检索结果-南通市图书馆

Difficult treatment decisions in autoimmune hepatitis

在线全文

学校读者我要写书评

暂无评论

World journal of Gastroenterology 2010年第8期16卷 934-947页

作者： albert j Czaja Division of Gastroenterology and Hepatology Mayo Clinic College of Medicine

Treatment decisions in autoimmune hepatitis are complicated by the diversity of its clinical presentations,uncertainties about its natural history,evolving opinions regarding treatment end points,varied nature of refractory disease,and plethora of alternative immu-nosuppressive agents. The goals of this article are to review the difficult treatment decisions and to provide the bases for making sound therapeutic judgments. The English literature on the treatment problems in au-toimmune hepatitis were identifi ed by Medline search up to October 2009 and 32 years of personal experi-ence. Autoimmune hepatitis may have an acute severe presentation,mild in? ammatory activity,lack autoan-tibodies,exhibit atypical histological changes (centri-lobular zone 3 necrosis or bile duct injury),or have variant features reminiscent of another disease (overlap syndrome). Corticosteroid therapy must be instituted early,applied despite the absence of symptoms,or modified in an individualized fashion. Pursuit of normal liver tests and tissue is the ideal treatment end point,but this objective must be tempered against the risk of side effects. Relapse after treatment withdrawal requires long-term maintenance therapy,preferably with azathioprine. Treatment failure or an incomplete response warrants salvage therapy that can include conventional medications in modified dose or empiricaltherapies with calcineurin inhibitors or mycophenolate mofetil. Liver transplantation supersedes empirical drug therapy in decompensated patients. Elderly and pregnant patients warrant treatment modifications. Difficult treatment decisions in autoimmune hepatitis can be simplified by recognizing its diverse manifestations and individualizing treatment,pursuing realistic goals,applying appropriate salvage regimens,and identifying problematic patients early.

关键词： Autoimmune hepatitis Fulminant hepatitis Salvage therapy Treatment end points

Liquid crystal-based structural color actuators

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applications) 2022年第9期11卷 1994-2017页

作者： Pei Zhang Laurens T.de Haan Michael G.Debije albert P.H.j.Schenning Stimuli-responsive Functional Materials and Devices Department of Chemical Engineering and ChemistryEindhoven University of TechnologyP.O.Box 5135600 MB EindhovenThe Netherlands Institute for Complex Molecular Systems Eindhoven University of TechnologyDen Dolech 25600 MB EindhovenThe Netherlands SCNU-TUE joint Lab of Device Integrated Responsive Materials(DIRM) National Center for International Research on Green OptoelectronicsSouth China Normal UniversityGuangzhou 510006China

Animals can modify their body shape and/or color for protection,camouflage and *** adaptability has inspired fabrication of actuators with structural color changes to endow soft robots with additional *** liquid crystal-based materials for actuators with structural color changes is a promising *** this review,we discuss the current state of liquid crystal-based actuators with structural color changes and the potential applications of these structural color actuators in soft robotic devices.

关键词： structural crystal approach.

基于LabVIEW的全陶瓷电主轴温度检测模块的设计与实验分析

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

机床与液压 2012年第17期40卷 60-63页

作者：吴玉厚田峰 albert j.shih 邵萌张丽秀沈阳建筑大学交通与机械工程学院 University of Michigan Ann Arbor Michigan 48105

电主轴的热态特性是电主轴整体性能的重要评价指标之一。以LabVIEW为软件平台,开发出一套专门用于全陶瓷高速电主轴的温升检测模块。该模块具有良好的实时性和可视性,能直观准确地检测出电主轴的内外温度场分布情况,并在试验中体现出良... 详细信息

电主轴的热态特性是电主轴整体性能的重要评价指标之一。以LabVIEW为软件平台,开发出一套专门用于全陶瓷高速电主轴的温升检测模块。该模块具有良好的实时性和可视性,能直观准确地检测出电主轴的内外温度场分布情况,并在试验中体现出良好的应用效果和实用价值。

关键词：陶瓷电主轴热态特性 LabVIEW软件平台温度场

It takes two to tango: Unraveling a new post-translational modification involved in SnRK2.6 activation

在线全文

学校读者我要写书评

暂无评论

Molecular Plant 2021年第11期14卷 1779-1781页

作者： Miguel Daniel-Mozo Armando albert Instituto de Quimica Ffsica Rocasolano Consejo Superior de Investigaciones Cientificas(IQFR-CSIC)Calle Serrano 11928006 MadridSpain

Protein kinases are a conserved superfamily of proteins that play an essential role in signal transduction by attaching a phosphoryl group to serine,threonine,or tyrosine residues of a protein,hence converting them to *** process,which can be reversed by protein phosphatases,regulates vital cellular processes in plants,including metabolism,proliferation,and *** is also key to trigger response mechanisms to drought,increased salinity,and other abiotic stresses(Zhu,2016).

关键词： hence reversed translational

Recent development and challenges in enhancing fire performance on wood and wood-based composites:A 10-year review from 2012 to 2021

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Bioresources and Bioproducts 2024年第1期9卷 27-42页

作者： Charles Michael albert Kang Chiang Liew Faculty of Tropical Forestry Universiti Malaysia SabahKota Kinabalu 88400Kota KinabaluSabah 88400Malaysia

Due to their durability,versatility,and aesthetic value,wood and wood-based composites are widely used as building *** fact that these materials are flammable,however,raises a major worry since they might cause fire hazards and significant loss of life and *** article investigates the variables that affect fire performance as well as the various fire-retardant treatments and their *** current developments and challenges in improving the fire performance of wood and wood-based composites treated with fire-retardant materials are summarized in this ***,organic chemicals,and densification are some recent developments in fire-retardant treatments that are also *** points from the review are summarized,along with potential areas for further research and development.

