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Surveillance and diagnosis of hepatocellular carcinoma: A systematic review

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World Journal of Clinical Cases 2019年第16期7卷 2269-2286页

作者： Sonia Pascual Cayetano miralles Juan M Bernabé Javier Irurzun Mariana Planells Liver Unit Hospital General Universitario de AlicanteAlicante 03010Spain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHDAlicante 03010Spain Radiology Department Hospital General Universitario de AlicanteAlicante 03010Spain

BACKGROUND Hepatocellular carcinoma (HCC) appears in most of cases in patients with advanced liver disease and is currently the primary cause of death in this *** of HCC has been proposed and recommended in clinical guidelines to obtain earlier diagnosis,but it is still controversial and is not accepted *** To review the actual evidence to support the surveillance programs in patients with cirrhosis as well as the diagnosis *** Systematic review of recent literature of surveillance (tools,interval,cost-benefit,target population) and the role of imaging diagnosis (radiological non-invasive diagnosis,optimal modality and agents) of *** The benefits of surveillance of HCC,mainly with ultrasonography,have been assessed in several prospective and retrospective analysis,although the percentage of patients diagnosed in surveillance programs is still *** of HCC permits diagnosis in early stages allows better access to curative treatment and increases life expectancy in patients with *** is a tumor with special radiological characteristics in computed tomography and magnetic resonance imaging,which allows highly accurate diagnosis without routine biopsy *** actual recommendation is to perform biopsy only in indeterminate *** The evidence supports the recommendation of performing surveillance of HCC in patients with cirrhosis susceptible of treatment,using ultrasonography every 6 *** diagnosis evaluation of HCC can be established based on noninvasive imaging criteria in patients with cirrhosis.

关键词： Surveillance Hepatocellular carcinoma Ultrasonography Cirrhosis Imaging diagnosis

Intravitreal fluorogold tracing as a method to label retinal neurons and the retinal pigment epithelium

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Neural Regeneration Research 2021年第10期16卷 2000-2001页

作者： Francisco Javier Valiente-Soriano Fernando Lucas-Ruiz Juan A.miralles de Imperial-Ollero Manuel Vidal-Sanz Marta Agudo-Barriuso Departamento de Oftalmología Facultad de MedicinaUniversidad de Murcia and Instituto Murciano de Investigación Biosanitaria-Virgen de la Arrixaca(IMIB-Arrixaca)MurciaSpain

Techniques to label the neuroretina and the retinal pigment epithelium(RPE)have been the topic of many studies for *** reliability and reproducibility of these techniques are essential to investigate retinal alterations of ocular pathologies and possible *** particular,the study of the integrity of the RPE is of great importance in pathologies such as retinitis pigmentosa or age-related macular degeneration(Gu et al.,2012;Fisher and Ferrington,2018;Zhang et al.,2019).The most common approaches use antibodies to identify different cell ***,we have described a novel technique to study the integrity of the neuroretina and the RPE,as well as the functionality of the RPE in rats(Valiente-Soriano et al.,2020).

关键词： epithelium al. alterations

Present and future of new systemic therapies for early and intermediate stages of hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第19期30卷 2512-2522页

作者： Juan Jose Urquijo-Ponce Carlos Alventosa-Mateu Mercedes Latorre-Sánchez Inmaculada Castelló-miralles Moisés Diago Hepatology Unit Department of Digestive Diseases Consorcio Hospital General Universitario of ValenciaValencia 46014Spain

Hepatocellular carcinoma(HCC)is a high mortality neoplasm which usually appears on a cirrhotic *** therapeutic arsenal and subsequent prognostic outlook are intrinsically linked to the HCC stage at *** the current deployment of treatments with curative intent(liver resection/local ablation and liver transplantation)in early and intermediate stages,a high rate of HCC recurrence persists,underscoring a pivotal clinical *** systemic therapies(ST),particularly immunotherapy,have demonstrate promising outcomes in terms of increase overall survival,but they are currently bound to the advanced stage of *** review provides a comprehensive analysis of the literature,encompassing studies up to March 10,2024,evaluating the impact of novel ST in the early and intermediate HCC stages,specially focusing on the findings of neoadjuvant and adjuvant regimens,aimed at increasing significantly overall survival and recurrence-free survival after a treatment with curative *** also investigate the potential role of ST in enhancing the downstaging rate for the intermediate-stage HCC initially deemed ineligible for treatment with curative ***,we critically discuss about the current relevance of the results of these studies and the encouraging future implications of ST in the treatment schedules of early and intermediate HCC stages.

