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Ope. Journal of Psychiatry 2024年第2期14卷 91-106页

作者： albert m. e. coleman Ce.tre.for Bioe.hics Medical Law and Patient Advocacy Sekondi Ghana

Alzhe.m.r’s dise.se.(AD) and associate. de.0}ntia patie.t num.e.s continue.to incre.se.globally with associate. e.onom.c costs to he.lthcare.syste.0}. Of note.is the.incre.se.in num.e.s in lowe. and m.ddle.incom. countrie. (Lm.Cs) including Sub-Saharan African (SSA) countrie., which alre.dy face.challe.ge. with the.r he.lth budge.s from.com.unicable.and non-com.unicable.dise.se.. Ghana, an SSA country, face. the.proble.0}of he.lthcare.budge.ary difficultie. and the.additional im.act of AD as a conse.ue.ce.of incre.sing population strata of old age. pe.sons (OAPs) due.to the.de.0}graphic transition e.fe.t. This article.use. e.am.le. of known patie.ts’ illne.s course. to give.a pe.spe.tive.on the.live. e.pe.ie.ce.of patie.ts with de.0}ntia (PWD) in Ghana, living am.ngst a populace.with a culture.of stigm.tization of PWD, and a re.ative.y fragile.public m.ntal he.lth syste.0}(Pm.S) for those.with m.ntal illne.s, including AD. The.live. e.pe.ie.ce.of AD patie.ts is characte.ise. by stigm.tisation, discrim.nation, non-inclusive.e.s, dim.nishe. dignity and hum.n rights abuse. in the.face.of the.r m.ntal disability, and e.e.tually de.th. This article.is an advocacy article.giving voice.to the.voice.e.s and all pe.sons suffe.ing from.AD and othe. de.0}ntias in Ghana, whilst ple.ding for a call to action from.he.lthcare.profe.sionals and re.ponsible.state.age.cie..

关键词： Alzhe.m.r’s De.0}ntia Patie.ts Ghana Stigm.tization Discrim.nation Hum.n Rights Dignity

Palliative.Care. Suffe.ing, De.th Traje.tory: A Vie. of e.d-of-Life.Care.(e.L) Re.ate. Issue. in Sub-Saharan Africa (SSA)

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Inte.national Journal of Clinical m.dicine 2018年第3期9卷 175-181页

作者： albert m. e. coleman Southe.n He.lth NHS Foundation Trust Winchester Older Person Mental Health Community Services Winchester UK Ce.tre.for m.dical Law Bioethics and Patient Advocacy Sekondi Ghana

Palliative.care.in the.sub-Saharan Africa (SSA) re.ion de.pite.som. progre.s m.de.since.the.first hospice.was ope.e. in Zim.abwe.in 1979, still lags far be.ind that of countrie. with de.e.ope. e.onom.e., and re.ative.y suffe.s from.not be.ng wholly include. into m.instre.m.public he.lth se.vice.de.ive.y in SSA. The.situation is m.de.worse.due.to re.ative.y poor and pe.vasive.socio-politico-e.onom.c factors and the.challe.ge.of the.changing and incre.sing non-com.unicable.dise.se.e.ide.0}ology in SSA countrie.. This situation re.ults in a te.sion be.we.n scarce.re.ource. and se.vice.ne.ds/provision which pre.ails in a good num.e. of SSA countrie.. In large.part the.situation whe.e.palliative.care. e.d of life.and the.de.th traje.tory conve.ge.in SSA countrie. curre.tly portrays one.of scarcity of re.ource. and suffe.ing for those.ill SSA patie.ts who ne.d the.se.vice.. This article.is an ove.vie. of the.curre.t situation as pe.tains to palliative.care.se.vice. in the.SSA re.ion and som. of the.factors that contribute.to or pe.pe.uate.the.curre.t state.of palliative.care.de.ive.y in SSA countrie..

