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B cell regulation in cancer and anti-tumor immunity

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Cellular & Molecular Immunology 2017年第8期14卷 662-674页

作者： Anushruti Sarvaria J alejandro Madrigal Aurore Saudemont Anthony Nolan and University College London LondonUK

The balance between immune effector cells and immunosuppressive cells and how this regulates the tumor microenvironment has been well described.A significant contribution of immune regulatory cells,including regulatory T cells,to tumor progression has been widely *** emerging body of evidence has recently recognized a role for B cells in modulating the immune response to tumors and lymphoid *** B cells(Bregs)are a newly designated subset of B cells that have been shown to play a pivotal role in regulating immune responses involved in inflammation,autoimmunity and,more recently,*** can suppress diverse cell subtypes,including T cells,through the secretion of anti-inflammatory mediators,such as IL-10,and can facilitate the conversion of T cells to regulatory T cells,thus attenuating anti-tumor immune *** B-cell subpopulations have been reported to be recruited to the tumor but to acquire their immunosuppressive properties within the tumor bed and thereby attenuate anti-tumor immune ***,despite a pivotal role for Bregs in promoting inflammation and carcinogenesis,the phenotypic diversity of the cell surface markers that are unique to Bregs remains unclear in mice and *** this review,we summarize the characteristics of Bregs and review our current knowledge of Bregs and their inhibition of anti-tumor immune responses in murine tumor models and cancer patients.

关键词： cancer immunotherapy regulatory B cells

Resilient Fault Diagnosis Under Imperfect Observations–A Need for Industry 4.0 Era

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IEEE/CAA Journal of Automatica Sinica 2020年第5期7卷 1279-1288页

作者： alejandro White Ali Karimoddini Mohammad Karimadini IEEE Vehicle Technology Directorate CCDC Army Research LaboratoryAberdeen Proving GroundMD 21005 USA Department of Electrical and Computer Engineering North Carolina Agricultural and Technical State UniversityGreensboroNC 27411 USA Department of Electrical Engineering Arak University of TechnologyArak ***Iran

In smart industrial systems,in many cases,a fault can be captured as an event to represent the distinct nature of subsequent ***-based fault diagnosis techniques are capable model-based methods for diagnosing faults from a sequence of observable events executed by the system under *** event-based diagnosis techniques rely on perfect observations of observable ***,in practice,it is common to miss an observable event due to a problem in sensorreadings or communication/transmission *** paper develops a fault diagnosis tool,referred to as diagnoser,which can robustly detect,locate,and isolate occurred *** developed diagnoser is resilient against missed observations.A missed observation is detected from its successive sequence of *** detecting a missed observation,the developed diagnoser automatically resets and then,asynchronously resumes the diagnosis *** is achieved solely based on postreset/activation observations and without interrupting the performance of the system under *** concepts of asynchronous detectability and asynchronous diagnosability are *** is shown that if asynchronous detectability and asynchronous diagnosability hold,the proposed diagnoser is capable of diagnosing occurred faults under imperfect *** proposed technique is applied to diagnose faults in a manufacturing *** examples are provided to explain the details of the proposed *** result paves the way towards fostering resilient cyber-physical systems in Industry4.0 context.

关键词： Cyber-physical systems discrete event systems fault diagnosis imperfect communication imperfect observation Industry 4.0 resilience

Quantum Transport Properties of Chemically Functionalized Long Semiconducting Carbon Nanotubes

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Nano Research 2010年第4期3卷 288-295页

作者： alejandro Lopez-Bezanilla Xavier Blase Stephan Roche Commissariat a l’Energie Atomique 38054 Grenoble CedexFrance Institut Néel CNRS and UniversitéJoseph FourierB.P.16638042 Grenoble Cedex 09France CIN2(CSIC-ICN)Barcelona Campus UABE-08193 BellaterraSpain

We present a first-principles study of the electronic transport properties of micrometer long semiconducting carbon nanotubes randomly covered with carbene functional groups. Whereas prior studies suggested that metallic tubes are hardly affected by such addends, we show here that the conductance of semiconducting tubes with standard diameter is, on the contrary, severely damaged. The configurational-averaged conductance as a function of tube diameter, with a coverage of up to one hundred molecules, is extracted. Our results indicate that the search for a conductance-preserving covalent functionalization route remains a challenging issue.

