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Increasingβ-hexosaminidase A activity using genetically modified mesenchymal stem cells

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Neural Regeneration Research 2024年第1期19卷 212-219页

作者： Alisa A.Shaimardanova Daria S.Chulpanova Valeriya V.solovуeva Shaza S.Issa Aysilu I.Mullagulova Angelina A.Titova Yana O.Mukhamedshina Anna V.Timofeeva Alexander M.Aimaletdinov Islam R.Nigmetzyanov Albert A.Rizvanov Institute of Fundamental Medicine and Biology Kazan Federal UniversityKazanRussia Department of Histology Cytology and EmbryologyKazan State Medical UniversityKazanRussia

GM2 gangliosidoses are a group of autosomal-recessive lysosomal storage disorde *** diseases result from a deficiency of lysosomal enzymeβ-hexosaminidase A(HexA),which is responsible for GM2 ganglioside *** deficiency causes the accumulation of GM2-gangliosides mainly in the nervous system cells,leading to severe progressive neurodegeneration and *** date,there is no treatment for these ***-mediated gene therapy is considered a promising treatment for GM2 *** study aimed to evaluate the ability of genetically modified mesenchymal stem cells(MSCs-HEXA-HEXB)to restore HexA deficiency in Tay-Sachs disease patient cells,as well as to analyze the functionality and biodistribution of MSCs in *** effectiveness of HexA deficiency cross-correction was shown in mutant MSCs upon intera ction with *** results also showed that the MSCs-HEXA-HEXB express the functionally active HexA enzyme,detectable in vivo,and intravenous injection of the cells does not cause an immune response in *** data suggest that genetically modified mesenchymal stem cells have the potentials to treat GM2 gangliosidoses.

关键词： adeno-associated viral vectors cell therapy cell-mediated gene therapy gene therapy GM2 gangliosidosis Sandhoff disease Tay-Sachs disease β-hexosaminidase

A Three-Dimensional Multi-scale Plasticity Model for Metal-Intermetallic Laminate Composites Containing Phases of the L12 Structure

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Acta Metallurgica Sinica(English Letters) 2018年第12期31卷 1265-1271页

作者： Yana D.Lipatnikova Vladimir A.Starenchenko Yuliya V.solov'eva Larisa A.Valuiskaya Tomsk State University of Architecture and Building Solyanaya Sq.2TomskRussia 634003 Siberian State Medical University 2 Moskovsky traktTomskRussia 634055

A three-dimensional plasticity model was developed and applied to metal-intermetallic laminate composites containingphases of the L12 structure. A multi-scale approach that combined the methods of continuum mechanics and dislocationkinetics was used. This model takes account of the different mechanisms of self-locking superdislocations, the dislocationsand the dislocation walls＇ density storage for each type of layer at the micro-scale. At the meso-scale, the solutions to thedislocation kinetics equations, in the form of stress-strain curves, were used to create the properties of a three-dimensionalrepresentative element. The numerical simulation study of the macroscopic deformation was carried out with the finiteelement method using the dynamic model of continuum mechanics, which included the classical conservation laws,constitutive equations and the equation of state. It was shown that the simulation results generated using this model were ingood agreement with the mechanical tests conducted on the single crystals of the L12 structure. The model provides anexcellent description of the high-temperature plastic strain superlocalization effect of single crystal intermetallics of theLI2 structure. This paper describes the numerical results of the study of the tension and compression tests of metal-intermetallic laminate composites containing phases of the L12 structure. The model allows the description of the dis-tribution of the accumulated plastic strain inhomogeneities and is capable of predicting the strengthening properties andplastic behaviour of the metal-intermetallic laminate composites containing phases of the L12 structure.

关键词： Plasticity model Metal-intermetallic laminate composites Layered composites L12 structure Tension Compression

Septic arthritis of the hand:Current issues of etiology,pathogenesis,diagnosis,treatment

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World Journal of Orthopedics 2022年第7期13卷 622-630页

作者： Konstantin V Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I solov'eva Urii E Cherkasov Department of General Surgery Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia Wound and Wound Infection Surgery State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115446Russia Department of General Surgery Physician of The Hospital for War Veterans No 3Moscow 129336Russia Department of General Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119048Russia

Septic arthritis of the hand is a serious disease that often results in dysfunction of the joint or even the need to perform amputation of the *** rank second in the frequency of occurrence after lesions of the knee *** points concerning the etiology,the timing of the development of cartilage destruction and the development of osteomyelitis,approaches to surgical treatment,the duration of antibiotic therapy,and the start of rehabilitation measures remain the subject of numerous *** on a search in the PubMed,Web of Science and Google Scholar databases down to 1990-2021,publications on septic arthritis of the hand were found and *** following inclusion criteria were used in our review:(1) Septic arthritis of the hand;(2) Published in a peer review journal;(3) Written in English;and(4) Full text version *** were excluded if they met any of the following criteria:(1) Letters;(2) Articles published in abstract form only;and(3) Cadaveric *** arthritis of the hand was characterized by the most frequent damage to the joints of the index and middle fingers(> 50% of cases).Up to 90% of cases,the infection enters the joint as a result of penetrating trauma,animal bites,*** aureus became the most frequently isolated microorganism(30%-55%),and its polyantibiotic-resistant form Methicillin-resistant Staphylococcus aureus was found,according to various sources,from 0% to 73% among all isolated Staphylococcus *** arthritis,Pasteurella multocida(6%-11%) is often isolated as a result of animal *** cartilage destruction in the experiment developed within 24-48 h after *** clinical studies,the development of osteomyelitis was noted when treatment was delayed by more than 10 d.X-ray data during the first two weeks were *** of surgical treatment of septic *** and surgical treatment,and with the development of osteomyelitis,the implementation of arthro