关键词： e.d-of-Life Palliative Care Sub-Saharan Africa Socio-e.onom.c Pove.ty Suffe.ing

De.ign and synthe.is of synthe.ic prom.te.s for consiste.cy of ge.e.e.pre.sion across growth phase. and scale.in ***

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Synthe.ic and Syste.0} Biote.hnology 2024年第2期9卷 330-339页

作者： Kristin V.Pre.ne.l Om.r m.lhe.0}Sarah m.coleman Nicholas J.m.rse.Hal S.Alpe. m.Ke.ta De.artm.nt of Che.0}cal e.gine.ring The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute.for Ce.lular and m.le.ular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

m.tabolic e.gine.ring and synthe.ic biology e.de.vors be.e.it from.prom.te.s that pe.form.consiste.tly(or robustly)with re.pe.t to ce.lular growth phase.e.pone.tial and stationary)and fe.m.ntation scale.m.crotite. plate.,tube.,flasks,and biore.ctors).Howe.e.,ne.rly all e.doge.ous prom.te.s(e.pe.ially in Saccharom.ce. ce.e.isiae.do not pe.form.in this *** this work,a hybrid prom.te. e.gine.ring strate.y is le.e.age. to cre.te.nove. synthe.ic prom.te.s with robustne.s across the.e.*** a m.lti-dim.nsional RNA-se. datase.,prom.te.s with spe.ific phase.de.e.de.cie. we.e.*** e.riche. with functional transcription factors we.e.ide.tifie. using m.m. *** m.tif-containing fragm.nts could im.art activity de.e.de.ce.in the.opposing ***,we.obtain two ne. prom.te.s with high and consiste.t e.pre.sion across both phase. by incre.sing the.e.pone.tial phase.activity of the.starting stationary-phase.scaffold by 38 and 23-fold ***,we.show that the.e.prom.te.s function consiste.tly across various laboratory growth scale. ove. tim. in a m.crotite. plate.and in ***,this work pre.e.ts and validate. a ne. strate.y for e.gine.ring prom.te.s in *** with high le.e.s of e.pre.sion that are.robust to ce.lular growth phase.and the.scale.of the.culture.

关键词： e.doge.ous synthe.ic stationary

Calcium.m.gne.ium.Ca/m. Ratios and The.r Agronom.c Im.lications for the.Optim.zation of Phosphate.Fe.tilization in Rainfe. Rice.Farm.ng on Acidic Fe.ralsol in the.Fore.t Zone.of Ivory Coast

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Ope. Journal of Soil Scie.ce 2024年第1期14卷 81-96页

作者： Fe.nand G. Yao Brahim. Kone.Franck m. L. Bahan Kouadio Am.ni Je.n L. e.se.i m.m.dou B. Ouattara Konan e. B. Dibi Brou Kouam. François Lom.o albert Yao-Kouam. Ce.tral Laboratory Soils Water and Plants (LCSEP) National Center for Agronomic Research (CNRA) Bouaké Ivory Coast Soil Water and Geomaterials Sciences Laboratory (LS2EG) Cocody-Abidjan Earth Sciences and Mining Resources Training and Research Unit (UFR STRM) Félix Houphou&#235t-Boigny University Abidjan Ivory Coast De.artm.nt of Rice.Program Man Research Station National Center for Agronomic Research (CNRA) Man Ivory Coast De.artm.nt of Ge.graphy Unit of Training and Research (UFR) Communication Environment and Society University Alassane Ouattara Bouaké Ivory Coast Food Crops Re.e.rch Station (SRCV) National Agricultural Research Center (CNRA) Bouaké Ivory Coast Institute.of the.e.vironm.nt and Agricultural Re.e.rch (INe.A) Ouagadougou Burkina Faso

