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Strong emissions of blue-yellow-red regions of La and Ti modified KNaNbO_(3) ferroelectric ceramics

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Journal of Advanced Ceramics 2015年第3期4卷 183-189页

作者： M.D.DURRUTHY-RODRIGUEZ M.HERNANDEZ-GARCIA J.PORTELLES J.fuentes M.A.HERNANDEZ-LANDAVERDE M.RAMIREZ CARDONA J.M.YANEZ-LIMON Departamento de Fisica Aplicada Instituto de CiberneticaMatematica y FisicaCITMA15#551VedadoLa HabanaCP 10400Cuba Facultad de Fisica Universidad de La HabanaSan Lazaro y LVedadoLa HabanaCP 10400Cuba CINVESTAV-Unidad Queretaro IPNLibramiento Norponiente 2000Fracc.Real de JuriquillaCP 76230QueretaroMexico Centro de Investigaciones en Ciencias de la Tierra y Materiales Universidad Autonoma del Estado de HidalgoMexico

In this work,the results of the study on the optical properties of the perovskite structure ABO3 with La^(3+) substitution for ions K^(+) and Na^(+) in the A site and Ti^(4+) substitution for ion Nb^(5+) in the B site are *** ceramics were sintered at 1100℃ and 1190℃ and formed at 10 MPa and 80 *** ceramics were obtained with 94% of the theoretical *** piezoresponse force microscopy(PFM)showed needle-shaped grains with a size of 30 nm for the samples formed at 10 MPa at both sintering ***,the high temperature and high pressure used in formation reduced the energy of the band gap(Eg)from 3.36 to 3.09 *** emissions to 2.19,1.86,2.5,and 2.31 eV were obtained by exciting the samples at 325,373,457,and 500 nm,respectively;these emissions corresponded to blue-yellow-red regions of the visible spectrum.

关键词： emission spectra condense matter ferroelectric materials band structure X-ray diffraction(XRD)

QualiTeam: A Support Tool When Learning Software Quality and Testing Concepts

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Journal of Software Engineering and Applications 2022年第1期15卷 1-17页

作者： Jorge Cervantes-Ojeda María del Carmen Gómez-fuentes Department of Applied Mathematics and Systems Universidad Autónoma Metropolitana Mexico City Mexico

QualiTeam is a web application to support the teaching-learning process on Software Quality Assurance, Quality Control and Testing introductory concepts. It has two main objectives: to facilitate the understanding of concepts learned in theory and to facilitate the monitoring of SW projects that students develop. The system gives the teacher control and the students a guide on the activities that must be carried out throughout a software project development. QualiTeam is a tool conceived to help in the challenge of providing students with concrete examples with which they can practice and clarify the topics taught in the classroom. With it, students can apply concepts that, in the initial training of a software engineer, are generally taught only at a theoretical level such as: review process, change requests, trouble reports, document version control and testing documentation management. QualiTeam is free and available online. It has been in operation for 5 years, through which improvements have been made until achieving a quite stable version.

关键词： Software Engineering Education Review Process Testing Documentation Teaching of SW Quality Assurance

Cerium extraction by metallothermic reduction using cerium oxide powder injection

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Journal of Rare Earths 2011年第1期29卷 74-76页

作者： J.S.Luna A A.Flores V R.Muiz V A.F.fuentes J.Torres N.Rodríguez R J.C.Ortiz P.Orozco CINVESTAV Unidad Saltillo Saltillo-Monterrey Highway Km.13.5P.O.Box 66325000SaltilloCoahuilaMéxico Faculty of Engineering Autonomous Univer-sity of CoahuilaCamporedondo UnitSaltilloCoahuilaMéxico Department of Metal Mechanics Technological Institute of SaltilloV.Carranza Blvd 2400SaltilloCoahuilaZC 25280México Academic Unit of Engineering Autonomous University of CoahuilaLopez Velarde Av.ZacatecasZac.ZC 98060

This work presented the feasibility of cerium recovery by Al-Mg alloy through the metallothermic reduction of CeO2 to obtain a master alloy Al-4%Ce. The master alloy obtained in this investigation was for the grain refinement and modification of Al-Si alloys. The reagent was incorporated into a molten alloy using the submerged powder injection technique, and metallic samples were obtained during injection. Chemical and microstructural analyses （by inductively coupled plasma （ICP） and scanning electron microscopy （SEM）, respectively） confirmed the possibility of Ce uptake in the bath （0 to 4 wt.%）, as CeO2 was reduced through metallothermic reactions in the molten alloys. Based on the characterization of reaction products, the sequence of the reaction was proposed.