关键词： Septic arthritis Hand Staphylococcus aureus Metacarpophalangeal joint Interphalangeal joint Rehabilitation

Septic arthritis of the hand: From etiopathogenesis to surgical treatment

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World Journal of Orthopedics 2022年第11期13卷 993-1005页

作者： Konstantin V Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I solov’eva Irina V Gorbacheva Alexander S Vorotyntsev Andrey Y Emelyanov General Surgery Department Institute of Clinical Medicine named after N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia General Surgery Department State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115142Russia General Surgery Department The Hospital for War Veterans N3Moscow 129336Russia General Surgery Department I.M.Sechenov First Moscow State Medical UniversityMoscow 119991Russia

BACKGROUND Septic arthritis of the hand,which is the second most common after damage of the knee joint,remains one of the leading causes of temporary *** inflammation can cause dysfunction of the joint,and in the most severe cases,the need for amputation of the finger may *** results of their treatment today,especially from a functional point of view,cannot be considered *** surgical treatment is extremely important in septic arthritis of the hand,as it helps to prevent cartilage destruction and the development of *** To explore the features of the course of septic arthritis of the hand as well as approaches to surgical treatment and its results,depending on the nature of the damage to the articular *** The results of the treatment of 170 patients with septic arthritis of the hand,which were treated in the period of 2020-2021,were *** of the interphalangeal and metacarpophalangeal joints(MCP)of fingers 1,2,and 3 was more often noted in 147(81.6%)*** most common cause of arthritis was a penetrating injury as a result of household trauma(101,59.4%),animal bite(30,17.6%),and clenched fist injury(15,8.8%).Septic arthritis with contiguous osteomyelitis was observed in 98(54.4%)*** treatment was completed with drainage and irrigation of the *** mobilization was used to restore *** patients with osteomyelitis,it was aimed at the formation of *** was not ***-term results of treatment were assessed in 142(83.5%)patients within 1 mo to 12 mo after discharge from the hospital[the median was 7 mo(IQR:4-9)].RESULTS The most commonly isolated organism was Staphylococcus aureus(35.3%).The median treatment delay in patients without osteomyelitis was 5 d(IQR:4-7);for septic arthritis with contiguous osteomyelitis,it was 14 d(IQR:5-21).Radiography for osteomyelitis within 2 wk was uninformative:41.2%of diagnoses.A single surgical treatment was

关键词： Septic arthritis Osteomyelitis Hand Surgical treatment Neoarthrosis

New classification for septic arthritis of the hand

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World Journal of Orthopedics 2023年第2期14卷 85-89页

作者： Konstantin V Lipatov Arthur Asatryan George Melkonyan Aleksandr D Kazantcev Ekaterina I solov’eva Irina V Gorbacheva Alexander S Vorotyntsev Andrey Y Emelyanov Department of General Surgery Institute of Clinical Medicine Named After N.V.SklifosovskySechenov First Moscow State Medical University(Sechenov University)Moscow 119021Russia Department of Wound and Wound Infection Surgery State Budgetary Institution“City Clinical Hospital named after S.S.Yudin of Moscow Healthcare Department”Moscow 115446Russia Department of General Surgery Hospital for War Veterans№3Moscow 129336Russia Department of General Surgery I.M.Sechenov First Moscow State Medical UniversityMoscow 119048Russia

The severity of septic arthritis of the hand and the prospects for restoration of joint function are determined by a complex of factors. Among them, the leading role belongs to local changes in tissue structures. This includes the destruction of articular cartilage and bone tissue with the development of osteomyelitis, the involvement of paraarticular soft tissues in the purulent process, and the destruction of the flexor/extensor tendons of the fingers. The currently missing specialized classification of septic arthritis could help in systematizing the diseases, determining treatment tactics, and predicting the results of *** classification of septic arthritis of the hand proposed for discussion is based on the following principle: Joint-Wound-Tendon(Jx Wx Tx);Jx characterizes damage to the osteochondral structures of the joint, Wx is the presence of paraarticular purulent wounds or fistulas, and Tx is destruction of the flexor/extensor tendons of the finger. The classification of the diagnosis makes it possible to assess the nature and severity of damage to the structures of the joint and may also be useful when comparing the results of treatment of septic arthritis of the hand.

关键词： Hand Septic arthritis Classification Osteomyelitis Paraarticular wounds

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葡萄球菌性皮肤病患者血液的噬菌作用

中华医学杂志 1952年第11期 997-997页

作者： solov’eva L V 牛鼐鄂

本文是对葡萄球菌性皮肤病患者血液中的噬菌作用的研究,在用葡萄球菌性"Antifagin"治疗期前,期间和期後都作了血液的检查。用加柠檬酸盐的血液标本与葡萄球菌愿液在37℃培养30分钟,再作涂片检查。噬菌作用程度是由已吞噬细菌的白血球数...

本文是对葡萄球菌性皮肤病患者血液中的噬菌作用的研究,在用葡萄球菌性"Antifagin"治疗期前,期间和期後都作了血液的检查。用加柠檬酸盐的血液标本与葡萄球菌愿液在37℃培养30分钟,再作涂片检查。噬菌作用程度是由已吞噬细菌的白血球数目和其中所包含的细菌数目而估计的。拿250例感染葡萄球菌性皮肤病患者的噬菌作用程度和100例健康者比较,基本上没有区别。注射Antifagin期间噬菌作用程度增加,在10—12次的注射以后达最高度。

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