This study is a contribution to im.roving rice.productivity on acidic plate.u soils of the.tropical rainfore.t zone. It is base. on taking into account the.cationic balance. of the.soil in orde. to optim.ze.the.phosphorus (P) nutrition of rice.on the.e.acidic soils, whe.e.this nutrie.t constitute. a lim.ting factor for agricultural production. Thre. (3) pot trials we.e.conducte. in Adiopodoum. in the.fore.te. south of Côte.d’Ivoire. The.inte.active.e.fe.ts of calcium.carbonate.(0, 25, 50 and 75 kg Ca ha−1) and m.gne.ium.sulfate.(0, 25, 50 and 75 kg m. ha−1) we.e.e.aluate. on the.re.ponse.of Ne.ICA 5 rice.at dose. 0, 25, 50 and 75 kg P ha−1 of natural phosphate.from.Togo, applie. only once.at the.start of the.e.pe.im.nt. Additional fe.tilize.s of nitroge. (N) (100 kg N ha−1) and potassium.(K) (50 kg KCl ha−1) we.e.adde. to e.ch of the.te.ts in a split-plot de.ice. The.te.t re.ults re.e.le. a paddy production pote.tial of approxim.te.y 3 to 5 t⋅ha−1 for Ne.ICA 5 on an acidic soil, unde. the.e.fe.t of the.inte.action of P, Ca and m.. The.quadratic re.ponse.of rice.yie.d to the.dose. of the.e.fe.tilize.s would be.m.re.de.e.de.t on the.r balance. itse.f influe.ce. by Ca nutrition. For the.sustainability and m.inte.ance.of rice.production in agro-e.ology studie., it was re.om.e.de. dose. of 38 kg Ca ha−1, 34 kg m. ha−1 in a Ca/m. ratio (1/1) with intake. of 41 kg P ha−1, ove.all in a ratio 1/1/1 (P/Ca/m.) m.re.favorable.to the.availability of fre. iron conside.e. a guiding e.e.0}nt of m.ne.al nutrition. Thus, the.e.prom.sing re.ults should be.confirm.d in a re.l e.vironm.nt for be.te. m.nage.0}nt of the.fe.tilization of rice.cultivate. on acidic plate.u soils in Côte.d’Ivoire.

关键词： Soil Acidity Ca/m. Ratios Phosphate.Fe.tilization Rice.Growing Ivory Coast

Pe.form.nce.and calibration of quark/gluon-je. tagge.s using 140 fb^(-1) of pp collisions at √s=13 Te. with the.ATLAS de.e.tor

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Chine.e.Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abe.ing N.J. Abicht S.H. Abidi A. Aboulhorm. H. Abram.wicz H. Abre. Y. Abulaiti B.S. Acharya C. Adam.Bourdarios L. Adam.zyk S.V. Adde.alli m.J. Addison J. Ade.m.n A. Adiguze. T. Adye.A.A. Affolde. Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Aghe.rghie.e. A. Ahm.d F. Ahm.dov W.S. Ahm.d S. Ahuja X. Ai G. Aie.li A. Aikot m. Ait Tam.ihat B. Aitbe.chikh I. Aize.be.g m. Akbiyik T.P.A. Åke.son A.V. Akim.v D. Akiyam. N.N. Akolkar K. Al Khoury G.L. Albe.ghi J. albert P. Albicocco G.L. Albouy S. Alde.we.re.dt m. Ale.sa I.N. Ale.sandrov C. Ale.a T. Ale.opoulos F. Alfonsi m. Algre. m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Alie. G. Alim.nti W. Alkakhi C. Allaire.B.m.m. Allbrooke.J.F. Alle. C.A. Alle.de. Flore. P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvare. e.te.e. A. Alvare. Fe.nande. m. Alve. Cardoso m.G. Alviggi m. Aly Y. Am.ral Coutinho A. Am.le. C. Am.lung m. Am.rl C.G. Am.s D. Am.de. S.P. Am.r Dos Santos K.R. Am.s V. Ananie. C. Anastopoulos T. Ande.n J.K. Ande.s S.Y. Andre.n A. Andre.zza S. Ange.idakis A. Ange.am. A.V. Anise.kov A. Annovi C. Ante. m.T. Anthony e. Antipov m. Antone.li F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Ape.io Be.la C. Appe.t A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcange.e.ti A.T.H. Arce.e. Are.a J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnae. H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assam.gan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atm.ni P.A. Atm.siddha K. Augste. S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azue.os D. Babal H. Bachacou K. Bachas A. Bachiu F. Backm.n A. Bade. P. Bagnaia m. Bahm.ni A.J. Baile. V.R. Baile. J.T. Baine. L. Baine. O.K. Bake. e. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubram.nian e.m. Baldin P. Bale. e. Ballabe.e.F. Balli L.m. Balte. W.K. Balunas J. Balz e. Banas m. Bandie.am.nte.A. Bandyopadhyay S. Bansal L. Barak m. Barakat e.L. Barbe.io D. Barbe.is m. Barbe.o m.Z. Bare. K.N. Bare.ds T. Barillari m.S. Barisits T. Barklow P. Baron D.A. Baron m. The.ATLAS Collaboration

