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Polybrominated diphenyl ethers(PBDEs)in ambient air samples at the electronic waste(e-waste)reclamation site

Waste Disposal and Sustainable Energy 2019年第1期1卷 79-89页

作者： Ajit Ghimire albert leo n.dela cruz Roberto Wong Panida navasumrit Stephania Cormier Slawomir M.Lomnicki Department of Environmental Sciences Louisiana State UniversityA&M CollegeBaton RougeLA 70803USA Department of Environmental Services City of Baton Rouge345 Chippewa StBaton RougeLA 70805USA Laboratory of Environmental Toxicology Chulabhorn Research InstituteBangkokThailand Department of Biological Sciences Louisiana State UniversityA&M CollegeBaton RougeLA 70803USA

Polybrominated diphenyl ethers(PBDEs)have been used as flame retardants in various building materials,plastic and other polymers,airplanes,electronics,*** or some of their congeners have been already banned in many countries,due to their persistency and adverse health *** this study,we are focusing on e-wastes as a source of emission of PBDEs in ambient air during reclamation *** ambient air particulate matter(PM)samples were collected at and near an e-waste reclamation site in Bangkok,*** showed the presence of various homologues,viz:tri-,tetra-,penta-,hexa-,and hepta-PBDEs in both PM2.5 and total suspended particle(TSP)*** comparison of samples as a function of distance from the reclamation site indicated elevated levels of PBDEs in close proximity to the e-waste ***,a shift in the congener pattern was observed with lower brominated PBDEs being more prevalent in nearby off-site samples as compared to the PM collected at the e-waste *** total penta-PBDEs concentration is almost double in the e-waste site PM2.5 compared to the control site *** TSP,tetra,penta,and hepta-PBDEs congeners are at higher concentrations at the e-waste sites and its vicinity compared to reference ***,a clear trend can be observed indicating a debromination of PBDEs to more toxic tri and tetra congeners during the reclamation process and PBDEs are being translocated from treated materials to ambient air *** 30 is uniquely detected in our studies as a dominant final debromination product,that can be used as a marker of thermal e-waste *** work indicates potential hazards related to the reclamation of e-wastes and remediation of sites containing *** particular,thermal treatment methods can lead to congener transformation and increased emissions of more toxic lower brominated congeners.

关键词： Polybrominated diphenyl ethers(PBDEs) PM(Particulate matter) PM2.5 TSP(Total suspended particle) e-waste(Electronic waste)

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Eosinophilic cholangitis is a potentially underdiagnosed etiology in indeterminate biliary stricture

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World Journal of Gastroenterology 2017年第6期23卷 1044-1050页

作者： Dirk Walter Sylvia Hartmann Eva Herrmann Jan Peveling-Oberhag Wolf O Bechstein Stefan Zeuzem Martin-leo Hansmann Mireen Friedrich-Rust Jorg G albert Department of Internal Medicine I Johann Wolfgang Goethe-University Hospital Dr.Senckenberg Institute for Pathology Johann Wolfgang Goethe-University Hospital Institute of Biostatistics and Mathematical Modeling Johann Wolfgang Goethe-University Hospital Department for Gastroenterology Hepatology and EndocrinologyRobert-Bosch Hospital Department of General and Visceral Surgery Johann Wolfgang Goethe-University Hospital

