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Individual and geospatial factors associated with receipt of colorectal cancer screening:a state-wide mixed-level analysis

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Family Medicine and community Health 2024年第S2期12卷 18-25页

作者： Jennifer E Bayly mara A Schonberg Marcia c castro Kenneth J Mukamal Beth Israel Deaconess Medical center BostonMassachusettsUSA Harvard Medical School BostonMassachusettsUSA Department of Global Health and Population Harvard T H Chan School of Public HealthBostonMassachusettsUSA

Background colorectal cancer(cRc)is the second leading cause of cancer death in US adults but can be reduced by *** roles of individual and contextual factors,and especially physician supply,in attaining universal cRc screening remains *** We used data from adults 50-75 years old participating in the 2018 New York(NY)Behavioural Risk Factor Surveillance System linked to county-level covariates,including primary care physician(PcP)density and gastroenterologist(GI)*** were analysed in *** analyses included(1)ecological and geospatial analyses of county-level cRc screening prevalence and(2)individual-level Poisson regression models of receipt of screening,adjusted for socioeconomic and county-level contextual *** Mean prevalence of up-to-date cRc screening was 71%(95%cI 70%to 73%)across NY’s 62 ***-level cRc screening demonstrated significant spatial patterning(Global Moran’s I=0.14,p=0.04),consistent with the existence of county-level contextual *** both county-level and individual-level analyses,lack of health insurance was associated with lower likelihood of up-to-date screening(?−1.09(95%cI−2.00 to-0.19);adjusted prevalence ratio 0.68(95%cI 0.60 to 0.77)),even accounting for age,race/ethnicity and *** contrast,county-level densities of both PcPs and GIs were completely unassociated with screening at either the county or individual *** expected,other determinants at the individual level included education status and *** In this state-wide representative analysis,physician density was completely unassociated with cRc screening,although health insurance status remains strongly *** similar screening environments,broadened insurance coverage for cRc screening is likely to improve screening far more effectively than increased physician supply.

关键词： state screening county

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Building Expertise on FAIR Through Evolving Bring Your Own Data(BYOD) Workshops: Describing the Data, Software, and Management-focused Approaches and Their Evolution

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Data Intelligence 2024年第2期6卷 429-456页

作者： césar H.Bernabé Lieze Thielemans Rajaram Kaliyaperumal claudio carta Shuxin Zhang celia W.G.van Gelder Nirupama Benis Luiz Olavo Bonino da Silva Santos Ronald cornet Bruna dos Santos Vieira Nawel Lalout Ines Henriques alberto c.mara ballesteros Kees Burger Martijn G.Kersloot Friederike Ehrhart Esther van Enckevort chris T.Evelo Alasdair J.G.Gray Marc Hanauer Kristina Hettne Joep de Ligt Arnaldo Pereira Nuria Queralt-Rosinach Erik Schultes Domenica Taruscio Andra Waagmeester Mark D.Wilkinson Egon L.Willighagen Mascha Jansen Barend Mons Marco Roos Annika Jacobsen Biosemantics Group Department of Human GeneticsLeiden University Medical CentreLeidenThe Netherlands NIHR Academic Fellow in General Practice University College London and The Royal Free NHS Foundation Trust National centre for Rare Diseases Istituto Superiore di SanitaRomeItaly Department of Medical Informatics Amsterdam UMC location University of AmsterdamMeibergdreef 9AmsterdamThe Netherlands Amsterdam Public Health Methodology&Digital HealthAmsterdamThe Netherlands Health-Rl UtrechtThe Netherlands Semantics Services and Cybersecurity groupUniversity of TwenteEnschedeThe Netherlands Department of Medical Imaging Radboud Institute for Health SciencesRadboud University Medical CenterNijmegenThe Netherlands Department of Medical BioSciences Radboud University Medical CenterNijmegenThe Netherlands The Duchenne Parent Project VeneendaalThe Netherlands Departamento de Biotecnologia-Biologia Vegetal Escuela Tecnica Superior de Ingenieria AgronomicaAlimentaria y de BiosistemasCentro de Biotecnologia y Genomica de PlantasUniversidad Politecnica de Madrid(UPM)-Instituto Nacional de Investigacion y Tecnologia Agraria y Alimentaria-CSIC(INIA-CSIC).Campus MontegancedoPozuelo de Alarcon(Madrid)Spain castor AmsterdamThe Netherlands Department of Bioinformatics-BiGcaT Maastricht UniversityMaastrichtThe Netherlands University Medical center Groningen University of GroningenGroningenThe Netherlands Maastricht centre for Systems Biology(MacSBio) Maastricht UniversityMaastrichtThe Netherlands Department of computer Science Heriot-Watt UniversityEdinburghUK INSERM US14-OrphanetPlateforme Maladies RaresParisFrance centre for Digital Scholarship Leiden University LibrariesThe Netherlands center for Molecular Medicine Cancer Genomics NetherlandsDepartment of GeneticsUniversity Medical Center UtrechtUniversity UtrechtThe Netherlands University of Aveiro DETI/IEETAAveiroPortugal GO FAIR Foundation LeidenThe Netherlands The Leiden Academic center for Drug Research LeidenThe Netherlands Micel