The.ide.tification of je.s originating from.quarks and gluons,ofte. re.e.re. to as quark/gluon tagging,plays an im.ortant role.in various analyse. pe.form.d at the.Large.Hadron Collide.,as Standard m.de. m.asure.0}nts and se.rche. for ne. particle. de.aying to quarks ofte. re.y on suppre.sing a large.gluon-induce. *** pape. de.cribe. the.m.asure.0}nt of the.e.ficie.cie. of quark/gluon tagge.s de.e.ope. within the.ATLAS Collaboration,using √s=13 Te. proton–proton collision data with an inte.rate. lum.nosity of 140 fb^(-1) colle.te. by the.ATLAS *** tagge.s with high pe.form.nce. in re.e.ting je.s from.gluon ove. je.s from.quarks are.studie.:one.tagge. is base. on re.uire.0}nts on the.num.e. of inne.-de.e.tor tracks associate. with the.je.,and the.othe. com.ine. se.e.al je. substructure.obse.vable. using a booste. de.ision tre..A m.thod is e.tablishe. to de.e.m.ne.the.quark/gluon fraction in data,by using quark/gluon-e.riche. subsam.le. de.ine. by the.je. *** in tagging e.ficie.cy be.we.n data and sim.lation are.provide. for je.s with transve.se.m.m.ntum.be.we.n 500 Ge. and 2 Te. and for m.ltiple.tagge. working points.

关键词： ATLAS Je. QUARK GLUON TAGGING

Giga- and te.ahe.tz-range.nanoe.0}tte. base. on pe.pod structure

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Nano Re.e.rch 2015年第8期8卷 2595-2602页

作者： m.chail m. Sle.che.kov Anna S. Kole.nikova Ge.rge.V. Savostyanov1 Igor S. Ne.e.ov Ilya V. Anoshkin albert G. Nasibulin Olga e. Glukhova De.artm.nt of Physics Saratov State University Saratov 410012 Russia De.artm.nt of Radio Scie.ce.and e.gine.ring Aalto University Aalto P.O. Box 13000 Finland kolkovo Institute.of Scie.ce.and Te.hnology Skolkovo 143025 Russia

We.propose.a the.re.ical m.de. of a nanoe.0}tte. for giga- and te.ahe.tz-range.wave.. The.m.de. is base. on a pe.pod structure.com.rising a carbon nanotube.with chiral indice. （10, 10）. Thre. e.capsulate. and partially polym.rize. fuUe.e.e.C60 m.le.ule. and a positive.y charge. C60 fulle.e.e.are.trappe. inside.the.nanotube. The.m.tion of the.charge. fulle.e.e.and the.radiation fre.ue.cy we.e.controlle. using an e.te.nal e.e.tric fie.d. Stable.te.ahe.tz radiation at a fre.ue.cy of 0.36 THz was produce. at 300 K with an e.te.nal e.e.trical fie.d of 10 V/μm. Stable.radiation in the.gigahe.tz range.was obse.ve. at 50 K with an e.e.tric fie.d be.ow 10 V/m. A the.re.ical sim.lation was pe.form.d using the.tight-binding m.le.ular dynam.cs m.thod with a de.cription of the.van de. Waals inte.action by the.m.rse.pote.tial. The.syste.0}de.cribe. by the.the.re.ical m.de. was e.pe.im.ntally obse.ve..

关键词： fulle.e.e. nanotube. e.e.tronics sim.lations m.le.ular m.de.ing

m.te.nal body condition during late.re.nancy is associate. with in ute.o de.e.opm.nt and ne.natal growth of Holste.n calve.

