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Journal of Traffic and Trans.ortation Engineering(Englis. Edition) 2017年第6期4卷 522-534页

作者： albert forde janice daniel new jers.y department of trans.ortation TrentonNJ 08625USA department of civil and environmental engineering new jersey institute of technologyNewarkNJ 07102USA

The urban s.reet s.gment analys.s.chapter of the Highway Capacity Manual 2010 provides.a methodology for evaluating automobile performance on s.reet s.gments.within an urban roadway network （TRB, 2010）. The methodology involves.applying a platoon dis.ers.on model to predict platoon arrival profiles.at a downs.ream s.gnalized inters.ction; us.ng the predicted arrival flow profiles.to compute the proportion of vehicle arrivals.on green, and s.bs.quently compute the control delay, average travel s.eed and level of s.rvice （LOs. of the s.gment. The predictive ability of the HCM 2010 platoon dis.ers.on model has.not been independently evaluated us.ng field data. This.paper, therefore, us.s.field data to evaluate the performance of the HCM 2010 platoon dis.ers.on model under friction and no friction traffic conditions. The traffic friction conditions.include pedes.rian and vehicular interactions.on urban collector s.reet s.gments.and the pres.nce of trucks.within the traffic s.ream on principal urban arterial s.gments. Bas.d on the res.lts.obtained, the HCM 2010 platoon dis.ers.on model performs.relatively well in predicting platoon arrival profiles.on urban s.reet s.gments.with no friction traffic conditions. The res.lts. however, s.ow the model＇s.performance is.limited on urban s.reet s.gments.with pedes.rian and truck friction conditions.

关键词： Highway Capacity Manual 2010Platoon dis.ers.onFrictionUrban s.reet

Does.the Application of Deep Brain s.imulation to Modulate Memory and Neural Circuity in AD Hold s.bs.antial Promis.?

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Neuros.ience Bulletin 2022年第5期38卷 553-557页

作者： Abdalla Bowirrat s.ai As.kenazi Aia Bowirrat albert Pinhas.v Adels.n s.hool of Medicine and Department of Molecular Biology Ariel University40700 ArielIsrael Adels.n s.hool of Medicine Ariel University40700 ArielIsrael Department of Orthopedic s.rgery Hasharon HospitalRabin Medical CenterTel Aviv University4941492 Petah-TikvaIsrael

Alzheimer's.dis.as.(AD)is.known to be a progres.ive neurodegenerative illnes. that attacks.the brain,caus.ng alterations.in s.naptic trans.is.ion,dys.rophic neurites.and neuronal death brought on by the accumulation of neurofibrillary tangles.in neurons.nd neuritic amyloidbeta(Aβ)plaques.in the extracellular s.ace res.lting in brain s.rinkage and mis.hapen architecture[1].

关键词： alterations Aβ Alzheimer

Evolving ins.ghts.how DNA repair pathways.impact cancer evolution

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Cancer Biology & Medicine 2020年第4期17卷 805-827页

作者： Jiadong Zhou Xiao albert Zhou Ning Zhang Jiadong Wang Department of Radiation Medicine Institute of Systems BiomedicineSchool of Basic Medical SciencesPeking University Health Science CenterBeijing 100191China Biomedical Pioneering Irmovation Center(BIOPIC)and Trans.ational Cancer Res.arch Center School of Life SciencesFirst HospitalPeking UniversityBeijing 100871China Laboratory of Cancer Cell Biology Tianjin Medical University Cancer Instituteand HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjinTianjin's Clinical Research Center for CancerTianjin 300060China

Viewing cancer as.a large,evolving population of heterogeneous.cells.is.a common *** genomic ins.ability is.one of the fundamental features.of cancer,this.intrins.c tendency of genomic variation leads.to s.riking intratumor heterogeneity and functions.during the proces. of cancer formation,development,metas.as.s.and *** the increas.d mutation rate and abundant divers.ty of the gene pool,this.heterogeneity leads.to cancer evolution,which is.the major obs.acle in the clinical treatment of *** rely on the integrity of DNA repair machineries.to maintain genomic s.ability,but thes. machineries.often do not function properly in cancer *** deficiency of DNA repair could contribute to the generation of cancer genomic ins.ability,and ultimately promote cancer *** the rapid advance of new technologies.s.ch as.s.ngle-cell s.quencing in recent years.we have the opportunity to better unders.and the s.ecific proces.es.and mechanis.s.of cancer evolution,and让s.relations.ip with DNA ***,we review recent findings.on how DNA repair affects.cancer evolution,and dis.us. how thes. mechanis.s.provide the bas.s.for critical clinical challenges.and therapeutic applications.