关键词： Hepatocellular carcinoma Early stage Intermediate stage Neoadjuvant Adjuvant Systemic therapy

CEO领导者对于公司在国际化路径中的绩效影响研究 ——以海尔集团为例

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CEO领导者对于公司在国际化路径中的绩效影响研究 ——以海尔集团...

作者： Jennifer miralles 大连理工大学

学位级别：硕士

本文研究了中国新兴市场公司的具体的国际化路径,阐释了领导力与中国公司成功的国际化进程中的绩效的关系.中国对外开放后,大量国际公司开始涌入国内市场。但是近年来,越来越多的处于不同市场领域的中国企业也克服了困难,在国际化路径... 详细信息

本文研究了中国新兴市场公司的具体的国际化路径,阐释了领导力与中国公司成功的国际化进程中的绩效的关系.中国对外开放后,大量国际公司开始涌入国内市场。但是近年来,越来越多的处于不同市场领域的中国企业也克服了困难,在国际化路径上取得了成功。其中,有很多因素能够促使中国企业取得成功。同时,我们也见证了中国领导者正逐渐成为促成公司优秀绩效的管理楷模。根据以上背景提出如下问题：中国企业在于国际大型企业的竞争中处于什么定位?它们如何在国际化路径上取得成功?领导者对于中国企业的国际化路径会产生什么影响?研究对象是海尔集团——家电市场的领导企业。第一部分采用描述性案例研究,基于主流的国际化理论,如新生市场定位战略和Uppsala模型,目的是分析中国企业的国际化现象。第二部分分析基于柔性领导理论进行解释性案例研究,目的是验证该理论,然后阐明领导者对于公司在国际化路径中的绩效的重要影响。本文主要运用二手数据,数据来源为显著可信的文献和海尔集团的官方网站等。本文建立了一个关于领导力对于公司绩效影响的新模型。该模型能够激励为想要在国内市场发展的同时进入国际化进程中的中国本土企业提供相关知识,同时也要意识到可能存在的很多局限性,因此需要考虑领导者在其中的影响。从研究结果来看,中国企业为了克服国内市场和国际化市场中的其他国际竞争对手的侵入威胁,可以实施创新管理系统。此外,通过适应竞争战略并加强组织有效性而产生的柔性领导力仍然适用于中国公司。

关键词：定位战略 Uppsala模型领导者影响国际化企业的绩效

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β-内啡肽与男性避孕和不育

国外医学（计划生育分册） 1990年第3期9卷 167-169页

作者： miralles-Garcia JM 余金牛

一、下丘脑-垂体已发现脑β-内啡肽(BEP)的最高浓度在下丘脑中部。BEP在促性腺激素水平抑制该激素,尤其是LH的分泌。给与纳洛酮显著增高血清LH水平,健康男子静注同类拮抗剂后24小时累积LH浓度及脉冲频率和幅度增高。但BEP的作用似非直... 详细信息

一、下丘脑-垂体已发现脑β-内啡肽(BEP)的最高浓度在下丘脑中部。BEP在促性腺激素水平抑制该激素,尤其是LH的分泌。给与纳洛酮显著增高血清LH水平,健康男子静注同类拮抗剂后24小时累积LH浓度及脉冲频率和幅度增高。但BEP的作用似非直接在垂体而是在下丘脑水平,其抑制紧张作用通过下丘脑促性腺激素释放激素(GnRH)发生。LH对GnRH的反应不因给与纳洛酮或吗啡而改变。快速给与GnRH释放不足的雄性大鼠吗啡,使其下丘脑中GnRH含量增加。

关键词：内啡肽男性避孕不育症

Peripheral nerve regeneration through nerve conduits evokes differential expression of growth-associated protein-43 in the spinal cord

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Neural Regeneration Research 2023年第8期18卷 1852-1856页

作者： Jesús Chato-Astrain Olga Roda David Sánchez-Porras Esther miralles Miguel Alaminos Fernando Campos Óscar Darío García-García Víctor Carriel Department of Histology(Tissue Engineering Group) University of GranadaInstituto de Investigación Biosanitaria ibs.GRANADAGranadaSpain Department of Human Anatomy and Embryology University of GranadaGranadaSpain Unit of Clinical Neurophysiology University Hospital San CecilioGranadaSpain