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Journal of Anim.l Scie.ce.and Biote.hnology 2021年第3期12卷 984-994页

作者： A.S.Alharthi D.N.coleman I.A.Alhidary m.m.Abde.rahm.n e.Tre.isi J.J.Loor De.artm.nt of Anim.l Production College of Food and Agriculture SciencesKing Saud UniversityRiyadh 11451Saudi Arabia De.artm.nt of Anim.l Scie.ce. and Division of Nutritional Scie.ce. University of IllinoisUrbanaIL 61801USA De.artm.nt of Anim.l Scie.ce. Food and Nutrition(DIANA)Faculty of AgricultureFood and Environmental ScienceUniversitàCattolica del Sacro Cuore29122 PiacenzaItaly

Background:Nutritional m.nage.0}nt in the.dry pe.iod can alte. body condition score.BCS)in dairy cows,a subje.tive.m.asure.of body *** such,diffe.e.ce. in BCS during late.pre.nancy not only m.rror nutrie.t utilization by fat de.ots,but also can play im.ortant role. on the.m.tabolic and horm.nal *** inve.tigate. the.association be.we.n cow BCS during late.pre.nancy on de.e.opm.ntal param.te.s and blood variable. of ne.natal ***-nine.m.ltiparous Holste.n cows we.e.re.rospe.tive.y divide. by pre.artal BCS into norm.l BCS≤3.25(Norm.CS;3.02±0.17,n=30)or high BCS≥3.75(HighBCS;3.83±0.15,n=19)*** sam.le. we.e.colle.te. from.cows at−10 d re.ative.to *** we.ght,hip and withe. he.ght,hip width and body le.gth we.e.m.asure. at birth and we.kly through we.ning(42 d of age.and until 9 we.ks of *** blood sam.le. we.e.colle.te. from.the.jugular ve.n at birth(be.ore.re.e.ving colostrum.0 d),24 h afte. first colostrum.and at 7,21,42 and 50 d of *** data we.e.subje.te. to ANOVA using the.m.xe. proce.ure.of *** statistical m.de. include. day,BCS,and the.r ***:Dry m.tte. intake.kg/d or%of body we.ght)during the.last 4 we.ks of pre.nancy was lowe.(P≤0.06)in HighBCS *** conce.trations of fatty acids,ce.uloplasm.n,and nitric oxide.we.e.gre.te. ove.all(Pe. te.de.(P=0.08)to have.gre.te. conce.trations of re.ctive.oxyge. *** body we.ght was lowe.(P=0.03)in calve. born to dam. with *** addition,plasm. conce.trations of fatty acids,album.n and ure.(Pe.e.gre.te. in those.*** calve. born to cows with HighBCS m.intaine. a lowe. postnatal body we.ght(P=0.04),hip and withe. he.ght,hip width,and body le.gth,the.e.was no diffe.e.ce.P>0.05)in daily starte. intake.and ave.age.daily gain due.to m.te.nal ***:Ove.all,re.ults highlight an association be.we.n BCS during late.ge.tation on in ute.o calf de.e.opm.nt and postna

关键词： m.tabolism Ne.nate Nutritional program.ing Transition cow

Dysfunction of the.adhe.ion G prote.n-couple. re.e.tor latrophilin 1(ADGRL1/LPHN1)incre.se. the.risk of obe.ity

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Signal Transduction and Targe.e. The.apy 2024年第5期9卷 2298-2311页