Since 2014,"Bring Your Own Data"workshops(BYODs)have been organised to inform people about the process and benefits of making resources Findable,Accessible,Interoperable,and Reusable(FAIR,and the FAIRification process).The BYOD workshops'content and format differ depending on their goal,context,and the background and needs of ***-focused BYODs educate domain experts on how to make their data FAIR to find new answers to research ***-focused BYODs promote the benefits of making data FAIR and instruct project managers and policy-makers on the characteristics of FAIRification ***-focused BYODs gather software developers and experts on FAIR to implement or improve software resources that are used to support ***,these BYODs intend to foster collaboration between different types of stakeholders involved in data management,curation,and reuse(*** experts,trainers,developers,data owners,data analysts,FAIR experts).The BYODs also serve as an opportunity to learn what kind of support for FAIRification is needed from different communities and to develop teaching materials based on practical examples and *** this paper,we detail the three different structures of the BYODs and describe examples of early BYODs related to plant breeding data,and rare disease registries and biobanks,which have shaped the structure of the *** discuss the latest insights into making BYODs more productive by leveraging our almost ten years of training experience in these workshops,including successes and encountered ***,we examine how the participants'feedback has motivated the research on FAIR,including the development of workflows and software.

关键词： FAIR FAIRification FAIR expertise Bring Your Own Data Workshop BYOD

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Hepatocellular carcinoma and food contamination: Ochratoxin A as a great prompter

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World Journal of Gastroenterology 2013年第24期19卷 3723-3725页

作者： Raphael JF Felizardo Niels OS c.mara Division of Nephrology Department of Medicine Federal University of Sao PauloSao Paulo CEP 05508-900 Brazil Department of Immunology Institute of Biomedical Sciences University of S o PauloSao Paulo CEP 05508-900 Brazil

Ochratoxin A (OTA) is a secondary metabolite of Asper-gillus and Penicillium, microorganisms that can be haz-ardous to health when present as food contaminants. OTA is a potent member of a group of mycotoxins. Prolonged exposure to mycotoxins in the diet is related to cancer, among other diseases. Hepatocellular car-cinoma (Hcc) accounts for 70%-90% of primary liver cancers and is the third leading cause of cancer-related deaths worldwide. In a recent study, Ibrahim et al proposed a correlation between the incidence of Hcc and contamination with OTA. Analysis of OTA in serum samples showed that Hcc patients had the highest incidence of OTA of the subjects examined (5-fold higher than that of the control group). OTA levels were significantly increased in Hcc patients. This study demonstrates that chronic exposure to high levels of OTA may be associated with a high risk of liver cancer development. Future epidemiologic studies of Hcc should focus on good practices in food preparation, food storage and the consumption of OTA-containing foods.

