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Tumor irradiation may facilitate the detection of tumor-specific mutations in plasma

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World Journal of Clinical Oncology 2021年第12期12卷 1215-1226页

作者： Ekaterina Kuligina Fedor Moiseyenko Sergey Belukhin Ekaterina Stepanova Maria Zakharova Vera Chernobrivtseva Ikram Aliev Tatiana Sharabura Vladimir Moiseyenko Svetlana Aleksakhina Tatiana Laidus aleksandr Martianov Maksim Kholmatov Aldon Whitehead Grigoriy Yanus Evgeny Imyanitov Department of Tumor Biology N.N.Petrov Institute of OncologySt.-Petersburg 197758Russia Department of Medical Genetics St.-Petersburg Pediatric Medical UniversitySt.-Petersburg 194100Russia Department of Therapy City Cancer CenterSt.-Petersburg 197758Russia Department of Surgery City Cancer CenterSt.-Petersburg 197758Russia Department of Radiology City Cancer CenterSt.-Petersburg 197758Russia Internal Medicine Residency Program The University of Illinois College of MedicineChicagoIL 60612United States Department of Oncology I.I.Mechnikov Northwestern Medical UniversitySt.-Petersburg 191015Russia

BACKGROUnD The mutation-based analysis of circulating tumor DnA(ctDnA)is a promising diagnostic tool for clinical ***,it has low success rate because many cancer patients do not have detectable ctDnA in the *** To evaluate whether preoperative tumor irradiation results in a transient increase of plasma ctDnA concentration due to the induction of apoptosis in radiationexposed *** This study focused on patients with locally advanced rectal cancer,because preoperative tumor irradiation is a part of their standard treatment *** subjects,whose tumors contained KRAS,nRAS or BRAF mutations,donated serial blood samples 1 h prior to the first fraction of irradiation(at baseline),immediately after the first fraction(time 0),and 1,3,6,12,24,36,48,72 and 96 h after the first *** amount of mutated gene copies was measured by droplet digital *** Five out of nine patients were mutation-negative by ctDnA test at baseline;two of these subjects demonstrated an emergence of the mutated DnA copies in the bloodstream within the follow-up *** were 4 patients,who had detectable ctDnA in the plasma at the start of the experiment;three of them showed an evident treatment-induced increase of the content of mutated RAS/RAF *** Local tumor irradiation may facilitate the detection of tumor-specific DnA in the *** data justify further assessment of the clinical feasibility of irradiation-assisted liquid biopsy.

关键词： Liquid biopsy Rectal cancer KRAS BRAF Mutations Tumor response Radiotherapy

Velocity hardening influence on the martensite transformation nature in constructional average alloy steel

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广东有色金属学报 2005年第2期15卷 224-224页

作者： Tsellermaer V. V Popova n. A Klimashin S. I Tihonikova O. V Konovalov S.V kozlov E. V Gromov V. E Siberian State Industrial University Novokuznetsk 651007. Russia Tomsk State Architectural-building University Tomsk 674003Russia

The quantitative study of the hardening velocity influence on the α-phase morphology in 30Crni3MoVA (0.3% C, 1% Cr,3% ni, 1% Mo, 1% V) cast average alloy steel after gomogenization (1125℃, 13 h), normalizing (980℃,... 详细信息

关键词：马氏体钢合金钢组成成分结构参数温度

Role of Ordering Energy in Formation of Grain Structure and Special Boundaries Spectrum in Ordered Alloys with L12 Superstructure

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Journal of Materials Science & Technology 2000年第6期16卷 585-590页

作者： O.B.Perevalova (Institute of Strength Physics and Material Science, Russian Academy of Sciences, Siberian Branch pr. Academicheskii, 2/1, 634048, Tomsk, Russia) E. V.Konovalova, n.A.Koneva and E. Vkozlov (State University of Architecture and Building, Sol Inst. of Strength Phys. Tomsk 634048 Russian Federation

It was revealed that an average energy of special boundaries is proportional to APB energy in the alloys with the L12 superstructure. This fact proves the appearance of the GAPBs in the planes of location of special boundaries in coincidence sites of ordered alloys. It was determined that the more energy of special boundaries in ordered alloys, the more energy of complex stacking fault. There is a correlation between the distribution of special boundaries as a function its relative energy and ordering energy: the more ordering energy, the more degree of washed away of distribution. The correlation between average relative energy of special boundaries and ordering energy was detected: the more ordering energy, the more average energy of special boundaries. The reverse dependence between ordering energy and average number of special boundaries in grains limited by boundaries of general type was discovered.

关键词： Role of Ordering Energy in Formation of Grain Structure and Special Boundaries Spectrum in Ordered Alloys with L12 Superstructure

Evolution of structural phase states of 08Cr18ni10Ti steel subjected to high-cycle fatigue with electrostimulation

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广东有色金属学报 2005年第2期15卷 220-220页

作者： Molotova K. Ye Konovalov S. V kozlov E. V Ivanov Yu. F Gromov V. E Siberian State Industrial University Novokuznetsk 654007 Russia Tomsk State Architecture-Construction University Tomsk 634003 Russia

This work contains analysis results from the study of defective substructure and phase state of steel subjected to fatigue loading and pulse current action in order to increase its fatigue life.

关键词：钢电刺激法疲劳程度结构特性微裂纹