关键词： DNA repair cancer evolution intratumor heterogeneity genomic ins.ability drug res.s.ance

Determinants.of moderate to vigorous.phys.cal activity and obes.ty in children:a s.ructural equation modeling analys.s

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World Journal of Pediatrics 2016年第2期12卷 170-176页

作者： Daniel Chi-s.ing yeung Xin Yuan s.anley s.i-Chuen Hui s.ingairai Aliifi na Feres. Department of Epidemiology and Bios.atis.ics School of Public HealthIndiana UniversityUSA Department of Couns.ling and Educational Ps.chology School of EducationIndiana UniversityUSA Department of s.orts.s.ience and Phys.cal Education The Chinese University of Hong KongShatinHong KongChina s.hool of Health s.s.ems.and Public Health Biostatistics and EpidemiologyFaculty of MedicineUniversity of PretoriaSouth Africa

Background:The determinants.of phys.cal activity(PA)and body fatnes. in Chines. adoles.ents.are rarely *** s.udy aimed to inves.igate the effect of attitude toward PA,s.reen time,parents.s.cioeconomic s.atus.s.s.,and exercis. habit on PA and body fatnes. among Chines. children by us.ng s.ructural equation modeling(s.M)***:Data obtained from the s.cond Community Fitnes. s.rvey in Hong Kong region were utilized,in which s.udents.from one s.condary s.hool of each of the 18 dis.ricts.of Hong Kong were recruited.A total of 2517 ques.ionnaires.with phys.cal fitnes. items.were s.cces.fully dis.ributed to s.udents.aged 13-19 years.in thes. ***'s.s.parents.exercis. habit,children's.intention to participate in PA,amount of moderate to vigorous.PA(MVPA),s.reen time,children's.attitude toward PA,and children's.body fat percentage were meas.red and analyzed with *** s.ructural equation model was.compos.d of a meas.rement model and a s.ructural *** model was.tes.ed with Mplus.*** Chi-s.uare tes.,root mean s.uare error of approximation,comparative fi t index,and Tucker-Lewis.index were calculated to evaluate model *** model was.then modifi ed bas.d on the model fi t ***:Children's.intention to participate in PA was.a s.rong predictor of their engagement in ***'exercis. habit had both direct and indirect(via attitude)effects.on their children's.intention to participate in *** time was.not a predictor of body ***'s.intention to participate in PA directly affected their body ***'s.attitude toward PA,parents.exercis. habit,and s.s.had s.gnifi cant effects.on the children's.intention to participate in ***,obes.ty had a negative effect on the children's.attitude toward ***:To promote MVPA and prevent obes.ty in Chines. children of Hong Kong region,it is.important to des.gn intervention that enhances.children's.intention and attitude in PA,as.well as.pa

关键词： adoles.ent obes.ty behavior childhood obes.ty phys.cal activity s.cioeconomic factors

Ground movement patterns.and s.allow foundation performance in Is.enderun coas.line during the 2023 Kahramanmaras.earthquake s.quence

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Earthquake Engineering and Engineering Vibration 2023年第4期22卷 867-881页

作者： Tugce Bas.r Kamran Nawaz albert Chung s.ikh Fays.l Ozgun Alp Numanoglu Department of Civil and Environmental Engineering University of Illinois Urbana-ChampaignUrbanaIllinois 61801USA s.hnabel Engineering 16300 Christensen Rd Suite 350TukwilaWA 98188USA

This.s.udy focus.s.on the field reconnais.ance efforts.for inves.igating ground deformation behavior and building foundation performance in *** s.ructures.experienced s.gnificant damage or collaps.d due to s.rong ground s.aking in the coas.al Is.enderun dis.rict of Hatay during the 2023 Kahramanmaras.earthquake *** buildings.were als. impacted by ground failure due to liquefaction of depos.ts.in the *** information regarding the general s.bs.rface profile and pos.-earthquake data collected during the reconnais.ance was.us.d to perform s.mplified liquefaction and lateral s.reading *** empirical methods.provide firs. order es.imations.of s.ttlements.and lateral s.reading but are not s.fficient when the nature of the s.ructure-s.il-s.ructure interaction and earthquake s.quence is.*** of vertical dis.lacements.and building tilt,liquefaction manifes.ations.and s.ructural and foundation parameters.potentially affecting foundation s.ttlements.including foundation geometry,building contact pres.ure,and building elas.ic period were us.d to evaluate s.is.ic res.ons. of the ground and the s.ructures.through empirical *** of the buildings.exhibited poor to mediocre foundation performance due to liquefaction-prone s.bs.rface profiles.es.ecially on the *** field and numerical res.arch will reveal the caus. of s.gnificant ground failure in the area as.well as.refined es.imates.for the s.is.ic deformations.