关键词： Ochratoxin A Mycotoxin Food contamination Hepatocellular carcinoma Liver cancer Egypt

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Exponential continuous Non-Parametric Neural Identifier With Predefined convergence Velocity

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IEEE/cAA Journal of Automatica Sinica 2022年第6期9卷 1049-1060页

作者： Mariana ballesteros Rita Q.Fuentes-Aguilar Isaac chairez Instituto Politécnico Nacional Centro de Innovación y Desarrollo Tecnológico en Cómputo Unidad Profesional Interdisciplinaria de Biotecnología 07340Mexico CityMexico Tecnológico de Monterrey School of Engineering and SciencesZapopanJalisco 45138Mexico Department of Bioprocesses UPIBIInstituto Politécnico Nacional07340Mexico City

This paper addresses the design of an exponential function-based learning law for artificial neural networks(ANNs)with continuous *** ANN structure is used to obtain a non-parametric model of systems with uncertainties,which are described by a set of nonlinear ordinary differential *** novel adaptive algorithms with predefined exponential convergence rate adjust the weights of the *** first algorithm includes an adaptive gain depending on the identification error which accelerated the convergence of the weights and promotes a faster convergence between the states of the uncertain system and the trajectories of the neural *** second approach uses a time-dependent sigmoidal gain that forces the convergence of the identification error to an invariant set characterized by an *** generalized volume of this ellipsoid depends on the upper bounds of uncertainties,perturbations and modeling *** application of the invariant ellipsoid method yields to obtain an algorithm to reduce the volume of the convergence region for the identification *** adaptive algorithms are derived from the application of a non-standard exponential dependent function and an associated controlled Lyapunov *** examples demonstrate the improvements enforced by the algorithms introduced in this study by comparing the convergence settings concerning classical schemes with non-exponential continuous learning *** proposed identifiers overcome the results of the classical identifier achieving a faster convergence to an invariant set of smaller dimensions.

关键词： Exponential Lyapunov functions learning laws non-parametric identifier predefined convergence rate

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State of the Art on Micromilling of Materials,a Review

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Journal of Materials Science & Technology 2012年第8期28卷 673-685页

作者： M.A.c.mara J.c. campos Rubio A.M. Abro J.P. Davim Department of Mechanical Engineering Universidade Federal de Minas GeraisAv.Ant onio Carlos6627-Pampulha Belo Horizonte MGCEP:31.270-901Brazil Department of Mechanical Engineering University of AveiroCampus Universitrio de Santiago3810-193AveiroPortugal

The trend towards miniaturization has increased dramatically over the last decade, especially within the fields concerned with bioengineering, microelectronics, and aerospace. Micromillin8 is among the principal manu- facturing processes which have allowed the development of components possessing micrometric dimensions, being used to the manufacture of both forming tools and the final product. The aim of this work is to present the principal aspects related to this technology, with emphasis on the work material requirements, tool ma- terials and geometry, cutting forces and temperature, quality of the finished product, process modelling and monitoring and machine tool requirements. It can be noticed that size effect possesses a relevant role with regard to the selection of both work material （grain size） and tooling （edge radius）. Low forces and temper- ature are recorded during micromillin8, however, the specific cutting force may reach high values because of the ploughing effect observed as the uncut chip thickness is reduced. Finally, burr formation is the principal concern with regard to the quality of the finished part.

关键词： Micro-milling Micromachining Size effect Miniaturization

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Determination of particulate polycyclic aromatic hydrocarbons in ambient air by gas chromatography-mass spectrometry after molecularly imprinted polymer extraction

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Journal of Environmental Sciences 2023年第2期124卷 644-654页

作者： Maria chiara Pietrogrande Giorgia Demaria mara Russo Department of chemical Pharmaceutical and Agraricultural SciencesUniversity of FerraraVia Fossato di Mortara 17/1944121 FerraraItaly

A solid phase extraction procedure(SPE)is described for the quantitative analysis of polycyclic aromatic hydrocarbons(PAHs)in atmospheric particulate matter(PM),as ubiquitous environmental pollutants routinely measured in air qualitymonitoring.A SPE cartridge was used based on a molecular imprinted polymer(MIP-SPE)properly tailored for selective retention of PAHs with 4 and more benzene fused *** performance of the clean-up procedure was evaluated with the specific concern of selective purification towards saturated hydrocarbons,which are the PM components mostly interfering Gc analysis of target *** optimized operative conditions,the MIP-SPE provided analyte recovery close to 95%for heavier PAHs,from benzo(α)pyrene to benzo(ghi)perylene,and close to 90%for four benzene rings PAHs,with good reproducibility(RSDs:2.5%-5.9%).Otherwise,c_(17)-c_(32) n-alkanes were nearly completely *** proposed method was critically compared with Solid Phase Micro Extraction(SPME)using a polyacrylate *** methods were successfully applied to the analysis of ambient PM2.5 samples collected at an urban polluted *** the two procedures,the MIP-SPE provided the highest recovery(R%≥93%)for PAHs with 5 and more benzene rings,but lower for lighter *** contrast,SPME showed a mean acceptable R%value(∼80%)for all the investigated PAHs,except for the heaviest PAHs in the most polluted samples(R%:110%-138%),suggesting an incomplete purification from the interfering n-hydrocarbons.