关键词： cerium recovery metallothermic reduction reaction products rare earths

Artificial intelligence in colorectal cancer screening in patients with inflammatory bowel disease

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Artificial Intelligence in Gastrointestinal Endoscopy 2022年第1期3卷 1-8页

作者： Kêmily fuentes Marques Alana fuentes Marques Marina Amorim Lopes Rodrigo Fedatto Beraldo Talles Bazeia Lima Ligia Yukie Sassaki Curso de Medicina Faculdades de DracenaFundação Dracenense de Educação e CulturaRua Bahia332DracenaSP17900-000São PauloBrasil Department of Internal Medicine São Paulo State UniversityMedical SchoolBotucatuBrazil

Artificial intelligence(AI)is a branch of computer science that develops intelligent *** recent years,medicine has been contemplated with this recent modality to aid in the diagnosis of diseases in several specialties,including gastroenterology and gastrointestinal *** new technology has superior ability to perform tasks mimicking human behavior and can identify possible pathological alterations,such as pre-malignant lesions and dysplasia,precursor lesions of colorectal cancer(CRC),and support medical *** is among the three most prevalent cancer types,and the second most common cause of cancer-related deaths worldwide;in addition,it is a leading cause of death in patients with inflammatory bowel disease(IBD).Patients with IBD tend to have greater inflammatory cell activity in the intestinal mucosa,which can favor cell proliferation and CRC *** can contribute to the detection of pre-neoplastic lesions in patients at risk of CRC development,such as those with extensive IBD or when additional CRC risk factors,such as smoking,are *** fact,AI systems could improve all aspects of care related to both the detection of pre-malignant and malignant lesions and the screening of patients with *** this review,we aimed to show the benefits and innovations of AI in the screening of CRC in patients with *** promising applications of AI have the potential to revolutionize clinical practice and gastrointestinal endoscopy,especially in at-risk patients,such as those with IBD.

关键词： Artificial intelligence Colorectal cancer Ulcerative colitis Crohn’s disease Inflammatory bowel disease

Preclinical models of idiosyncratic drug-induced liver injury(iDILI):Moving towards prediction

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Acta Pharmaceutica Sinica B 2021年第12期11卷 3685-3726页

作者： Antonio Segovia-Zafra Daniel E.Di Zeo-Sanchez Carlos Lopez-Gomez Zeus Perez-Valdes Eduardo Garcıa-fuentes Raul J.Andrade M.Isabel Lucena Marina Villanueva-Paz Unidad de Gestio´n Clı´nica de Gastroenterologı´a Servicio de Farmacologıa ClınicaInstituto de Investigacio´n Biomedica de Malaga-IBIMAHospital Universitario Virgen de la VictoriaUniversidad de MalagaMalaga 29071Spain Centro de Investigacion Biomedica en Red en el Area Tematica de Enfermedades Hepaticas y Digestivas(CIBERehd) Madrid 28029Spain Platform ISCIII de Ensayos Clınicos UICEC-IBIMAMalaga 29071Spain Unidad de Gestion Clınica de Aparato Digestivo Instituto de Investigacion Biomedica de Malaga(IBIMA)Hospital Universitario Virgen de la VictoriaMalaga 29010Spai

Idiosyncratic drug-induced liver injury(iDILI) encompasses the unexpected harms that prescription and non-prescription drugs,herbal and dietary supplements can cause to the *** remains a major public health problem and a major cause of drug *** the lack of biomarkers for iDILI prediction,diagnosis and prognosis,searching new models to predict and study mechanisms of iDILI is *** of the major limitations of iDILI preclinical assessment has been the lack of correlation between the markers of hepatotoxicity in animal toxicological studies and clinically significant ***,major advances in the understanding of iDILI susceptibility and pathogenesis have come from the study of well-phenotyped iDILI ***,there are many gaps for explaining all the complexity of iDILI susceptibility and ***,there is a need to optimize preclinical human in vitro models to reduce the risk of iDILI during drug ***,the current experimental models and the future directions in iDILI modelling are thoroughly discussed,focusing on the human cellular models available to study the pathophysiological mechanisms of the disease and the most used in vivo animal iDILI *** also comment about in silico approaches and the increasing relevance of patient-derived cellular models.