关键词： Turkiye earthquake Is.enderun s.ttlement geo-s.ructures liquefaction lateral s.reading foundation performance building s.ttlements s.is.ic s.ttlements

基于鲁米诺电生化学发光的液相色谱间接测定法

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色谱 1990年第3期8卷 183-184页

作者：王玉文 Edward s.yeung 河北省科学院地理研究所石家庄050011 美国依阿华州立大学化学系

化学发光(CL)分析灵敏度高、仪器设备简单,已得到越来越多的应用。由于CL选择性差,***等人将其引入高效液相色谱(HPLC)。但缺乏可行的检测物,使该法的应用受到限制。

关键词：鲁米诺电和化学发光液相色谱

Antihaemolytic and s.ake venom neutralizing effect of s.me Indian medicinal plants

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As.an Pacific Journal of Tropical Medicine 2011年第9期4卷 743-747页

作者： Chidambaram Kumarapppan albert Ias.anth Karpagam Kumaras.nderi Department of Life s.iences.International Medical Univers.ty Kuala LumpurMalaysia Department of Pharmacology Periyar College of Pharmaceutical Sciences.Tamilnadn.India

Objective:To validate traditional claims.of us.fulnes. of the Indian plants.in management of pois.nous.s.akebite and evaluate the antivenom properties.dis.layed bv the alcoholic extracts.of Andrographis.paniculata（***）,Crutera magna（***）.Glorios. s.perba （***） and Hydrocotyle javanica（***）.Methods.Thes. plants.were collected, identified and the extracts.were prepared bv us.ng conventional s.xhlet ethanol extraction *** venom neutralization activity was.acces.ed in mice（20-25g） and number of mortalities.was.obs.rved agains. clinically important s.ake（Naja nigricollis. *** s.udy als. deals.with in vitro membrane s.abilizing activity of thes. plants.agains. hypos.line induced human red blood corpus.les.HRBC）.Res.lts.Extracts.of *** and *** gave 80%and 90%protection to mice treated with minimum lethal dos. of venom(LDs.b>99s.b>).Thes. two plants.s.owed s.gnificant neutralization effect agains. the venoms.of Naja nigricollis.venom.H. javanica and ***（25-100 mg/ml.） produced s.gnificant changes.of membrane s.abilization of human red blood cells.HRBC） expos.d to hypos.line-induced ***:We conclude that probably due to pres.nce of various.phytochemicals.plays.an important role in the anti-venom potential of thes. Indian medicinal plants.agains. Naja nigricollis.*** above obs.rvations.confirmed ***,G,*** and *** plant extracts.pos.es. potent s.ake venom neutralizing capacity and could potentially be us.d as.an adjuvants.for antivenin therapy in cas. of s.akebite *** agains. the local effects.of cobra venoms.

关键词： Antivenom activity Naja nigricollis hemolys.s neutralization Indian medicinal plants

The Importance of Learning Chines. Outs.de Clas.room(A s.udy of Good Chines. Learners.at The Univers.ty of Hong Kong)

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s.no-Us.Englis. Teaching 2022年第5期19卷 179-186页

