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Tissue engineering using mesenchymal stem cells with periosteal wrap for bone defect repair in rabbits

Plastic and Aesthetic Research 2015年第1期2卷 340-345页

作者： Trung-Hau LêThua Dang-Nhat Pham Khanh-Linh Lê Minh-Tuan Lê Quang-Ton-Quyen Nguyen Phan-Huy Nguyen Ngoc-Vu Tran Ngoc-Luong Nguyen Willy Boeckx albert demey Department of Plastic Reconstructive and Hand SurgeryCenter of Orthopaedic and Plastic SurgeryHue Central HospitalHue City 531120Vietnam Department of Hematology Hue Central HospitalHue City 531120Vietnam Department of Biology College of SciencesHue UniversityHue City 521120Vietnam Department of Plastic Surgery Brugmann University HospitalUniversitélibre de Bruxelles1020 BrusselsBelgium

Aim:Mesenchymal stem cells(MSCs)are an excellent potential source of cells for bone tissue engineering due to their excellent renewal ability and osteogenic differentiation *** study was designed to evaluate the bone formation properties of a demineralized cancellous bone scaffold seeded with MSCs,with or without periosteum,in a critical size bone defect model in ***:Rabbit culture-expanded bone marrow(BM)-MSCs were seeded onto a human demineralized cancellous bone(HDCB)*** defects measuring 15 mm in length were created in each radius.A total of 56 bone defects in 28 rabbits were randomly assigned to one of the 4 groups for scaffold implantation:Group 1:HDCB graft only;Group 2:periosteum-wrapped HDCB graft;Group 3:HDCB graft seeded with BM-MSCs and Group 4:periosteum-wrapped HDCB graft seeded with *** rabbits were sacrificed 12 weeks after surgery for gross observation,radiological assessment,histological analyses and biomechanical ***:New bone(NB)formation and bone healing were successfully achieved,both radiologically and histologically,on demineralized cancellous bone graft seeded with *** were improved when BM-MSCs were associated with ***:This study demonstrates that repair of bone defects in a rabbit model can be achieved through bone grafting using BM-MSCs,implanted on a demineralized cancellous bone *** formation of NB was optimized when combined with the preservation of periosteum at the site of injury.

关键词： Bone defects bone marrow bone tissue engineering mesenchymal stem cells periosteum

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