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Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma

World Journal of Clinical Oncology 2021年第12期12卷 1215-1226页

作者： Ekaterina Kuligina Fedor Moiseyenko Sergey Belukhin Ekaterina Stepanova Maria Zakharova Vera Chernobrivtseva Ikram Aliev Tatiana Sharabura Vladimir Moiseyenko Svetlana Aleksakhina Tatiana Laidus aleksandr Martianov Maksim Kholmatov Aldon Whitehead Grigoriy Yanus Evgeny Imyanitov Department of Tumor Biology N.N.Petrov Institute of OncologySt.-Petersburg 197758Russia Department of Medical Genetics St.-Petersburg Pediatric Medical UniversitySt.-Petersburg 194100Russia Department of Therapy City Cancer CenterSt.-Petersburg 197758Russia Department of Surgery City Cancer CenterSt.-Petersburg 197758Russia Department of Radiology City Cancer CenterSt.-Petersburg 197758Russia Internal Medicine Residency Program The University of Illinois College of MedicineChicagoIL 60612United States Department of Oncology I.I.Mechnikov Northwestern Medical UniversitySt.-Petersburg 191015Russia

BACKGROUnD The mutation-based analysis of circulating tumor DnA(ctDnA)is a promising diagnostic tool for clinical ***,it has low success rate because many cancer patients do not have detectable ctDnA in the *** To evaluate whether preoperative tumor irradiation results in a transient increase of plasma ctDnA concentration due to the induction of apoptosis in radiationexposed *** This study focused on patients with locally advanced rectal cancer,because preoperative tumor irradiation is a part of their standard treatment *** subjects,whose tumors contained KRAS,nRAS or BRAF mutations,donated serial blood samples 1 h prior to the first fraction of irradiation(at baseline),immediately after the first fraction(time 0),and 1,3,6,12,24,36,48,72 and 96 h after the first *** amount of mutated gene copies was measured by droplet digital *** Five out of nine patients were mutation-negative by ctDnA test at baseline;two of these subjects demonstrated an emergence of the mutated DnA copies in the bloodstream within the follow-up *** were 4 patients,who had detectable ctDnA in the plasma at the start of the experiment;three of them showed an evident treatment-induced increase of the content of mutated RAS/RAF *** Local tumor irradiation may facilitate the detection of tumor-specific DnA in the *** data justify further assessment of the clinical feasibility of irradiation-assisted liquid biopsy.

关键词： Liquid biopsy Rectal cancer KRAS BRAF Mutations Tumor response Radiotherapy

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