关键词： Drug-induced liver injury Preclinical models Mechanisms Oxidative stress Mitochondrial damage Immune response Personalized medicine

Spinal alignment evolution with age:A prospective gait analysis study

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World Journal of Orthopedics 2017年第3期8卷 256-263页

作者： Sébastien Pesenti Benjamin Blondel Emilie Peltier Elke Viehweger Vincent Pomero Guillaume Authier Stéphane fuentes Jean-Luc Jouve Pediatric orthopedics Timone Enfants Aix-Marseille University Institute of Movement Sciences (CNRS UMR 7287) Gait Analysis Laboratory Hopital Timone Enfants Aix-Marseille University Spine Unit Hopital de la Timone Spine unit Timone Aix-Marseille University Neurosurgery Timone Enfants Aix-Marseille University

AIM To describe,using gait analysis,the development of spinal motion in the growing *** Thirty-six healthy children aged from 3 to 16 years old were included in this study for a gait analysis(9m-walk).Various kinematic parameters were recorded and analyzed such as thoracic angle(TA),lumbar angle(LA)and sagittal vertical axis(SVA).The kinetic parameters were the net reaction moments(N.m/kg)at the thoracolumbar and lumbosacral *** TA and LA curves were not statistically correlated to the age(respectively,P=0.32 and P=0.41).SVA increased significantly with age(P<0.001).Moments in sagittal plane at the lumbosacral junction were statistically correlated to the age(P=0.003),underlining the fact that sagittal mechanical constraints at the lumbosacral junction increase with *** in transversal plane at the thoracolumbar and lumbosacral junctions were statistically correlated to the age(P=0.0002and P=0.0006),revealing that transversal mechanical constraints decrease with *** The kinetic analysis showed that during growth,a decrease of torsional constraint occurs while an increase of sagittal constraint is *** changes in spine biomechanics are related to the crucial role of the trunk for bipedalism acquisition,allowing stabilization despite lower limbs *** the acquisition of mature gait,the spine will mainly undergo constraints in the sagittal plane.

关键词： Sagittal balance Spine biomechanics Gait analysis Thorcic kyphosis Spine growth

Systemic epigallocatechin gallate protects against retinal degeneration and hepatic oxidative stress in the P23H-1 rat

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Neural Regeneration Research 2022年第3期17卷 625-631页

作者： Lorena Perdices Lorena fuentes-Broto Francisco Segura Ana Cavero Elvira Orduna-Hospital Gema Insa-Sánchez Ana Isabel Sánchez-Cano Laura Fernández-Sánchez Nicolás Cuenca Isabel Pinilla Aragón Institute for Health Research(IIS Aragón) ZaragozaSpain Pharmacology Physiology&Legal and Forensic MedicineUniversity of ZaragozaZaragozaSpain Department of Applied Physics University of ZaragozaZaragozaSpain Health Sciences Faculty San Jorge UniversityVillanueva de GállegoSpain Department of Ophthalmology Miguel Servet University HospitalZaragozaSpain Department of Physiology Genetics and MicrobiologyUniversity of AlicanteAlicanteSpain Department of Surgery Gynecology and ObstetricsUniversity of ZaragozaZaragozaSpain/Department of OphthalmologyLozano Blesa University HospitalZaragozaSpain