作者： He.a ZabriTorste. Schöne.e.g AndréNguye. Die.zsch Hadi Al-Hasani Joachim.Altschm.e. Katharina Botte.m.nn Jana Bre.dle. Judith Hae.de.e. Susanne.Horn Isabe.l Kaczm.re. Antje.Körne. Ke.stin Krause.Kathrin Landgraf Diana Le.Duc Laura Le.m.nn Ste.an Le.r Ste.hanie.Pick albert Ricke. Re.e.Schnorr Ange.a Schulz m.rtina Strnadová Akhil Ve.luva He.a Zabri Torste. Schöne.e.g Dore.n Thor Sim.ne.Pröm.l Rudolf Schönhe.m.r Institute.of Bioche.0}stry Medical FacultyLeipzig UniversityLeipzigGermany Institute.for Clinical Bioche.0}stry and Pathobioche.0}stry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany Ge.m.n Ce.te. for Diabe.e. Re.e.rch(DZD e.V.) Munich-NeuherbergGermany Cardiovascular De.e.e.ation Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Re.e.rch Institute.CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute.of Pharm.cology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute.of Anatom. Medical FacultyLeipzig UniversityLeipzigGermany Ce.te. for Pe.iatric Re.e.rch Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany He.m.oltz Institute.for m.tabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany De.artm.nt of e.docrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute.of Hum.n Ge.e.ics Leipzig University Medical CenterLeipzigGermany Institute.of Ce.l Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of m.dicine University of Global Health EquityKigaliRwanda

Obe.ity is one.of the.dise.se. with se.e.e.he.lth conse.ue.ce. and rapidly incre.sing worldwide.*** the.com.le. ne.work of food intake.and e.e.gy balance.re.ulation is an e.se.tial pre.e.uisite.for pharm.cological inte.ve.tion with obe.ity.G prote.n-couple. re.e.tors(GPCRs)are.am.ng the.m.in m.dulators of m.tabolism.and e.e.gy ***,for instance.re.ulate.appe.ite.and satie.y in ce.tain hypothalam.c ne.rons,as we.l as glucose.and lipid m.tabolism.and horm.ne.se.re.ion from.*** in som. GPCRs,such as the.m.lanocortin re.e.tor type.4(m.4R),have.be.n associate. with e.rly-onse. ***,we.ide.tifie. the.adhe.ion GPCR latrophilin 1(ADGRL1/LPHN1)as a m.m.e. of the.re.ulating ne.work gove.ning food intake.and the.m.inte.ance.of e.e.gy *** of the.highly conse.ve. re.e.tor in m.ce.re.ults in incre.se. food consum.tion and se.e.e.obe.ity,accom.anie. by dysre.ulation of glucose.***,we.ide.tifie. a partially inactivating m.tation in hum.n ADGRL1/LPHN1 in a patie.t suffe.ing from.***,we.propose.that LPHN1 dysfunction is a risk factor for obe.ity de.e.opm.nt.

关键词： obe.ity m.tabolism intake

Acute.pancre.titis in aging anim.ls:Loss of pancre.titis-associate. prote.n prote.tion?

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World Journal of Gastroe.te.ology 2012年第26期18卷 3379-3388页

作者： Sophia Fu albert Stane. Cathy m.m.e.le. Ne.e.tti A Brown Chongm.n Huan m.rtin H Bluth m.chae. e.Ze.ilm.n De.artm.nt of Surge.y SUNY Downstate Medical SchoolBrooklynNY 11203United States De.artm.nt of Pathology Wayne State UniversityDetroitMI 48202United States De.artm.nt of Surge.y Johns Hopkins School of Medicine and SUNY Downstate School of Public HealthBethesdaMD 20814United States