关键词： Nanotubes functionalization carbene electronic transport

Development and maintenance of the ligular region of maize leaves

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Molecular Plant 2024年第8期17卷 1175-1177页

作者： Josh Strable alejandro Aragon-Raygoza Department of Molecular and Structural Biochemistry North Carolina State UniversityRaleighNCUSA

Roughly 1.2 billion tons of grain produced from maize(Zea mays)hybrids were harvested worldwide in 2022 on more than 200 million hectares(Food and Agricultural Organization statistics).Hybrid maize adapted to increased planting density,largely attributed to the upright angle of leaf blades,is a key factor for driving high grain yields over the last 50 years(Duvick et al.,2004).Leaf angle(LA)is a major breeding target for crop productivity due to its effects on canopy architecture,which impacts the amount of light intercepted by the leaf blade(Cao et al.,2022).

关键词： breeding planting maize

Central nervous system and peripheral cell labeling by vascular endothelial cadherin-driven lineage tracing in adult mice

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Neural Regeneration Research 2020年第10期15卷 1856-1866页

作者： alejandro Soto-Avellaneda Brad E.Morrison Biomolecular Ph.D.Program Boise State UniversityBoiseIDUSA Department of Biological Sciences Boise State UniversityBoiseIDUSA

Understanding the contribution of endothelial cells to the progenitor pools of adult tissues has the potential to inform therapies for human *** address whether endothelial cells transdifferentiate into non-vascular cell types,we performed cell lineage tracing analysis using transgenic mice engineered to express a fluorescent marker following activation by tamoxifen in vascular endothelial cadherin promoter-expressing cells(VEcad-CreERT2;B6 Cg-Gt(ROSA)26Sortm9(CAG-tdTomato)Hze).Activation of target-cell labeling following 1.5 months of ad libitum feeding with tamoxifen-laden chow in 4–5 month-old mice resulted in the tracing of central nervous system and peripheral cells that include:cerebellar granule neurons,ependymal cells,skeletal myocytes,pancreatic beta cells,pancreatic acinar cells,tubular cells in the renal cortex,duodenal crypt cells,ileal crypt cells,and hair follicle stem *** Nestin expression has been reported in a subset of endothelial cells,Nes-CreERT2 mice were also utilized in these *** tracing of cells in adult Nes-CreERT2 mice revealed the labeling of canonical progeny cell types such as hippocampal and olfactory granule neurons as well as ependymal ***,Nestin tracing also labeled skeletal myocytes,ileal crypt cells,and sparsely marked cerebellar granule *** findings provide support for endothelial cells as active contributors to adult tissue progenitor *** information could be of particular significance for the intravenous delivery of therapeutics to downstream endothelial-derived cellular *** animal experiments were approved by the Boise State University Institute Animal Care and Use Committee(approval No.006-AC15-018)on October 31,2018.

关键词： endothelial lineage tracing progenitor cells transdifferentiation ve-cadherin

Morphological control of cadmium sulfide nanostructures by electrophoretic deposition

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Particuology 2016年第1期14卷 73-77页

作者： alejandro Vazquez Thelma Serrano Boris Kharisov Idalia Gomez Universidad Autonoma de Nuevo Leon UANL Facultad de Ciencias Quimicas Av. Universidad S/N San Nicolas de los Garza Nuevo Leon 66451 Mexico

Thin films and one-dimensional CdS nanostructures were formed by electrophoretic deposition of nanoparticles with morphological control, Particles less than 1Ohm in diameter were prepared by a microwave assisted synthesis using trisodium citrate as capping agent. The particles were character- ized by UV-Vis spectrophotometry, dynamic light scattering, and X-ray diffraction. Nanoparticles in the resulting aqueous dispersion were electrodeposited without any further treatment on aluminum plates. The nanostructures consisted of thin films with surface roughness being tuned with the applied voltage. One-dimensional nanostructures were formed by varying the applied voltage and by changing the molar ratio of the precursors in the nanocrystal synthesis. These results illustrate two different mechanisms of electrophoretic deposition that lead to the formation of different nanostructures,

关键词： Electrophoretic deposition Nanostructure Nanoparticle

Hot corrosion mechanism of yttria-stabilized zirconia powder in the presence of molten Na_(2)SO_(4)+V_(2)O_(5) salts

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Rare Metals 2021年第5期40卷 1307-1316页