关键词： Polycyclic aromatic hydrocarbons Atmospheric particle matter Molecularly imprinted polymers-solid-phase extraction Solid phase micro extraction Gc/MS analysis

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Reconstruction of debris-flow activity in a temperate mountain forest catchment of central Mexico

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Journal of Mountain Science 2019年第9期16卷 2096-2109页

作者： Osvaldo FRANcO-RAMOS Markus STOFFEL Juan Antonio ballesteros-cANOVAS Instituto de Geografia. Universidad NacionalAutonoma de Mexico Ciudad Universitaria Coyoacan 04510 Mexico Dendrolab.ch Department of Earth Sciences University of Geneva 13 rue des Maraichers CH-1205 Geneva Switzerland climate change Impacts and Risks in the Anthropocene (c-cIA) Institute for Environmental Sciences University of Geneva 66 Boulevard Carl-Vogt CH-1205 Geneva Switzerland Department F.-A. Forelfor Environmental and Aquatic Sciences University of Geneva 66 Boulevard Carl-Vogt CH- 1205 Geneva Switzerland

The use of dendrochronology to study and date geomorphic processes in volcanic environments is still incipient, even more so on the volcanic slopes covered by temperate forests in central Mexico. Mass movements, such as debris flows, often impact forest stands where they cause damage to individual trees, thereby generating growth disturbances(GD) in the tree-ring records. The identification and dating of GD enables reconstruction of the age of trees colonizing bare surfaces after major events, but also allows the assessment of the frequency or spatial distribution of past geomorphic process activity. Here we used increment cores from 65 Pinus leiophylla, Abies religiosa, and Alnus jorullensis trees growing in the Axal gorge, on the southern slopes of La Malinche volcano, to unravel past debris-flow activity both temporally and spatially. Based on the combination of GD records, a weighted tree response index(Wit), field evidence and hydrometeorological records, we reconstructed 23 debris flows since ***, almost two-thirds of the reconstructed years with debris-flow activity in Axal gorge match with events recorded in Axaltzintle gorge located on the NE slopes of La Malinche. These findings suggest a regional triggering mechanism, most likely related to the occurrence of hurricanes. This research could be useful for disaster risk management of the La Malinche National Park.

关键词： Debris flows La Malinche volcano Dendrogeomorphology Temperate forest Hydrometeorological phenomena

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Long-term reconstruction of flash floods in the Qilian Mountains,china,based on dendrogeomorphic methods

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Journal of Mountain Science 2022年第11期19卷 3163-3177页

作者： QIE Jia-zhi ZHANG Yong TRAPPMANN Daniel ZHONG Yi-hua ballesteros-cÁNOVAS Juan Antonio FAVILLIER Adrien STOFFEL Markus Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources ResearchChinese Academy of SciencesBeijing 100101China climate change Impacts and Risks in the Anthropocene(c-cIA) Institute for Environmental SciencesUniversity of GenevaGeneva CH-1205Switzerland Dendrolab.ch Department of Earth SciencesUniversity of GenevaGeneva CH-1205Switzerland National Museum of Natural Sciences MNCN-CSICC/Serrano 115bis28006MadridSpain Department F.-A.Forel for Environmental and Aquatic Sciences University of GenevaGeneva CH-1205Switzerland