To investigate presence and extent of eosinophilic cholangitis (EC) as well as IgG4-related disease in patients with indeterminate biliary stricture (IBS).METHODSAll patients with diagnosis of sclerosing cholangitis (SC) and histopathological samples such as biopsies or surgical specimens at University Hospital Frankfurt from 2005-2015 were included. Histopathological diagnoses as well as further clinical course were reviewed. Tissue samples of patients without definite diagnosis after complete diagnostic work-up were reviewed regarding presence of eosinophilic infiltration and IgG4 positive plasma cells. Eosinophilic infiltration was as well assessed in a control group of liver transplant donors and patients with primary sclerosing *** hundred and thirty-five patients with SC were included. In 10/135 (13.5%) patients, no potential cause of IBS could be identified after complete diagnostic work-up and further clinical course. After histopathological review, a post-hoc diagnosis of EC was established in three patients resulting in a prevalence of 2.2% (3/135) of all patients with SC as well as 30% (3/10) of patients, where no cause of IBS was identified. 2/3 patients with post-hoc diagnosis of EC underwent surgical resection with suspicion for malignancy. Diagnosis of IgG4-related cholangitis was observed in 7/135 patients (5.1%), whereas 3 cases were discovered in post-hoc analysis. 6/7 cases with IgG4-related cholangitis (85.7%) presented with eosinophilic infiltration in addition to IgG4 positive plasma cells. There was no patient with eosinophilic infiltration in the control group of liver transplant donors (n = 27) and patients with primary sclerosing cholangitis (n = 14).COnCLUSIOnEC is an underdiagnosed benign etiology of SC and IBS, which has to be considered in differential diagnosis of IBS.

关键词： Indeterminate biliary stricture endoscopy endoscopic retrograde cholangiopancreatography eosinophilic cholangitis bile duct stenosis IgG4-related disease primary sclerosing cholangitis

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Specific bone region localization of osteolytic versus osteoblastic lesions in a patient-derived xenograft model of bone metastatic prostate cancer

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Asian Journal of Urology 2016年第4期3卷 229-239页

作者： Takeshi Hirata Seung Chol Park Michelle T.Muldong Christina n.Wu Tomonori Yamaguchi Amy Strasner Omer Raheem Hiromi Kumon Robert L.Sah nicholas A.Cacalano Catriona H.M.Jamieson Christopher J.Kane Koichi Masuda Anna A.Kulidjian Christina A.M.Jamieson Department of Urology Okayama University Graduate School of MedicineDentistry and Pharmaceutical SciencesOkayamaJapan Department of Urology Wonkwang University School of Medicine and HospitalIksanSouth Korea Moores Cancer Center University of CaliforniaSan DiegoLa JollaCAUSA Department of Urology University of CaliforniaSan DiegoLa JollaCAUSA Department of Surgery University of CaliforniaSan DiegoLa JollaCAUSA Department of Medicine University of CaliforniaSan DiegoLa JollaCAUSA Department of Orthopaedic Surgery School of MedicineUniversity of CaliforniaSan DiegoLa JollaCAUSA Department of Bioengineering University of CaliforniaSan DiegoLa JollaCAUSA Department of Radiation Oncology University of California at Los AngelesLos AngelesCAUSA

Objective:Bone metastasis occurs in up to 90%of men with advanced prostate cancer and leads to fractures,severe pain and *** metastases induce a spectrum of types of bone lesions which can respond differently to therapy even within individual prostate cancer ***,the special environment of the bone makes the disease more complicated and incurable.A model in which bone lesions are reproducibly induced that mirrors the complexity seen in patients would be invaluable for pre-clinical testing of novel *** microstructural changes in the femurs of mice implanted with PCSD1,a new patient-derived xenograft from a surgical prostate cancer bone metastasis specimen,were ***:Quantitative micro-computed tomography(micro-CT)and histological analyses were performed to evaluate the effects of direct injection of PCSD1 cells or media alone(Control)into the right femurs of Rag2/gc/male ***:Bone lesions formed only in femurs of mice injected with PCSD1 *** volume(BV)was significantly decreased at the proximal and distal ends of the femurs(pnd bone shaft diameter(pnificantly increased along the femur ***:PCSD1 cells reproducibly induced bone loss leading to osteolytic lesions at the ends of the femur,and,in contrast,induced aberrant bone formation leading to osteoblastic lesions along the femur ***,the interaction of PCSD1 cells with different bone region-specific microenvironments specified the type of bone *** approach can be used to determine if different bone regions support more therapy resistant tumor growth,thus,requiring novel treatments.

关键词： Bone metastatic prostate cancer Patient-derived xenograft microenvironment Microstructural CT Osteolytic lesions Osteoblastic lesions

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