作者： Jhonattan De la Roche Juan Manuel Alvarado-Orozco alejandro Toro Tribology and Surfaces Group Universidad Nacional de ColombiaMedellin 050041Colombia Centro de Ingeniena y Desarrollo Industrial-CIDESI Queretaro 76125Mexico Consorcio de Manufactura Aditiva-CONMAD Queretaro 76125Mexico

The hot corrosion behavior of yttria-stabilized zirconia(YSZ)powder specimens exposed to Na_(2)SO_(4)/V_(2)O_(5) salts mixtures at high temperature was *** tests were carried out at 1000℃ for 10 h,the salt concentrations varied from 0.1 wt%to 1.00 wt%,and the Na_(2)SO_(4)/V_(2)O_(5) mass ratios were between 0.20 and 0.44 following a factorial design 22.X-ray diffraction(XRD)analyses of the tested samples showed with a confidence of95%that the mixture composed of 32 wt%Na_(2)SO_(4)+68 wt%V_(2)O_(5),and 1.00 wt% salt concentration led to high destabilization of the t’-YSZ phase and formation of YVO_(4) products.A second set of experiments were conducted to assess the influence of temperature on the hot corrosion response of the YSZ in the range between 490 and 1100℃.Thermogravimetric analysis(TGA)experiments and Rietveld adjustments of XRD patterns showed that the mass loss of the samples varied with testing temperature and also that the major destabilization of tetragonal phase occurred at 900℃.

关键词： Hot corrosion Molten salts Yttria-stabilized zirconia Thermal barrier coatings

Outcome of surgical resection in Klatskin tumors

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World Journal of Gastrointestinal Oncology 2013年第7期5卷 147-158页

作者： alejandro Serrablo Luis Tejedor Medicine School of Zaragoza University HPB Surgical UnitMiguel Servet University Hospital50009 ZaragozaSpain General Surgery Department Punta Europa Hospital11207 AlgecirasSpain

Cholangiocarcinomas are the second most frequent primary hepatic malignancy,and make up from 5% to 30% of malignant hepatic *** cholangiocarcinoma(HCC) is the most common type,and accounts for approximately 60% to 67% of all cholangiocarcinoma *** is not a staging system that permits us to compare all series and extract some conclusions to increase the long-survival rate in this dismal *** the extension of resection,according to the sort of HCC,is a closed *** authors defend limited resection(mesohepatectomy with S1,S1 plus S4b-S5,local excision for papillary tumours,etc.) while others insist in the compulsoriness of an extended hepatic resection with portal vein bifurcation removed to reach *** there is not an ideal adjuvant therapy,R1 resection can be justified to prolong the survival *** and mortality rates changed along the last decade,but variability is the rule,with morbidity and mortality rates ranging from 14% to 76% and from 0% to 19%,***:Surgical resection continues to be the main treatment of *** resection margins achieved with major hepatic resections are associated with improved *** management with biliary drainage,portal vein embolization and staging laparoscopy should be considered in selected *** evidence is needed to fully define the role of orthotopic liver *** and lymph node involvement worsen the prognosis and long-term survival,and surgery is the only option that can lengthen *** in adjuvant therapy are essential for improving long-term ***,the lack of effective chemotherapy drugs and radiotherapy approaches leads us to can consider R1 resection as an option,because operated patients have a longer survival rate than those who not undergo surgery.

关键词： Cholangiocarcinoma Klatskin tumor Outcome Pronostic factors Survival rate

New concepts for generating interspecies chimeras using human pluripotent stem cells

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Protein & Cell 2022年第4期13卷 234-238页

作者： alejandro De Los Angeles Jun Wu Department of Psychiatry Yale University School of MedicineNew HavenCTUSA Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA

The worldwide paucity of transplantable organs for patients is a devastating *** different approaches have been conceived to address this donor organ shortage,one strategy that has garnered significant attention recently is the prospect of producing human organs in animals through a technique called interspecies blastocyst complementation based on the generation of interspecies *** blastocyst complementation works by injecting pluripotent stem(PS)cells from one species into organogenesis-disabled blastocysts of another species(Kobayashi et al.,2010).As the chimeric embryo develops,donor cells can fill the vacated developmental organ niche and enrich in a target organ of *** principle,interspecies blastocyst complementation may one day allow the generation of human organs inside ***,some ethical issues concerning research and potential human clinical use with chimeras persist(Hyun,2019).

关键词： organs donor generating