Growth-associated protein 43 plays a key role in neurite outgrowth through cytoskeleton *** have previously demonstrated that structural damage of peripheral nerves induces growth-associated protein 43 upregulation to promote growth cone ***,the limited regenerative capacity of the central nervous system due to an inhibitory environment prevents major changes in neurite outgrowth and should be presumably associated with low levels of growth-associated protein 43 ***,central alterations due to peripheral nerve damage have never been assessed using the growthassociated protein 43 *** this study,we used the tubulization technique to repair 1 cm-long nerve gaps in the rat nerve injury/repair model and detected growth-associated protein 43 expression in the peripheral and central nervous ***,histological analysis of the regeneration process confirmed an active regeneration process of the nerve gaps through the conduit from 10 days *** growth-associated protein 43 expression profile varied across regions and follow-up times,from a localized expression to an abundant and consistent expression throughout the regeneration tissue,confirming the presence of an active nerve regeneration ***,spinal cord changes were also histologically assessed,and no apparent changes in the structural and cellular organization were observed using routine staining ***,remarkable differences and local changes appeared in growth-associated protein 43 expression at the spinal cord level,in particular at 20 days post-repair and ***-associated protein 43 protein was first localized in the gracile fasciculus and was homogeneously distributed in the left posterior *** findings differed from the growth-associated protein 43 pattern observed in the healthy control,which did not express growth-associated protein 43 at these *** results revealed a differential expression in growth-associate

关键词： growth-associated protein 43(GAP-43) immunohistochemistry nerve guide nerve tissue regeneration peripheral nerve repair spinal cord tissue engineering

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韦戈大学

安家 2007年第11期 190-191页

作者： Enric miralles Benedetta Tagliabue miralles Tagliabue—EMBT

做一个特别的设计,为一所大学在未来的姿态和在此地所持有的品质的重新定义,也许正合适宜。我们从看上去背道而驰的两个方向出发,因为他们已经惯于这里早已存在的两种不同品质的旧有建筑。

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生命之光巴塞罗那KáLIDA SANT PAU癌症疗养中心

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室内设计与装修 2019年第8期 42-47页

作者：〔西班牙〕miralles TAGLIABUE EMBT Lluc miralles(摄) 海棠(编译) miralles TAGLIABUE EMBT

KáLIDA SANT PAU中心是一个为癌症患者及其家人、朋友提供情感交流和社交的场所。作为对传统医疗的补充,它如同一个家,向人们敞开着怀抱。在这里,患者可以得到专业医疗人士的帮助。该疗养中心位于西班牙巴塞罗那,坐落在一个新建医院和... 详细信息

KáLIDA SANT PAU中心是一个为癌症患者及其家人、朋友提供情感交流和社交的场所。作为对传统医疗的补充,它如同一个家,向人们敞开着怀抱。在这里,患者可以得到专业医疗人士的帮助。该疗养中心位于西班牙巴塞罗那,坐落在一个新建医院和原有的新艺术风格建筑群之间,项目内包括一栋400 m^2的小型建筑和宽敞的室外花园,主要立面与区域内新规划的道路平行。建筑师的基本理念是想打造一处种植有五彩斑斓花朵的花园,因此疗养中心被设计为一个带有花园凉棚的场所,模糊了内外空间的界限。疗养中心为使用者提供了光线充足、温馨惬意、保护患者私密的庇护之地。

关键词： LIDA SANT PAU 巴塞罗那

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圣卡塔利亚市场改造

安家 2007年第11期 188-189页

作者： Enric miralles Benedetta Tagliabue miralles Tagliabue—EMBT

该项目荣获2001年卡泰罗尼亚政府奖,2005年西班牙ASCER建筑奖苏塔特威拉与巴塞罗那其他的广场不同,它本身就好像一座城市,从历史的中心这一出发点来看待它,这里的一切都变得意义深厚。现有的设计不足以承载它的丰富性,改造与重建绝非只... 详细信息

该项目荣获2001年卡泰罗尼亚政府奖,2005年西班牙ASCER建筑奖苏塔特威拉与巴塞罗那其他的广场不同,它本身就好像一座城市,从历史的中心这一出发点来看待它,这里的一切都变得意义深厚。现有的设计不足以承载它的丰富性,改造与重建绝非只是一时之作,它将在这里扎根、生长。

关键词：塔特广场