In china,flash floods are one of the main natural disasters causing loss of life and damage to *** threat of flash floods is exacerbated with climate change and increased human activities,such that the number of disasters has shown a clear upward trend in recent ***,due to the scarcity of instrumental data or overly short timeseries,we are still lacking critical data to understand spatio-temporal patterns and driving factors of extreme flash *** missing knowledge is however crucial for a proper management of these hazards,especially in remote mountain *** forested catchments,dendrogeomorphology allows the reconstruction of past process activity based on growth disturbances(GDs)in trees that have been affected by past flash ***,in our study,for the first time,we reconstruct past flash floods in the Qilian Mountains,northeast Tibetan Plateau,over past *** this end,we sampled 99 Qinghai spruce(Picea crassifolia)trees affected by flash floods,with a total of 194increment cores,and identified 302 GDs induced by past flash *** GDs have been caused by at least 21 flash floods that we are able to reconstruct over the last 170 *** position of GDs within tree rings and the intra-seasonal dating of past events also allowed discussion of the likely synoptic situations that may have led to the triggering of flash floods in the *** regression analysis confirms that significant correlation exists between cumulative maximum 5-day August-September precipitation and reconstructed flash floods,which is corresponding to the majority of scars and related tangential rows of traumatic resin ducts(TRDs)found in the latewood portion of growth *** results support the idea that abundant precipitation occurring at the end of the summer season and early fall is the key factor driving flash floods in our study *** research not only fills the gaps regarding historical flash flood histories in

关键词： Tree ring Dendrogeomorphology Flash floods Qinghai spruce Qilian Mountains

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Banach Upper Density Recurrent Points of c^0-flows

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Acta Mathematica Sinica,English Series 2016年第11期32卷 1312-1322页

作者： Qi YAN Jian Dong YIN ballesteros MARNELLIE Wei Ling WU Department of Mathematics Nanchang University

Let X denote a compact metric space with distance d and F ： X×R→ X or Ft ： X→X denote a c0-flow. From the point of view of ergodic theory, all important dynamical behaviors take place on a full measure set. The aim of this paper is to introduce the notion of Banach upper density recurrent points and to show that the closure of the set of all Banach upper density recurrent points equals the measure center or the minimal center of attraction for a c0-flow. Moreover, we give an example to show that the set of quasi-weakly almost periodic points can be included properly in the set of Banach upper density recurrent points, and point out that the set of Banach upper density recurrent points can be included properly in the set of recurrent points.

关键词： c0-flow measure centre weakly almost periodic point quasi-weakly almost periodicpoint Banach upper density recurrent point

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Uncovering the uncertainty: Risk factors and clinical relevance of P1 lesions on small bowel capsule endoscopy of anemic patients

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World Journal of Gastroenterology 2016年第38期22卷 8568-8575页

作者： Tiago cúrdia Gon?alves mara Barbosa Bruno Rosa Maria Jo?o Moreira José cotter Gastroenterology Department Hospital da Senhora da Oliveira School of Health Sciences University of Minho IcVS/3B’s PT Government Associate Laboratory

AIM To identify risk factors for P1 lesions on small bowel capsule endoscopy(SBcE) and to describe the natural history of anemic patients with such type of *** One hundred patients were consecutively selected for a case-control analysis performed between 37 cases with P1 lesions and 63 controls with negative SBcE. Age, gender, comorbidities and regular medication were collected. Rebleeding, further investigational studies and death were also analyzed during the *** No significant differences on gender, median age or charlson index were found between groups. Although no differences were found on the use of proton pump inhibitors, acetylsalicylic acid, anticoagulants or antiplatelet agents, the use of non-steroidal antiinflammatory drugs(NSAID) was associated with a higher risk of P1 lesions(OR = 12.00, 95%cI: 1.38-104.1). From the 87 patients followed at our center, 39 were submitted to additional studies for investigation of iron-deficiency anemia(IDA), and this was significantly more common in those patients with no findings on SBcE(53.7% vs 30.3%, P = 0.033). A total of 29 patients had at least one rebleeding or IDA recurrence episode and 9 patients died of non-anemia related causes but no differences were found between cases and *** P1 lesions are commonly found in patients with IDA submitted to SBcE. The use of NSAID seems to be a risk factor for P1 lesions. The outcomes of patients with P1 lesions do not differ significantly from those with P0 lesions or normal SBcE.

关键词： P1 lesions Iron-deficiency anemia Small bowel capsule endoscopy Risk factors Rebleeding

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