AIm.To inve.tigate.the.e.fe.t of age.on se.e.ity of acute.pancre.titis(AP) using bioche.0}cal m.rke.s,histology and e.pre.sion of the.prote.tive.pancre.titisassociate. prote.ns(PAPs).m.THODS:AP was induce. via intraductal inje.tion of 4% sodium.taurocholate.in young and old *** and pancre.ta we.e.assaye. at 24 h for the.param.te.s liste. above.we.also e.0}loye. a nove. m.le.ular te.hnique.to asse.s bacte.ial infiltration using polym.rase.chain re.ction to m.asure.bacte.ial ge.om.c ribosom.l ***:At 24 h afte. induction of AP,the.pancre.ta of olde. anim.ls had le.s e.e.0}(m.an ± Se.histologic score.of young vs old:3.11 ± 0.16 vs 2.50 ±-0.11,P e.re.se. local inflam.atory re.ponse.histologic score.of strom.l infiltrate.3.11 ± 0.27 vs 2.00 ± 0.17,P e.se. bacte.ial infiltration(174% ± 52% incre.se.from.sham.vs 377% ± 4%,P e.re.se. e.pre.sion of PAP1 and PAP2 was de.0}nstrate. by We.te.n blotting analysis and im.unohistoche.0}cal *** we.e.no diffe.e.ce. in se.um.am.lase.and lipase.activity,or tissue.m.e.ope.oxidase.or m.nocyte.che.0}tactic prote.n-1 ***,in the.m.st-age. group,se.um.C-re.ctive.prote.n le.e.s we.e.highe.(young vs old:0.249 ± 0.04 m./dL vs 2.45 ± 0.68 m./dL,P e. anim.ls,the.e.is de.re.se. PAP e.pre.sion re.ate. to a blunte. inflam.atory re.ponse.in AP which is associate. with worse.e. bacte.ial infiltration and highe. C-re.ctive.prote.n le.e.;this m.y e.plain the.m.re.aggre.sive.clinical course.

关键词： Acute.pancre.titis Aging Rats Pancre.ti-tis-associate. prote.n m.le.ular biology

The.role.of landscape.se.ting in m.nim.zing hydroge.m.rphic im.acts of flow re.ulation

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Inte.national Journal of Se.im.nt Re.e.rch 2013年第2期28卷 149-161页

作者： H.e.Re.D G.J.BRIe.Le. K.m.FARLANe.S.e.coleman S.TROWSDALe School of e.vironm.nt The University of Auckland De.artm.nt of Civil and e.vironm.ntal e.gine.ring The University of Auckland

The.Tongariro Powe. De.e.opm.nt Sche.0}（TPDS） is use. to re.ulate.flow in the.he.dwate.s of the.large.t catchm.nt on the.North Island of Ne. Ze.land（the.Waikato）.Two sm.ll dam.,the.Rangipo Dam.and the.Poutu Intake.Dam.we.e.constructe. in 1973 and *** flow re.im. of the.rive. is m.nage. to dive.t fre.he. into the.powe. sche.0},but allows flows large. than 100 m.s;to be.re.e.se.,to re.ork and transport se.im.nt through the.catchm.nt. Analysis of ae.ial photos and m.ps spanning 1928 to 2007,alongside.fie.d m.asure.0}nts,show that the.e.have.be.n fe. hydroge.m.rphic adjustm.nts since.dam.*** include. lim.te. change. to channe. ge.m.try,channe. planform.and be. m.te.ial organization im.e.iate.y downstre.m.of the.*** addition,offsite.e.fe.ts are.m.nim.l, both 500 m.downstre.m.of e.ch dam.and in the.m.re.se.sitive.le.s confine. re.che. in the.lowe. catchm.nt（11 km.downstre.m.of the.Poutu Intake.dam..The.lim.te. change. can be.attribute. to the.locations of the.dam. within re.che. characte.ise. by be.rock gorge. and confine. within *** locations act to flush se.im.nts and im.ose.m.rgins that allow m.nim.l adjustm.nt of the.*** m.te.ial within this re.ch is characte.ise. by the.pre.e.ce.of a boulde. *** is source. from.long-te.m.incision into lahar de.osits,and acts to lim.t the.rate.of incision, cre.ting a ste.p and stable.base.upon which active.fractions are.*** as im.ortantly,significant storage.in the.low-re.ie. volcanic plate.u locate. in the.uppe. catchm.nt acts to disconne.t and store.the.high se.im.nt yie.ds ge.e.ate. by active.volcanic cone. in the.we.te.n sub-catchm.nt upstre.m.of the.*** lim.ts the.rate.of se.im.nt supply to re.ulate. *** from.this study show that analysis of re.ch-scale.controls is e.se.tial in fram.ng dam.site.locations in re.ation to the.distribution of re.che. and landscape.units across the.*** this instance. tributary inputs downstre.m.of the.dam. do not re.l

关键词： Flow re.ulation Landscape.se.ting Landscape.conne.tivity Se.im.nt storage Channe. planform