consumption of reagents was high. On the other hand, Ag extraction depended neither on thiosulfate/ammonia concentration nor granulometry of WPCBs and it showed efficiency of 90% also with the biggest particle size (0.50 < Ø < 1.00 mm). Pd extraction, similarly to Au, showed the best efficiency with the smallest and the medium WPCB sizes, but required less reagents compared to Au. The results showed that precious metal leaching is a complex process (mainly for Au, which requires more severe conditions in order to achieve high extraction efficiencies) correlated with reagent concentrations, precious metal concentrations and WPCB particle sizes. These results have great potentiality, suggesting the possibility of a more selective recovery of precious metals based on the different granulometry of the WPCBs. Furthermore, the high extraction efficiencies obtained for all the metals bode well in the perspective of large-scale applications.

关键词： Thiosulfate Printed circuit boards Precious metals Leaching Hydrometallurgy

Branched chain amino acids in hepatic encephalopathy and sarcopenia in liver cirrhosis:Evidence and uncertainties

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World Journal of Gastroenterology 2023年第19期29卷 2905-2915页

作者： Giuseppe Marrone amato Serra Luca Miele Marco Biolato Antonio Liguori Antonio Grieco Antonio Gasbarrini Medical and Surgical Sciences Fondazione Policlinico Universitario A.Gemelli-IRCCSUniversita Cattolica del Sacro CuoreRome 00168Italy

Liver cirrhosis is commonly associated with nutritional alterations,reported in 20% of patients with compensated disease and over 60% of patients with decompensated *** disturbances are associated with a worse prognosis and increased risk of *** levels of branched-chain amino acids(BCAAs)are decreased in patients with liver *** imbalance of amino acids levels has been suggested to be associated with the development of complications,such as hepatic encephalopathy and sarcopenia,and to affect the clinical presentation and prognosis of these *** studies investigated the efficacy of BCAAs supplementation as a therapeutic option in liver cirrhosis,but uncertainties remain about the real efficacy,the best route of administration,and dosage.

关键词： Branched-chain amino acids Hepatic encephalopathy Sarcopenia Liver cirrhosis

In vivo murine models for the study of glaucoma pathophysiology:procedures,analyses,and typical outcomes

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Annals of Eye Science 2022年第3期7卷 72-82页

作者： Rosario amato Department of Biology University of PisaPisaItaly

Background:The complexity of the glaucoma pathophysiology is directly reflected on its experimental modeling for studies about pathological mechanisms and treatment ***,a variety of in vivo models are available for the study of glaucoma,although they do not reach an exact reproduction of all aspects characterizing the human ***,a comprehensive view of disease onset,progression and treatment efficacy can only be obtained by the integration of outcomes deriving from different experimental ***:The present article summary experimental procedures and analytical methodologies related with two experimental models of glaucoma belonging to the classes of induced intraocular pressure(IOP)-elevation and genetic models,methyl cellulose(MCE)-induced ocular hypertension and DBA/2J mouse ***-point protocols are reported with a particular focus on the critical point for the realization of each ***,typical strength and drawbacks of each model are described in order to critically handle the outcomes deriving from each ***:This paper provides a guideline for the realization,analysis and expected outcomes of two models allowing to study IOP-driven neurodegenerative mechanisms rather than IOP-independent *** complementary information from these models could enhance the analysis of glaucomatous phenomena from different points of view potentiating the basic and translational study of glaucoma.

关键词： Mouse model intraocular pressure(IOP) neurodegeneration retinal ganglion cells(RGCs)

From post-COVID-19-associated myocarditis to hemopericardium: a dangerous domino effect

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Journal of Geriatric Cardiology 2023年第5期20卷 391-396页

作者： Francesco Bellanti Ripalta amato Antonio Centola Valeria Ercolano Lucia Barbera Annamaria Tesse Grazia Divittorio Cristiano Capurso Aurelio Lo Buglio Gianluigi Vendemiale Department of Medical and Surgical Sciences University of Foggiaviale Pinto 171122 FoggiaItaly Department of Internal and Geriatric Medicine Policlinico Riunitiviale Pinto 171122 FoggiaItaly Department of Cardiology Policlinico Riunitiviale Pinto 171122 FoggiaItaly

The majority of patients infected with Severe Acute Respiratory Syndrome-COrona-Virus-2(SARS-CoV-2)either completely recover from symptoms in a few days or stay asymptomatic.[1−3]Nevertheless,a consistent proportion of subjects with a history of probable or confirmed SARS-CoV-2 infection refers persistency,new occurrence,relapse,or fluctuation of symptoms,and these manifestations are defined as post-COVID-19 condition.[4]Of note,the post-acute sequelae of COVID-19 include several cardiac manifestations,including direct myocardial and pericardial injury/inflammation,as well as cardiomyopathies and arrythmias,sustained by viral infiltration and/or dysregulation of adaptive immune response.[5]Even though rare,acute myocarditis may be an important post-COVID-19 condition and may be associated with the occurrence of new-onset atrial fibrillation.

关键词： myocarditis acute sustained