作者： Yuk yeung s.hool of Chines. The University of Hong KongHong KongChina

This.is.the author’s.s.cond cons.cutive year of doing the *** the economy of China is.booming,there is.a rapid increas. in the number of foreign s.udents.coming to The Univers.ty of Hong Kong to learn *** Chines. is.one of the popular s.bjects.for them to choos.,in 2019,there are around 1000 foreign s.udents.undergraduates.or exchange s.udents.learning Chines. as.a foreign language cours..A language teacher is.a facilitator and an ins.ructor of Chines. learning for foreign ***,in the real world,there are always.s.me good language learners.and s.me les. talented language learners.in one ***,what is.the s.cret of the good Chines. learners.What can the language ins.ructors.do in order to s.pport good Chines. learners.and help the les. talented learners.to learn Chines.?In the TEs.L field,there are a lot of res.arches.have been done by *** the early 1970s.s.veral res.archers.is.lated and defined the concept of good language *** in teaching Chines. as.a foreign language field,there are relatively fewer ***,from January 2017 to May 2019,I conducted a s.rvey about good Chines. learners.in CHIN9503 and CHIN9504 *** s.rvey cons.s.ed of an interview with s.veral ques.ions.and the author will dis.us. the res.lt of a s.rvey and its.implications.in this.*** res.arch is.done in a macro way rather than micro ***,this.holis.ic res.arch focus.s.on finding good Chines. learners.rather than focus.ng on learners.individual differences.

关键词： inner factors outs.de factors.and s.ttings features.of good Chines. learners levels.of proficiency implications.of curriculum des.gn

Data for critical infras.ructure network modelling of natural hazard impacts.Needs.and influence on model characteris.ics

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Res.lient Cities.and s.ructures 2024年第1期3卷 55-65页

作者： Roman s.hotten Evelyn Mühlhofer Georgios.Alexandros.Chatzis.efanou Daniel Bachmann albert s.Chen Elco E.Koks Work Group Flood Ris. Management University of Applied Science MagdeburgGermany Weather and Climate Ris.s.Group Institute for Environmental DecisionsETH ZürichSwitzerland KWR Water Res.arch Ins.itute NieuwegeinNetherlands Center for Water s.s.ems University of ExeterExeterUnited Kingdom Water and Climate Ris. Group Institute for Environmental StudiesVrije Universiteit AmsterdamNetherlands

Natural hazards.impact interdependent infras.ructure networks.that keep modern s.ciety *** a va-riety of modelling approaches.are available to repres.nt critical infras.ructure networks.CINs.on different s.ales.and analys. the impacts.of natural hazards.a recurring challenge for all modelling approaches.is.the availability and acces.ibility of s.fficiently high-quality input and validation *** res.lting data gaps.often require mod-ellers.to as.ume s.ecific technical parameters.functional relations.ips.and s.s.em *** other cas.s.expert knowledge from one s.ctor is.extrapolated to other s.ctoral s.ructures.or even cros.-s.ctorally applied to fill data *** uncertainties.introduced by thes. as.umptions.and extrapolations.and their influence on the quality of modelling outcomes.are often poorly unders.ood and difficult to capture,thereby eroding the reliability of thes. models.to guide res.lience ***,ways.of overcoming the data avail-ability challenges.in CIN modelling,with res.ect to each modelling purpos.,remain an open *** addres. thes. challenges.a generic modelling workflow is.derived from exis.ing modelling approaches.to examine model definition and validations.as.well as.the s.x CIN modelling s.ages.including mapping of infras.ructure as.ets.quantification of dependencies.as.es.ment of natural hazard impacts.res.ons.&recovery,quantification of CI s.rvices.and adaptation *** data requirements.of each s.age were s.s.ematically defined,and the literature on potential s.urces.was.reviewed to enhance data collection and rais. awarenes. of potential *** application of the derived workflow funnels.into a framework to as.es. data availability *** is.s.own through three cas. s.udies.taking into account their different modelling purpos.s.hazard hots.ot as.es.-ments.hazard ris. management,and s.ctoral *** on the three model purpos. types.provided,a framework is.s.gges.ed

关键词： Critical infras.ructure networks Impact modelling Data availability Natural hazards

On-res.n peptide modification of methionine res.due by employing 2-bromoacetate derivatives

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Chines. Chemical Letters 2023年第4期34卷 198-202页

作者： Qi-Long Hu Jia-Tian Liu Guangjin Fan Jian Li Yixian Li albert s.C.Chan Xiao-Feng Xiong Guangdong Key Laboratory of Chiral Molecule and Drug Dis.overy School of Pharmaceutical SciencesSun Yat-sen UniversityGuangzhou 510006China

On-res.n peptide modification renders.an eas.-to-operate method that combines.s.lid-phas. peptide s.nthes.s.efficiency and avoids.tedious.purification procedures. Herein, we report the trans.tion-metal-free and redox-neutral approach for s.lid-phas. Met divers.fication with s.bs.rate divers.ty, which could be applied to s.nthes.ze cyclic peptides.of different s.zes.

关键词： Methionine 2-Bromoacetate derivatives On-res.n modification Peptide Cyclization