Retinitis pigmentosa(RP) is a group of inherited retinal disorders that lead to photoreceptor *** has been reported to be related to oxidative stress,autophagy,and inflammation.(-)-Epigallocatechin gallate(EGCG),the most abundant catechin-based flavonoid in green tea leaves,has significant antioxidant,anti-carcinogenic,antimicrobial,and neuroprotective ***,given its low molecular weight and hydrophilic properties,can cross the blood-retinal barrier and is able to reach different ocular tissues such as the lens,cornea,and *** has been shown to provide retinal protection against ischemia;sodium nitroprusside-,N-methyl-D-aspartate-,lipopolysaccharide-,light-,sodium iodate-,or H2 O2-induced damage and diabetic *** suggests that systemic EGCG administration has the potential to protect against retinal degenerative or neurodegenerative diseases such as *** aim of this work was to investigate whether EGCG can protect against RP progression in the animal P23 H line 1,the model of *** P23 H rats were crossed with pigmented Long Evans rats to produce offspring exhibiting the clinical features of *** P23 H rats were treated via intraperitoneal injection with saline or EGCG at a dose of 25 mg/kg every week from P100 to P160 and then compared to wild-type Long Evans *** treated with EGCG showed better visual and retinal electrical function with increased contrast sensitivity and b-wave values compared with those observed in P23 H rats treated with *** reduced lipid peroxidation and increased total antioxidant capacity and catalase and superoxide dismutase *** differences were observed in visual acuity,nitrate levels,nitrite levels or glutathione S-transferase *** conclusion,EGCG not only reduced the loss of visual function in P23 H rats but also improved the levels of antioxidant enzymes and reduced oxidative *** study was approved by the Institutional Animal Care and Use Committee(CE

关键词： antioxidants contrast sensitivity electroretinogram green tea neurodegeneration oxidative stress retinal degeneration retinitis pigmentosa systemic visual acuity

Revisit Language Modeling Competition and Extinction: A Data-Driven Validation

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Journal of Applied Mathematics and Physics 2018年第7期6卷 1558-1570页

作者： Chosila Sutantawibul Pengcheng Xiao Sarah Richie Daniela fuentes-Rivero Department of Physics University of Evansville Evansville USA Department of Mathematics University of Evansville Evansville USA

Understanding language competition and extinction is an interdisciplinary challenge, and math models provide a tool for interpreting linguistic census data and possibly predict the language shift trend at the population scale. In this study, new data from previously examined areas were modeled, specifically Catalan and Spanish in Catalonia, Spanish and English in Houston, Texas, Dutch and French in Brussels, Euskera and Spanish in Spain and French and English in Canada. Three mathematical models of the language competition have been validated. The first is the Abrams-Strogatz model, which treats populations as having two monolingual groups. The second is the Castelló model, which considers bilingual speakers. The third is the Mira model, which considers language competition when the two languages have high similarities. It was found that the some of the data matched Abrams-Strogatz original model, but some divergences could still be addressed. It was also found that the Mira model needs some improvement in how it treats the differences between languages.

关键词： Language Competition Model Parameter Estimation Nonlinear Regression

Annotated expressed sequence tags and xenobiotic detoxification in the aphid Myzus persicae （Sulzer）

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Insect Science 2007年第1期14卷 29-45页

作者： C.C. FIGUEROA N. PRUNIER-LETERME C. RISPE F. SEPOLVEDA E. fuentes-CONTRERAS B. SABATER-MUNOZ J.-C. SIMON D. TAGU Instituto de Ecologia y Evolucion Facultad de Ciencias Universidad Austral de Chile Valdivia Chile INRA Rennes UMR 1099 BiO3P INRA - Agrocampus BP 35327 35653 Le Rheucedex France and Departamento de Produccion Agrfcola Facultad de Ciencias Agrarias Universidad de Talca Talca Chile

Aphids （Hemiptera： Aphididae） are phytophagous insects that are important agricultural pests. The enormous negative economic impacts caused by aphids worldwide are well known, and are mostly due to their high multiplication rate and the transmission of phytopathogenic viruses. Aphid management strategies mainly involve chemical treatments which are pollutants and are increasingly inefficient, since aphids have developed multiple insecticide-resistant mechanisms. Among the most economically important species is the green peach aptfid Myzus persicae Sulzer （Aphididae： Macrosiphini）, which is able to colonize a wide range of host plants belonging to many different families, and transmits numerous plant viruses. Because of its large prevalence, M. persicae has been the target of massive insecticide treatments; consequently, it has evolved several insecticide-resistant mechanisms. In this work, a collection of expressed genes from M. persicae is presented in order to identify putative genes involved in xenobiotic detoxification. After cDNA cloning and sequencing, 959 expressed sequence tags （EST） were annotated. Most sequences matched known genes corresponded to metabolism proteins （26%）, ribosomal proteins （ 23 % ） and structural proteins （8%）. Among them, several sequences corresponded to proteins putatively involved in sensing, degradation or detoxification of plant xenobiotic products.

关键词： aphid detoxification EST genomics insect-plant relationships Myzuspersicae