关键词： Fire performance Fire-retardant materials Wood Wood-based composite Nanoparticles coating Surface charring Bio-based fire retardant Densification

NFA:A neural factorization autoencoder based online telephony fraud detection

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Digital Communications and Networks 2024年第1期10卷 158-167页

作者： Abdul Wahid Mounira Msahli albert Bifet Gerard Memmi Department of Computer Sciences and Networks(INFRES) LTCITelecom ParisInstitut Polytechnique de ParisPalaiseau91120France Artificial Intelligence Institute The University of WaikatoPrivate Bag 31053240HamiltonNew Zealand

The proliferation of internet communication channels has increased telecom fraud,causing billions of euros in losses for customers and the industry each *** constantly find new ways to engage in illegal activity on the *** reduce these losses,a new fraud detection approach is *** fraud detection involves identifying a small number of fraudulent calls from a vast amount of call *** an effective strategy to combat fraud has become *** much effort has been made to detect fraud,most existing methods are designed for batch processing,not real-time *** solve this problem,we propose an online fraud detection model using a Neural Factorization Autoencoder(NFA),which analyzes customer calling patterns to detect fraudulent *** model employs Neural Factorization Machines(NFM)and an Autoencoder(AE)to model calling patterns and a memory module to adapt to changing customer *** evaluate our approach on a large dataset of real-world call detail records and compare it with several state-of-the-art *** results show that our approach outperforms the baselines,with an AUC of 91.06%,a TPR of 91.89%,an FPR of 14.76%,and an F1-score of 95.45%.These results demonstrate the effectiveness of our approach in detecting fraud in real-time and suggest that it can be a valuable tool for preventing fraud in telecommunications networks.

关键词： Telecom industry Streaming anomaly detection Fraud analysis Factorization machine Real-time system Security

An acoustofluidic scanning nanoscope using enhanced image stacking and processing

在线全文

学校读者我要写书评

暂无评论

Microsystems & Nanoengineering 2022年第4期8卷 191-198页

作者： Geonsoo jin joseph Rich jianping Xia albert jHe Chenglong Zhao Tony jun Huang Thomas Lord Department of Mechanical Engineering and Material Science Duke UniversityDurhamNC 27708USA Department of Biomedical Engineering Duke UniversityDurhamNC 27708USA Department of Physics University of Dayton300 College ParkDaytonOH 45469USA Department of Electro-Optics and Photonics University of Dayton300 College ParkDaytonOH 45469USA

Nanoscale optical resolution with a large field of view is a critical feature for many research and industry areas,such as semiconductor fabrication,biomedical imaging,and nanoscale material *** scanning microscopes have been developed to resolve the inverse relationship between the resolution and field of view;however,those scanning microscopes still rely upon fluorescence labeling and complex optical *** overcome these limitations,we developed a dual-camera acoustofluidic nanoscope with a seamless image merging algorithm(alphablending process).This design allows us to precisely image both the sample and the microspheres simultaneously and accurately track the particle path and ***,the number of images required to capture the entire field of view(200×200μm)by using our acoustofluidic scanning nanoscope is reduced by 55-fold compared with previous ***,the image quality is also greatly improved by applying an alpha-blending imaging technique,which is critical for accurately depicting and identifying nanoscale objects or *** dual-camera acoustofluidic nanoscope paves the way for enhanced nanoimaging with high resolution and a large field of view.

关键词： image overcome stacking

Elderly patients with acute coronary syndromes: a continuous tsunami

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

journal of Geriatric Cardiology 2019年第2期16卷 100-102页

作者： Francesc Formiga albert Ariza-Sole Geriatric Medicine Unit Internal Medicine DepartmentBellvitge University HospitalL Hospitalet de LlobregatBarcelonaSpain Department of Cardiology Bellvitge University HospitalL'Hospitalet de LlobregatBarcelonaSpain

The progressive ageing of the population and the high incidence of acute coronary syndromes(ACS)in the elderly is leading to an important increase in the number of elderly patients admitted for ACS.[1]Nevertheless,the information about the optimal clinical management in this age group is scarce due to the exclusion of older patients from clinical trials.[2]Higher comorbidity and frailty are common in this clinical setting and they are associated with higher rates of complications and consumption of healthcare resources.[3]These are the main reasons for launching this special issue about management of ACS in the elderly,in which several experts in the field address some of the most important questions about how to deal with ACS in patients at older ages.

关键词： Acute coronary syndromes Management Prognosis The elderly

Highly efficient synthesis of β-amino esters via Mannich-type reaction under solvent-free conditions using ZnCl_2 catalyst

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2009年第4期20卷 407-410页

作者： albert S.C.Chan School of Pharmaceutical Science Sun Yat-Sen University

β-Amino esters were synthesized via ZnCl2-catalyzed Mannich-type reaction of imines and malonate esters under solvent-free conditions in 6 min. The β-amino ester was converted into the corresponding aspartic acid de... 详细信息

关键词： β-Amino esters Aspartic acid derivativates Mannich-type reaction Solvent-free Krapcho decarboxylation reaction Zinc chloride